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Intracellular in Medical News

AlphaRx Presents Positive Preclinical Data on Zysolin(TM) Inhalable Nanoparticles at Controlled Release Society Annual Meeting

... development of a drug that targets and eradicates intracellular pathogens, which to date, have proven to be very ... patients. Zysolin(TM) improves the intracellular activity of Tobramycin - in layman's term, ... thus improving its antibacterial activity against intracellular Klebsiella, Pseudomondas aeruginosa and ...

Life Sciences Discovery awards health research program grants

... rural communities, and developing highly-targeted intracellular drug delivery mechanisms. (See Backgrounder ... $7,163,794 Program title: Center for intracellular Delivery of Biologics Program focus: To better ... conditions. This program will identify new intracellular drug vehicles for clinical use that could result ...

Parasites that live inside cells use loophole to thwart immune system

... scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key ... within macrophages themselves. To do so, these intracellular pathogens deploy an arsenal of weapons to avoid ... no one had really explored the possibility that intracellular pathogens could directly exploit ...

Persistent bacterial infection exploits killing machinery of immune cells

... However, some harmful bacteria, known as intracellular pathogens, live inside cells and can even survive ... says Dr. Murray. "We wanted to determine just how intracellular bacteria were turning on the genes that make ... The research team discovered that intracellular pathogens increase levels of arginase, thereby ...

Duska Therapeutics Sponsored University of Pennsylvania Study Demonstrates ATP Improves Sperm Motility and In Vitro Fertilization in Animals

... associated with a rapid increase in the level of intracellular calcium. The effect was inhibited by two P2 ... mediated by P2 receptors and increased level of intracellular calcium. The data further support the development ... mediated by P2 receptors and increased level of intracellular calcium and that the data further support the ...

Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent

... two distinct activities. It inhibits the RAS/MAPK intracellular signaling pathway, which is mutated in many ... may avoid some of the redundancies inherent in intracellular signaling, Falardeau said. The agent also ... which is over-expressed in multiple cancers. This intracellular PBR binding may allow the drug to accumulate ...

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Intracellular in Medical Technology

Intra-Cellular Therapies Presents Data on Its Schizophrenia and Cognition in Schizophrenia Programs at the 14th Biennial Winter Workshop on Schizophrenia and Bipolar Disorders

... over D2 receptors. In vivo, ITI-007 produced an intracellular protein phosphorylation pattern consistent with ... orally active and a potent inhibitor of a novel intracellular target and was designed to amplify but not ... with a proprietary and unique window into the intracellular action of Central Nervous System (CNS) drugs or ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... small molecule inhibitor of the immunoproteasome. The proteasome is an intracellular complex present in most cells that mediates the degradation of intracellular proteins, including key components of pathways that contribute to cancer ...

Arena Pharmaceuticals Announces Initiation of Phase 1 Clinical Trial of Type 2 Diabetes Drug Candidate in Partnership with Ortho-McNeil-Janssen Pharmaceuticals

... response to increases in blood glucose. The GDIR signals through a similar intracellular pathway as the GLP-1 receptor, with common downstream effects, but unlike ... stimulation has also been found to increase the levels and activity of intracellular factors thought to be involved in the preservation of beta cells, and GDIR ...

Parasites That Live Inside Cells Use Loophole to Thwart Immune System

... to live and proliferate within macrophages themselves. To do so, these intracellular pathogens deploy an arsenal of weapons to avoid and counterattack ... nitric oxide. "However, no one had really explored the possibility that intracellular pathogens could directly exploit arginase-activation as a defense until ...

Sequella Presents Data on Synergy Between Investigational New TB Drugs SQ109 and TMC207

... included synergy studies, rate of killing, post antibiotic effect and intracellular activity against MTB in macrophages. There were no antagonistic ... and showed increased rate of killing, enhanced post antibiotic effect and intracellular killing activity. Results showed that the SQ109 and TMC207 drug ...

New Data Support Role for Monitoring of Cell-Mediated Immunity in Adult Patients Following Renal Transplantation

... Santander, Spain, used the Cylex ImmuKnow assay to prospectively monitor intracellular adenosine triphosphate (ATP) concentrations following CD4 cell activation ... immune status." *Sanchez-Velasco P, Rodrigo E, Valero R, et al. intracellular ATP concentrations of CD4 cells in kidney transplant patients with and ...

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Intracellular in Medical Products

DHT RIA Test

Description:... with the nuclear membrane. DHT exerts its biological action by intracellular binding to the androgen receptor; and this complex is then transferred to ... effects on DNA transcription [2]. Most of the residual DHT undergoes intracellular metabolism to 3a -androstanediol and 3a -androstanediol glucuronide. Only ...
Company:Diagnostic Systems Laboratories, Inc.

Insulin RIA Test

Description:... specific cell-surface receptors [3] and facilitates substrate uptake and intracellular utilization, resulting in net increases in intracellular lipid, protein and glycogen [1,2,3,4]. Insulin is rapidly cleared both by ...
Company:Diagnostic Systems Laboratories, Inc.

Series 590 Low Cost Whole Blood Aggregometers

Description:... which simultaneously measure aggregation and ATP secretion. intracellular Ionized Calcium aggregometers, which measure intracellular ionized calcium flux simultaneously with aggregation. Small, low cost WBA ...
Company:Chrono-log Corporation

Series 490 Low Cost Automatic Optical Aggregometers

Description:... which simultaneously measure aggregation and ATP secretion. intracellular Ionized Calcium aggregometers, which measure intracellular ionized calcium flux simultaneously with aggregation. Small, low cost WBA ...
Company:Chrono-log Corporation

Series 500 Aggregometers

Description:... which simultaneously measure aggregation and ATP secretion. intracellular Ionized Calcium aggregometers, which measure intracellular ionized calcium flux simultaneously with aggregation. Small, low cost WBA ...
Company:Chrono-log Corporation

Series 400 Aggregometers

Description:... which simultaneously measure aggregation and ATP secretion. intracellular Ionized Calcium aggregometers, which measure intracellular ionized calcium flux simultaneously with aggregation. Small, low cost WBA ...
Company:Chrono-log Corporation

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Intracellular in Medical Definition

Cryostasis (clathrate hydrates)

... between the ice crystals. Additionally, as the cells shrink, the solutes inside the cells are concentrated in the remaining water, increasing the intracellular ionic strength and interfering with the organization of the proteins and other organized intercellular structures. Eventually, the solute ...
Intracellular in Medical Dictionary

Intracellular

... intracellular CONC ENT RATION: The concentration (eg, of a drug ) within a cell . intracellular : Within a cell . INTRA CRANIAL: Within the cranium . M. avium- intracellular e M. marinum M. ulcer ans M. kansasii M. ...

Protein

... (cAMP) and that catalyzes the activity of intracellular protein s. There are two isozymes of protein ... substrate (reactant) molecules. Virtually all intracellular chemical reactions are catalyzed by enzyme s. ... how the extracellular Wnt ligand stimulates intracellular signaling, we recently demonstrated that members ...

Dementia

... speech problems and dementia . withdrawal ... cytomegalovirus infections of the eyes ; generalized infection with Mycobacterium avium- intracellular e, or "MAI" (an organ ism resembling the cause of tuberculosis ); and numerous neurological disorders, including progressive dementia . ...

Enzyme

... Enzyme Protein or RNA chain that catalyzes a particular biochemical reaction involving specific substrate (reactant) molecules. Virtually all intracellular chemical reactions are catalyzed by enzyme s. An example of an enzyme is Lactase . Home ... Enzyme A type of protein , produced in the ...

Eye infections

... Eye Infections , Viral - Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva , iris , eyelids, etc. Eye ...

Folate

... of folic acid . Folate antagonists are used to treat cancer . Also called anti folate . FOLFOX ... ANTI FOLATE : An agent that inhibits intracellular production of folinic acid . Folic acid ( folate ) is a B vitamin that is needed to make new cells in the body.2 What do we know already ...

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Intracellular in Biological News

Fluorescent proteins illuminating biomedical research

... throughout the body or to watch how cells manage intracellular debris, preventing premature aging. These new ... interactions, the growth and collapse of intracellular structures, and many other biological questions," ... to provide accurate insight into the timing of intracellular processes, such as activation or inhibition of ...

Life Sciences Discovery Fund awards health research program grants

... rural communities, and developing highly-targeted intracellular drug delivery mechanisms. (See Backgrounder ... $7,163,794 Program title: Center for intracellular Delivery of Biologics Program focus: To ... conditions. This program will identify new intracellular drug vehicles for clinical use that could result ...

Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo

... created. The dyes vary in their ability to detect intracellular or extracellular reactive oxygen species and by ... angiotensin II and hydro-Cy3 displayed intense intracellular fluorescence, whereas control cells incubated ... that the cellular fluorescence was due to intracellular reactive oxygen species production," said Murthy. ...

Evolution of root nodule symbiosis with nitrogen-fixing bacteria

... for nodulation, as these symbioses both involve intracellular relationships. One clue was that several genes, ... constituted an important step in the evolution of intracellular nodule symbiosis, reports Parniske. Most plants ... therefore suggest a common evolutionary origin of intracellular root symbioses with nitrogen-fixing bacteria. ...

Paradigm shift in Alzheimers's research: new treatments

... of intraneuronal A" and thioflavine-S-positive intracellular material but not with extracellular A" deposits. ... degenerative mechanism, which is independent from intracellular A" aggregation. No intracellular A" was detected in these neurons. The reduced ...

Features of replication suggest viruses have common themes, vulnerabilities

... virus co-opts a cell's membranes to create an intracellular lair where it can safely replicate its genes. ... the Wisconsin group found, the virus co-opts intracellular membranes of mitochondria, critical ... the virus is reorganizing the cell to make a new intracellular architecture for its own purposes, according to ...

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Intracellular in Biological Technology

Novel compound may treat acute diarrhea

... toxins that bring about elevations of a group of intracellular messengers, cyclic nucleotides, that stimulate ... ability of several bacterial toxins to elevate intracellular levels of cyclic nucleotides, and inhibits fluid ... are responsible for increasing the production of intracellular messenger molecules. These molecules contribute ...

Nastech Assigns Intellectual Property Related to the Development of RNA-Based Therapeutics to its Subsidiary, MDRNA, Inc.

... for Lipid and Polypeptide Based siRNA intracellular Delivery -- Compositions and Methods for ... Cations -- Cationic Peptides for siRNA intracellular Delivery -- Formulations for intracellular Delivery dsRNA -- Compositions and Methods ...

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

... increase cardiac cell contractility by increasing the concentration of intracellular calcium, which further activates the cardiac sarcomere. This effect on ... myosin activators have been shown to work in the absence of changes in intracellular calcium by a novel mechanism that directly stimulates the activity of the ...

LNA-Based HIF-1 Alpha Inhibitor Shows Early Signs of Clinical Benefit

... cell metabolism, cell proliferation, cell death (apoptosis) and cell invasion. HIF-1 alpha protein is low in normal cells, but reaches high intracellular concentrations in a variety of cancers and is strongly correlated with poor prognosis and resistance to therapy. Enzon is currently conducting two ...

Rib-X Pharmaceuticals Announces Presentations at the 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)

... 2009 3:30pm Clinical novel oxazolidinone, is Relevance active against intracellular S. aureus, L. monocytogenes and L. pneumophila phagocytosed ...

Rigel Announces First Quarter 2009 Financial Results

... develops novel, small-molecule drugs for the treatment of inflammatory/autoimmune diseases and metabolic diseases. Our pioneering research focuses on intracellular signaling pathways and related targets that are critical to disease mechanisms. Rigel's productivity has resulted in strategic collaborations with ...

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Intracellular in Biological Products

BD Phosflow Perm/Wash Buffer I from BD Biosciences Pharmingen

Description:... The BD PhosFlow Perm/Wash Buffer I can be used in intracellular staining of post-translationally modified ... keep the cells in the presence of saponin during intracellular staining. Applications: intracellular Staining (Flow) Storage Temperature: ...
Company:BD Biosciences Pharmingen

LEUCOPERM Suspension fixation and permeabilization solution from GeneTex

Description:... B. This procedure gives antibodies access to intracellular structures and leaves the morphological scatter ... restricted primarily to cell surface molecules. intracellular structures such as cytoplasmic or nuclear ... such as CD3 and CD22. LEUCOPERMTM reagents allow intracellular antigen analysis with the same ease as surface ...
Company:GeneTex

eBioscience IC Fixation Buffer 125 ml from eBioscience

Description:... eBioscience intracellular (IC) Fixation Buffer, used in conjunction with eBioscience ... 00-8333), can be used to fix and permeabilize cells prior to performing intracellular staining of cytokines and other cytoplasmic and/or nuclear antigens. These ...
Company:eBioscience

BD Phosflow Perm Buffer III from BD Biosciences Pharmingen

Description:... following fixation of PBMCs (or lysed whole blood) for staining for intracellular kinases and appropriate CD markers simultaneously. Applications: intracellular Staining (Flow) Storage Temperature: Room ...
Company:BD Biosciences Pharmingen

BD Phosflow Fix Buffer I from BD Biosciences Pharmingen

Description:... used for the simultaneous fixation and permeabilization of cells prior to intracellular staining. Applications: intracellular Staining (Flow) Storage Temperature: Refrigerate(2 to ...
Company:BD Biosciences Pharmingen

Rat Anti-Vitamin D Receptor Monoclonal Antibody, Unconjugated, Clone 9A7 from ABR-Affinity BioReagents

Description:... the DNA binding domain of the VDR.Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to ... Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor ...
Company:ABR-Affinity BioReagents

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Intracellular in Biological Definition

Signal transduction

... Types of signals 2.1 Extracellular 2.2 intracellular 2.3 Intercellular 2.4 Hormones 3 ... at the transmembrane hormone receptor 5 intracellular signal transduction 5.1 Ca2+ as a second ... for oily surroundings (see hydrophobic ). intracellular Often, but not always, ...

Transmembrane receptor

... domain 2 The transmembrane domain 3 The intracellular domain 4 Regulation of receptor activity ... been determined by crystallography). The intracellular domain The intracellular (or cytoplasmic ) domain of the receptor ...

Electrophysiology

... are four main types of cellular electrophysiological recordings: 1. intracellular recording. This technique entails impaling a cell, usually a neuron , ... is possible to obtain large, whole cell currents without washing out the intracellular medium. Disadvantages: Impossible to record from single channels. ....

Virus

... that infects cells in biological organisms. Viruses are obligate intracellular parasites ; they can only reproduce by invading and taking over other ... of the host to reproduce. For this reason, viruses are called obligate intracellular parasites . Before a virus has entered a host cell, it is called a ...

Active transport

... which allows three sodium ions into the cell to transport one calcium out. Many cells also posses a calcium ATPase, which can operate at lower intracellular concentrations of calcium and sets the normal or resting concentration of this important second messenger . But the ATPase exports calcium ions more ...

Adenosine triphosphate

... see ATP (disambiguation) Adenosine triphosphate ( ATP ) is the nucleotide known in biochemistry as the " molecular currency" of intracellular energy transfer; that is, ATP is able to store and transport chemical energy within cells . ATP also plays an important role in the synthesis of ...

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Intracellular in Biological Dictionary

Lysosomes

... material in a process ... The primary sites of intracellular digestion are organelles known as the ... various hydrolytic enzymes that function in intracellular Explore the structure and function of ... material and release the ... Some tricks that intracellular parasites use to avoid destruction by ...

Transmembrane receptor

... comprise a large protein family ... receptor protein n. An intracellular protein or protein fraction having a ... Membrane or Transmembrane ... terminology,biology terms, ... 2 The transmembrane domain. 3 The intracellular domain. 4 Regulation of receptor activity ... exact: transmembrane ...

Second messenger

... altering gene expression. ... Second messenger . Synonym(s) intracellular second messengers . Definition(s) ... Examples of second messenger ... Activate Second Messenger Systems. Stephen M. Stahl, M.D., Ph.D. ... intracellular second messenger that carries the information from the ... ...

Parasitism

... & Pop Music. Compare prices and buy online at Shopzilla. Shop for intracellular Parasitism - Books at Shop.com. Books|Non-Fiction|English |Hardcover|Science|CRC Pr I Llc|James W. Moulder intracellular Parasitism Books Examples of Parasitism . Endoparasites. ...

Liposomes

... a bilayer ... Nano- liposomes and ... Investigating the uptake and intracellular fate of pH-sensitive liposomes by ... Gadolinium-loaded liposomes ... resources about Liposomes , furthermore the related entries: Memosomes, intracellular Contrast Agents, ... Drug delivery with liposomes as carrier ...

Adenosine triphosphate

... as a coenzyme that is the "molecular unit of currency" of intracellular energy transfer. In this role, ... ATP ( ) n. An adenosine -derived ... ' ... cAMP is derived from adenosine triphosphate and used for intracellular signal ... Adenosine triphosphate (ATP) is a cell's charged storage ...

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