Bcl6 gene sculpts helper T cell to boost antibody production

... germinal centers, the B cells not only proliferate but they also undergo hypermutation in their immunoglobulin genes so they can produce a diverse class of ... likely producing the wrong type of antibody at great volume. Genetic hypermutation among B cells in germinal centers creates a hotbed of genomic instability, ...

Yale study offers insight into possible cause of lymphoma

... and an increased risk of cancer." The lymph system is made up of infection-fighting B cells. Schatz and his colleagues examined the somatic hypermutation (SHM) process, which introduces random mutations in B cells' antibody genes to make them more effective in fighting infection. SHM occurs in two ...

hypermutation in Biological Technology

Anaptys Biosciences Appoints R. Scott Greer to Board of Directors

... Coopers & Lybrand. About Anaptys Biosciences Anaptys is a privately-held biopharmaceutical product company and the leader in the use of somatic hypermutation (SHM) for antibody discovery and protein optimization. The company's proprietary Omnitope-SHM(TM) System provides a robust platform for evolving and ...

hypermutation in Biological Definition

Evolution

... and by exposure to radiation , chemicals, or viruses , or can occur deliberately under cellular control during processes such as meiosis or hypermutation . In multicellular organisms, mutations can be subdivided into germline mutations, which can be passed on to progeny and somatic mutations , which ...

Molecular evolution

... and by exposure to radiation , chemicals, or viruses , or can occur deliberately under cellular control during the processes such as meiosis or hypermutation . Mutations are considered the driving force of evolution , where less favorable (or deleterious ) mutations are removed from the gene pool by ...

hypermutation in Biological Dictionary

Somatic hypermutation

... Somatic hypermutation (or SHM) is a mechanism inside cells that is ... the immune system to ... Somatic hypermutation Somatic hypermutation (or SHM ) is a mechanism inside cells that is ...