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Homology in Medical News

American Chemical Society's weekly PressPac -- Jan. 23, 2008

... Leikin, John M. Seddon, and Alexei A. Kornyshev and colleagues say the homology recognition between sequences of several hundred nucleotides occurs ... #1 FOR IMMEDIATE RELEASE DNA Double Helices Recognize Mutual Sequence homology in a Protein Free Environment DOWNLOAD ARTICLE ...

Apes Love a Good Laugh, Too

... critics have argued that such terminology is anthropomorphic or that human laughing is a unique display in the animal world. But, in fact, there is a homology not just based on the facial expression, which we have suspected since Darwin, but also in the details of the breathing patterns and sounds of the ...

VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting

... in their RECIST scores. About Lenocta(TM) Lenocta(TM) is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the SRC homology PTPase (SHP-1 & SHP-2) and PTB-1B, based on data from several preclinical studies conducted at the Cleveland Clinic. These intracellular enzymes are ...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

... confirms AKT1 as an oncogene in breast, colorectal and ovarian cancer. The mutation alters the electrostatics of binding pocket in the pleckstrin homology domain, the portion of the enzyme that docks with phospholipids on the cell membrane," said Dr. Kerry L. Blanchard, Executive Director, Discovery ...

'Origin Of Sex' Can Be Revealed By Sperm Proteome

... underpinnings of sperm characteristics, and may have application to mammalian sperm function. The Drosophila sperm proteins show substantial homology with the axoneme accessory structure of mouse sperm.' Professor Manyuan Long, Professor of Genetics & Evolution at the University of Chicago, ...

Evoprinter, a multigenomic comparative tool for rapid identification of functionally important DNA

... are accomplished either by simultaneous or sequential pair wise alignments of input DNAs, with alignment gaps introduced to optimize the overall homology comparisons. Researchers, writing in the October issue of the Proceedings of the National Academy of Sciences have developed a simple, yet ...
Homology in Medical Technology

VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor

... for the treatment of the parasitic disease leishmaniasis, is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the src homology PTPase (SHP-1 & SHP-2) and PTP1B. Lenocta has also been demonstrated to augment cytokine signaling and responses in hemopoietic cell lines, which ...

VioQuest Pharmaceuticals Completes Enrollment of Phase I Trial of Lenocta(TM)

... ready to enroll patients." About Lenocta(TM) Lenocta(TM) is an inhibitor of multiple protein tyrosine phosphatases (PTPases), specifically the SRC homology PTPase (SHP-1 & SHP-2) and PTB-1B, based on data from several preclinical studies conducted at the Cleveland Clinic. These intracellular enzymes are ...

Testing for Human Papillomavirus

... Editor Human papillomaviruses (HPVs) are small, closed circle, double-stranded DNA viruses, which are classified by nucleic acid sequence homology rather than serologic reactivity. Genital HPVs are the most prevalent sexually transmitted pathogens. Of the approximately 50 anogenital HPVs, ...
Homology in Medical Products

Erythropoietin RIA Test

Description:... form of EPO has an estimated molecular mass of ~30.5 kDa. Although EPO itself appears to have a unique structure, the EPO receptor bears some homology to several other growth factor receptors, including those for interleukins 2 and 6, prolactin and growth hormone, suggesting possible functional ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-1 EIA Endocrine Function 026-AC-27F1 Insulin Growth Factor

Description:... daltons), and is one of a number of related insulin-like growth factors present in the circulation. The molecule shows approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. The peptide is growth hormone (GH) dependent to a high degree, but ...
Company:ALPCO Diagnostics
Homology in Biological News

Biophysical Society announces 2008 International Travel Awards

... of the Unliganded gp120 Based on Structural homology and Molecular Dynamics Symulations. Ariel ... Model of Epithelial Sodium Channel Based on the homology with Acid-Sensing Ion Channel. Alexandra I. ... Council of Medical Research, New Delhi, India, homology Modeling of Signalling Glycoprotein from Camel ...

Protein that promotes cancer cell growth identified

... cancer cell line that is deficient in Caspase-8 and that EGF signaling can be restored by reconstituting the cells with wildtype Caspase-8. Sequence homology studies helped to identify a RXDLL motif in the protein, a sequence that has been shown in other proteins to function in cell signaling. The ...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... by the administration of the active ingredient of this oil, thymoquinone. Furthermore, it was envisioned that since thymoquinone shares a structural homology with ubiquinone (mitochondrial component) it is likely that it may act as a mitochondrial antioxidant. Indeed pretreatment of pancreatic beta-cells ...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

... genome should find those matching sequences. But this didn't work. The homology searches yielded far fewer targets than expected and could not account for ... scientists were trying to predict the microRNA targets using the sequence homology of the full-length microRNAs. In their Cell article, Han and his ...

What recognizes what in plant disease resistance?

... their leucine-rich repeat domain, the authors show that association is mediated by a completely different region on N's Toll-interleukin-1 receptor homology domain, which is structurally similar to animal innate immunity molecules. These findings provide novel insights into how R proteins recognize ...

Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu

... Pipeline (iGAP), to analyze avian flu genomes. (The iGAP suite of bioinformatics applications are designed specifically for protein structural homology recognition and functional annotation.) The San Diego-based researchers will also develop a robust production environment for routine computational ...

Common mechanisms for viral DNA replication

... of replication. The structure shows that although T-ag and its functionally analogous protein, papilloma virus E1, share no detectable sequence homology in this region, the two domains bind the DNA in similar ways. In both cases, DNA binding is thought to initiate assembly of a complex of the ...

A valuable fly for research into disease

... the fundamental principles of biology and genetics. Only in recent years, however, and thanks in large part to the discovery of the high degree of homology between the genetic make-up of flies and vertebrates, has Drosophila emerged as one of the most effective model systems to analyze the function of ...

Genes involved in biofilms

... as: Esp de Enterococcus faecalis , mus20 of Pseudomonas putida , and sty2875 of Salmonella typhi . Thus, taking into account the structural homology between Bap and Esp, it was decided to analyse for a possiblerelationship between the presence of the esp gene and the ability to produce biofilm by ...

Molecular fossils uncover link between viruses and the immune system

... which have permitted detailed comparison of viral structures in atomic detail. Such comparison led to the discovery that viruses without any sequence homology may be related. Earlier approaches to delineate evolutionary history of viruses have failed. Since Charles Darwin evolutionary history of ...

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Homology in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

... that researchers from the University of Pennsylvania presented results at AACR from an independent laboratory study examining the role of Bcl-2 homology (BH) family proteins in the development of chemotherapy resistance in neuroblastoma (Abstract # 3269). Using human-derived neuroblastoma cell lines, ...

ChemAxon Launches Marvin and JChem Version 5.2; Web Services, native .NET API, Homology Groups, 3D Alignment and Structural Frameworks

... to the JChem API from .NET. In the patent space we introduce new features for drawing and searching Markush structures, including support for homology groups and repeating units. Our Markush project works toward robust support for Chemical IP, including identification of overlap of Markush libraries ...

Use of the DCode System to Detect the Food-Borne Bacterial Pathogen Listeria monocytogenes

... has 99.2 % and 98.5% nucleotide homology with the corresponding molecule of the ... fragments from these two species reveals sequence homology where base assignments have been made ... fragments possess sequence homology or the same G+C content remains to be ...

siRNA Design Guidelines

... 16-17 contiguous base pairs of homology to other coding sequences. We suggest using ... lacks significant sequence homology to the genome . To design a negative control ... conduct a search to make sure it lacks homology to any other gene. Additional ...

Trouble-shooting: Smeared bands

... href="#Option5">Mispriming caused by excessive homology at 3' ends of primers (primer ... of template, snapback, or excessive homology at 3' ends of primers ... there is no more than 2 bases of homology at the 3' end. Use a primer design program ...

Trouble-shooting: No product

... structure of template, snapback, or excessive homology at 3' ends of primers ... of template, snapback, or excessive homology at 3' ends of primers ... there is no more than 2 bases of homology at the 3' end. Use a primer design program ...

Trouble-shooting: Misincorporation or low fidelity

... template, snapback, or excessive homology at 3' ends of primers ... of template, snapback, or excessive homology at 3' ends of primers ... there is no more than 2 bases of homology at the 3' end. Use a primer design program ...

Trouble-shooting: Non-specific bands

... template, snapback, or excessive homology at 3' ends of primers ... of template, snapback, or excessive homology at 3' ends of primers ... there is no more than 2 bases of homology at the 3' end. Use a primer design program ...

General Notes on Primer Design in PCR*

... extended by the polymerase if there is a short homology at the 3' end. In general, a melting ... to be designed with absolutely no intra-primer homology beyond 3 base pairs. If a primer has ... related danger is inter-primer homology. Partial homology in the middle regions of two primers ...

Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and Discover New Genes

... of clones that do not have significant nucleotide homology to clones in public databases.* Therefore using ... Clones having significant nucleotide homology to one or more characterized sequences in the ... and UniGene number. Clones having significant homology to one or more Expressed Sequence Tag ...

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Homology in Biological Products

Anti-VAMP-2 (Vesicle-Associated Membrane Protein 2, Synaptobrevin 2) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Membrane Protein 2, Synaptobrevin 2). The epitope does not share homology with any other known proteins. SPECIES REACTIVITIES: It is expected ... will also react with human, Macaca multata and bovine due to sequence homology (25/26). Other species have not been ....
Company:CHEMICON

Anti-Taste Receptor 2 (TR2) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Recognizes rat Taste Receptor 2 (TR2). The immunogen shows no significant sequence homology with TR1, gustducin or other pheromone ....
Company:CHEMICON

PatternHunter - academic version from Bioinformatics Solutions Inc.

Description:... Superior homology search software - in all the flavours of blast, with increased sensitivity and speed. Free windows version for academic ....
Company:Bioinformatics Solutions Inc.

PatternHunter from Bioinformatics Solutions Inc.

Description:... Superior homology search software - in all the flavours of blast, with increased sensitivity and ...
Company:Bioinformatics Solutions Inc.

Anti-Potassium Channel, Inward Rectifier Kir4.1 Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Recognizes Kir4.1. The epitope does not share homology with any other known proteins. SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Other ...
Company:CHEMICON

Anti-K+-Cl- Cotransporter 1 (KCC1) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Recognizes K+ Cl- Cotransporter-1 (KCC1). The immunogen shows no significant sequence homology with other KCCs or CCC. SPECIES REACTIVITIES: The immunogen sequence is 100% conserved in human, mouse, porcine and rabbit. Reactivity with other ...
Company:CHEMICON

Rabbit Anti-mTOR Monoclonal Antibody,, Clone ZMD.414 from Invitrogen

Description:... protein. On Western blots it identifies the target band at ~235 kDa. Reactivity: Human (positive control: HEK293 cell lysates). Based on sequence homology reactivity with mouse and rat is expected. Applications: Immunoprecipitation Western ...
Company:Invitrogen

Rabbit Anti-PKCZeta (C-term) Monoclonal Antibody,, Clone ZMD.330 from Invitrogen

Description:... does not cross-react with PKCiota/lambda. Reactivity: Mouse Rat (positive controls: mouse and rat kidney and brain homogenates). Based on sequence homology reactivity with Human and rabbit is expected. Applications: Western blotting Immunofluorescence ...
Company:Invitrogen

Rabbit Anti-Human Connexin 36 Monoclonal Antibody,, Clone ZMD.257 from Invitrogen

Description:... Reactivity: Mouse (positive control: mouse Connexin 36-transfected HeLa cell lysates mouse brain retina and pancreas homogenates). Based on sequence homology reactivity with Human rat and zebrafish. Applications: Western blotting ELISA Immunohistochemistry ...
Company:Invitrogen

Anti-PEBP Polyclonal Antibody, unconjugated, Clone ZLK.17 from Invitrogen

Description:... The PhosphatidylEthanolamine-Binding Protein (PEBP) does not share significant homology with other serine protease inhibitors. PEBP is expressed in the central nervous system, spleen, testis, ovary, muscle, and stomach. One important ...
Company:Invitrogen

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Homology in Biological Definition

Bioinformatics

... in bioinformatics research is the notion of homology . In the genomic branch of bioinformatics, homology is used to predict the function of a gene: if the ... In the structural branch of bioinformatics homology is used to determine which parts of the protein ...

Bioinformatics

... in bioinformatics research is the notion of homology . In the genomic branch of bioinformatics, homology is used to predict the function of a gene: if the ... In the structural branch of bioinformatics homology is used to determine which parts of the protein ...

Charles Darwin

... joined Grant in pioneering investigations of the life cycle of marine animals on the shores of the Firth of Forth where Grant found evidence for homology , the radical theory that all animals had similar organs differing only in complexity. In March 1827 Darwin made a presentation to the Plinian ...

Cladistics

... consider polyphyletic groups to be errors in classification, often occurring because convergence or other homoplasy was misinterpreted as homology . Following Hennig, cladists argue that paraphyly are as harmful as polyphyly. The idea is that monophyletic groups can be defined objectively, in ...

Flagellum

... These differences mean that the bacterial and archaeal flagella are a classic case of biological analogy , or convergent evolution, rather than homology . However, in comparison to the decades of well-publicized study of bacterial flagella (e.g. by Berg), archaeal flagella have only recently begun to ...

Gene duplication

... genes that code for proteins with similar function but that exists in different species. Orthologs are created from a speciation event. (See homology of sequences in genetics ) It is important (but often hard) to differentiate between paralogs and orthologs in biological research. Experiments on ...

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Homology in Biological Dictionary

Sequence homology

... In evolutionary biology, homology refers to any similarity between ... mathematics, particularly algebraic topology and homology theory, the Mayer–Vietoris sequence is an ... invariants of topological spaces, known as their homology and cohomology ... BSI provides ...

Homology

... In evolutionary biology, homology refers to any similarity between ... There are examples ... In mathematics, homology is a certain general procedure to associate a ... such as a topological space or a group. See homology theory for more background, or singular ...

Homologies

... In evolutionary biology, homology refers to any similarity between ... In genetics, homology can be observed in DNA sequences that code for proteins ... homology (anthropology), analogy between human beliefs, ...

Synapomorphy

... approaches attempt to construe ... and phylogeny, which define homology as synapomorphy (Cracraft ... ... event, recognized by possessing ... the Elongation Factor 1α gene in lineages ... The establishment of homology qua synapomorphy ... qua synapomorphy , i.e. as similarity due to ...

Sequence similarity

... In evolutionary biology, homology refers to any similarity between characteristics that is due to their ... (EBI) ... ... one example of homology. In evolutionary biology , homology refers to any similarity between ... Sex chromosomes have a shorter ...

UvrA

... both have ATPase/GTPase activity. The UvrA dimer binds with UvrB and forms a trimer which is able to detect DNA ... ... acid sequence homology with the E. coli UvrA protein comprising 940 residues. ... defined by the mutation in DB7 represents a homolog of the E. coli uvrA gene. ... ...

Sense strand

... modification of any of the purine ... molecule of claim 1, wherein the sense strand includes a terminal cap moiety at ... ( A) Base pair homology comparison of 736 siRNA sense strand with TNFR1 mRNA. ... 736 SENSE STRAND ACTIVITY IS INHIBITED BY CHEMICAL AND SEQUENCE MODIFICATION ... ...

RecA protein

... long been studied (Ogawa et al. ... When ATP is bound to recA , the protein adopts an active conformation and has a ... The search for DNA homology does not limit stable homologous pairing promoted by RecA protein ... E. coli RecA protein promotes homologous pairing in two ... In ...

Molecular evolution

... studies that advance the understanding of phylogeny and evolution . Provides information on the journal and subscriptions. Molecular homology has been acclaimed as the field of study that saved the house of evolution from collapsing by serving as an independent check that confirms ... ...

Leucine zipper

... fusion proteins retain the leucine zipper domain of AF10 but not its PHD domain. ... Rather, the leucine zipper is the only region of homology between ... proteins, where the process is referred to as leucine zipper formation. ... induce high-order aggregation of leucine zipper ...

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