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Hemolysis in Medical News

SkinMedica to Co-Promote ACZONE(R) (dapsone) Gel 5% to Pediatricians in the U.S.

... Oral dapsone treatment has produced dose-related hemolysis and hemolytic anemia. Individuals with ... dehydrogenese (G6PD) deficiency are more prone to hemolysis with the use of certain drugs. There was no evidence of clinically relevant hemolysis or anemia in patients treated with ACZONE(R) Gel ...

Researchers to Present Additional Data on Soliris(R) (eculizumab) for the Treatment of PNH at the ASH Annual Meeting

... Manage Intravascular Breakthrough hemolysis in Patients with Paroxysmal Nocturnal ... -- "Effect of Reducing Intravascular hemolysis on Ferritin Homeostasis in Eculizumab ... blood cells, or hemolysis. In patients with PNH, hemolysis can cause life-threatening thromboses, recurrent ...

Alexion Pharmaceuticals and PDL BioPharma Resolve Patent Dispute

... by the destruction of red blood cells, or hemolysis. In patients with PNH, hemolysis can cause life-threatening thromboses, recurrent pain, kidney disease, ... urine (hemoglobinuria). Soliris is the only treatment that blocks this hemolysis before it occurs. About Alexion Alexion Pharmaceuticals, ....

Studies examine quality of care for hospitalized sickle cell disease patients

... in several organs. Patients treated with hydroxyurea had reduced hemolysis and improved total hemoglobin in comparison to the group of patients not ... yearly number of admissions to the hospital, and increased intensity of hemolysis in comparison to patients who did not receive hydroxyurea. Side ...

Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells

... in crisis rate, the primary endpoint of that study. Clearly, further work is necessary to understand how the reduction in RBC dehydration and hemolysis demonstrated from the results of this Phase II study impacts the complex pathophysiology of sickle cell disease." ...
Hemolysis in Medical Technology

Soliris(R) Improved Fatigue Independent of Changes in Anemia in Patients with PNH by Controlling Hemolysis

... Data Suggest Role of hemolysis in PNH-Related Fatigue Presentation at the ... by patients with PNH is related directly to hemolysis -- the red blood cell destruction that defines ... anemia. Taken together, these data suggest that hemolysis likely contributes to fatigue experienced by ...

PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity

... PNH to reduce hemolysis. In patients with PNH, hemolysis can cause thromboses, kidney disease, ... Data were analyzed by levels of baseline hemolysis (as indicated by baseline quartiles of lactate ... received a median of 22 months of treatment. hemolysis was significantly reduced with eculizumab ...

Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH

... same clinical studies, the long-term reduction in hemolysis with Soliris therapy was associated with ... Paroxysmal Nocturnal Hemoglobinuria." Soliris, hemolysis and PNH Soliris, developed by Alexion ... at ASH indicates that sustained reduction in hemolysis with Soliris therapy is associated ...

Soliris(R) Demonstrates Reductions in Hemolysis and Improvements in Fatigue, Overall Quality of Life and Anemia in a Broad Population of PNH Patients

... -- Soliris(R) (eculizumab) therapy reduced hemolysis and improved fatigue, overall quality of life and ... in a future print edition of Blood. Soliris, hemolysis and PNH Soliris, developed by Alexion ... PNH to reduce hemolysis. In patients with PNH, hemolysis can cause thromboses, kidney disease, liver ...

PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials

... UK. "In several clinical trials, Soliris reduced hemolysis in all PNH patients and significantly improved ... for PNH patients.(3,7) Thrombosis is related to hemolysis in patients with PNH, and patients with both ... Soliris for up to 54 months. Soliris reduced hemolysis in all treated patients and reduced thrombosis by ...

Alexion Reports Positive Results from AEGIS Registration Study of Soliris in Japanese Patients With PNH

... (PNH). The pre-specified primary efficacy endpoint of change in hemolysis was achieved with an 86 percent reduction (P<0.001). Key secondary ... treatment (P<0.001; normal range 103-223 U/L). -- Control of hemolysis resulted in an improvement in anemia as indicated by a reduction in ...

Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder

... in several organs. Patients treated with hydroxyurea had reduced hemolysis and improved total hemoglobin in comparison to the group of patients not ... yearly number of admissions to the hospital, and increased intensity of hemolysis in comparison to patients who did not receive hydroxyurea. Side ...

BioMarin Announces Positive Results From Phase 2A Clinical Study of 6R-BH4 in Sickle Cell Disease

... shifted the focus away from the physical sickling of red blood cells and more toward the deteriorating health of the blood vessels resulting from hemolysis and the release of hemoglobin from red cells." Study Design The Phase 2a multi-center, open-label study enrolled 32 subjects and was conducted at ...

First U.S. Patient to Receive New Heart-Assist Device Doing Well After Surgery at University of Michigan

... heart transplants. "This trial will test the DuraHeart's potential to overcome some of the issues that have been seen with other devices, including hemolysis caused by shear stress on red blood cells, and clotting risk caused by blood that does not circulate rapidly enough from all areas of the chamber," ...

Terumo Heart Summarizes Results of DuraHeart(TM) LVAS Implants

... last 22 patients after implementing a less intensive anticoagulation/anti-platelet regimen. There was no pump mechanical failure, pump thrombosis, or hemolysis throughout the support duration. Dr. Chisato Nojiri commented; "We are very pleased with the long term results of the device and recently reached a ...
Hemolysis in Medical Products

SAFE-T-FILL Lithium Heparin & Lithium Heparin Gel

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for ...
Company:RAM Scientific, Inc.

SAFE-T-FILL Serum Bili Gel Capillary Collection Tubes

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.

SAFE-T-FILL Sodium Fluoride

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.

SAFE-T-FILL Serum Bili

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.

SAFE-T-FILL Serum Gel Capillary Collection Tubes

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.

SAFE-T-FILL Serum Gel Mini Capillary Collection Tubes

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.

SAFE-T-FILL Serum Mini Capillary Collection Tubes

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.

SAFE-T-FILL Serum

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.

SAFE-T-FILL EDTA Capillary Collection Tubes

Features:... No Scooping Reduces hemolysis Yields tissue-free samples Increases patient comfort Reduces re-draws Capillary Blood Sampling Fills end-to-end for easy ...
Company:RAM Scientific, Inc.
Hemolysis in Medical Dictionary

Hemolysis

... hemolysis Related Category: Pathology (hml´ss), ... rate of destruction sometimes occurs. hemolysis : The destruction of red blood cells which ... into the blood plasma . Etymology: The word " hemolysis " is made up of "hemo-", blood + "lysis", the ...

Hemolytic

... by the breakup of red blood cells ( hemolysis ) and kidney failure . HEMOLYTIC U REM IC ... condition with involves the rupture ( hemolysis ) of red blood cells, subsequent anemia , low ... The term for destruction of red blood cells is hemolysis . There are two types of hemolytic anemia : ......

Hemolytic anemia

... The term for destruction of red blood cells is hemolysis . There are two types of hemolytic anemia : ... ... . Possible chemical or physical causes of hemolysis of red blood cells and hemolytic anemia ... that results from the cellular destruction ( hemolysis ) of red blood cells due to antibodies formed ...

Concomitant

... responsible for management of the Commissioned Corps personnel system. hemolysis Lysis (opening) of red blood cells, with concomitant leakage of cell contents from the cells. Hemolytic anemia Anemia due to hemolysis . Jaundice Yellowish skin color due to liver disease . ...

Sucrose

... Alternate Names : Sucrose hemolysis Test Definition This is a blood test to detect increased fragility of red blood cells by swelling them in low-salt solution. Sucrose hemolysis test What the risks are: Risks associated with having blood drawn are ...

Anemia

... risk of infections and uncontrolled bleeding . AUTO IMMUNE HEMOLYTIC ANEMIA - A condition that results from the cellular destruction ( hemolysis ) of red blood cells due to antibodies formed to components on the surface of the red blood cells. Anemia , which literally means no blood , ...

Folic Acid

... contribute to neural tube defects such as anencephaly . Prevention : ... Vitamin E and folic acid (both anti -oxidants) may help decrease hemolysis in G6PD-deficient individuals. Prognosis ... Preventing Birth Defects — Take 400 micrograms (0.4 mg) each day of folic acid , a ...

HELLP syndrome

... The answer is in the MedicineNet Medical Dictionary. The entry there reads: ... HELLP syndrome : A syndrome featuring a combination of "H" for hemolysis (the breakdown of red blood cells), "EL" for elevated liver enzyme s, and "LP" for low platelet count (an essential blood clotting ....

Hemochromatosis

... deficiency , which is the absence of a particular enzyme in the liver ... Increased levels may be seen in the following: hemochromatosis , hemolysis , hemolytic anemia , hepatitis , liver necrosis , hemosiderosis, iron poisoning , and lead toxic ity. find out why you are anemic ...

Hemoglobin

... usualmente medida por la reduccin en la cantidad de hemoglobin a, ... HEMOGLOBIN : The component of red blood cells that carries oxygen . hemolysis : The rupture of red blood cells. hemoglobin . The red, iron-rich protein that enables red blood cells to carry oxygen from the lungs ...

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Hemolysis in Biological Technology

Soliris(R) Reduced Measures of Thrombosis and Inflammation, and Decreased Indicators of Pulmonary Hypertension, in Studies of Patients with PNH

... (2) At the start of the study, levels of hemolysis and nitric oxide consumption were shown to be ... to Successfully Manage Intravascular Breakthrough hemolysis in Patients with Paroxysmal Nocturnal ... . A poster titled "Reducing Intravascular hemolysis on Ferritin Homeostasis in Eculizumab Treated ...

PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials

... UK. "In several clinical trials, Soliris reduced hemolysis in all PNH patients and significantly improved ... for PNH patients.(3,7) Thrombosis is related to hemolysis in patients with PNH, and patients with both ... Soliris for up to 54 months. Soliris reduced hemolysis in all treated patients and reduced thrombosis by ...

Alexion Reports Third Quarter 2008 Results

... PNH is a rare, debilitating and life-threatening blood disorder defined by the destruction of red blood cells, or hemolysis. In patients with PNH, hemolysis can cause life-threatening thromboses, recurrent pain, kidney disease, disabling fatigue, impaired quality of life, severe anemia, pulmonary ...

Alexion Reports First Quarter 2008 Results

... PNH is a rare, debilitating, and life-threatening blood disorder defined by the destruction of red blood cells, or hemolysis. In patients with PNH, hemolysis can cause life-threatening thromboses, recurrent pain, kidney disease, disabling fatigue, impaired quality of life, severe anemia, pulmonary ...

Alexion Reports Fourth Quarter and Full Year 2007 Results

... PNH is a rare, debilitating, and life-threatening blood disorder defined by the destruction of red blood cells, or hemolysis. In patients with PNH, hemolysis can cause life-threatening thromboses, recurrent pain, kidney disease, disabling fatigue, impaired quality of life, severe anemia, pulmonary ...

Robust High Throughput RNA Isolation from Blood Samples

... than samples from fresh blood or blood stored at 4C (data not shown). RNA degradation may result from hemolysis during thawing; however, the RNA can still be used for successful qRT-PCR yielding valuable gene expression ...

Quantification of Nucleosomes in Serum by the Cell Death Detection ELISAplus

... The standardization of the preanalytic handling of the samples was essential for the reliable quantification of nucleosomes in serum. Whereas hemolysis and prolongation of the period between venipuncture and centrifugation to more than two hours resulted in elevated values, the delayed addition ...
Hemolysis in Biological Definition

Blood type

... B. Matching the Rhesus factor in the ABO system is very important, as mismatching (an Rh positive donor to an Rh negative recipient) will cause hemolysis . The converse is not true: Rh+ patients do not react to Rh- blood. Rh disease occurs when an Rh negative mother who has already had an Rh ...
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