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Inducer in Medical News

Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results and Highlights

... of antiviral activity with ANA773, our oral inducer of endogenous interferons that acts via the TLR7 ... ANA773 is an oral prodrug of a small molecule inducer of endogenous interferons that acts via the ... polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 ...

Prescription Copay Assistance for Patients taking Gleevec or Tasigna for Philadelphia chromosome-positive Chronic Myelogenous Leukemia (Ph+ CML)

... may need to be increased, depending on patient tolerability. If the strong inducer is discontinued, the Tasigna dose should be reduced to the indicated dose. ... be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may ...

Anadys Pharmaceuticals, Inc. Announces Pricing of Common Stock and Warrant Offering

... polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C. Safe Harbor Statement ...

Anadys Pharmaceuticals to Present at the Citi Biotech Day

... hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...

Gleevec(R) substantially reduces risk of cancer returning in patients with life-threatening gastrointestinal stromal tumors (GIST), The Lancet reports

... of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may significantly interact with Gleevec include ketoconazole, acetaminophen, ...

Synthetic gene circuit allows precise dosing of gene expression

... defense against the drug." The gene expression circuit built by Balzsi and colleagues produces a linear relationship between the dose of an inducer that regulates the circuit and the level of gene expression. Gene network built to repress The team first synthesized a gene network designed ...

New approaches to protecting transplanted organs make first steps toward patients

... could do that as well: "That is part of the experiment we still need to look at," Dr. Mellor said. However it also may be that short-term IDO inducer therapy will enable long-term graft survival. "It may get it through that window of difficulty." The team also will explore the more localized ...

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... Vitro Assessment of Drug Interactions Sitagliptin is not an inhibitor of CYP isozymes CYP3A4, 2C8, 2C9, 2D6, 1A2, 2C19 or 2B6, and is not an inducer of CYP3A4. Sitagliptin is a p-glycoprotein substrate, but does not inhibit p-glycoprotein mediated transport of digoxin. Based on these results, ...

Avalon Pharmaceuticals names lead development candidate in beta-catenin inhibitor program

... clinical development candidate in its Beta-catenin Pathway Inhibitor program. This novel compound inhibits the Beta-catenin pathway and is a potent inducer of cancer cell death. The Company plans to begin clinical testing of AVN316 in patients in 2009. Beta-catenin is one of the most commonly ...

What roles does TSP-1 play in liver fibrogenesis?

... In the view of the authors, the results of this study suggest TSP-1 might contribute to the wound healing response to liver injury as an inducer of angiogenesis, and could be a potential target in the manipulation of angiogenesis in chronic inflammatory liver diseases ending with cirrhosis. ...
Inducer in Medical Technology

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

... may need to be increased, depending on patient tolerability. If the strong inducer is discontinued, the Tasigna dose should be reduced to the indicated dose. ... be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... be carefully monitored in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may ... may need to be increased, depending on patient tolerability. If the strong inducer is discontinued, the Tasigna dose should be reduced to the indicated dose. ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may significantly interact with Gleevec include ketoconazole, acetaminophen, ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

... hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

... of Gleevec should increase by at least 50%, and clinical response should be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may significantly interact with Gleevec include ketoconazole, acetaminophen, ...

Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting

... must be co-administered a strong CYP3A4 inducer, the dose of Tasigna may need to be increased, depending on patient tolerability. If the strong inducer is discontinued, the Tasigna dose should be reduced to the indicated dose. Tasigna is a competitive inhibitor of CYP3A4, CYP2C8, CYP2C9, CYP2D6, and ...

EpiCept Announces Successful Completion of Enrollment for Phase I Trial of EPC2407

... trial for EPC2407. The trial has met all of its objectives. EPC2407 is EpiCept's novel small molecule vascular disruption agent (VDA) and apoptosis inducer for the treatment of patients with advanced solid tumors and lymphomas. (Logo: http://www.newscom.com/cgi-bin/prnh/20020513/NYM112LOGO ) EpiCept ...

Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC

... RDEA806 (EC50 = 1.67 ng/ml). Evaluation of the drug-drug interaction liability, in vitro and in vivo, demonstrated that RDEA806 is unlikely to be an inducer or inhibitor of major P450 enzymes or be affected by CYP3A4 inhibitors. When given together with ritonavir, an HIV protease inhibitor and potent ...

EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound

... discovered through EpiCept's Anti-cancer Screening Apoptosis Program (ASAP). EPC2407, a novel small molecule vascular disruption agent and apoptosis inducer for the treatment of cancer patients with advanced, solid tumors and lymphomas, is currently in Phase I clinical development by EpiCept. In July ...

Myriad Genetics Presents Azixa's Mode of Action at AACR

... at the annual meeting of the American Association for Cancer Research (AACR) in Los Angeles, California. Azixa has been previously shown to be an inducer of apoptosis, and a potent inhibitor of human tumor cell growth and survival in cell culture, regardless of the multiple drug resistance ...

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Inducer in Medical Products

Dual Media Kit

Description:... E. coli manipulation, is not a good medium for repression of protein expression during cell expansion, nor is it ideal for protein expression when inducer is ....
Company:Zymo Research Corporation
Inducer in Medical Dictionary

Tryptophan

... , an amino acid used by the body to make the neurotransmitter serotonin . Foods such as warm milk or turkey have a natural sleep inducer called L- tryptophan . Exercise regularly, but not in the last two hours before going to bed. N- alpha acetyltransferase; peptide ...
Inducer in Biological News

Oxidative stress: Mechanism of cell death clarified

... mitochondria to the cell nucleus, was identified as another important event in this signaling cascade. The fact that oxidative stress is a major inducer of cell death is a well accepted current model. Until now however, the source and nature of the reactive oxygen species has remained obscure, as have ...

1 person out of every 1,000 has synaesthesia, in which an individual can smell a sound

... perception of a determined stimulus activates a different subjective perception with no external stimulus (in science, the evoker stimulus is called inducer and the additional experience concurrent). In the department of Experimental Psychology and Physiology at the University of Granada , a ...

Scientists solve structure of key protein in innate immune response

... and Technology. "LPS is the most famous and probably the most important inducer of the innate immune response." Dr. Lee and his colleagues solved the ... time without clear success," explains Dr. Lee. "Since LPS is an important inducer of septic shock, blocking LPS receptors such as CD14 are among the most ...

Developing uses for sugar-cane bagasse: Biotechnology applied to the paper industry

... Furthermore, this process can be adapted to the processing of other raw materials (wood, cereals). Investigation of the use of methanol as laccase inducer can, similarly, be envisaged as a way of recycling this compound, which constitutes one of the main pollutants emitted by the paper industry. ...

Antioxidant protects against lung damage in silicosis

... from lung lesions, it could also represent a novel biomarker for evaluating the severity of silicosis. In their mouse studies, hemin, a potent inducer of HO-1, suppressed acute inflammation after silica exposure, whereas zinc protoporphyrin, an inhibitor of HO-1, accelerated the development of ...

New genes implicated in rheumatoid arthritis

... was also found over-expressed in the synovial tissue of OA patients. The third most significantly over-expressed gene was cysteine-rich, angiogenic inducer 61 (Cyr61), well-established for its role in the formation of new blood vessels. "Our findings provide the first evidence that laeverin is ...

The evolutionary triumph of flower power

... is that flowers are exploiting an emotional niche. They make us happy," McGuire says. "Because they are a source of pleasure ?a positive emotion inducer ?we take care of them. In that sense they're like dogs. They are the pets of the plant world." Psychologist Haviland-Jones had conducted three ...

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Inducer in Biological Technology

Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights

... ANA773 is an oral prodrug of a small molecule inducer of endogenous interferons that acts via the ... a Phase I Healthy Volunteer with ANA773, an Oral inducer of Endogenous Interferons that Acts Via TLR7, for ... polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 ...

Anadys Pharmaceuticals Reports Second Quarter 2009 Financial Results and Program Highlights

... 2009. ANA773 ANA773 is the Company's oral inducer of endogenous interferons that acts via the toll like receptor 7 (TLR7) ... has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, ...

Video: Higher Initial Dose of Gleevec Achieved Better Early Responses than Standard Dose for Patients with Chronic Myeloid Leukemia

... be carefully monitored, in patients receiving Gleevec with a potent CYP3A4 inducer such as rifampin or phenytoin. Examples of commonly used drugs that may ... may need to be increased, depending on patient tolerability. If the strong inducer is discontinued, the Tasigna dose should be reduced to the indicated dose. ...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

... polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C. Safe Harbor Statement Statements ...

Anadys Pharmaceuticals to Report Second Quarter 2009 Financial Results

... polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C. Safe Harbor Statement ...

Anadys Pharmaceuticals, Inc. Announces Strategic Restructuring to Focus Operations on Continuing the Advancement of ANA598

... polymerase inhibitor for the treatment of hepatitis C. The Company has also investigated the potential of ANA773, an oral, small-molecule inducer of endogenous interferons that acts via the Toll-like receptor 7, or TLR7, pathway in hepatitis C. Safe Harbor Statement ...

Anadys Pharmaceuticals to Report First Quarter 2009 Financial Results

... hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...

Anadys Pharmaceuticals to Present at Future Leaders in the Biotech Industry

... hepatitis C, the Company is developing two potentially complementary agents, ANA598, a non-nucleoside polymerase inhibitor and ANA773, an oral inducer of endogenous interferons that acts via the TLR7 pathway. The Company is also developing ANA773 for the treatment of cancer. Safe Harbor ...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at AASLD 2008

... is a good candidate for combination therapies with STAT-C agents in the absence of interferon or ribavirin. -- "Nitazoxanide (NTZ) is an inducer of eIF2a and PKR phosphorylation," Elazar et al., Tuesday, November 4, 8:00 AM - 12:30 PM PST (Poster #1881) This poster presentation by ...

Portola Pharmaceuticals Initiates Phase II Trial of Betrixaban, its Novel Oral Factor Xa Inhibitor for Stroke Prevention in Atrial Fibrillation

... and may be the only novel oral anticoagulant available for patients with severe renal disease. And because betrixaban is neither an inhibitor nor an inducer of cytochrome P450 enzymes, it minimizes the risk of drug-drug interactions often seen with other Factor Xa inhibitors in development and with ...

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Inducer in Biological Products

Mast Cell Degranulation colorimetric Assay Kit from CHEMICON

Description:... control. Calcium Ionophore A23187 (Calcimycin) is included in the kit for degranulation induction of samples. Calcimycin has been a well-documented inducer of tryptase release from human mast cells (2,3). A tryptase inhibitor, protamine, is included as a test inhibitor for screening purposes. ...
Company:CHEMICON

S-Gal/LB Agar/Kanamycin Blend from Sigma-Aldrich

Description:... S-Gal (3,4-cyclohexenoesculetin -D-galactopyranoside, a patented autoclavable chromogenic substrate for -galactosidase.1 The blend also contains the inducer isopropyl -D-thiogalactoside (IPTG) and the antibiotic ....
Company:Sigma-Aldrich
Inducer in Biological Dictionary

Inducer

... In molecular biology, an inducer is a molecule that starts gene expression. ... from "http://en.wikipedia.org /wiki/ inducer " ... inducer n. One that induces, especially a substance that ...

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