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Introns in Medical News

RNA-associated introns guide nerve-cell channel production

... Abnormalities in the dendrite electrical channel are involved in epilepsy, neurodegenerative diseases, and cognitive disorders, among others. introns are commonly looked on as sequences of "junk" DNA found in the middle of gene sequences, which after being made in RNA are simply excised in the ...

Genetic Test for Type II Diabetes Moves Closer

... well as biological studies will be needed to identify the causative variant. Two further loci were found in the study; the first located in the introns of exostosin 2 (EXT2), which modulates hedgehog signaling, early pancreatic development and insulin synthesis. The second is located in ...
Introns in Biological News

Yale scientists visualize the machinery of mRNA splicing

... her research team into the nature of group II introns , a particular type of intron within gene ... removal during the maturation of RNA. Group II introns are found throughout nature, in all forms of ... applications of the work, Pyle said, Group II introns hold promise in the future as agents of gene ...

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

... the raw or unedited RNA copy of DNA includes excess RNA segments called introns that need to be edited out in order for the RNA's message to be functional. Once the introns are removed, the remaining segments -- called exons -- are pasted ...

Researchers develop new self-training gene prediction program for fungi

... and non-coding sequences (introns and intergenic regions). Most introns start from the dinucleotide guanine-thymine (abbreviated GT) and end with ... significant variability in genome size, gene number and average number of introns per gene. The results showed that by including branch site information in ...

Scientists find a fingerprint of evolution across the human genome

... splicing Previous researchers assumed that mutations in the middle of introns do not affect the final protein, so they simply accumulate. In the new ... even in these regions of the genome. Although the selection is weak, introns are not neutral, in their effect on survival, says CSHL professor Michael ...

Genome of marine organism tells of humans' unicellular ancestors

... 25,000 genes. Interestingly, the choanoflagellate has nearly as many introns - non-coding regions once referred to as "junk" DNA - in its genes as humans do in their genes, and often in the same spots. introns have to be snipped out before a gene can be used as a blueprint for a ...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

... that 3' end processing for telomerase RNA uses a fundamentally different and novel pathway." "We demonstrate that the machinery that removes introns from messenger RNAs also functions in generating the mature 3' end of the telomerase RNA subunit," said Jessica Box, Research Technician I and ...

Trichoplax genome sequenced -- 'rosetta stone' for understanding evolution

... Earlier sequencing work showed that the mitochondrial genome of Trichoplax is over twice the size of those found in most animals with genes, introns and spacer sequences like the most primitive organisms. However, size is not all that matters. DNA sequences that organisms share in common ...

Evolution of fruit size in tomato

... the mutation consisted of an insertion in the first intron, which is a non-coding sequence embedded within the protein coding sequence. Although introns are not part of a gene's protein code and are removed from the RNA sequence before translation into proteins, they are nevertheless structurally and ...

The earliest animals had human-like genes

... contain extra bits of DNA sequence, called introns ?information which has to be removed as cells create new molecules. The number of introns in genes, however, varies greatly among animals. While humans have many introns in their genes, common animal models such as ...

Reversal of role for a viral protein associated with the development of lymphoma

... non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form ... how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for ... called recursive splicing, removes long introns by steadily paring them down in a predictable ...

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Introns in Biological Technology

Amplification of Epstein-Barr Virus Exon C with Difficult Primers Using Eppendorf Mastercycler gradient

... genes.1 LMP-1 gene consists of three exons separated by short introns (Fig. 1).2 One of our investigation efforts attempted to study ... The three exons (EA, EB and EC) are separated by two short introns (I-1 and I-2). Arrows indicate the position of the forward and ...

SNPs Powerful Tools for Association Studies

... Intronic SNPs Single nucleotide polymorphisms that occur in noncoding regions of a gene that separate the exons (i.e., introns). introns are transcribed into RNA, but are not translated into protein. Linkage map See genetic map Meiosis Meiosis is the process ...

Quantitative Analysis of GFP in Plant Extracts Using the VersaFluor Fluorometer System

... the comparative assessment of expression levels directed and influenced by attached genetic sequences, such as promoters, introns and terminators. The ability to test gene sequences in this way is a prerequisite for the correct deployment of useful gene ...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

... 10. Moran, J. V., Zimmerly, S., Eskes, R., Kennell, J. C., Lambawitz, A. M., Butow, R. A. and Perlman, P. S., Mobile group II introns of yeast mitochondrial DNA are novel sitespecific retroelements, Mol. Cell Biol., 15 , 2828-2838 (1995). 11. ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... polymorphisms are drawn to introns, which often show a greater degree of site and size variation than coding regions. introns may be amplified using conserved primers targeted to flanking exon sequence, a strategy termed exon-primed intron-crossing ...

DNA-free A NEW Method to Remove DNA

... as the expected cDNA product. (Pseudogenes arise from a processed mRNA that is reverse transcribed and then integrated into the genome; no introns are present). Figure 2 illustrates how primer design can be used to detect most DNA contamination, and why a "minus-RT" control ...
Introns in Biological Products

TargeTron Gene Knockout System from Sigma-Aldrich

Description:... for the rapid and specific disruption of bacterial genes by insertion of group II introns. The method exploits the retrohoming ability of group II introns and utilizes a simple PCR step to re-target the TargeTron group II intron for specific insertion into the host genome. Utility of the technology has ...
Company:Sigma-Aldrich
Introns in Biological Definition

Gene

... internally by non-coding sequences called introns , which can be many times longer than the genes themselves. introns are removed on the heels of transcription by ... a gene, by keeping the exons and removing the introns . So, the DNA strand needs to be in an exon to ...

Intron

... introns are sections of DNA within a gene that do ... before it is exported from the cell nucleus . introns exist mainly (but not only) in eukaryotic ... remain in the spliced mRNA are called exons . introns sometimes allow for alternative splicing of a ...

Splicing (genetics)

... known as exons (expressed codons) and introns (interrupting codons). In contrast to ... called pre-mRNA that is composed of both introns and exons (see transcription ). Pre-mRNA has to ... be translated into protein. During splicing, the introns are removed from the mRNA using one of three ...

Alternative splicing

... the pre-mRNA has been transcribed from the DNA , it includes several introns and exons . In nematodes , the mean is 4-5 exons and introns; in the fruit fly Drosophila there are more than 100 introns and exons in one transcribed pre-mRNA. But what is an intron and what is ...

Spliceosome

... complex of RNA and many protein subunits, that remove the non-coding introns from unprocessed mRNA . The mRNA of prokaryotes is simpler, and they ... splicing Alternative splicing (the re-combination of different introns ) is a major source of genetic diversity in eukaryotes. For example ...

Enhancer

... some have been found to bind several hundreds of thousands base pairs upstream or downstream of the start site. Enhancers can also be found inside introns . An enhancer's orientation may even be reversed without affecting its function. Furthermore, an enhancer may be excised and inserted elsewhere in ...

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Introns in Biological Dictionary

Splicing

... of an RNA after transcription, in which introns are removed and exons are joined. This is ... Splicing Mechanisms and Conservation of Minor introns in Voltage ... Wire Rope splicing , wire rope ... the most common of which ... Group 1 introns are self- splicing : they pinch themselves out ...

Self-splicing

... of an RNA after transcription, in which introns are removed and exons are joined. This is ... the self - splicing activities of 12 group I introns from various organisms ... Since the discovery ... the occurrence of self - splicing group I introns in viruses that infect ... A self - splicing ...

RNA Splicing

... of an RNA after transcription, in which introns are removed and exons are joined. This is ... lacking. Splicing is the stage during which introns are removed from the strand, and the ... An ... 14.10, p. 289 ... This process of removing introns is called RNA splicing . ... RNA splicing ...

Introns

... introns are common in eukaryotic pre-mRNA, but in prokaryotes they are only ... The discovery of introns led to the Nobel Prize in Physiology or Medicine in ... introns is an album by LCD Soundsystem released in March ...

Intron

... effects, drug interactions, warnings, and ... introns are sections of DNA that will be spliced out ... English dictionary and encyclopedia. intra, introns ... intron - sequence of a eukaryotic gene's ... cause or aggravate fatal or life ... ... are introns ...

Group I introns

... machinery is ... Group I catalytic introns are large self-splicing ribozymes. They ... essentially two domains ... Most Group I introns then simply catalyze their own circularization. ... these days, and so far as we know, Group I introns in multi-cellular organisms are rare. ... ...

Group II introns

... structure to identify and catalog group II introns in bacteria and other organisms, maintained by ... Zimmerly Laboratory at the ... Group II introns are self-splicing RNAs and retroelements found in bacteria and ... Some group II introns also encode a reverse transcriptase (RT) ORF ...

Exons

... their flanking regions" ... Exons and introns | World of Genetics. Exons and introns summary with 2 pages of encyclopedia entries, ... Are exons ... What are the ... introns and extrons ... ...

Spliceosome

... is a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA (hnRNA) segment. This process is generally ... which is a large RNA-protein complex ... The major spliceosome splices introns containing GU at the 5' splice site and AG ... Definition of ...

Mature transcript

... as precursor messenger RNA, it consists exclusively of exons, with all introns removed. Mature , transcript ,biological ,biology dictionary,biology ... expressed transcripts . Databases - Sequences. dbEST ... ... introns are spliced from the primary transcript , resulting in a mature mRNA. ....

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