Navigation Links
Histone in Medical News

Wistar Institute team finds key target of aging regulator

... a specific site (lysine at position 16 or K16) on histone H4histones are proteins that package and organize ... of the acetylation mark along with disrupted histone organization at telomeres. Deacetylation of ... on histones, like this acetylation on histone H4 lysine 16, are persistent and are maintained ...

Proteasome inhibition affects epigenetic mechanisms

... in the turnover of transcriptional factors, histone modifying enzymes, and, therefore, affected ... ethanol feeding was related to an increase in histone acetylation, and it is hypothesized that the proteasome proteolytic activity regulated histone modifications by controlling the stability ...

Work with fungus uncovering keys to DNA methylation

... of eukaryotic cells, DNA is wrapped around histone proteins to form chromatin, and one histone, H3, ... enzyme that adds a methyl group onto lysine 9 of histone H3. "This was the first solid indication that ... into an intricate regulatory network involving histone ...

Mouse model highlights histone methylation as distinguishing feature for leukemia subtypes

... Cancer Cell , also validates examination of histone modification as a strategy for distinguishing ... enhance gene expression by recruiting the histone H3 lysine79 (H3K79) methytransferase, DOT1L. ... that widespread differences in an epigenetic histone modification can distinguish different cancer ...

Tackling a hard-to-treat childhood cancer by targeting epigenetic changes

... Armstrong. "If you could inhibit that abnormal histone modification, you might be able to reverse the ... an enzyme called DOT1L, which modifies the histone H3 by attaching a methyl group to a particular ... that inhibit DOT1L," says Armstrong. "Reversal of histone modifications could be an important therapeutic ...

Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes

... "If you could inhibit that abnormal histone modification, you might be able to reverse the ... an enzyme called DOT1L, which modifies the histone H3 by attaching a methyl group to a particular ... DOT1L," says Armstrong. "Reversal of histone modifications could be an important therapeutic ...

More>>

Histone in Medical Technology

Presentation of Data on Progen's Cancer Epigenetic Targets Platform

... enzyme identified to specifically demethylate histone proteins (demethylates Lysine 4 of histone H3) and plays an important role in the regulation ... the action of LSD-1, causing increased levels of histone methylation, resulting in the reactivation of the ...

HUYA Bioscience Int'l Announces First Pre-IND Outcome for a Development Stage Compound Sourced From China - HBI-8000, Promising New Cancer Compound

... HBI-8000 is an orally bioavailable histone deacetylase (HDAC) inhibitor derived from the benzamide class. histone deacetylase inhibitors are a new class of cancer ... appear to promote tighter winding of DNA around histone proteins, which leads to reduced access by gene ...

Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor

... the company's novel highly-selective histone deacetylase (HDAC) inhibitor. The study, entitled "A novel histone deacetylase 8 (HDAC8)-specific ... appears in the February 7 issue of Leukemia. histone deacetylases are a family of related enzymes ...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

... About Epigenetic Therapy DNA methylation and histone deacetylation are the two most studied epigenetic ... of drugs targeting DNA methylation and histone deacetylation can either increase ... epigenetic alterations including changes in histone acetylation, have been identified. In addition, ...

Chipscreen and HUYA Bioscience to Present Clinical Data on Novel HDAC Inhibitor at the 2009 ASCO Annual Meeting

... 2009, in Orlando, Florida. Chidamide/HBI-8000 is a novel benzamide class histone deacetylase (HDAC) inhibitor in development by Chipscreen and HUYA for ... 1 study of chidamide (CS055/HBI-8000), a novel histone deacetylase inhibitor, in patients with advanced ...

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

... has a robust proprietary pipeline including SB939, the company's lead histone deacetylase (HDAC) inhibitor, which is currently in Phase 1 trials in ... molecule drugs for the treatment of cancer with leading programs around histone deacetylases (HDAC) and kinases. S*BIO's lead candidate, SB939, entered ...

More>>

Histone in Medical Dictionary

Chromosomes

... A type of protein found in chromosomes . Histones bind to DNA, help give chromosomes their shape, and help control the activity of genes . histone deacetylase ... Clotting factors are needed for blood to clot normally. (Clotting is also called coagulation.) These genes are located on ...
Histone in Biological News

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

... Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell . The histone H3 protein is an important component of ... transcription of the message encoded in the DNA. histone H3 can be altered by adding (methylating) or ...

Scientists discover key patterns in the packaging of genes

... called ChIP-Seq, the team identified 39 histone modifications, including a "core set" of 17 ... that chemical changes at particular locations in histone complexes influence how tightly the DNA is ... into short segments, which remained attached to histone "spools." For each of 39 ...

Scientists clarify a mechanism of epigenetic inheritance

... and others solved this mystery. They found that histone modification is controlled by complicated ... that only that part of the chromosome gets these histone modifications, Dr. Martienssen says. If the whole chromosome were to get those histone modifications, youd be dead. All in the ...

Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk

... machinery required for the translation of histone crosstalk, or communication between histones. Published in todays issue of Cell, histone Crosstalk between H2B Monoubiquitination and H3 ... yeast homologue of the mammalian MLL complex, a histone methylase involved in the development of ...

Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease

... regions within the CFTR gene that correlate with histone acetylation, a process that modifies ... a region associated with acute acetylation of histone H4, one of the major core histones, they ... Our findings suggest the therapeutic potential of histone modification strategies to treat CFTR-associated ...

NCI renewal grant to develop new cancer therapies

... the activity of a novel class of agents, known as histone deacetylase inhibitors, in the treatment of ... support ongoing basic and clinical research. histone deacetylase inhibitors represent a diverse group ... proteins, notably histones. However, histone deacetylase inhibitors acetylate other proteins ...

More>>

Histone in Biological Technology

Pharmacyclics Announces Multiple Presentations at the American Association for Cancer Research Annual Meeting

... Several presentations relate to the company's histone deacetylase(HDAC) inhibitor, which is now in a ... follows: Sunday, April 13, 2008: -- Session: histone Deacetylase Inhibitors and Cell Cycle Inhibitors Poster presentation: The histone deacetylase-8 selective inhibitor PCI-34051 ...

Pharmion and MethylGene Announce Collaboration to Develop Sirtuin Inhibitors as Anti-Cancer Agents

... (including SIRT1) have been shown to deacetylate histone proteins and numerous transcription factors, ... inhibitors of DNA methylation and histone deacetylation. Two epigenetic therapy ... of gene expression, and DNA methylation and histone deacetylation are two of the more ...

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

... basal B subtype were not. However, when the latter was pre-treated with a histone deacetylase inhibitor, such as the suberoylanilide hydroxamic acid (SAHA), ... is achieved is believed to be the de-silencing of ER expression by the histone deacetylase inhibitor, followed by CYP1A1 induction and subsequent AFP ...

S*BIO Completes US$26 Million Equity Financing

... SB939 belongs to a new class of targeted anti-cancer therapeutics called histone deacetylase (HDAC) inhibitors. SB939 is designed to be a "best-in-class" ... molecule drugs for the treatment of cancer with leading programs around histone deacetylases (HDAC) and kinases. S*BIO's lead candidate, SB939, entered ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... as an attractive target for the development of anti-cancer agents. histone Deacetylase (HDAC) DNA in chromatin is wound around proteins called ... Biochemistry & Cell Biology; 2007, 39(7-8):1476-82. (iv) Johnstone, RW. histone deacetylase inhibitors: novel drugs for the treatment of cancer. Nature ...

CuraGen and TopoTarget Announce Initiation of an NCI-sponsored Phase II Clinical Trial of Belinostat for Thymoma and Thymic Carcinoma

... the efficacy and safety of intravenous belinostat, a small molecule histone deacetylase (HDAC) inhibitor, for the treatment of patients with ... developing diverse approaches for the treatment of cancer including the histone deacetylase inhibitor, belinostat, and the antibody-drug conjugate, ...
Histone in Biological Products

Rabbit Anti-Human Histone H3, acetyl Polyclonal Antibody, Unconjugated from Lake Placid Biologicals

Description:... Antibody specific for histone H3 acetylated at any of the five N-terminal lysine residues. Rabbit polyclonal serum. Antigen: Synthetic peptide derived from histone H3 N-terminal region, mulitpliy ...
Company:Lake Placid Biologicals

Rabbit Anti-Human Histone H3, phospho (Ser10 / Ser28) Polyclonal Antibody, Unconjugated from Lake Placid Biologicals

Description:... Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or ...
Company:Lake Placid Biologicals

Mouse Anti-Human Histone H3, trimethyl (Lys27) Monoclonal Antibody, Unconjugated from Lake Placid Biologicals

Description:... Antibody specific for trimethyl-Lys27 of histone H3. Mouse monoclonal. Antigen: Synthetic peptide derived from histone H3, trimethylated at lysine ...
Company:Lake Placid Biologicals

Rabbit Anti-HDAC4 Polyclonal Antibody, Unconjugated from GeneTex

Description:... to HDAC4 - ChIP Grade HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C-terminal ... to be commercially sensitive Specificity: The antibody detects ~140 kDa histone deacetylase 4. It does not cross-react with other HDAC proteins including ...
Company:GeneTex

Mouse Anti-HDAC8 Monoclonal Antibody, Unconjugated, Clone HDAC8-48 from GeneTex

Description:... enzymes responsible for reversible acetylation/deacetylation processes are histone acetyltransferases(HATs) and histone deacetylases (HDACs), respectively. HATs act as transcriptional ...
Company:GeneTex

Rabbit Anti-Human acetyl-Histone H3 (Lys 4) Antibody, Unconjugated from Upstate

Description:... 4) Immunogen: KLH-conjugated, synthetic peptide containing the sequence ... Ac ... in which [ Ac K] corresponds to acetyl lysine 4 of human histone H3 Accession Number: NM_003493 Molecular Weight: Mr ~17kDa Quality Assurance: Routinely evaluated by ....
Company:Upstate

More>>

Histone in Biological Definition

Barr body

... state of the Barr body. These changes include histone modifications, such as histone H3 methylation and histone H2A ubiquitylation , as well as direct ...

Chromatin

... of double-stranded DNA. The major proteins involved in chromatin are histone proteins . In a eukaryotic cell , nearly all DNA is found compacted ... form of double-stranded DNA. The major proteins involved in chromatin are histone proteins. In a eukaryotic cell, nearly all DNA is found compacted in ...

Histone

... 3 Structure 4 History 5 See also Classes Six histone classes are known: H1 (sometimes called H5 .) H2A H2B H3 ... were discovered. See also Gene silencing Genetics histone deacetylase ...

Nucleosome

... repeating subunit of eukayotic DNA , and is made up of DNA and histone proteins. It is found in the cell nucleus in eukaryotes . All ... exist as a zig-zag structure in vivo) with a packing ratio of ~40. The H1 histone stabilizes this structure. Beyond 30 nm fiber the structure of chromatin ...

Centromere

... The centromeric DNA is normally in a heterochromatin state, which is probably essential for its function. In this chromatin, the normal histone H3 is replaced with CENP-A, a centromere-specific variant. The presence of CENP-A is believed to be important for the assembly of the kinetochore ...

Gene

... strands. The DNA strand may also be silenced through DNA methylation or by chemical changes to the protein components of chromosomes (see histone ). This is a permanent form of regulation of the transcription. The RNA is often edited before its translation into a protein. Eukaryotic ...

More>>

Histone in Biological Dictionary

Histones

... of multiple copies of 5 kinds of histones . ... histone Modifications ... All the "standard" histones ... histones to DNA, thereby letting NGFI-A ... histone ( ) n. Any of several small, basic proteins ... ... Archive for the histones ' Category ... histone Modifications Regulate Pluripotency in the Early ...

Histone

... Nonpolar interactions between the histone and deoxyribose sugars on DNA ... For an example of histone modifications in transcription regulation see RNA ... histone ( ) n. Any of several small, basic proteins ...

Chromatin

... of the DNA of ... Chromatin , Epigenetics, histone code readers and writers, histone variants, Development, DNA repair ... Chromatin ... including cytosine methylation and histone modifications ... Chromatin fibers are made ...

Phosphorylation

... Nuclear Signaling abwire — the ... phosphorylation , has led to the histone code hypothesis', in ... example, histone H3 phosphorylation levels are increased in ... A phosphorylation ...

Nucleosome

... : nucleosome organization [273 gene products] ... A second histone (H1 in the illustration) fastens the DNA to the nucleosome core. ... Nucleosomes are usually packed together, with the aid of a histone (H1,) to form ... Nucleosome summary with 9 pages of encyclopedia ...

DNA methylation

... Epigenetics and Chromatin regulation ... DNA Methylation Antibodies. histone and histone ... While DNA methylation has been correlated with tumor ...

More>>

Other Contents
(Date:7/11/2014)... surgery to repair damage to the anterior cruciate ligament (ACL) ... -- could increase a young athlete,s risk for further injuries, ... patients, aged 8 to 16, who had ACL reconstruction surgery. ... after their injury, 37 had surgery six to 12 weeks ... after their injury. The youngsters who had surgery later ...
(Date:7/11/2014)... CA (PRWEB) July 11, 2014 Ticket ... Bryan Tickets at the Sleep Train Amphitheatre in Wheatland, ... venues that can compare to what the Sleep Train Amphitheatre ... musical events and special attractions over the course of its ... 16th, the Sleep Train Amphitheatre in Wheatland (Sacramento metro area) ...
(Date:7/11/2014)... The “Proteomics Market by Technology (Protein Microarray, Mass ... X-ray Crystallography) - Instruments, Reagents & Services - ... major market drivers, restraints, and opportunities in North ... World (RoW). , The proteomics market has experienced ... due to the increasing need of proteomic outcomes ...
(Date:7/11/2014)... who screened positive for a history of hazardous or ... 50 percent after receiving mobile phone text messages following ... study published online yesterday in Annals of Emergency ... Young Adult Emergency Department Patients: A Randomized Clinical Trial ... 50,000 adults ages 18 to 24 visit ERs and ...
(Date:7/11/2014)... By Steven Reinberg ... -- Stress, hostility and depression may increase the risk for ... depression seemed to raise the risk of a stroke or ... also found that stress apparently raised stroke or TIA risk ... said. A TIA is a mini-stroke caused by a temporary ...
Breaking Medicine News(10 mins):Health News:Delaying Kid's Knee Surgery Could Be a Bad Play, Study Finds 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 2Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 3Health News:Proteomics Market Worth $20,696.4 Million by 2018 - New Report By MarketsandMarkets 4Health News:Text message medicine: Texts from the ER can reduce binge drinking 2Health News:Stress, Depression May Boost Stroke Risk, Study Finds 2Health News:Stress, Depression May Boost Stroke Risk, Study Finds 3
(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
(Date:7/11/2014)... evidence has demonstrated that transplantation of mesenchymal stem cells ... or mouse models of Alzheimer,s disease (AD) and improve ... ischemia. Few studies are reported on the therapeutic effect ... AD and on the effect on oxidative injury and ... Yan and her team, School of Life Sciences, Tsinghua ...
(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
Other TagsOther Tags