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Homologous in Medical News

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

... ahead of the June 2009 print issue has found that homologous immunoglobulin (lg) alleles pair up in the ... on one lg allele induces repositioning of its homologous partner to pericentromeric heterochromatin (a ... machineries. Skok and researchers propose that homologous pairing of alleles undergoing recombination has a ...

Penn researchers identify first sex chromosome gene involved in meiosis and male infertility

... of cell division that produces gametes in both sexes. During meiosis, homologous chromosomes undergo pairing, synapsis, recombination and faithful ... asynapsis during the process of gamete formation. This means that homologous chromosomes failed to pair together during meiosis and chromosomes formed ...

BRIT1 allows DNA repair teams access to damaged sites

... factor at the damage site. The team showed that normal BRIT1 aids repair of double-stranded DNA breaks by allowing access to two repair pathways: homologous recombination (HR) and non-homologous end-joining (NHEC). DNA repair efficiency dropped by between 40 and 60 percent in cells with BRIT1 knocked ...

Scripps research scientists model 3D structures of proteins that control human clock

... light. Photolyases have also been found in bacteria and in some animals, but not in human cells. Humans and mammals, on the other hand, possess a homologous protein known as cryptochrome that modulates the circadian clock. "This is an amazing, and very puzzling, family of proteins, because they do one ...

First Treatment for Muscular Dystrophy in Sight: Scientists Harness Exon-Skipping in Large Animal to Successfully Treat Duchenne Muscular Dystrophy

... Association, the Annals of Neurology, treated dogs with naturally occurring canine X-linked muscular dystrophy, a disease which is genetically homologous to the Duchenne muscular dystrophy that strikes 1 of every 3,500 boys born in the United States and worldwide each year. Duchenne muscular ...

First treatment for muscular dystrophy in sight: Scientists successfully harness exon-skipping

... Association, the Annals of Neurology , treated dogs with naturally occurring canine X-linked muscular dystrophy, a disease which is genetically homologous to the Duchenne muscular dystrophy that strikes 1 of every 3,500 boys born in the United States and worldwide each year. Duchenne muscular ...
Homologous in Medical Technology

Sunesis Pharmaceuticals to Present Non-Clinical Data at the Annual Meeting of the American Association for Cancer Research

... Hall B-F, San Diego Convention Center -- Sensitivity to SNS-595 is related to activation of double strand DNA break repair pathways including homologous recombination Session: Stress Responses Abstract #1859 8:00 a.m. - 12:00 p.m. Exhibit Hall B-F, San Diego Convention Center -- Ex vivo ...

Pharmacyclics Announces Presentations on Its Novel and Selective HDAC and Bruton's Tyrosine Kinase Inhibitor Compounds

... Agent Resistance Poster Presentation: Novel histone deacetylase (HDAC) inhibitor PCI-24781 disrupts RAD51 foci and inhibits homologous recombination Abstract #1966: 8:00 a.m. -12:00 p.m. Presenter: Shanthi Adimoolam, Ph.D., Pharmacyclics, Inc. Wednesday, April 18, ...
Homologous in Medical Products

Vysis UroVysion Bladder Cancer Kit

Description:... in patients previously diagnosed with bladder cancer. The UroVysion Kit consists of a four-color, four-probe mixture of DNA probe sequences homologous to specific regions on chromosomes 3, 7, 9, and 17. The UroVysion probe mixture consists of Chromosome Enumeration Probe (CEP) CEP 3 SpectrumRed, CEP ...
Company:Abbott Diagnostics

LH ELISA Test

Description:... Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH and FSH production and secretion are stimulated by gonadotropin-releasing ...
Company:Diagnostic Systems Laboratories, Inc.

LH IRMA Test

Description:... Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique beta-subunit. Both LH and FSH production and secretion are stimulated by gonadotropin-releasing ...
Company:Diagnostic Systems Laboratories, Inc.

Solcosept Microfilter Blood Transfusion Sets

Description:... way to add the safety of microfiltration for a variety of transfusion needs. Whether for intraoperative or postoperative applications, autologous or homologous transfusions, the Solcosept microfilter provides both convenience and versatility in the removal of microaggregates from blood. The two-stage, ...
Company:Davol, Inc.

Corlok

Description:... Dovetail geometry permitting a precise interlocking fit with adjacent vertebrae. Corlok Allografts are processed from donor vertebral bodies creating homologous spinal allograft implants. Specially designed instruments facilitate the insertion of the Corlok ....
Company:Alphatec Spine, Inc.

Corlok Lumbar Allograft System

Description:... Dovetail geometry permitting a precise interlocking fit with adjacent vertebrae. Corlok Allografts are processed from donor vertebral bodies creating homologous spinal allograft implants. Specially designed instruments facilitate the insertion of the Corlok ....
Company:Alphatec Spine, Inc.

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Homologous in Medical Definition

Artificial induction of immunity

... have a lifespan of only about 3-6 months. Every placental mammal (including humans) has experienced temporarily-induced immunity by transfer of homologous antibodies from its mother across the placenta , giving it passive immunity to whatever its mother was immune to. This allows some protection for ...
Homologous in Medical Dictionary

AST

... ] [ Search ] [ Ask the Doctor Forums ] ... BL AST : Abbreviation for Basic Local Alignment Search Tool, a computer program that identifies homologous genes in different organ isms (such as worms , the fruit fly, mice, and humans). AST levels may be high when a disease first develops, ...
Homologous in Biological News

Iowa State University researchers develop process for 'surgical' genetic changes

... new technique harnesses a natural process called homologous recombination to precisely introduce DNA at a ... get the research to the point where you can have homologous recombination. Now, we've done it." Using this ... allows scientists to take greater advantage of homologous recombination, according to Wright and Townsend. ...

Is this the beginning of the end of plant breeding?

... up and dividing phases. The first lining up is of homologous chromosomesall chromosomes in an adult cell have ... from the mother and father of the celland these homologous chromosomes are each made up of two chromatids. The first division divides homologous pairs of chromosomes while the second meiotic ...

The structure of the Mre11 protein bound to DNA

... the error-free method of DNA repair called homologous recombination. In an article in the online ... open the door to the predetermined control of homologous recombination for cancer therapeutics and gene targeting." The power of homologous recombination ...

Genome communication

... how paramutagenic alleles communicate with their homologous partners are still unknown, but the work of ... and others suggests that both direct contact of homologous regions and changes induced by intermediary RNA ... intermediary molecule, being sent to silence the homologous allele. A third component is the placement of ...

Enhanced DNA-repair mechanism can cause breast cancer

... repair protein RAD51. RAD51 is involved in homologous recombination, a method used by cells to repair damaged DNA. In homologous recombination, organisms heal broken chromosomes ... of elevated levels of RNAs for genes involved in homologous recombination. They found that the level of RNA ...

Methods for studying DNA repair and protein modification are featured in CSH Protocols

... involved in DNA repair and post-translational modification of proteins. homologous recombination is an important mechanism for the repair of damaged ... provides researchers a biochemical means to dissect the mechanisms of the homologous recombination machinery. The protocol is freely accessible on the website ...

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Homologous in Biological Technology

J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology

... to finish creating the synthetic bacterial genome using a method called homologous recombination (a process that cells naturally use to repair chromosome ... were inserted into yeast cells in one step and through the mechanism of homologous recombination were assembled into the synthetic M. genitalium genome. ...

Venter Institute Scientists Create First Synthetic Bacterial Genome

... years of work perfecting chemical assembly, the team found they could use homologous recombination (a process that cells use to repair damage to their ... well, and that they were able to assemble the fragments together by homologous recombination. This process was used to assemble the last cassettes, from ...

Cellectis and Regeneron Sign an Agreement Over the use of Homologous Recombination Technology

... be held no later than October 30, 2008. About the licensed patents: The agreement relates to Institut Pasteur's patents covering certain uses of homologous recombination (US patents #6 528 313, 6 638 768 and 6 528 314, Japanese patents #3059481, #3298842 and #3298864 and European patents EP #419 621 and ...

Real-time observation of the DNA-repair mechanism

... of the cell and lead to the creation of a cancerous cell. One major DNA-repair mechanism involved in repairing these breaks is known as homologous recombination. This mechanism has been observed for the first time by Delft University of Technology researchers in real time and at the level of a ...

New force-fluorescence device measures motion previously undetectable

... other nucleic acid systems and their interaction with proteins and enzymes. The Holliday junction is a four-stranded DNA structure that forms during homologous recombination for example, when damaged DNA is repaired. The junction is named after geneticist Robin Holliday, who proposed the model of DNA-strand ...

RNA Interference and Gene Silencing: History and Overview

... of both the introduced gene and the homologous endogenous gene was suppressed (homologous transcript is made, but that it is ... was sufficient to completely silence the homologous gene's expression. Furthermore, injection of ...

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Homologous in Biological Products

Sheep NP-SSA (Sheep Serum Albumin), Unconjugated from Biosearch Technologies

Description:... 4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to ....
Company:Biosearch Technologies

Sheep NP-SGG (Sheep Gamma Globulin), Unconjugated from Biosearch Technologies

Description:... 4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SGG (Sheep gamma globulin) lysine through amide bonds. This product is homologous to ....
Company:Biosearch Technologies

Anti-Potassium Channel, Inward Rectifier Kir2.1 Polyclonal Antibody, Unconjugated from CHEMICON

Description:... in any other known protein. SPECIES REACTIVITIES: The immunogen sequence is identical in rabbit, bovine, porcine and guinea pig. It is highly homologous in rat and mouse (17/19 residues) and chick (15/19 residues). Other species have not been ....
Company:CHEMICON

BacMagic™ DNA Kit from Novagen

Description:... sequence in a compatible transfer plasmid, such as the pBAC™or pTriEx™ vectors, is cotransfected with BacMagic DNA into insect cells. homologous recombination within the cells restores the function of the virus ORF1629 while the target coding sequence replaces the BAC sequence. Only the ...
Company:Novagen

Anti-Cullin-3 (CUL-3) Ab-1 Polyclonal Antibody, Unconjugated from Lab Vision

Description:... CUL-3 is a member of the family of human cullin genes (CUL-1, -2, -3, -4a, -4b, and -5), homologous to the S. cerevisiae cdc53 gene. Cullin-3 is proposed to be a part of E3 protein-ubiqutinnn ligase. It forms a tight complex with cyclin E and ...
Company:Lab Vision
Homologous in Biological Definition

Chromosomal crossover

... occurs when two chromosomes , normally two homologous instances of the same chromosome, break and then ... chromosome being lost during cell division . If homologous chromosome are not perfectly aligned an unequal ... can create duplicate genes. Any pair of homologous chromosomes may be expected to cross over three ...

Meiosis

... of chromosomes for prophase is different. homologous chromosomes join into tetrads (so called ... the chromosomal material is tightly coiled. homologous chromosomes derived from maternal and paternal ... the structures and then "zip up". The paired homologous chromosomes, now known as bivalents, shorten and ...

Y chromosome

... are fixed by following the template on the homologous chromosome . This repair technique is called ... Y chromosome (and one X chromosome.) Without a homologous chromosome, the Y chromosome cannot utilize this ... exchanging information with matching genes on the homologous chromosome, a process called "crossing over." But ...

Bioinformatics

... of a gene: if the sequence of gene A , whose function is known, is homologous to the sequence of gene B, whose function is unknown, one could infer ... is used to predict the structure of a protein once the structure of a homologous protein is known. This currently remains the only way to predict protein ...

Bioinformatics

... of a gene: if the sequence of gene A , whose function is known, is homologous to the sequence of gene B, whose function is unknown, one could infer ... is used to predict the structure of a protein once the structure of a homologous protein is known. This currently remains the only way to predict protein ...

Flagellum

... bacterial (or eubacterial) flagellum; in the 1980s they were thought to be homologous on the basis of gross morphology and behavior (Cavalier-Smith, 1987). Both ... one basic kind of prokaryotic flagellum, and that archaeal flagella are homologous to it (an example is Cavalier-Smith (2002), who is aware of the ...

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Homologous in Biological Dictionary

Synapsis

... Synapsis is the pairing of two homologous chromosomes that occurs during meiosis. It is a ... Synapsis takes place during prophase I. When homologous chromosomes synapse, they come closer together ... n. , pl. -ses . The side-by-side association of homologous paternal and maternal chromosomes during the ...

Sister Chromatids

... by a centromere. Compare sister chromatids to homologous chromosomes, which are the two different copies ...... Is the choice between sister chromatid and homologous chromosome in the two ... At meiosis I, ... chromatids attach to the same spindle pole while homologous ... Cohesin is localized on paired sister ...

RecA protein

... and serves as an archetype for this class of homologous DNA ... RecA promotes the ... ... In vitro, RecA Protein helps promote homologous recombination through a multiple ... RecA ... promotes the exchange of strands between two homologous DNA ... In vitro, RecA protein alone can ...

Homologous recombination

... homologous recombination , also known as general ... DNA. The process involves several steps ... homologous recombination , also known as general ... DNA. The process involves several steps ... homologous Recombination Method (and ... final products ...

Homologous chromosomes

... homologous chromosomes are chromosomes in a biological ... that is due to their shared ancestry. The word homologous derives from the ancient Greek ομολογειν, ... are examples ... ... below illustrate a homologous pair of chromosomes before (on the ... Cells ...

Homologous chromosome

... homologous chromosomes are chromosomes in a biological ... chromosomes may have genes encoding ... homologous chromosomes are chromosomes with the same genes, but ... 3 homologous chromosome sets. 4 See also. 5 References. ...

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