NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

... Igh and Igk recombination; introduction of a double-strand break on one lg allele induces repositioning of its homologous partner to pericentromeric heterochromatin (a repressive compartment of the nucleus). This repositioning, surprisingly enough, depends on the DNA damage sensing factor ATM. It appears that ...

Cancer stem cell marker also drives transcription in normal cells

... Importantly, the deubiquitylation module of the Drosophila TFTC/STAGA complex was an enhancer of position effect variegation and counteracted heterochromatin silencing while both the Drosophila and the human deubiquitylation module were shown to be required for full transcriptional activation by the ...

New Gene Silencing Mechanism To Prevent Cancer

... would be an ideal solution. Diseases coupled with cell division and cell proliferation, such as various types of cancers, appear to be controlled by heterochromatin formation and it’s functioning. Understanding the role of gene silencing might thus pave a way to use it as a possible therapy for cancers and ...

Heterochromatin in Biological News

When every photon counts

... in the rod nuclei is inverted: Here the heterochromatin is lumped in the nuclear interior whereas the ... than euchromatin. This has no effect when the heterochromatin lies in the periphery of the nucleus. However when it is lumped in the nuclear core, the heterochromatin acts as a minute collecting lens. As the rod ...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

... focus by identifying a critical requirement for heterochromatin to be established in the nucleus. In a report ... Molecular Cell , they show that the assembly of heterochromatin depends on the strength with which a protein ... to the double helix. RNAi's role in heterochromatin formation In a typical chromosome -- roughly ...

CSHL researchers map changing epigenetic modifications that enable transposons to run amok

... (RNAi). The discovery that modifications of heterochromatin -- densely packed, genetically "inactive" regions ... -- the epigenetic changes resulting in a loss of heterochromatin and transposon "re-activation" are not due to a ... profiling study now implicates siRNA-driven heterochromatin restructuring as a mechanism that might lead to ...

Scientists clarify a mechanism of epigenetic inheritance

... form heterochromatin. The dense packing of heterochromatin hides the DNA sequence from the cellular ... that reads its genetic information, so the DNA in heterochromatin is silenced. The genes it contains are ... new puzzle, though: Since genes contained within heterochromatin are silenced, how can they give rise to the RNA ...

Stowers Institute's Workman Lab discovers novel histone demethylase protein complex

... elongation," said Chia-Hui Lin, Predoctoral Researcher and lead author on the paper. "Surprisingly, we found that dKDM4a associates with heterochromatin Protein 1a (HP1a), a classic transcriptional silencing factor. The binding of HP1a stimulates the histone demethylation activity of dKDM4A. In fruit ...

Exploring the dark matter of the genome

... DNA found in regions of chromosomes known as heterochromatin was called "junk." Like dark matter in the universe, the true nature of heterochromatin was unknown. Now members of the Drosophila heterochromatin Genome Project (DHGP), headed by Gary Karpen of ...

Regulating the nuclear architecture of the cell

... California at Berkeley. The epigenetics of heterochromatin Controlling functions of the cell and ... DNA sequence. The chromosomal material known as heterochromatin mediates gene silencing, chromosome inheritance, ... which is situated at the specific site in the heterochromatin where ribosomal DNA -- consisting of large genes, ...

Heterochromatin in Biological Definition

Cell nucleus

... compacted. Regions of DNA which constitute heterochromatin generally contain genes which are not expressed by the cell (this type of heterochromatin is known as facultative heterochromatin) or are ... centromeres of the chromosomes (this type of heterochromatin is known as constitutive heterochromatin). In ...

Chromosome

... that is active, e.g., expressed as protein. heterochromatin , which consists of mostly inactive DNA. It seems ... purposes during the chromosomal stages. heterochromatin can be further distinguished into two types: Constitutive heterochromatin , which is never expressed. It is located around ...

Centromere

... breakage during mitosis. The centromeric DNA is normally in a heterochromatin state, which is probably essential for its function. In this chromatin, ... pombe (and likely in other eukaryotes) the formation of centromeric heterochromatin is connected to RNAi * . In nematodes such as Caenorhabditis elegans ...

Chromatin

... the DNA molecule are now present) (5) Chromosome during metaphase . Two distinct types of chromatin can be distinguished: Euchromatin heterochromatin Chromatin is the extended form of DNA-protein complex present in the nucleus during interphase in eukaryotic cells. It can be made visible by ...

Nucleosome

... into loops along a central protein scaffold to form transcriptionally active euchromatin . Further compaction leads to transcriptionally inactive heterochromatin . ...

Heterochromatin in Biological Dictionary

Heterochromatin

... heterochromatin is a tightly packed form of DNA. Its major ... regulation of the transcription initiation. heterochromatin , ... III.7 heterochromatin does not participate in genetic recombination ....

Euchromatin

... research information, and more. ... acetylation of euchromatin and heterochromatin ... Euchromatin versus Heterochromatin. Nucleosomes and ... terminology,biology terms,biology abbreviations ... Euchromatin versus heterochromatin ... euchromatin . Definition from Wiktionary, a free dictionary. Jump ...

Polytene

... Dictionary.com a free online dictionary ... Search another word or see polytene on Thesaurus | Reference ... posted to variegation polytene heterochromatin h3k9me2 h3k20me2 h1 euchromatin ... posted to inversion phylogenetics polytene by cisevol to the group Drosophila ... Polytene ...

Nuclear membrane

... its biological research under the guidance of 59 faculty investigators, employing a ... how nuclear membrane forms during ... Dense patches of heterochromatin are seen just inside the inner membrane . Nuclear lamina. The inner membrane of the nuclear envelope lies next to a layer of thin ... An ...

G-banding

...omal... What is G-banding ? Meaning of G-banding medical term. What does G-banding mean? ... for nucleolar organizer regions, C-banding for heterochromatin or G-banding for ... A-Z Index Librarians Newsletter Subscriptions About Advisory Board ... del(11)(q21) G-banding . Arrow indicates partial ...

Cell nucleus

... The cell nucleus and its content. The most intelligent review made of questions and answers. ... Cell Nucleus Review - Image Diversity: heterochromatin euchromatin ... Nucleus biology, membrane-bound structure of a cell that plays two crucial roles. ... The Cell Nucleus I ... The ...

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