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Kinetochore in Medical News

Molecule tracking reveals mechanism of chromosome separation in dividing cells

... Cancer Research Center. To understand how the kinetochore functions, the scientists sought to uncover the ... according to the researchers, is that the kinetochore has to be strong yet dynamic. It has to keep a ... "This ability," the researchers said, "allows the kinetochore to harness microtubule shortening and lengthening ...
Kinetochore in Biological News

Key mechanism in genetic inheritance during cell division identified

... cells that are responsible for the faithful segregation of chromosomes during cell division. "In test tube experiments, we've found that the kinetochore proteins form rings around the microtubules and this ring formation promotes microtubule assembly, stabilizes against disassembly, and promotes ...
Kinetochore in Biological Definition

Anaphase

... poles. This is achieved by shortening of the kinetochore microtubules, and forces are mainly exerted at ... processes. Anaphase A involves shortening kinetochore mictrotubules by depolymerisation at both ends. ... motor proteins at the kinetochores pull on the kinetochore microtubules. Anaphase B involves both the ...

Centromere

... region of a eukaryotic chromosome where the kinetochore is assembled. Thus, it is the site where ... believed to be important for the assembly of the kinetochore on the centromere and may play a role in the ... or a primary constriction, and a "diffuse" kinetochore assembles along the entire length of the ...

Mitosis

... point by which chromosomes may be secured. The kinetochore is an enormously complex structure that is not yet fully understood. The key feature of a kinetochore is that it contains a molecular motor that uses ... the cell. Proper segregation requires that every kinetochore be attached to a microtubule before separation ...

Mitosis

... point by which chromosomes may be secured. The kinetochore is an enormously complex structure that is not yet fully understood. The key feature of a kinetochore is that it contains a molecular motor that uses ... the cell. Proper segregation requires that every kinetochore be attached to a microtubule before separation ...

Meiosis

... Metaphase I In Metaphase I , the nuclear envelope has already dispersed into vesicles. Spindle fibres ( microtubules ) attach only to one kinetochore of both whole centromeres , lining up the bivalents along the equator so that each centromere is equidistant above and below the equator. The ...

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Kinetochore in Biological Dictionary

Prometaphase

... of prometaphase is completed when all of the kinetochore ... Late prophase, or prometaphase , begins ... Day, and word games. Fourteen prometaphase kinetochore microtubule bundles have been examined in ... ... of ... During prometaphase I, the outer kinetochore protein, HIM-10 (A, red), co ... B) Mitosis ...

Kinetochore

... The kinetochore is the protein structure on chromosomes ... Keywords - chromatin component, assembles the kinetochore during meiosis and mitosis ... concluded that Cid directs kinetochore formation and function by ... Perhaps most ...

Satellite RNA

... ... This alpha satellite RNA is required for the association of kinetochore proteins ... PLoS ONE: an inclusive, peer-reviewed, open-access ... the ... This alpha satellite RNA is required for the association of kinetochore proteins ... ... biology > genetics > molecular genetics ...

Centromere

... sister chromatids join in the double ... The centromere is also where kinetochore formation takes place: proteins bind on ... ... DNA segment in the yeast centromere binds to specific proteins, which, ... The kinetochore is a protein structure that forms at the centromere before mitosis. .....

Telophase

... of Telophase and Cytokinesis ... occur in telophase and cytokinesis, respectively. ... Telophase is also marked by the dissolution of the kinetochore ... In telophase , the daughter chromosomes arrive at the spindle poles and are eventually redistributed into chromatin. ... fourth ...

Spindle Fibers

... spindle fibers are formed by long ... In this way the spindle fiber appears to move, or "pull" ... This allows the proteins of the kinetochore to form, which in turn attach to the spindle fibers . ... ...

Mitotic spindle

... Bub3 is a conserved component of the mitotic spindle assembly complex. ... attachment of chromosomes to the mitotic spindle via the kinetochore is vital ... Mitotic spindle assembly was carried out as described (Sawin and Mitchison, 1991) ... To find KRPs involved in mitotic ...

Metaphase

... for moving the chromosomes ... Perhaps most recognizable phase of mitosis is termed metaphase where the chromosomes, attached to the kinetochore microtubules, begin to align in one plane (the ... For almost 15 years Metaphase has been focused on developing products that ... ©2009 ...

Dynein

... drive microtubule sliding ... All the retrieved sequences by this profile are dynein heavy chains. ... The action of a dynein motor at the kinetochore during mitosis remains elusive. Immunolocalization of dynein to the kinetochores of tissue culture cells, ... Welcome to the Dynein ...

Anaphase

... of meiosis or mitosis when chromosomes move toward ... A summary of Metaphase and Anaphase in 's Mitosis. ... During anaphase , the kinetochore microtubules retract, increasing the seperation ... Mitosis. Interphase. Prophase. Metaphase. Anaphase . Telophase ... In anaphase two ...

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