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Homeostasis in Medical News

Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells

... drugs worked by reprogramming the innate protein homeostasis machinery of the cell to repair the mutant ... calcium channel blockers restore partial enzyme homeostasis in cell lines derived from patients suffering ... also partially restored lysosomal enzyme homeostasis in cell lines derived from patients suffering ...

Millennium and Harvard Medical School Sign Cooperative Agreement for Research in Novel Field of Cancer Biology

... Pioneers Invest in Evolving Field of Protein homeostasis - CAMBRIDGE, Mass., Jan. 31 ... scientific progress in the field of protein homeostasis makes this agreement a natural fit for our ... in, and commitment to the field of protein homeostasis at Millennium. VELCADE(R) (bortezomib) for ...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

... Inhibitor of Soluble Epoxide Hydrolase, AR9281, Improves Glucose homeostasis in Diet-Induced Obese Mice" (Wong, K, Zhang, L-N, Vincelette, J, ... obese individuals to diabetes. -- "Improvement of Glucose homeostasis by AR9281, a Novel Inhibitor of Soluble Epoxide Hydrolase, in ...

Scientists Create Mice Resistant to Obesity

... people. They also shed light on the brain circuitry that controls energy homeostasis -- the balance between how much energy (i.e., food) an animal takes in and ... According to lead study author Qingchun Tong, most research into energy homeostasis has involved what scientists call genetically encoded neuropeptides, ...

Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer

... of AP1903, a small-molecule dimerizer agent developed by ARIAD Pharmaceuticals, Inc. (Nasdaq: ARIA ). In this way, the immune system's innate homeostasis is overridden and a potent and durable antigen-specific T cell response may be generated. The dose-escalation trial will evaluate the safety ...

Study aims to induce recovery from ankylosing spondylitis

... different species of pathogenic bacteria has been implicated in dozens of chronic disease states. ARF has discovered how to restore nuclear receptor homeostasis so that the body's own immune system can fight these pathogenic bacteria. The East-West partnership, which will eventually include subjects ...

Six Scientists Receive Awards for Contributions to Alzheimer's Disease Research

... winner of the 2009 Best Paper in Alzheimer's Disease Neuroimaging Award for his article entitled Ab Plaques Lead to Aberrant Regulation of Calcium homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks. Dr. Backsai will receive $5,000. Jennifer Whitwell, PhD, ...

6 scientists receive awards for contributions to Alzheimer's disease research

... winner of the 2009 Best Paper in Alzheimer's Disease Neuroimaging Award for his article entitled Ab Plaques Lead to Aberrant Regulation of Calcium homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks. Dr. Backsai will receive $5,000. Jennifer Whitwell, PhD, of the ...

Study further expands understanding of leptin's role in brain neurocircuitry

... of novel anti-diabetic drug targets." First identified in 1994 as an appetite and weight-regulation hormone, leptin plays a key role in energy homeostasis through its effects on the central nervous system. Over the years, investigators have pinpointed a region of the brain's hypothalamus known as the ...

AGA Institute presents cutting-edge research during DDW

... members. S. Ohashi et al. (8:22 a.m.) Microbial-innate Immune Interactions at the Epithelial Cell Interface. D. Polk (8:39 a.m.) Changes in Mucosal homeostasis Leading to Hypersensitivity to Mucosal Injury in NHE3 Knockout Mice. D. Laubitz et al. (9:04 a.m.) Colitis-associated variant of TLR2 causes ...

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Homeostasis in Medical Technology

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

... analogs play a distinct biological role from the PTH (parathyroid hormone) peptide by activating different signaling responses--PTH regulates calcium homeostasis and bone resorption by acting primarily on target cells in bone and kidney, whereas PTHrP and its analogs regulate cell proliferation and ...

Neuroscience Researcher Has Positive Message for International Alzheimer's Awareness Week, July 6 - 12: 'Even Though World Economy is Declining, Alzheimer's Research is Advancing'

... treat age related memory loss and the diseases of aging. The company's therapeutic products focus on alleviating the consequences of impaired calcium homeostasis - the imbalance of calcium ions thought to be related to neurodegenerative diseases such as Alzheimer's and Parkinson's. Web: ...

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

... of drug metabolism testing. Research has demonstrated that enterohepatic circulation is the mechanism that maintains quantitative whole body homeostasis of arachidonic acid. There is extensive research focused on blocking arachidonic acid metabolism along cytochrome P450, leukotriene, prostaglandin, ...

Overweight Siblings of Children With Type 2 Diabetes Likely to Have Abnormal Blood Sugar Levels

... or type 2 diabetes) than other overweight children. However, investigators found no significant differences in insulin resistance, as measured by the homeostasis model assessment. Type 2 diabetes is caused by a combination of both genetic and environmental factors. Known risks include obesity, ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... role of bile acid signaling via the nuclear hormone receptor FXR and the G protein-coupled receptor TGR5. These receptors are key mediators of energy homeostasis and are involved in maintaining integral functions of the liver, intestine and kidney, organs exposed to bile acid flux. The company's ...

Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome

... improvement in insulin sensitivity in testosterone treated patients at six and 12 months (p=0.05 and p=0.01, respectively), as measured by homeostasis model assessment as an index of insulin resistance (HOMA-IR). Further, measured by the Index of Erectile Function (IIEF), patients using the ...

Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models

... cells and accelerated cell repair by stimulating the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. "This study reinforces our belief that NU206 is a potent regenerative agent," said Dr. Ted W. Love, chairman and chief executive ...

Radius Completes Enrollment of Phase II Clinical Trial of BA058 for Osteoporosis

... protein) is a critical peptide for promoting new bone formation, with a role distinct from PTH (parathyroid hormone), which regulates calcium homeostasis and bone resorption. BA058 is an analog of hPTHrP that is designed to build bone without inducing hypercalcemia or significant resorption. In ...

Arena Pharmaceuticals Announces APD668 Initial Clinical Study Results Suggest Glucose-Dependent Insulinotropic Receptors May Improve Glucose Control in Patients With Type 2 Diabetes

... agonist into preclinical development. "We are encouraged by the clinical study results supporting GDIR agonists as effective modulators of glucose homeostasis in patients with type 2 diabetes, and we look forward to the results of Ortho-McNeil advancing another of Arena's GDIR compounds into development," ...
Homeostasis in Medical Definition

Osmotherapy

... example, osmotherapy can be used to treat a patient who has cerebral hemorrhage . This might include the use of mannitol to maintain the brain's homeostasis . External links | A rather technical, but informative article ...
Homeostasis in Biological News

Iron is involved in prion disease-associated neuronal demise

... Imbalance of iron homeostasis is a common feature of prion disease-affected ... in diseased brains. The imbalance of brain iron homeostasis worsens with disease progression, and is not an ... strategies targeted at restoring brain iron homeostasis in prion disorders. ...

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

... disease. This suggests that Charcot-Marie-Tooth disease is related to some fundamental and unknown function the protein plays in the development and homeostasis of the nervous system. Because the unknown function is common to both humans and flies, it probably evolved hundreds of millions of years ago before ...

Drinking 100 percent fruit juice is associated with lower risk of obesity and metabolic syndrome

... non-consumers, 100% juice consumers had lower mean Body Mass Index (BMI), smaller waist circumference and lower insulin resistance (as estimated by homeostasis model assessment, HOMA). The researchers noted an inverse association between level of juice intake (oz/day) and these parameters. Based on the ...

ASBMB Annual Meeting to feature talks on the biochemistry of aging

... evidence that efforts in humans just might work. The Role of Insulin-like Signaling for the Central and Peripheral Regulation of Nutrient homeostasis and Life Span Morris White, Children's Hospital Boston, MA (Tue, April 21 3:30 PM - 5:50 PM, Room: 356) White will discuss some of his group's ...

Penn biologists discover how 'silent' mutations influence protein production

... genes, provides an explanation for how a cell "knows" how much of each protein to make, providing just the right amount of protein to maintain homeostasis yet not too much to cause cell toxicity. In the study, Penn biologists analyzed how protein levels are governed by synonymous, or silent, ...

DREAM: 1 gene regulates pain, learning and memory

... rather than the culprit for the disease. And Calcium regulation is also responsible for tuning the activity of the DREAM-gene. Calcium homeostasis may thus be the link between pain perception, learning and memory. This is supported by observations of patients suffering from chronic pain: very ...

Tips from the American Journal of Pathology

... another FPR family member, FPR-2. The data by Gastardelo et al "provide in vivo evidence that endogenous annexin A1 is an essential mediator for homeostasis during the inflammatory process." They go on to propose "that these experimental findings may impact the development of novel therapeutics based on ...

Scripps research team sheds light on immune system suppression

... may well be caused by viruses that persist without destroying the differentiated cells they infect, alter their functions, and by this means alter homeostasis and cause disease," says Oldstone. "Examples would be viruses that persistently infect neurons and cause problems in learning and behavior, viruses ...

From Canada to the Caribbean: Tree leaves control their own temperature, Penn study reveals

... most likely occurs when leaf temperatures are about 21C, with latitude or average growing-season temperature playing little, if any, role. This homeostasis of leaf temperature means that in colder climates leaf temperatures are elevated and in warmer climates tree leaves cool to reach optimal conditions ...

Biologists at UC San Diego identify key protein in cell's 'self-eating' function

... about 40 years ago, but has recently become a topic of great interest in cell biology because it is linked to cell growth, development aging and homeostasis -- helping cells to maintain a balance among synthesis, degradation and recycling. The UC San Diego researchers report in their paper that they ...

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Homeostasis in Biological Technology

New Insights into the Mechanism of Action of Antipsychotic Drugs

... and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia" (1). This publication highlights the discovery of a ... and regulation of fatty acids and cholesterol supports a key role of lipid homeostasis in schizophrenia." Schizophr Res. 2009 Mar; 108(1-3):134-42. ...

Scripps Research Institute Highlights Groundbreaking Work of aTyr Pharma Scientific Co-Founder

... hidden in the synthetases have a role in normal human physiology. Identification of these novel cell signaling proteins that can be used to restore homeostasis in patients with inflammatory, cardiovascular and metabolic diseases is the discovery engine for aTyr Pharma's product development program and we are ...

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

... NR7-009 Common effect of antipsychotics on biosynthesis and regulation of fatty acids and cholesterol supports a role of lipid homeostasis in schizophrenia. NR1-092 Selective estrogen receptor modulators share the antipsychotic gene expression profile, suggesting their ...

Nuvelo Announces Positive Results from Phase 1 Clinical Trial of NU206 in Healthy Volunteers

... secreted protein that acts as a key regulator of the Wnt pathway, the critical pathway that stimulates cell growth and differentiation during homeostasis and pathogenesis in specific tissues including the GI epithelium and bone. Preclinical studies suggest it can promote growth and repair in animal ...

Metabolex Announces Positive Results From Phase 1a Clinical Trial of MBX-2982

... secretion. In addition, MBX-2982 stimulates release of the incretin GLP-1 from the gut. This dual action is unique and may offer improved glucose homeostasis over existing diabetes therapies, with potential for weight loss and improved islet health. The Phase 1a study was a randomized, ...

Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia

... nor maintain a state of balance (homeostasis) between calcium and phosphate in the body. The low levels of active vitamin D hormone and lack of homeostasis between calcium and phosphate is detected by the parathyroid gland, which, in turn, continues to secrete PTH, resulting in excessive levels of PTH in ...

Nuvelo Initiates Phase 1 Clinical Trial of NU206 in Healthy Volunteers

... secreted protein that acts as a key regulator of the Wnt pathway, the critical pathway that stimulates cell growth and differentiation during homeostasis and pathogenesis in specific tissues including the GI epithelium and bone. Preclinical studies suggest it can promote growth and repair in animal ...

Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040

... presentation titled, "Preclinical development of LOR-253, a novel anticancer drug candidate that functions by modulating intracellular labile zinc homeostasis leading to cell cycle arrest," will be presented on April 16, 2008. In this presentation, Lorus provided data on the preclinical development of ...

Millennium Over-Delivers on 2007 Goals and Financial Guidance

... to treat ulcerative colitis and Crohn's disease and is on track to enter pivotal trials in late 2008/early 2009. -- Protein homeostasis oncology program -- MLN4924 (novel Nedd8-activating enzyme inhibitor) -- An investigational new drug (IND) application for MLN4924 was ...

Recombinant Human Renin - Crystallographic Grade

... human renin and native human renin from human kidney. Human Renin is an important enzyme in the regulation of blood pressure and electrolyte homeostasis and therefore is of great clinical importance. Kinetic and mechanistic functions of human renin are of importance for the development of hypertension ...
Homeostasis in Biological Definition

Apoptosis

... 1.2 Response to stress or DNA damage 1.3 homeostasis 1.4 Development 1.5 Immune cell regulation ... to start the apoptotic process. homeostasis In the adult organism, the number of cells ... death. This balancing process is part of the homeostasis required by living organisms to maintain their ...

Biology

... universality, evolution, diversity, continuity, homeostasis and interactions. Universality: ... adapting to change Main article: homeostasis homeostasis is the property of an open system to regulate ...

Homeostasis

... homeostasis or homoeostasis is the property of an open ... 1 Overview 1.1 Properties of homeostasis 1.2 Mechanisms of homeostasis: feedback 2 Ecological homeostasis 3 ...

Warm-blooded

... its core body temperature at a nearly constant level regardless of the temperature of the surrounding environment (that is, to maintain thermal homeostasis ). This can involve not only the ability to generate heat , but also the ability to cool down if necessary. Also known as endotherms , warm-blooded ...

Life

... require both energy and matter in order to continue living. Living organisms are composed of at least one cell . Living organisms maintain homeostasis . Species of living organisms will evolve . All life on Earth is based on the chemistry of carbon compounds. Some assert that this ...

Osmoregulation

... Osmoregulation is the active regulation of the osmotic pressure of body fluids to maintain the homeostasis of the body's water content, that is it keeps the body from becoming too dilute or too concentrated. Osmotic pressure is a measure of the ...

Physiology

... during elevated physical activity. Within the field of exercise physiology , studies have been conducted that show the effects of dehydration on homeostasis . Topics Respiration Circulation Diving mammals See also Pathophysiology Important publications in physiology ...

Thermoregulation

... organism to keep its body temperature within certain boundaries, even when temperature surrounding is very different. This process is known as homeostasis : a dynamic state of stability between an animal's internal environment and its external environment (the study of such processes in zoology has ...

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Homeostasis in Biological Dictionary

Homeostasis

... homeostasis is the property of a system, either open or ... organism, the concept came ... Human homeostasis refers to the body's ability to regulate ... liver, the kidneys, and the brain help maintain homeostasis . The liver ... ...

Osmoregulation

... Osmoregulation is the active regulation of the osmotic pressure of an organism's fluids to maintain the homeostasis of the organism's water content; that is it keeps the organism's fluids from becoming too dilute or ... Osmoregulation . ...

Enzymes

... igestive enzymes are responsible for digestion of nutrients as well as their ... Enzymes allow many chemical reactions to occur within the homeostasis ... Enzymes function as organic catalysts. ... Many enzymes function by lowering the ... Digestive enzymes are complex proteins involved ...

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