Molecular biology fills gaps in knowledge of bat evolution
...es of all bat families. Their results support the hypothesis that the group of large fruit-eating bats from the tropics, that fly mostly during the day - known to biologists as megabats - emerged from four major lineages of smaller and more widely dispersed, mostly insect-eating, night-flying bats, known as mi...Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
...those with the highest. "[T]hese data support the hypothesis that deficient DNA repair capacity is associated with susceptibility to breast cancer and may be a valuable in vitro biomarker to identify high-risk subjects, especially in familial breast cancer families," the authors write. "It is unclear at this t...Neuronal 'traffic jam' marks early Alzheimer's disease
...transport deficit and plaque deposition. "So, our hypothesis is that in familial Alzheimer's disease -- or in disorders such as Down syndrome where beta-APP is overexpressed -- those defects cause early failure in cellular transport," he said. "And those failures then stimulate further production of A-beta pep...Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
... to the biology, the authors then offer a unifying hypothesis for the development, growth and evolution of the disease, and complete the review with a discussion of the clinical implications for practicing physicians. ...HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
...d with protease inhibitors. They investigated the hypothesis that the widely-used protease inhibitors may, in fact, be linked to the development of heart rhythm problems through the mechanism of blocking a channel. Ultimately researchers from the University of Wisconsin led by Craig January, M.D., Ph.D., disco...Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen
... JNK pathway. This observation led to the original hypothesis that JIP1 acts as a cytoplasmic anchor for JNK.JIP1 has been shown to bind selectively to JNK but not to the ERK or p38 MAP kinases; it has also demonstrated selectivity in its binding to specific proteins of the JNK pathway. In addition to JNK, JIP1...Structural Determination of Flavonoids Using MSn
...n and the spectrum is illustrated in Figure 5. The hypothesis that the m/z 271 originated from the m/z 433...is similar to the MS/MS spectrum of apiginin. This hypothesis is tested via the MS 4 experiment of the m/z 271 ion. The spectrum (Figure 6) is an exa...Monitoring Microbial Populations Using Real-Time qPCR on the MJ Research Opticon 2 System
...n combination. 4 The JRGC study tests the hypothesis that specific environmental conditions affect the population size of ammoniaoxidizing bacteria (AOB). AOB are responsible for the oxidation of ammonia to nitrite in the nitrification process. This process is essential for makin...The New Affymetrix GeneChip Scanner 3000
... the HG-U95Av2 and HG-U133A probe arrays. The null hypothesis was defined as the GeneArray 2500 performance significantly exceeded the GeneChip Scanner 3000 performance at a p>0.95 confidence level. Therefore, p-values less than or equal to (≤) 0.95 were interpreted as contradicting the null hypothesi...NimbleGen microarrays speed genetic findings
...arry the inversion. The research was based on the hypothesis that the genome contains "hotspots" that are prone to instability and flanked on each side by large, repetitive regions of DNA, termed "segmental duplications." It is because of the repetitive nature of these regions that, during replication, the gen...... As the game progressed they had to come up with a hypothesis for the cause of death. The results of the program were better than expected - each of the students, even the typically uncommunicative ones, got into the roles and changed their ideas continually through the game, Jan said. Since it took place in a...Cats to protect children from asthma
...g of allergic reactions. Supporters of cleanliness hypothesis reasoned that exposure to cats might be protecting from asthma by strengthening the Th1 system. To prove this Thomas Platts-Mills and his colleagues from the University of Virginia looked at the immune reactions of 226 children to cat allergens in t......isfying sexual encounter. There are two preeminent hypothesis based on the findings. The "in-suck" surmise argues that contraction during orgasm draws in the sperm after ejaculation. Arousal has also been shown to reduce acidity inside the vagina. According to this theory an acidic vagina lessens the chances ...Regular exercise linked to extended menstrual cycles
... a day. "These findings lend modest support to the hypothesis that moderate levels of physical activity can lengthen the menstrual cycle," Sternfeld and her colleagues conclude. Relatively moderate activity, they add, may have hormonal effects that may lengthen the menstrual cycle, resulting, over a lifetime, ...Fewer teeth & Increased Ischemic Stroke risk
...4 percent higher for men with 9 or fewer teeth. A hypothesis that is gaining momentum is that the infection associated to periodontal disease and tooth loss causes inflammation that affects the arteries. Doctors also claim that earlier studies have shown that tooth loss is related to disease of the carotid ar......s. Researchers say that the findings support their hypothesis that common genetic factors contribute both to the risk of non-insulin dependent diabetes and decreased pre-natal growth"....Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control
... using bench top analyzers. The authors tested the hypothesis that immediately available results could improve glycemic control by changing either physician or patient behavior or both. They concluded that immediate feedback based on HbA1c results at the time of patient encounters resulted in a significant impr......nitiating our Phase III trials to further studyour hypothesis that our oral, once-daily anticoagulant withsuperior pharmaceutical properties, including a relatively flatpeak to trough concentration ratio, will lead to better outcomesfor patients." About EXPERT EXPERT (Evaluation of the Factor Xa Inhibitor, PR...Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
...shed this week in CNSDrugs(1) further supports the hypothesis that acatechol-O-methyltransferase (COMT) inhibitor that acts in thebrain would be a useful agent to address profound cognitivedeficits in schizophrenia and bipolar disorder. CeNeS has anongoing discovery programme to develop novel COMT inhibitors. ......the pain but not the underlying problem.Columbia's hypothesis is that administering lidocaine vaginally,using its proprietary bioadhesive delivery system (BDS) technology,can minimize or prevent the severe cramping that results in thedebilitating pain of dysmenorrhea. About Columbia Laboratories Columbia Labo......ing metabolism. Thesepreclinical data validate our hypothesis that by inhibitingghrelin's normal function with a potent, small moleculetherapeutic, one can effectively improve glucose control, managebody weight, and regulate metabolism. Should this approach beconfirmed in clinical testing, we believe ghrelin in...