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Inhibitor in Medical News

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

... the first orally-administered irreversible dual inhibitor of EGFR and HER2,(1) to reach Phase III ... Ingelheim compound, BIBF 1120, an angiogenesis inhibitor that simultaneously inhibits vascular endothelial ... Li D et al. "BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer ...

ViroPharma Incorporated Reports Second Quarter 2009 Financial Results

... million in net sales of Cinryze(TM) (C1 esterase inhibitor [human]), of which $2 million was previously ... commercializes Cinryze(TM) (C1 esterase inhibitor [human]) for routine prophylaxis against ... hereditary angioedema (HAE), also known as C1 inhibitor deficiency (for prescribing information on ...

For Treatment of Type 2 Diabetes, 89 Percent of Surveyed Endocrinologists Identify a Need for Additional GLP-1 Analogues and 71 Percent Say the Same About DPP-IV Inhibitors

... therapies from the GLP-1 analogue and DPP-IV inhibitor drug classes for the treatment of type 2 ... indicate that the shortcomings of Merck's DPP-IV inhibitor Januvia include less glucose-lowering compared to ... a need for additional agents from the DPP-IV inhibitor class. Forty-five percent of MCOs indicate that a ...

MO BIO Laboratories, Inc. Launches PowerFood(TM) Microbial DNA Isolation Kit

... Microbial DNA Isolation Kit incorporates patented inhibitor Removal Technology(R) (IRT) to remove ... MO BIO's Power(R) kits contain patented inhibitor Removal Technology(R) for removal of PCR ... procedure. For samples that do not require inhibitor removal, MO BIO's UltraClean(R) line includes ...

Burrill Merchant Banking Advises Pfizer Inc. on Dermatology Portfolio Divestment

... is a novel Cholesterol-Aceyltransferase (ACAT) inhibitor currently in Phase 2 development for the ... An earlier-stage Stearoyl CoA Desaturase 1 (SCD1) inhibitor targeting the same indication was also included ... as was an Activin-Like Kinase 5 (ALK-5) inhibitor currently in preclinical development for reducing ...

Bayer HealthCare Awards $2.5 Million to Advance Hemophilia Research and Improve Patient Care

... Funding priorities include research into inhibitor development and its treatment; the investigation ... of hemophilia in underserved areas. inhibitor formation is considered by many patient groups as ... system and specific factors have on the risk of inhibitor development. "Through our support of ...

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Inhibitor in Medical Technology

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... to be a best-in-class nucleoside/tide polymerase inhibitor with demonstrated antiviral activity and ... coming months from our non-nucleoside polymerase inhibitor and protease inhibitor programs, we are closer to achieving our ultimate ...

Tibotec Pharmaceuticals Announces Agreement to Develop and Commercialize a New Fixed-Dose Combination of TMC278 and Truvada(R) With Gilead Sciences

... non-nucleoside reverse transcriptase inhibitor (NNRTI) TMC278 (rilpivirine hydrochloride 25 mg) ... with a non-nucleoside reverse transcriptase inhibitor or a protease inhibitor as a preferred regimen for patients initiating ...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

... of the immune system, vicriviroc is an HIV entry inhibitor designed to prevent the virus from infecting ... therapy. Atazanavir is a product in the protease inhibitor (PI) class of HIV medications. Truvada is a ... in the nucleoside(tide) reverse transcriptase inhibitor (NRTI) class. The standard of care for ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... Medicine, Proteolix's selective immunoproteasome inhibitor PR-957 was shown to block disease progression in ... print edition in an article titled: A Selective inhibitor of the Immunoproteasome Subunit LMP7 Blocks ... is the first highly selective, small molecule inhibitor of the immunoproteasome. The proteasome is an ...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

... activity as a highly selective and potent inhibitor of the proteasome for treatment of solid tumor ... for carfilzomib as a promising new protease inhibitor in hematologic and solid tumor malignancies. ... including a selective, oral proteasome inhibitor and a selective immunoproteasome inhibitor. For ...

New Study: Antidepressants Commonly Prescribed with Tamoxifen Put Women at Much Higher Risk for Recurrent Breast Cancer

... "We've known that these CYP2D6 inhibitor drugs block the activation of tamoxifen ... far lower levels in the blood stream when CYP2D6 inhibitor drugs are present, and it is the first study to ... that patients used tamoxifen and a CYP2D6 inhibitor concurrently was 340 days. The analysis ...

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Inhibitor in Medical Products

Pefakit TAFI

Description:... Thrombin Activatable Fibrinolysis inhibitor Assay ...
Company:Centerchem, Inc.

STA FIBRINOGEN 5

Description:... Quantitative determination of Fibrinogen by STA Analyzers (Clauss Method). Freeze-dried human thrombin (~100NIH units/mL) with heparin inhibitor and ....
Company:Diagnostica Stago, Inc.

FIBRI-PREST AUTOMATE 2

Description:... Quantitative determination of Fibrinogen (Clauss Method). Freeze-dried human thrombin (~100NIH units/mL) with heparin inhibitor and ....
Company:Diagnostica Stago, Inc.

Shoulder Subluxation Inhibitor (SSI)

Description:... Shoulder Subluxation inhibitor (SSI) is an ideal bracing system to keep athletes on the field by reducing the risk of shoulder injury. The SSI is the only brace that allows TOTAL ...
Company:Boston Brace International

VerifyNow System

Description:... the second assay developed for use on the system is to aid in the detection of platelet dysfunction due to aspirin ingestion. The GP IIb/IIIa inhibitor class of intravenous antiplatelet agents, has demonstrated benefit in treating patients undergoing coronary interventions (e.g. PTCA and stent ...
Company:Accumetrics

BD Vacutainer® Fluoride Tubes - Plastic

Features:... PET (Polyethylene Terephthalate) - Plastic only Plastic plasma tube Glycolytic inhibitor 4 mg Potassium Oxalate 6 mg Na2EDTA 8 mg Potassium Oxalate 12 mg Potassium Oxalate 3 mg Sodium Fluoride 5 mg Sodium Fluoride 10 mg ...
Company:BD Diagnostic Systems
Inhibitor in Medical Definition

Sexual orientation and medicine

... Dr. Dean Hamer publishes a paper suggesting a genetic component to sexual orientation. [3] 1995 Saquinavir , the first protease inhibitor is approved for public use by the FDA . HAART radically changes the prognosis of HIV/AIDS . 1996 The US Department of Defense includes ...
Inhibitor in Medical Dictionary

Angioedema

... referred to as Quinke's disease .) Persons with it are born lacking an inhibitor protein (called C1 esterase inhibitor) that normally prevents activation ... urticaria . Occasionally an inherited deficiency of the C1 esterase inhibitor enzyme leads to a non-itchy form of urticaria and swelling called ' ...

Angioma

... atic vessels. Antibody ... AngioMA RK (MS-325) Former trademark name; see MS-325. Angioma x (bivalirudin); formerly Hirulog* A direct thrombin inhibitor (synthetic). Spider Nevi ( Spider Angioma ) Spider Vein ( Spider Angioma ) Spider Angioma Spina Bifida Spinal Dysraphism ( Spina ...

Anti

... , however. nonsteroidal anti -inflammatory drug NSAID. A drug that decreases fever , swelling , pain , and redness. nonsteroidal aromatase inhibitor ... In developing anti -retro viral drugs, scientists have taken advantage of critical steps in HIV 's life cycle. Take mild pain and ...

Antihypertensives

... levels may be seen in the condition of excess fat in the blood (hyperlipidemia). Drugs that may cause decreased ACE levels include ACE inhibitor antihypertensives ... Because many people who have cancer take prescription medications that can interfere with sexual function, including ...

Bulimia

... B12 for up to five years, so it's rare for diet to cause this anemia . Prozac (fluoxetine hydro chloride ) A selective serotonin reuptake inhibitor (SSRI) initially approved by the FDA for the treatment of clinical depression ; subsequently approved for the treatment of obsessive-compulsive ...

Bulimia nervosa

... ) Bulk ( Fiber ) Bullae Bullous Myringitis (Infectious Myringitis) ... Prozac (fluoxetine hydro chloride ) A selective serotonin reuptake inhibitor (SSRI) initially approved by the FDA for the treatment of clinical depression ; subsequently approved for the treatment of obsessive-compulsive ...

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Inhibitor in Biological News

UCSF researchers identify new drug target for Kaposi's sarcoma

... are structurally similar," Craik explained. "The inhibitor we found knocks out not only KS, but also the ... here could be a target for a broad-acting inhibitor against the entire viral family." To their ... said, this is the first small-molecule inhibitor of a herpes virus protease to not only act ...

Building memories with actin

... phosphorylation and inactivation of cofilin, an inhibitor of actin filament assembly, the team found. ... pathways. The researchers showed that a ROCK inhibitor stalled actin polymerization and resulted in a ... in LTP, however. The team discovered that the Rac inhibitor prolonged cells' vulnerability to a molecule that ...

Purdue researcher invents molecule that stops SARS

... herpes and cancer, Ghosh said. "The molecular inhibitor we developed is very potent against the SARS ... "This is the first design and discovery of an inhibitor for this class of proteins. We are hopeful that ... structure-based design. "The design of this inhibitor was a challenge because we did not know the ...

Scripps Florida scientists awarded $1.5M to fight major water and food parasites

... number of different parasites, and that synthetic inhibitor libraries have already been developed against this enzyme family. As a result, a wealth of inhibitor leads already exist, many of which have been ... to invasive Entamoeba histolytica." The new inhibitor designed by Roush's laboratory attacks the EhCP1 ...

TGen and Washington University researchers discover new approach to treating endometrial cancer

... Louis discovered that introducing a particular inhibitor drug can turn "off'' receptors responsible for ... endometrial cancer. And, they found that the inhibitor drug proved effective even in cancer tumors ... By introducing a commercially available inhibitor drug, PD173074, TGen researchers showed that they ...

Argyrin: Natural substance raises hope for new cancer therapies

... of a certain protein - a so-called cyclin-kinase inhibitor - in the development of cancer. In the process, ... that mice in which the breakdown of the kinase inhibitor was suppressed by genetic change have a ... line in which the quantity of the cyclin kinase inhibitor can be measured using simple optical methods. ...

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Inhibitor in Biological Technology

InterMune Reports Second Quarter 2009 Financial Results and Business Highlights

... inhibitors and at least one other HCV protease inhibitor in development. In an initial Phase 1 study of ... in combination with nucleoside polymerase inhibitor R7128, but no interferon or ribavirin, in ... hepatology portfolio includes the HCV protease inhibitor compound ITMN-191 (referred to as R7227 at Roche) ...

Curis and Debiopharm Sign an Exclusive License Agreement Covering the HSP90 Inhibitor CUDC-305

... including CUDC-305, the company's lead Hsp90 inhibitor candidate. Under the terms of the ... CUDC-101, our first-in-class HDAC/EGFR/Her2 inhibitor that is currently enrolling patients in a Phase I ... fund our further investment in our multi-targeted inhibitor programs, including CUDC-101." "Debiopharm ...

Sunesis Reports Financial Results for the Second Quarter 2009

... BIIB ) for the selection of a Raf kinase inhibitor development candidate for the treatment of ... co-development and co-promotion of the Raf kinase inhibitor resulting from this collaboration. On July ... and $1.5 million for the Biogen Idec Raf kinase inhibitor milestone referred to above. Revenues in the 2008 ...

Idenix Pharmaceuticals Reports Second Quarter and Six Month 2009 Financial Results

... the first kilogram of its lead protease inhibitor drug candidate and has initiated 28-day chronic ... applications from our non-nucleoside polymerase inhibitor and protease inhibitor programs. These efforts will take us closer to ...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

... SPC3649 is a potent and specific inhibitor of microRNA-122 known to be involved in ... results of the jointly developed Hif-1alpha inhibitor targeting solid tumors at the AACR meeting in ... Survivin targeting cancer. SPC4955-ApoB inhibitor Santaris Pharma has in rodent and primate ...

Global Small Molecule Kinase Inhibitors Market to Reach $16.2 Billion by 2015, According to a New Report by Global Industry Analysts, Inc.

... market. World market for small molecule kinase inhibitor drugs is projected to reach $16.2 billion by the ... tumor cell resistance to single targeted kinase inhibitor drugs is fingered as the key reason triggering ... new market research report. New generation kinase inhibitor drugs like Nexavar are forecast to witness ...

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Inhibitor in Biological Products

Caspase Inhibitor Ac-DEVD-CHO, Unconjugated from Promega

Description:... Ac-DEVD-CHO is an inhibitor of caspase-3/7 (DEVDase) activity. The concentration of inhibitor required to inhibit caspase activity must be determined empirically for each system. Ten micromolar inhibitor is sufficient to inhibit caspase activity in ...
Company:Promega

MMP-2/MMP-9 Inhibitor IV [SB-3CT] from CHEMICON

Description:... MMP-2 / MMP-9 inhibitor IV is a potent, selective, slow binding and mechanism based inhibitor of human gelatinases. • Molecular weight: ... Molecular Formula: C(15)H(14)O(3)S(2). • The inhibitor is soluble in DMSO ....
Company:CHEMICON

SUPERaseIn from Ambion

Description:... SUPERaseIn RNase inhibitor (patent pending) is a protein based inhibitor of nonhuman origin that noncovalently binds and ... SUPERaseIn is the most effective RNase inhibitor available providing a higher level of protection ...
Company:Ambion

ANTI-RNase from Ambion

Description:... ANTI-RNase is a protein ribonuclease inhibitor that noncovalently binds and inactivates neutral ... is distinct from human placental ribonuclease inhibitor in that it has a more robust interaction with ... in any application where placental ribonuclease inhibitor is used. It is ideal for use in in vitro ...
Company:Ambion

RNase Inhibitor (Cloned) from Ambion

Description:... Ambion's RNase inhibitor is a recombinant human protein produced in E. coli and is a potent inhibitor of neutral pancreatic RNase A type enzymes. The mode of inhibition is noncompetitive; the inhibitor tightly binds RNases in a 1:1 ratio. The enzyme ...
Company:Ambion

RNaseOUT Recombinant Ribonuclease Inhibitor from Invitrogen

Description:... RNaseOUT Recombinant Ribonuclease inhibitor is a potent noncompetitive inhibitor of pancreatic-type ribonucleases such as RNase A. ... inhibitors RNaseOUT Recombinant Ribonuclease inhibitor is an acidic protein with a molecular weight ~52 ...
Company:Invitrogen

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Inhibitor in Biological Definition

Competitive inhibitor

... molecules cannot enter the active site while the inhibitor is there, and inhibitors cannot enter the site ... vice-versa. In noncompetitive inhibition , the inhibitor works by occupying some other site on the enzyme. Because of this, the substrate and inhibitor do not compete for access to the same site. ...

Active site

... but cannot be processed by the enzyme. In noncompetitive inhibition , the inhibitor binds to the enzyme at another site, the allosteric site , and this ... inhibition , is similar to noncompetitive inhibition except that the inhibitor can only bind the enzyme-substrate complex rather than the free enzyme. ...

Apoptosis

... by a defective death signal in a type of lung cancer cells called NCI-H460 (human non-small cell lung cancer cells). They found that the X-linked inhibitor of apoptosis protein (XIAP) is overexpressed in H460 cells. XIAPs bind to the processed form of caspase-9, and suppress the activity of apoptotic ...

Cancer

... also has been shown to reduce risk of second primary tumors among patients with primary head and neck cancer . Finasteride , a 5-alpha reductase inhibitor , has been shown to lower the risk of prostate cancer. Other examples of drugs that show promise for chemoprevention include COX-2 inhibitors ...

Neurotransmitter

... vesicles. Post-synaptic effect A neurotransmitter's effect is determined by its receptor. For example, GABA can act as a rapid or slow inhibitor , depending on whether an ionotropic or metabotropic receptor is the target of the molecule. Small molecule transmitters tend to have consistently ...

Proton pump

... transmembrane ATPase active transport cytochrome mitochondrion chloroplast electron transfer chain proton pump inhibitor ATP synthase ...

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Inhibitor in Biological Dictionary

RNase

... against RNase 1, ... Recombinant murine RNase inhibitor does not contain the pair of cysteines ... RNase Assay: ... RNase inhibitor is a recombinant human placental protein ... ... Incubation of 200 units of RNase inhibitor with 1 µg of RNA at 37°C for 1 hour ... Part ...

Proton pump

... proton pump inhibitors? ... Proton pump inhibitor Proton pump inhibitors (or 'PPI's) are a ... of various acid-peptic ... Proton pump inhibitor relabeling for cancer risk not warranted. ... ... topic layout ... Nevertheless, proton pump inhibitor chemistry is the most mechanistically ... See ...

Proteasome

... , COP9 signalosome, TPPII ... Proteasome inhibitor drug for treating cancer. ... Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome . ... The Proteasome ... An orally-administered anti-cancer proteasome inhibitor would have the advantage ... Pfam is a large ...

Competitive inhibition

... of enzyme inhibition where binding of the inhibitor to the enzyme prevents binding of the ... . ... In competitive inhibition the inhibitor is similar in structure to the substrate ... ... ... In pure competitive inhibition , the inhibitor is assumed to bind to the free ... The ...

Topoisomerase

... generated by winding/unwinding of DNA. ... See also topoisomerase inhibitor ... Eukaryotic type II topoisomerase cannot introduce supercoils; ... distinct topoisomerases: type IA and type IB Topoisomerase inhibitor Topoisomerase inhibitors are agents designed to interfere with the ...

Ribonuclease

... pairs in the DNA for the enzyme Ribonuclease ? ... Ribonuclease inhibitor Top view of porcine ribonuclease inhibitor (PDB accesion code 2BNH) ... authors methodology in ribonuclease ...

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