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Intron in Medical News

RNA-associated introns guide nerve-cell channel production

... channel, called the BK channel, contains an intron that is present outside the nucleus. This intron plays an important role in ensuring that ... serves a critical cellular function. The intron acts like a guide or gatekeeper, says Eberwine. ...

PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon Therapy

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa- 2b, recombinant) for ... in patients with hypersensitivity to intron A or any component of the product, ...

Schering-Plough Reports Financial Results for 2009 First Quarter

... 3% REBETOL 66 59 12% CAELYX 61 74 (18%) intron A 54 55 (3%) PROVENTIL / ALBUTEROL CFC 54 50 7% REMERON ...

Schering-Plough Reports Financial Results for Third Quarter of 2008

... / SUBOXONE 63 55 15% 178 163 10% REMERON c/ 61 - - 190 - - intron A 61 61 - 177 176 1% CERAZETTE c/ 49 - - 142 - - ...

Schering-Plough Reports Financial Results for Third Quarter of 2007

... AVELOX 78 63 24% 269 201 34% CAELYX 64 52 23% 191 156 22% intron A 61 57 7% 176 180 (2%) REBETOL 60 72 (16%) 206 237 (13%) ...

Gene Variation Associated With Better Mobility For Older Individuals

... for this is unclear, but there appears to be a strong genetic component. A certain gene variation (an insertion [I]/deletion [D] polymorphism in intron 16 of the angiotensin-converting enzyme [ACE]) gene has been identified as a potential marker for differential response to exercise in younger ....
Intron in Medical Technology

Schering-Plough Provides Update on Boceprevir Clinical Development and Introduces Potent Next-Generation Oral HCV Protease Inhibitor for Treating Patients With Chronic Hepatitis C

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, autoimmune ...

Boceprevir Phase II Study Showed High Rate of Sustained Response With 28- and 48-Week Regimens in Genotype 1 Treatment-Naive Hepatitis C Patients

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, ...

Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, ...

Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, ...

Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Hepatitis C Data Presentations at Digestive Disease Week (DDW) Annual Meeting

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, ...

Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, ...

Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL)

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, ...

Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa-2b, recombinant) for Injection ... in patients with hypersensitivity to intron A or any component of the product, ...

Pegintron(TM) Plus Weight-Based Rebetol(R) Resulted in Higher SVR Than Flat Dosing; Low Relapse Rates in Patients With Chronic Hepatitis C

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa- 2b, recombinant) for ... in patients with hypersensitivity to intron A or any component of the product, ...

Schering-Plough Reports Top-Line Results of the IDEAL Study

... disorders resolve after stopping PEGINTRON and/or intron A therapy. Use with Ribavirin: Ribavirin may ... CHC patients before or during treatment. intron A (Interferon alfa- 2b, recombinant) for ... in patients with hypersensitivity to intron A or any component of the product, ...
Intron in Medical Dictionary

Relapse

... treatment should be administered 10 times each year in the summer season. Rebetron combination therapy Combines Rebetol (ribavirin) capsules and intron A (interferon alfa-2b, recombinant) injection for the treatment of chronic hepatitis C in patients with compensated liver disease who have ...

Viral hepatitis

... cage, around the front, and into the groin . Viral hepatitis is treated with anti viral medications, such as interferon alpha (Roferon-A, intron A), ribavirin (Copegus, Rebetol, Virazole) for hepatitis C and lamivudine (Epivir) for hepatitis B . VIRAL HEPATITIS - Hepatitis c aused by ...
Intron in Biological News

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

... unedited RNA molecule, the boundaries between an intron and its two flanking exons are called splice ... guided to the splice site at the beginning of an intron by one of its components, a small nuclear RNA ... to recognize this splice site at the start of the intron is strongest when up to 11 bases are paired up. ...

Yale scientists visualize the machinery of mRNA splicing

... research team into the nature of group II introns , a particular type of intron within gene transcripts that catalyzes its own removal during the ... II introns hold promise in the future as agents of gene therapy. A free intron is an infectious element that is special because it targets DNA sites very ...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

... could have such a function, as the two steps of removing an internal piece of RNA and gluing the flanking ends together are tightly coupled during intron removal. To our knowledge this is the first example where uncoupling of the first and second step of splicing generates a functional product in a ...

Researchers develop new self-training gene prediction program for fungi

... the exon-intron structure of eukaryotic genes, we didn't search for branch point sites, but doing so in the new program helps to better delineate intron regions inside fungal genes," added Borodovsky, who is also a Regents' Professor in the Coulter Department of Biomedical Engineering and the ...

Evolution of fruit size in tomato

... into proteins, they are nevertheless structurally and functionally important, as demonstrated in this locus. The presence of an insertion in this intron reduces expression of the fas gene. The scientists looked at where and when the gene is expressed and found it dramatically reduced in developing ...

Scientists find a fingerprint of evolution across the human genome

... consequences. Other sequences must likewise be preserved in the regions to be retained. The scientists found a preference for some letters across intron regions, and the opposite preference in coding regions. Together, these regions make up at least a third of the genome, which is thus under selective ...

Scientists find missing evolutionary link using tiny fungus crystal

... fungus, had adapted to take over some of the RNA molecule's chemical reaction jobs inside cells. The protein stabilizes the RNA molecule - called an intron - so that the RNA can cut out non-functional genetic material and splice together the ends of a functional gene, Paukstelis said. "The RNA ...

Reversal of role for a viral protein associated with the development of lymphoma

... mutations occur at standard signals where intron removal takes place through direct splicing. ... tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he ... these ratchetting points mediate the removal of intron subfragments in one direction as the gene is ...

Carnegie Mellon University research reveals how cells process large genes

... mutations occur at standard signals where intron removal takes place through direct splicing. ... tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he ... these ratchetting points mediate the removal of intron subfragments in one direction as the gene is ...

Program finds lost genes in nematode genome

... C. Elegans is able to use more accurate models of intron length than previous analyses. This is important ... the coding machinery of proteins. While getting intron length is helpful for gene annotation, the ... less accurate methods. Being able to define intron length has implications for the human genome, ...

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Intron in Biological Technology

Drug Royalty Corporation (DRC) Announces Acquisition Regarding PEG-INTRON(R) From Enzon Pharmaceuticals, Inc. (ENZN)

... pleased to be working with Enzon Pharmaceuticals. We believe that PEG- intron is one of the most advanced medications to treat Hepatitis C on the market ... for less frequent dosing and to yield greater efficacy, as compared to intron A. PEG-INTRON is marketed worldwide by Schering-Plough and its affiliates. ...

Schering-Plough Reports Financial Results for 2009 Second Quarter

... 67 70 (4%) 134 130 3% CAELYX 68 78 (14%) 128 152 (16%) intron 67 61 10% 121 116 4% PROVENTIL / ALBUTEROL 56 38 46% 110 89 24% ...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

... the efforts to genetically engineer complex mammalian and plant cells." The technology innovation in DNE successfully bridges the fields of intron homing, protein-DNA interactions, DNA recombination, molecular modeling, and molecular catalysis. The design and production pathway for the DNE is ...

Schering-Plough Reports Financial Results for First Quarter of 2008

... ZEMURON c/ 63 - N/M REBETOL 59 71 (17%) intron A 55 60 (8%) SUBUTEX / SUBOXONE 54 56 (4%) ...

Schering-Plough Reports Financial Results for 2007 Fourth Quarter, Full Year

... 1% REBETOL 71 75 (6%) 277 311 (11%) CAELYX 66 49 33% 257 206 25% intron A 57 57 - 233 237 (2%) SUBUTEX / SUBOXONE 57 51 11% 220 203 8% ...

Sub-Micron Gold Particles Are Superior to Larger Particles for Efficient Biolistic Transformation of Organelles and Some Cells

... gene on plasmid YEp352 and a plasmid carrying intron 2 from the COXI gene (either pJVM161 ... 161) containing a deletion within intron 2 of the COXI gene (Zimmerly, et al., 1995) and ... P. S. and Lambowitz, A. M., A group II intron RNA is a catalytic component of a DNA ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... used to amplify muscle-type lactate dehydrogenase intron six. Oligonucleotides were prepared by ... (Rhode Island to Virginia) were examined. The LDH intron appeared to be virtually invariant, ... amplification. 7 When the size of a homologous intron varies among species, one may analyze ...

Ambion Custom

... control is guaranteed Figure 1. Crystals of Group I intron From Bacteriophage Twort. Today's laboratory demands ... milligram quantities of RNA--3.75 mg purified group I intron from bacteriophage Twort--for crystallography (Figure 1). The ...

Successful PCR amplification and subcloning of a GC-rich DNA fragment

... is regulated by a mechanism of transcriptional block in the first intron and alternative splicing. In order to further investigate the role of the c-myb intron in expression, we attempted to amplify the Myb-INT gene ...

The use of the Mastercycler gradient for single-cell PCR and preimplantation diagnosis

... of the DF508 mutation, a female heterozygous for the CA repeat in intron 45 of the DMD gene, and an individual heterozygous for the ... Figure 5: The result of an amplification for intron 45 of the DMD gene. Lanes 18, 19, 20, 24, 25, and 26 show ...

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Intron in Biological Products

TargeTron Gene Knockout System from Sigma-Aldrich

Description:... PCR step to re-target the TargeTron group II intron for specific insertion into the host genome. ... of the output primer sets to mutate the TargeTron intron template via PCR, ligation of the fragment into ... TargeTron algorithm that predicts optimal intron insertion sites and designs primers for mutating ...
Company:Sigma-Aldrich

T7 RNA polymerase from Chimerx

Description:... promoter. Transcripts can be used as hybridization probes, templates for in vitro translation, substrates in RNA processing systems, or for exon and intron mapping of genomic ....
Company:Chimerx
Intron in Biological Definition

Alternative splicing

... exons in one transcribed pre-mRNA. But what is an intron and what is an exon is not decided yet. This ... sites can be spliced with the other exons. intron retaining mode : in this case, instead of splicing out an intron, the intron is retained in the mRNA transcript. However, ...

Intron

... remove themselves on their own. The amount of intron DNA varies widely between species . The ... species Fugu rubripes has a very low amount of intron DNA, whereas related species have higher ... known function that is not part of a gene. intron evolution There are two competing theories as ...

Gene therapy

... of transfected cells. If the gene is inserted in a bad place — for example within the sequence of an important gene, or within non-coding ( intron ) regions that the cell will never translate to produce protein — then the new gene would not be properly expressed and the cell could be ...

Splicing (genetics)

... molecular structures composed of small nuclear ribonuclear proteins (snRNPs (pronounced "snurps")), splice the 3' end of the first exon, form the intron into a lariat , splice the 5' end of the next exon, and fuse the exon-exon junction; Self-splicing : specialized introns serves as ribozymes , ...
Intron in Biological Dictionary

Self-splicing

... - splicing of the Tetrahymena thermophila rRNA intron ... We report the occurrence of self - ... in viruses that infect ... A self - splicing intron in the small subunit rRNA gene of Pneumocystis ...... The Tetrahymena pre-rRNA self - splicing intron is shown to function in the ... In addition, ...

Introns

... online English dictionary and encyclopedia. ... intron - sequence of a eukaryotic gene's DNA that is ... school ... and to be a distinguished webpage of intron education. Copyrights-By Introns .net ... ... medical term. What does Introns mean? ... intron /in·tron/ (in'tron) a noncoding sequence ...

Intron

... An intron is a DNA region within a gene that is not ... removed by a process called ... intron n. A segment of a gene situated between ... and does not function in coding for protein intron sequence of a eukaryotic gene's DNA that is ...

Group I introns

... Group II intron is a class of self-catalytic ribozymes and ... pyocin nucleases, as well as to some group I intron ORFs (9,10) ... Human Molecular Genetics 2 ... ... The catalytic machinery for group II intron splicing probably evolved into the ... ...

Group II introns

... Group II intron is a class of self-catalytic ribozymes and ... ... The catalytic machinery for group II intron splicing probably evolved into the ... ... Functional motifs of a typical group II intron encoded maturases. Pro domain ... Euglena ...

Spliceosome

... that publishes full-length research papers in all disciplines of science, as well as ... This machinery, called the spliceosome , splices out intron sequences that ... The spliceosome presents special challenges to structure determination. ... Splicing is catalyzed by the spliceosome which ...

RNA Splicing

... will remove the introns and join the exons to give the mature RNA . ... RNA involvement in self‐ splicing is stoichiometric, but the excised intron does ... ...

Ribosomal RNA

... The other ribosomal RNA genes are found in an "operon"-like structure that's ... In some species the 28S ribosomal RNA gene contains an intron near the 3′ end. ... Created by George Rice, Montana State University Ribosomes ... The section (or gene) that codes for ribosomal RNA in a ...

Ribosomal DNA genes

... Back to main news page ... ... and in the small- and large-subunit ribosomal DNA genes of a limited number of ... spliceosomal-type intron occurs in a ribosomal protein gene ... DNA . Scope Note: DNA sequences encoding ribosomal RNA and the segments of DNA separating the ...

Primary transcript

... found that the primary RNA transcript produced by adenovirus type 2 ... The primary transcript of this gene contains an intron with two possible ... PLoS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC ... Northern blot analysis of pri-miR-433 and ...

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