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Kinase in Medical News

EntreMed Reports Second Quarter 2009 Financial Results

... is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of ... inhibit a distinct profile of angiogenic tyrosine kinase targets in addition to the Aurora A kinase. ...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

... (NTU). "BIBW 2992 is an irreversible tyrosine kinase inhibitor(1) whose clinical benefit we are hoping ... signal transduction inhibition and cell-cycle kinase inhibition. BIBW 2992 entered Phase IIb/III ... NSCLC, is ongoing. In the area of cell-cycle kinase inhibition, Boehringer Ingelheim is developing ...

Sunesis Pharmaceuticals Receives Milestone Payment From Biogen Idec

... Idec (Nasdaq: BIIB ) for the selection of a Raf kinase inhibitor development candidate for the treatment ... IND-enabling GLP preclinical work with the Raf kinase development candidate. "While our internal ... being made by Biogen Idec to advance a Raf kinase inhibitor toward the clinic," said Daniel ...

Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha

... Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds ... has multiple protein functions other than the kinase activity. A Japanese research group, led by Dr ... gene that completely and exclusively lacks its kinase activity. They examined hippocampal synaptic ...

The vulnerable cancer cell

... promising drug targets: serine/threonine kinase 33 (STK33) and polo-like kinase 1 (PLK-1), as well as a host of other proteins. ... is that cancers bearing oncogenic mutations in a kinase are dependent on ...

Cylene to Announce New Data on Its First-in-Class Oral CK2 Inhibitor Against Cancer at BIO Conference

... of CX-4945, the Company's oral protein kinase inhibitor currently in Phase I clinical trials. ... a potent and selective oral inhibitor of protein kinase CK2, a previously unexploited molecular target ... therapeutic potential. Cylene's Serine/Threonine kinase Inhibitor program has also delivered orally ...

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Kinase in Medical Technology

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

... of clinical data for its Aurora A/angiogenic kinase inhibitor, ENMD-2076, at the American Society of ... ) ENMD-2076, a small molecule, oral kinase inhibitor that targets Aurora A and other kinases ... is an orally-active, Aurora A/angiogenic kinase inhibitor with a ...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

... through the PI3K/PTEN pathway. About PI3 kinase Phosphatidylinositol 3 kinases (PI3K) are ... and survival/apoptosis. Dysregulation of the PI3 kinase signaling cascades can lead to cancer and ... focused on small molecule modulators of the PI3 kinase and PTEN cell signaling pathway, a promising ...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

... through the PI3K/PTEN pathway. About PI3 kinase Phosphatidylinositol 3 kinases (PI3K) are ... and survival/apoptosis. Dysregulation of the PI3 kinase signaling cascades can lead to cancer and ... focused on small molecule modulators of the PI3 kinase and PTEN cell signaling pathway, a promising ...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... 2992, an Irreversible, Dual EGFR / HER2 Tyrosine kinase Inhibitor, Suggests Activity in Second-line ... It is the first irreversible EGFR-TKI (tyrosine kinase inhibitor) to reach Phase III for ... 'activating' mutations that arise in the tyrosine kinase (TK) domain of the EGFR gene are associated with ...

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

... in clinical development. Bruton's tyrosine kinase is the gene that is disrupted in the ... 2009 8:00 am - 12:00 pm Poster Session kinase Inhibitors 3 Experimental and Molecular ... #3740 A Clinical Trial of the Bruton's Tyrosine kinase (Btk) Inhibitor PCI-32765 in Naturally Occurring ...

Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor

... Resulting from Inhibiting Multiple Pathways) kinase platform by designing a small molecule that was ... SF2626 is the first combination PI3K and MEK kinase inhibitor that, in preclinical studies, blocks ... to rational drug design for combination pathway kinase inhibitors. Semafore's dual ...

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Kinase in Medical Products

Creatine Kinase (CK-MB) ROSALKI

Description:... CKMB method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase MB isoenzyme activity in serum and ...
Company:Randox Laboratories Ltd.

Creatine Kinase (CK-NAC) SZASZ

Description:... The CK method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase activity in serum and ...
Company:Randox Laboratories Ltd.

InSite™ Her-2/neu Kit

Description:... The Her-2/neu protein is a 185 kD trans-membrane glycoprotein associated with tyrosine kinase activity. Approximately 20-30% cases of breast cancer show an amplification and/or over-expression of Her-2/neu in tumor cells. Since the ...
Company:BioGenex Laboratories

Human Cardiac-Specific Troponin-I Enzyme Immunoassay (cTnI ELISA)

Description:... Myocardial infarction is diagnosed when blood levels of sensitive and specific biomarkers, such as cardiac troponin, the MB isoenzyme of creatine kinase (CK-MB), and myoglobin, are increased in a clinical setting of acute ....
Company:Diagnostic Automation, Inc.

BacLite™

Description:... Acolytes core technology relates to the ultrasensitive measurement of Adenylate kinase (AK), an enzyme found in all living cells. ATP produced by the AK reaction is measured using bioluminescence. By coupling AK Technology to ...
Company:Acolyte Biomedica Ltd

Creatine Kinase Kinetic Reagent

Description:... For the quantitative determination of creatine kinase in human ....
Company:Teco Diagnostics

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Kinase in Medical Definition

Neuropsychiatry

... S L, Alexander, L., Shaw, S.H., & Kelsoe, J. (2003) Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. Molecular Psychiatry, 8, 546−557. Baughman, F.A., & Hovey, J. (2006) The ADHD Fraud: How Psychiatry ...
Kinase in Medical Dictionary

Intracellular

... extracellular. RET encodes a receptor tyrosine kinase with extracellular, trans membrane , and ... tissue s to treatment s. ^ Top ... Protein kinase A: An enzyme system that is activated by cyclic ... protein s. There are two isozymes of protein kinase A, type I and type II. Also possible in the ...

Protein

... failure , your child will need to avoid excess protein . Protein kinase A: An enzyme system that is activated by cyclic adenosine monophosphate ... of intracellular protein s. There are two isozymes of protein kinase A, type I and type II. Protein uria describes a condition in which ...

Anemias

... extent of brain damage in a comatose person ... There are several inherited anemias that are more common among dark-skinned people. Pyruvate kinase deficiency ( PKD ) is part of a group of disorders called hereditary nonspherocytic hemolytic anemia s. Hereditary nonspherocytic anemias are ...

Bladder

... s, bladder , rectum , liver , spleen , lungs and veins. Flukes first mature inside freshwater snails. Moreover, the gene for Aurora kinase resides at a chromosomal "hot-spot" frequently associated with various human cancer s such as those of breast , bladder , colon , ovary , ...

Colon

... sometimes gain access to the urinary tract . If these bacteria are allowed to multi ply, infection results. Moreover, the gene for Aurora kinase resides at a chromosomal "hot-spot" frequently associated with various human cancer s such as those of breast , bladder , colon , ovary , ...

Craniotomy

... vascular coil embolization is not possible, aneurysm clipping with craniotomy is done. Craniotomy , UMHS discharge instructions Creatine kinase (CK) total test Creatinine clearance test Creatinine , blood ( serum ) test for Crohn's disease * Crutches, how to use - illustration * ...

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Kinase in Biological News

Structural biology scores with protein snapshot

... of the large bacterial protein diacylglycerol kinase (DAGK), a complex of three subunits that each ... the methods that we used for diacylglycerol kinase and applying them to high value targets such as G ... lab 17 years ago. DAGK is the smallest known kinase (a protein that adds chemical groups called ...

Enzyme doesn't act alone in atrial fibrillation

... Researchers knew that an enzyme called calmodulin kinase II is overactive in several heart diseases and ... rate is a very specific activator of calmodulin kinase II. The research team found that mice with the ... they used a drug to block activity calmodulin kinase II, and the mices' heart rates were raised, the ...

Key protein regulating inflammation may prove relevant to controlling sepsis

... Tergaonkar and his colleagues discovered that the kinase enzyme IκB kinase 2 (IKK2), which is known for causing inflammation ... entitled, "Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP," ...

New method for detection of phosphoproteins reveals regulator of melanoma invasion

... with mutations in the gene encoding the protein kinase B-Raf. Kinases are proteins that regulate the ... by the mitogen-activated protein (MAP) kinase signaling pathway. Identification and characterization of MAP kinase target proteins is critical for understanding the ...

Rare disease provides clues about enzyme role in arrhythmias

... researchers showed that the enzyme, calmodulin kinase II (CaM kinase II), contributes to arrhythmia in an extremely ... by age 3, involves activation of the enzyme CaM kinase II. We also showed that inhibiting this enzyme ...

Scientists uncover Ebola cell-invasion strategy

... reactions called the phophoinositide-3 kinase pathway (named for an enzyme found in the cell membrane). By activating the PI3 kinase pathway, they found, an Ebola virus particle ... to reproduce itself. However, if the PI3 kinase pathway is shut down as the UTMB team did with a ...

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Kinase in Biological Technology

Sunesis Reports Financial Results for the Second Quarter 2009

... Idec (Nasdaq: BIIB ) for the selection of a Raf kinase inhibitor development candidate for the treatment ... in the co-development and co-promotion of the Raf kinase inhibitor resulting from this collaboration. ... them, and $1.5 million for the Biogen Idec Raf kinase inhibitor milestone referred to above. Revenues ...

Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.

... a comprehensive global report on Small Molecule kinase Inhibitors market. World market for small molecule kinase inhibitor drugs is projected to reach $16.2 ... by the rising interest over the potential of kinase inhibitors in effectively blocking, and modifying ...

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... monitoring has demonstrated inhibition of PI-3 kinase activity at doses as low as 1 mg per patient. ... patients, as well as clearcut inhibition of PI-3 kinase activity, even in the early cohorts in this dose ... kinase, which distinguishes it from other PI-3 kinase inhibitors currently in clinical development." ...

Quest Diagnostics to Present Genomic Studies Related to New Testing Techniques for Leukemia and Prostate Cancer at 2009 ASCO Meeting

... protein in CML patients with resistance to kinase inhibitors." (Abstract No: 7026) Link to ASCO ... undescribed) mutations along the BCR-ABL tyrosine kinase that may constitute a new class of mutations that ... termination as a mechanism of resistance to kinase inhibitors." (Abstract No: 7028) Link to ASCO ...

Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis

... molecule inhibitor of phosphotidylinositol-3 kinase ("PI-3 kinase"), a key point of control of ... and growth, migration and metabolism. "PI-3 kinase is part of a signaling pathway that is believed ... These results suggest that inhibition of the PI-3 kinase pathway might be beneficial in such human lung ...

EntreMed ENMD-2076 Phase 1 Data to Be Presented at ASCO Annual Meeting

... in evaluating the mechanistic effects of kinase inhibitors like ENMD-2076 in cancer patients. ... is an orally-active, Aurora A/angiogenic kinase inhibitor with a unique kinase selectivity profile and multiple mechanisms of ...

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Kinase in Biological Products

Rat Anti-Kinase Suppressor Of Ras Monoclonal Antibody, Unconjugated, Clone MINT/1/4 from GeneTex

Description:... Rat Antibody to kinase Suppressor Of Ras Recognises the kinase suppressor of Ras (KSR). Immunogen: Recombinant human KSR protein Specificity: human kinase supressor of ...
Company:GeneTex

Custom Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences

Description:... Microarrays designed for proteomic scale kinase profiling, quantitative measurement of kinase kinetic activities, and drug discovery research ... available as part of our comprehensive Protein kinase Substrate - Peptide Microarray Service. Custom ...
Company:LC Sciences

Protein Kinase Substrate (PKS) Peptide Microarray - Comprehensive Service from LC Sciences

Description:... LC Sciences provides a comprehensive kinase analysis service utilizing high density protein kinase substrate (PKS) peptide microarrays synthesized on Paraflo microfluidic chips for proteomic scale kinase profiling, quantitative measurement ...
Company:LC Sciences

Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen

Description:... cascade is one of three identified MAP kinase pathways in mammals. JNK pathway activation ... as Islet Brain-1 and mitogen-activated protein kinase 8-interacting protein-1,) is a cytoplasmic ... is related to the SH3 domains of the tyrosine kinase c-Fyn and the p85 subunit of ...
Company:Invitrogen

Standard Protein Kinase Substrate (PKS) Peptide Microarray from LC Sciences

Description:... Microarrays designed for proteomic scale kinase profiling, quantitative measurement of kinase kinetic activities, and drug discovery research ... available as part of our comprehensive Protein kinase Substrate - Peptide Microarray Service. Probe ...
Company:LC Sciences

Mouse Anti-Protein Kinase C Beta 2 Monoclonal Antibody, Unconjugated from AbD Serotec

Description:... MOUSE ANTI PROTEIN kinase C BETA 2 Immunogen: Protein kinase C beta ...
Company:AbD Serotec

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Kinase in Biological Definition

Long-term potentiation

... (1994) "Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 ... "A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation". ... ^ Sweatt JD (2001) "The neuronal MAP kinase cascade: a biochemical signal integration system ...

Cell growth

... reaching the normal size ( wee mutants). The Wee1 protein is a tyrosine kinase . It normally phosphorylates the Cdc2 cell cycle regulatory protein on a ... size regulation in mammals The protein mTOR is a serine/threonine kinase that regulates translation and cell division. Nutrient availability ...

Glycolysis

... forming 1,3-bisphosphoglycerate. In the next step, phosphoglycerate kinase generates a molecule of ATP while forming 3-phosphoglycerate. At this step ... of pyruvate and a molecule of ATP by means of the enzyme pyruvate kinase . This serves as an additional regulatory step. After the formation of ...

Muscle

... /rigidity, myoclonus (twitching) and myalgia (muscle pain). Diagnostic procedures that may reveal muscular disorders include testing creatine kinase levels in the blood and electromyography (measuring electrical activity in muscles). Neuromuscular diseases are those that affect the muscles ...

Nucleotide

... roles in cellular energy transport and transformations (notably ATP and NAD+/NADH ), and in enzyme regulation (see for example, protein kinase ). The nucleobase can be a purines or pyrimidines , the sugar can be deoxyribose in DNA or ribose in RNA, and the phosphate chain can be a ...

Oncogene

... GTPases , for example, the Ras protein . Cytoplasmic Serine / Threonine kinases and their regulatory subunits , for example, the Raf kinase , and cyclin-dependent kinases (through overexpression ). Adaptor proteins in signal transduction . Transcription factors . ...

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Kinase in Biological Dictionary

Transmembrane receptor

... transmembrane protein - receptor tyrosine kinase - the ligand Jelly belly activates Alk ... ... receptor protein serine/threonine kinase signalling pathway ... as a consequence of a transmembrane receptor serine/threonine kinase binding to ... ... as a consequence of a ...

Polynucleotide Kinase

... enzymology, a polynucleotide 5'-hydroxyl- kinase (EC 2.7.1.78) is an enzyme that catalyzes the chemical reaction Use this polynucleotide kinase to: phosphorylate 5_ -ends of DNA or RNA ... T4 Polynucleotide kinase ; 3'-phosphatase-free. Alkaline Phosphatase, ...

Kinase

... In chemistry and biochemistry, a kinase , alternatively known as a phosphotransferase, is ... An enzyme ... A protein kinase is a kinase enzyme that modifies other proteins by ...

Isoenzyme

... mic adj. ... isoenzyme (biochemistry) Pyruvate kinase Deficiency. Pleurothallis ... Definition and ... and ... Elevated skeletal muscle creatine kinase MB isoenzyme levels in marathon runners. ... ... ... CPK Isoenzymes (CK - Isoenzymes, Creatine kinase - Isoenzymes, Creatine ... Isoenzyme testing ...

Isozymes

... of differential effects of Pb2+ on protein kinase C isozymes . ... What is Isozymes ? Meaning ... of differential effects of Pb2+ on protein kinase C isozymes . ... The full text of the IUBMB ... measuring the activity of ... Protein kinase C (PKC) isozymes regulate epithelial barrier ...

Proto-oncogene

... cancer cell. The RET proto - oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family ... ret proto - oncogene ( proto -ret) encodes a receptor type tyrosine kinase with ... Proto - oncogene definition - Medical Dictionary ...

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