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Islets in Medical News

Pancreatic Islets in Forefront of Diabetes Research

... involves the transplantation of pancreatic islets from a donated pancreas to a person with ... such as limited engraftment [acceptance of the islets within the recipient], chronic immunosuppression ... To meet the increasing demand for human islets for transplantation and research, islet-sharing ...

Cell transplantation and diabetes: New sites, new devices

... perhaps most supportive, microenvironment for islets - is the pancreas itself," said Van der Windt and ... for selecting a donor at an age when the islets have favorable properties, when islet-like cell ... islet cells can provide an unlimited source of islets and in quantities that may satisfy the metabolic ...

Pancreatic Cells Turned Into Insulin-Producing Beta Cells

... them into beta cells, then coalescing them into islets or groups of beta cells to transplant into patients. Currently, some diabetics are treated with islets taken from human cadavers, but it takes two ... treatment for some diabetics is to transplant islets into the liver, so we know that liver cells are a ...

UIC in NIH-funded islet transplantation study for type 1 diabetes

... and generate an unlimited supply of islets so that many more people would benefit from this ... Islet transplantation involves isolating islets from a donor pancreas and infusing the cells into ... liver. If the transplant is successful, the islets lodge in the small blood vessels of the liver and ...

Suspected cause of type 1 diabetes caught 'red-handed' for the first time

... structures in the pancreas known as the islets of Langerhans. They caught the immune cells, ... because the immune system has destroyed the islets of Langerhans, which contain the body's only beta ... Scientists detected dendritic cells in the islets years ago. Dendritic and other antigen-presenting ...

Studies test new approaches to islet transplantation

... to transplanting clusters of insulin-producing islets in adults with difficult-to-control type 1 ... In islet transplantation, clusters of islets are extracted from a donor pancreas and infused ... liver. In a successful transplant, the islets become embedded in the liver and begin producing ...

Curing Diabetes, Pigs Turn to Lions

... conditions such as blindness, stroke and heart attack. Replacing islets is the basis for the potential diabetes cure. Spring Point Project ... high-health, 'medical-grade' pig donors are produced as a source for the islets suitable for human transplantation. The Lions Clubs, ....

Popular diabetes treatment could trigger pancreatitis, pancreatic cancer

... the pancreas particularly how they affected beta cells in the pancreas's islets of Langerhans. Beta cells are responsible for releasing insulin in people ... in sufficient amounts in diabetes patients. HIP rats approximate both the islets and metabolism of people with Type 2 diabetes. The drugs were tested in 40 ...

University of Minnesota receives $40 million for type 1 diabetes research

... Project, a nonprofit organization that raises medical-grade pigs to supply islets for transplantation. The researchers are currently developing a cell ... help us find the best cure faster. Stem cells provide another source of islets for transplantation and offer us tremendous potential to conquer this ...

Montreal researchers prove that insulin-producing cells can give rise to stem-like cells in-vitro

... three additional types of cells that along with β-cells make up the islets of Langerhans. Together, these islet cells produce insulin and other ... for dedifferentiation of all the different cells that make up the islets of Langerhans is a totally new finding," Dr. Rosenberg said. "At this ...

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Islets in Medical Technology

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... monoclonal antibody engineered to alter the function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic ...

CureDM's Diabetes Therapy Achieves Major Development Milestone

... reverse both type 1 and type 2 diabetes. Patients with type 1 diabetes will require pretreatment with an immune tolerance agent to protect new islets formed by HIP. CureDM, Inc., located at the Lankenau Institute for Medical Research on the Lankenau Hospital campus in Wynnewood, PA, is developing ...

Senesco Expands on Recently Announced Preclinical Pancreatic Islet Data

... intraperitoneally, but was still shown to have significant penetration into isolated islets, meaning that difficult delivery directly into the islets may be avoided. Once delivered, the siRNA allowed treated islet cells to produce 30-40% more insulin than untreated cells. This increased insulin ...

Rigel's R788 Shows Preclinical Activity in Type 1 Diabetes Model

... also called juvenile diabetes or insulin-dependent diabetes, occurs when the body's immune system attacks and destroys beta cells within the islets of the pancreas. Beta cells normally produce insulin, a hormone that helps the body move glucose from food into the body's cells to be used for ...

New Data Shows Ranexa(R) Increases Glucose-Stimulated Insulin Secretion

... of Cardiology 57th Annual Scientific Session in Chicago showed that ranolazine increased glucose-stimulated insulin secretion (GSIS) in pancreatic islets isolated from animals and humans. The Company believes that the increase in GSIS seen with ranolazine may contribute to the statistically ...

Metabolex Initiates Phase 1 Trial of MBX-2982

... in the 6-cohort ascending-dose study. MBX-2982 is an agonist of GPR119, a G-protein coupled receptor (GPCR) that is expressed in pancreatic islets and the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent ...

MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus

... monoclonal antibody engineered to alter the function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic ...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

... acute spinal cord injury, the functional characterization of hESC-derived islets for diabetes, and hESC-derived chondrocytes for arthritis and other ... cells. The endocrine cells appeared as bud-like clusters resembling the islets of Langerhans and included the major islet cell types that produce the ...

Opexa Advances Monocyte Derived Islet Technology to Proof of Principle in stz-induced NOD/SCID Mice

... to generate pancreatic endocrine cell clusters known as monocyte-derived islets (MDIs). MDIs express pancreatic specific factors as well as hormones ... glucagon and somatostatin characteristic hormones found in pancreatic islets and function in a glucose responsive manner. Dr. Winnier commented, "The ...
Islets in Medical Products

Insulin EIA Diabetes and Obesity Markers 008-10-1113-01

Description:... Insulin is the principal hormone responsible for the control of glucose metabolism. It is synthesized in the b-cells of the islets of Langerhans as the precursor, proinsulin, which is processed to form C-peptide and insulin. Both are secreted in equimolar amounts into the portal ...
Company:ALPCO Diagnostics

Insulin Ultrasensitive EIA Diabetes and Obesity Markers 008-10-1132-01

Description:... Insulin is the principal hormone responsible for the control of glucose metabolism. It is synthesized in the b-cells of the islets of Langerhans as the precursor, proinsulin, which is processed to form C-peptide and insulin. Both are secreted in equimolar amounts into the portal ...
Company:ALPCO Diagnostics

Iso-Insulin EIA Diabetes and Obesity Markers 008-10-1128-01

Description:... Insulin is the principal hormone responsible for the control of glucose metabolism. It is synthesized in the b-cells of the islets of Langerhans as the precursor, proinsulin, which is processed to form C-peptide and insulin. Both are secreted in equimolar amounts into the portal ...
Company:ALPCO Diagnostics
Islets in Medical Dictionary

Glucagon

... you resume exercise . in the million or so cellular islands (the islets of Langerhans) embedded between the exocrine units of the pancreas . ... , which helps control carbohydrate metabolism . Alpha cells of the islets secrete glucagon ... entero cyte; Entero cytozoon; Entero cytozoon ...

Insulin

... oma : A tumor of the beta cells in areas of the pancreas called the islets of Langerhans. Insulin and diabetes : Manage your blood sugar to ... and embryonic pathways that regulate the development of pancreatic islets of Langerhans, the source of insulin in post -natal animals. About ...

Beta

... pancreas (the organ of the digestive system located behind the stomach ). Within the pancreas , the beta cells are located in areas called the islets of Langerhans. Beta -carotene Definition: This is a test that measures the amount of beta -carotene in blood (see also Vitamin A test). ...

Delta

... (the organ of the digestive system located behind the stomach ). Within the pancreas , the delta cells are located in areas called the islets of Langerhans. Delta -ALA is a test to measure the amount of delta -ALA in urine . Alternative Names: Delta -aminolevulinic acid How the ...

Diabetes mellitus

... Edmonton protocol New method for islet transplantation for the treatment of type 1 diabetes mellitus . The Edmonton protocol uses fresh islets (without being culture d) harvested from the pancreas of two separate cadaveric donors. Other benefits may be a reduced risk of the development ...

Endocrine

... menopause . Embedded throughout the mass of exocrine tissue are the grape-like clusters of hundreds of thousands of endocrine cells, known as islets of Langerhans. These occur alone (inherited MTC) or as part of a familial cancer syndrome known as multi ple endocrine neoplasia (MEN) type ...

Hyperglycemia

... glucose ( sugar ) metabolism caused by inadequate production or use of insulin , a hormone produced in specialized cells ( beta cells in the islets of ... Hyperglycemia . Hyperglycemia is an abnormally high level of glucose in the blood . People with diabetic ketoacidosis have ...

Hypoglycemia

... glucose ( sugar ) metabolism caused by inadequate production or use of insulin , a hormone produced in specialized cells ( beta cells in the islets of ... Hypoglycemia occurs when your body's blood sugar , or glucose , is abnormally low. The term insulin shock is used to describe ...

Insulinoma

... Insulinoma : A tumor of the beta cells in areas of the pancreas called the islets of Langerhans. Insulinoma Powered by: This information is provided by an independent source. Merck & Co., Inc. is not responsible for this ...

Pancreas

... ). Gallbladder and bile ducts. A CT scan can be used to investigate blockage of the bile ducts. The Edmonton protocol uses fresh islets (without being culture d) harvested from the pancreas of two separate cadaveric donors. presence in the system of an above-normal amount of ...

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Islets in Biological News

JDRF-funded researchers discover proteins regulating human beta cell replication

... alone or with cyclin D, when injected into human islets by viral delivery methods, triggered the beta cells to replicate. These transduced islets were then transplanted into diabetic mice for six ... better than control (non-modified) human islets as measured by blood glucose levels and glucose ...

Researcher tricks immune system in diabetic mice

... a way to trick the immune system of mice into believing those transplanted islets are its own cells. This new technique eliminated the need for the ... without pre-treated cells, the immune system rejected the transplanted islets within 15 days. In an upcoming study, Miller and Luo will work with ...

New technique eliminates toxic drugs in islet transplant in diabetic mice

... a way to trick the immune system of mice into believing those transplanted islets are its own cells. This new technique eliminated the need for the ... without pre-treated cells, the immune system rejected the transplanted islets within 15 days. In an upcoming study, Miller and Luo will work with ...

NIBIB invests in quantum research

... replacement strategy for treating diabetes. Transplantation of pancreatic islets to restore insulin production is promising; however, the donor pancreata ... and do not meet medical needs. The development of these tissue engineered islets will provide a new source of insulin-producing cells and help realize the ...

Breakthrough research identifies how cells from pigs may cure diabetes

... issues, researchers are now working to transplant porcine islets in an engineered pre-vascularized, cytoprotective and immune-privileged ... will be able to provide unlimited islet tissue in a few years. Pig islets from young disease-free donors are superior to cadaver human islets. ...

LSUHSC student awarded top national honor for diabetes research

... Beta cells are located in islet cell clusters throughout the pancreas. Diabetes mellitus type 1 results from the destruction or dysfunction of islets and their beta cells. Type 2 diabetes results from the body's inability to use insulin properly and a gradual decrease in the pancreas's ability to ...

Human beta cells can be easily induced to replicate, according to study in Diabetes

... the cells replicated. Stimulation was further enhanced by increasing production of another cell cycle molecule called cyclin D1. Untreated human islets did not replicate. "After we transplanted some of these engineered human beta cells under the outer layer of a kidney in a diabetic mouse, we saw ...

American Chemical Society's Weekly PressPac -- July 2, 2008

... United States. In the new study, Yuji Teramura and Hiroo Iwata point out that transplantation of the pancreas's insulin producing cells, so-called islets of Langerhans, is a promising experimental technique for treating patients with insulin-dependent diabetes. However, the procedure is not ...

Type 1 diabetes triggered by 'lazy' regulatory T-cells: McGill researchers

... including blindness, heart attack and stroke. The genetic and cellular mechanisms by which the immune system goes out of control and destroys the islets has been an enigma and an area of great interest over the last few decades, said Dr. Piccirillo, Canada Research Chair in Regulatory Lymphocytes of ...

New data from NIH lab confirms protocol to reverse type 1 diabetes in mice

... the activity of the immune cells that destroy islets in type 1 diabetes. They also introduced donor ... cells to retrain the immune system not to attack islets and found that the protocol not only halted the ... diabetes, in which regeneration of remaining islets may be the dominant mechanism. ...

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Islets in Biological Technology

Novel Diabetes Drug Discovery Has Potential to Reverse Disease

... triggers islet neogenesis. Restoring functional islets as a therapeutic approach is fundamental to ... restoration as a therapeutic approach. Pancreatic islets contain four primary cell types and are ... insulin-producing beta cells by generating new islets that contain alpha, beta, gamma and delta cells, ...

BioLife Solutions HypoThermosol(R) Adopted by MicroIslet for Processing Pancreatic Islet Cells to Treat Diabetes

... BioLife that with HypoThermosol, quality islets could still be successfully isolated from the ... criteria tested. The recovery of the islets processed after using HypoThermosol as a cold ... the necrotic and apoptotic cell death profiles of islets from pancreata stored in HypoThermosol ...

Novocell Reports Successful Use of Stem Cells to Generate Insulin in Mice

... is performed by transplanting donor-derived human islets combined with chronic immunosuppression. ... the limited availability of donated pancreatic islets and the adverse side effects of long-term ... tested in human clinical trials using human islets isolated from donor organs. "By developing ...

Breakthrough research identifies how cells from pigs may cure diabetes

... issues, researchers are now working to transplant porcine islets in an engineered pre-vascularized, cytoprotective and immune-privileged ... will be able to provide unlimited islet tissue in a few years. Pig islets from young disease-free donors are superior to cadaver human islets. ...

iZumi Bio and Pierian Merge to Form iPierian to Advance Cellular Reprogramming

... Research, is professor of Medicine and associate director for research at the Diabetes Center at UCSF. The main focus of his lab is to understand how islets of Langerhans, the endocrine component of the pancreas, are formed during organogenesis, how their function is regulated in the mature organism, and ...

Pigs to Be Genotyped to Improve Selection and Breeding for Pancreatic Islet Cell Research

... quality DNA information to link DNA profiles with characteristics of islet tissue. The information will help Spring Point Project supply the optimum islets for transplantation. "We are thrilled to donate our genotyping services in support of Spring Point Project's charitable efforts to improve care ...

University of Minnesota Receives $40 Million for Type 1 Diabetes Research

... in stem cell, transplantation and immunology research. These synergies will help us find the best cure faster. Stem cells provide another source of islets for transplantation and offer us tremendous potential to conquer this complicated disease," said Firpo. Internal and external advisory boards ...

Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982

... of treatments for serious unmet medical needs." About MBX-2982 MBX-2982 is an agonist of GPR119, a GPCR that is expressed in pancreatic islets and the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent ...

Two Metabolex Projects Recognized in Windhover's Top 10 Lists for Partnering Opportunities

... conference in Philadelphia, PA. MBX-2982 MBX-2982 is an agonist of GPR119, a G protein-coupled receptor that is expressed in pancreatic islets and the gastrointestinal tract. Pre-clinical studies conducted by Metabolex and others show that GPR119 agonists can stimulate glucose-dependent ...

Spring Point Project Names New Members to Board of Directors

... experience in finance and business will be invaluable not only in providing direction for daily operations but also in further development of pig islets to a clinical entity." Currently, there are about 25 million people in the United States with diabetes, representing approximately eight percent of ...
Islets in Biological Products

Dog Anti-Pig Pancreatic Islets of Langerhans Cells Polyclonal Antibody, Unconjugated from Abcam

Description:... Dog polyclonal to Porcine Pancreatic islets of Langerhans Cells ( Abpromise for all tested applications). Antigen: ... preparation (Pig): Sonicated crude membrane fraction of porcine pancreatic islets of langerhans ....
Company:Abcam

COPAS 500 from Union Biometrica

Description:... embryos to first instar larvae, other like-sized model organisms, cells, pollen, seeds and beads even delicate cell clusters such as pancreatic islets and embryoid bodies. Analysis is performed based on up to five parameters size, optical density, and three fluorescent spectra. Sorting is based ...
Company:Union Biometrica
Islets in Biological Definition

Insulin

... insula , "island", as it is produced in the islets of Langerhans in the pancreas ) is a ... "little heaps of cells", later known as the islets of Langerhans , was unknown, but Edouard Laguesse ... were made to isolate the secretion of the islets as a potential treatment. In 1906 Georg Ludwig ...

Diabetes mellitus

... , in which the body's own immune system attacks the beta cells in the islets of Langerhans of the pancreas , destroying them or damaging them ... induced diabetes in dogs by giving them an extract from the pancreatic islets of Langerhans of healthy dogs 8 . They went on to isolate the hormone ...
Islets in Biological Dictionary

Islets of Langerhans

... The islets of Langerhans are the regions of the pancreas ... pathological anatomist Paul Langerhans , the islets of Langerhans constitute approximately 1 to 2% ... human pancreas contains about 1,000,000 islets . The ...

Insulin

... n. A polypeptide hormone secreted by the islets of Langerhans and functioning in the regulation ... is made specifically by the beta cells in the islets of ... Insulin lowers the level of glucose ... (Latin insula, "island", as it is produced in the islets of Langerhans) ... Insulin is used medically in ...

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(Date:7/11/2014)... to understand the best available treatment for patients, from ... less costly for taxpayers than the existing clinical trial ... van Staa, carried out while he was a member ... is now based at The University of Manchester,s Health ... ( HTA ) today (Friday 11 July) looked at ...
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