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Hypoxia in Medical News

$16.8 million study will breathe new life into cancer battle

... state that is common to all solid tumours. hypoxia causes a huge problem in cancer therapy because ... respond less well to treatment. Furthermore, hypoxia also appears to increase the chance that a tumour ... of the process of metastasis and why hypoxia plays such a key role. The researchers in this ...

JCI table of contents: March 23, 2009

... examine how human lung tumors without regions of hypoxia develop and found that tumors rely on hypoxia to promote their own expansion. In the study, ... hypoxia, leading the authors to conclude that hypoxia seems to be a key factor driving tumor ...

Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack

... the body tends to correlate with their degree of hypoxia resistance." Crowder says it may be possible ... inhibiting translation likely protects cells from hypoxia by reducing energy consumption because making ... were surprised by the degree of resistance to hypoxia when the translation rate was cut. They wanted to ...

Sleep disordered breathing and obesity: Independent effects, causes

... Clinic found that the chronic intermittent hypoxia that often characterizes OSA, a common form of ... "We have developed a mouse model of intermittent hypoxia and have demonstrated that a combination of a high-fat diet and intermittent hypoxia leads to liver disease in those mice. We plan on ...

Study of Everest Climbers Questions Oxygen Use

... low levels would work for ER patients with hypoxia remains unclear WEDNESDAY, Jan. 7 ... could lead to a change in the treatment of the hypoxia often seen in people in emergency rooms, like ... he said. More Information What hypoxia can do to the brain is described by the U.S. ...

The mental health dangers of birth hypoxia

... during pregnancy and birth, such as birth hypoxia - the shortage of oxygen in the body - are ... for schizophrenia. However, it is not clear why hypoxia increases the risk for schizophrenia. The ... a specific indicator of fetal distress following hypoxia was more likely to be present among people who ...

Researchers identify unusual molecular switch for common form of advanced breast cancer

... orchestrate angiogenesis, the tumor response to hypoxia and progression of tumors to form large locally ... observed that elevated levels of 4E-BP1 trigger hypoxia inhibition of conventional protein synthesis in ... and angiogenesis, thereby functioning as a hypoxia controlled switch for tumor growth and survival. ...

Breaking Studies - Masimo's Technologies the Focus of Multiple Clinical Studies at Last Week's American Society of Anesthesiologists' Annual Meeting

... be involved in the physiopathological process of hypoxia of acute CO poisoning patients." The application ... especially Masimo ear sensor, can detect hypoxia as soon as or even sooner than finger," adding ... and ear) can also sense recovery state from hypoxia sooner than finger." (5) In addition, a study ...

Long-term study shows low oxygen levels in prostate tumors can predict recurrence

... as tumor grade, PSA level, and tumor size, the team determined that hypoxia was a significant independent predictor of an increase in PSA levels. ... score, tumor size, age, and other prostate cancer risk factors, tumor hypoxia alone could predict the likelihood of increased PSA levels, and ...

U of I study shows benefits of hormone found in fat tissue

... plays a key role in regulating the immune system. When we exposed mice to hypoxia (simulating an event, such as a heart attack, in which a part of the body ... another group was fed a normal diet. The obese mice recovered from acute hypoxia five times faster than the mice fed normal diets. In a second ...

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Hypoxia in Medical Technology

Diffusion Pharmaceuticals Announces Initiation of a Phase I/II Clinical Trial in Patients with Peripheral Arterial Disease (PAD)

... transport and thus treating the symptoms of hypoxia at their source. In 2007, the Company ... determine the effect of TSC on potential hypoxia biomarkers; and evaluate the impact of TSC ... to alleviate the claudication pain caused by hypoxia in the tissues of the legs. Additional Clinical ...

Zevalin(R) Combined With High-Dose Chemotherapy and Autologous Stem-Cell Transplantation (ASCT) Produces High Overall Survival and Progression-Free Survival Rates in Patients With Relapsed Non-Hodgkin's Lymphoma

... OS and PFS were 88.9 percent and 69.8 percent, respectively. The primary toxicities observed included grade 3 or 4 mucositis in 21 patients, grade 3 hypoxia in eight patients, and grade 3 pneumonitis, which responded to corticosteroids, in 3 patients. Transplantation-related mortality at 100 days was 0 ...

Threshold Pharmaceuticals Announces Multiple Presentations on Oncology Pipeline at the 2007 American Association for Cancer Research (AACR) Annual Meeting

... 8:00am to 12:00pm: Poster 3988: In Vivo Anti-Cancer Efficacy of a hypoxia Activated Prodrug, TH-302 Poster Session: Angiogenesis Inhibitors Poster 3985: Anti-Tumor Activity of a hypoxia Activated Prodrug, TH-302, in Pancreatic and Prostate Orthotopic ...

Data to be Presented at ASCO 2007 Highlights sanofi-aventis Commitment to Cancer Care and Research

... study, one patient died from eosinophilic pneumonia in the Eloxatin(R) combination arm. The combined incidence of cough, dyspnea, and hypoxia was 43% (7% grade 3 and 4) in the Eloxatin(R) plus 5-FU/LV arm compared to 32% (5% grade 3 and 4) in the irinotecan plus 5-FU/LV arm ...

Kosan Presents Promising Phase 1 Data on Second-Generation Hsp90 Inhibitor, Alvespimycin, Showing Antitumor Activity in Refractory Breast and Ovarian Cancers at ASCO

... arthralgia, nausea). One patient with multiple prior trastuzumab and doxorubicin containing regimens experienced a dose-limiting toxicity of hypoxia and left ventricular ejection fraction reduction at 100 mg/m2. Two patients treated at 80 mg/m2 experienced reversible Grade 3 ocular keratitis; ...

Phase 2 Results for EntreMed's Panzem NCD Brain Cancer Study Presented at ASCO

... apoptosis (programmed cell death), tumor cell cycle inhibition at the G2/M phase of mitosis, and disruption of angiogenesis through the inhibition of hypoxia inducible factor-1 alpha (HIF-1alpha), a protein required for angiogenesis and cell survival under stress. By these mechanisms, Panzem(R) has ...

Clinical Results From EntreMed's Panzem NCD and Taxol Breast Cancer Study Presented at ASCO

... (PR), and one patient with a 30% reduction in tumor volume. Patients also underwent sequential biopsies of their tumors to evaluate biomarkers of hypoxia and angiogenesis. Paclitaxel causes an increase in tumor HIF-1alpha expression, which is downregulated by 2ME2. Changes were observed in HIF-1 ...

Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer

... EFAPROXYN was generally well tolerated. The most common Grade 3-4 adverse events that occurred more often in the EFAPROXYN arm included headache, hypoxia and vomiting. Adverse events in the study appeared to be similar to those observed in previous clinical studies with EFAPROXYN. "Although we are ...

YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial

... of opioids) were not administered to any subjects in the trial. AeroLEF does not appear to increase the risk of key adverse events (such as hypoxia and bradypnea) and has the potential to minimize certain otherwise expected adverse effects of interest to patients and physicians, warranting ...

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Hypoxia in Medical Products

Hypoxia Chamber

Description:... For the easy and economical generation of a hypoxic environment for tissue culture. The hypoxia Incubator Chamber utilizes a surface-type seal where all portions of the O-ring are uniformly compressed by a stainless steel ring clamp for a ...
Company:StemCell Technologies, Inc.

Extra Long Gentle-Flo® Suction Catheter -Vactrol® Connector

Features:... during suctioning. Vactrol® connector allows fingertip vacuum control, avoids unnecessary suction during insertion, reduces risk of hypoxia and prevents splashback. Extra long length. 20 per box. ...
Company:Nellcor

Gentle-Flo® Suction Catheter - Vactrol® Connector

Features:... during suctioning. Vactrol® connector allows fingertip vacuum control, avoids unnecessary suction during insertion, reduces risk of hypoxia and prevents splashback. Vactrol® connectors. 100 per box. ...
Company:Nellcor

D-Line Coude' Tip Suction Catheter

Features:... into the desired bronchus. Vactrol® connector allows finger tip vacuum control, avoids unnecessary suction during insertion, reduces risk of hypoxia and prevents splashback. Directional line provides visualization of tip direction. Atraumatic tip reduces risk of trauma. Four circumferential ...
Company:Nellcor
Hypoxia in Medical Definition

Breath-holding spells

... a minute or two, but some will fall asleep for an hour or so. Physiologically, there is often hypocapnea (low levels of carbon dioxide) and usually hypoxia (low levels of oxygen). The events are thought to occur due to a variety of factors, including the fact that the child is not breathing, there is ...

Gastric lavage

... , this is more likely to occur if hydrocarbons are ingested or in patients without a protected airway. Other complications include laryngospasm , hypoxia , bradycardia , epistaxis , hyponatremia , hypochloremia , water intoxication , or mechanical injury to the stomach. References ...

Pathology

... the injury. In the short term, cells may activate specific genetic programs to protect their vital proteins and organelles from heat shock or hypoxia , and may activate DNA repair pathways to fix damage to chromosomes from radiation or chemicals. Hyperplasia is a long-term adaptive response ...
Hypoxia in Medical Dictionary

Hypoxia

... Cerebral hypoxia Definition: The term cerebral hypoxia technically refers to a lack of oxygen supply ... lack of oxygen supply to the entire brain. hypoxia , or altitude sickness , reduces the amount of ...

Hypothyroid

... in weight gain , hair loss , sluggishness and thickening of the skin . hypoxia ... hypothyroid ism Too little thyroid hormone . Symptoms include ... skin , and sensitivity to the cold . Also called underactive thyroid. hypoxia ... Treatment of hypothyroid ism is generally straightforward. A ...

Hypothyroidism

... in weight gain , hair loss , sluggishness and thickening of the skin . hypoxia ... hypothyroidism Too little thyroid hormone . Symptoms include ... skin , and sensitivity to the cold . Also called underactive thyroid. hypoxia ... Treatment of hypothyroidism is generally straightforward. A ...

Weight gain

... in weight gain , hair loss , sluggishness and thickening of the skin . hypoxia An abnormal condition resulting from decreased availability of oxygen ... skin , and sensitivity to the cold . Also called underactive thyroid. hypoxia ... Changes in your body: Weight gain and swollen breasts , belly, ...

Altitude sickness

... ) ... Altitude, high: Altitude sickness occurs at high altitude. So what is high altitude? Altitude is defined on the following scale: ... hypoxia Hypoxia, or altitude sickness , reduces the amount of oxygen in the brain causing such symptoms as dizziness , shortness of breath, and mental ...

Amphetamine

... . Sinus tachycardia occurs in response to exercise , exertion, excitement, pain , fever , excessive thyroid hormone , low blood oxygen ( hypoxia ), stimulant drugs (such as caffeine and amphetamine s), ... Sedatives ("sleeping pills") (secobarbitol, chloral hydrate) IX. Stimulants ( ...

Asphyxia

... die. The inflamed epiglottis mechanically obstructs the airway ; the work of breathing increases, and the retention of carbon dioxide and hypoxia (low oxygen ) may result. Clearance of secretions is also impaired. These factors may result in fatal asphyxia ... Increased ammonia levels ...

Blood gases

... chest Echocardiogram ... Neurotrend System designed for continuous monitoring of blood gases for determination of cerebral ischemia and/or hypoxia in patients suffering from closed-head trauma and during surgical intervention. Mfg: Diametrics Medical. Tests may include blood and urine ...

Blood pressure

... A specific statement or proposition, stated in a testable (researchable) form, predicting a particular relationship among multi ple variables. hypoxia : Reduction of oxygen supply to tissue . Their strenght helps maintain blood pressure while the heart is between beats. Smaller arteries ...

Breathing

... sometimes a fish may flit around the tank or even jump from it. There may be a loss of colouration, labor ed breathing , and symptoms of hypoxia " or lack of oxygen . Drug resistance The result of cells' ability to resist the effects of a specific drug . Dysphagia Difficulty in ...

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Hypoxia in Biological News

NOAA forecast predicts large 'dead zone' for Gulf of Mexico this summer

... 1990 and currently oversees the two national hypoxia programs authorized by the Harmful Algal Bloom and hypoxia Research and Control Act. Data from the U.S. ... is available on the NOAA's Gulf of Mexico hypoxia Watch Web page. The objective ...

U-M researcher and colleagues predict large 2009 Gulf of Mexico 'dead zone'

... in bottom and near-bottom waters. The Gulf hypoxia research team is supported by the U.S. National ... Bay shaped Scavia's 2009 forecast for that hypoxia zone. The Bay's oxygen-starved zone is ... nitrogen, which remains one of the key drivers of hypoxia in the Bay." Farmland runoff containing ...

Simple drug treatment may prevent nicotine-induced SIDS: Study

... increasing the newborn's ability to respond to hypoxia and likely reducing the incidence of SIDS. The ... those episodes, specific proteins sensitive to hypoxia stimulate the cell to release catecholamines. A ... glands do not release catecholamines during hypoxia for example during birth or a self-asphyxiation ...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

... condition characteristic of cancer cells hypoxia (lack of oxygen). The drug candidate may provide ... studies have shown that higher levels of tumor hypoxia correlate with poor treatment outcomes for a variety of solid tumors. It is believed that hypoxia may severely limit the curability of tumors. ...

Study shows continued spread of 'dead zones'

... largest dead zone, in the Baltic Sea, experiences hypoxia year-round. Chesapeake Bay experiences seasonal, summertime hypoxia through much of its main channel, occupying about ... 5% of its volume. Diaz and Rosenberg note that hypoxia tends to be overlooked until it starts to affect ...

A new gene trigger for pregnancy disorder identified

... preeclampsia, says Kalluri. During pregnancy, hypoxia is associated with the formation of new blood ... when the fetus is undergoing rapid development, hypoxia levels are high. As the pregnancy progresses, hypoxia levels should naturally come down as fetal blood ...

Researchers confirm dead zone off Texas coast since 1985

... the cause of dead zones since 1985, he adds. hypoxia oxygen-depleted water occurs when the oxygen ... that were even one-half of that, meaning severe hypoxia has occurred. DiMarco says a comparison would ... samples and to test the concentration levels of hypoxia from several sites. ...

American Chemical Society's Weekly PressPac -- Oct. 31, 2007

... the U. S. Congress and the President a so-called hypoxia Action Plan in 2001, which aimed to reduce the ... model estimates and real-world data from other hypoxia reduction experiences in North Carolina and Hong ... ARTICLE #2 FOR IMMEDIATE RELEASE Reassessing hypoxia Forecasts for the Gulf of Mexico DOWNLOAD PDF ...

Gulf of Mexico dead zone to be studied by University of Texas at Austin marine scientists

... through NOAAs Northern Gulf of Mexico (NGOMEX) hypoxia and Ecosystems Research Program. UTMSI ... accurate models that predict the development of hypoxia on the Louisiana continental shelf. The ... Thomas and Buskey are studying the impacts of hypoxia on the biology of fish and benthic invertebrates, ...

Low oxygen in coastal waters impairs fish reproduction

... Society B. Laboratory studies showed that hypoxia caused endocrine disruption through decreasing ... This study suggests that when persistent coastal hypoxia occurs, there is a potential long-term threat to ... will aim to further elucidate the effects of hypoxia on fish endocrine and reproductive systems at the ...

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Hypoxia in Biological Technology

Oncothyreon highlights corporate and clinical objectives for 2008

... in the second half of 2008. PX-478 is a small molecule inhibitor of hypoxia inducible factor-1a (HIF-1a), a component of a transcription factor that ... (Trx-1), a protein that regulates many other proteins including hypoxia inducible factor (HIF)-1 alpha, vascular endothelial growth factor (VEGF) ...

Shanghai ChemPartner and ELARA Pharmaceuticals Expand Drug Discovery Collaboration to a New Level

... research findings into novel cancer treatments. The company is developing a portfolio of highly-potent orally-available inhibitors of the hypoxia signalling pathway. The lead compound shows an excellent in vivo profile and is expected to move into formal preclinical development this year. ...

Oncothyreon appoints Diana Hausman as Vice President of Clinical Development

... of cancer drug development will be very important as we prepare to move both PX-866, our inhibitor of PI-3 kinase, and PX-478, our inhibitor of hypoxia inducible factor 1-alpha, into Phase 2 trials. We are delighted to have her join our team." "I am very pleased to join Oncothyreon at this ...

VisualSonics and Seno Medical Instruments Sign Exclusive Opto-Accoustic Licensing Agreement for Preclinical Research

... biological structures, functions and processes at the cellular and molecular level as well as potentially provide the ability to monitor and quantify hypoxia (oxygenated vs. deoxygenated tissue or cells), and to reveal information on tumor development, disease progression and inflammation processes that ...

Oncothyreon initiates Phase 1 trial of PX-866 cancer compound

... in advanced pancreatic cancer, a Phase 1b trial of PX-12 in advanced metastatic cancer, and a Phase 1 trial of PX-478, a small molecule inhibitor of hypoxia inducible factor-1 alpha, in patients with advanced solid tumors or lymphomas. Oncothyreon's partner, Merck KGaA of Darmstadt, Germany, is conducting ...

Brazil's biotech firms: From imitators to innovators in health-related products

... from snake venom (COINFAR, of So Paulo); and fetal, neonatal and adult stem cell therapies for cardiac disease, type I diabetes and neonatal hypoxia (Cryopraxis, Rio de Janeiro). Barriers to development Major challenges include: A patent regime in desperate need of reform The ...

Data for Oncothyreon's PX-12 and PX-866 presented at AACR Annual Meeting

... of PX-866. About PX-12 PX-12 is an irreversible inhibitor of thioredoxin (Trx-1), a protein that regulates many transcription factors including hypoxia inducible factor (HIF)-1 alpha, vascular endothelial growth factor (VEGF) and activator protein 1 (AP-1). These factors play a critical role in ...

Oncothyreon's PX-478 is effective in preclinical model of human lung cancer

... by Jorg J. Jacoby, Ph.D., Instructor, University of Texas M.D. Anderson Cancer Center, Houston. Oncothyreon's PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a Phase 1 trial in patients with advanced metastatic cancer and lymphoma. The study employed a model of ...

JCI table of contents: Dec. 3, 2007

... This inflammation-induced ischemia resulted in tissue hypoxia, as the oxygen content of the tracheal tissue decreased with blood flow loss. The hypoxia and ischemia preceded fibrosis of the trachea. The authors therefore suggested that revascularization following lung transplantation might be the key ...

New Study Shows Promise for Hydrogen Sulfide in Reducing Heart-Attack Damage, Ikaria Announces

... and anti-inflammatory molecule: research previous to the present study has shown it to be effective in experimental models of inflammation, lethal hypoxia and a number of other diseases. About Ikaria Holdings Ikaria Holdings is a fully integrated biotherapeutics company focused on the development and ...
Hypoxia in Biological Products

Mouse Anti-Human HIF-1 beta Monoclonal Antibody, Unconjugated, Clone H1beta234 from Assay Designs/Stressgen Bioreagents

Description:... This antibody detects an ~92 kDa protein corresponding to the apparent molecular mass of the beta subunit of hypoxia Inducible Factor-1 (HIF-1beta) on Western ....
Company:Assay Designs/Stressgen Bioreagents
Hypoxia in Biological Definition

Lung

... able to extract a greater concentration of oxygen from inhaled air. Birds are thus equipped to fly at altitudes at which mammals would succumb to hypoxia . Reptilian lungs Amphibian lungs The lungs of most frogs and other amphibians are simple balloon-like structures, with gas ...

Redox

... ) whose interconversion is dependent on these ratios. An abnormal redox state can develop in a variety of deleterious situations, such as hypoxia , shock , and sepsis . See also Bioremediation Calvin cycle Citric acid cycle Electrochemistry Galvanic cell ...

Redox

... ) whose interconversion is dependent on these ratios. An abnormal redox state can develop in a variety of deleterious situations, such as hypoxia , shock , and sepsis . See also Bioremediation Calvin cycle Citric acid cycle Electrochemistry Galvanic cell ...
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