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Helicase in Medical News

How defects in 1 gene cause 3 distinct and devastating human diseases

... biochemical activity of an enzyme known as XPD helicase taken from Sulfolobus archaea, microbes distinct ... the repair of damaged DNA. In both instances, the helicase parts the two DNA strands at either the ... mutations in XPD all fall in sites where the helicase binds ATP (the energy currency of the cell) or ...

Scientists identify new gene responsible for puberty disorders

... gene in a large sample of patients diagnosed with delayed puberty but not CHARGE," Dr. Layman says. The identified gene is called chromodomain helicase DNA binding protein 7, or CHD7. In 101 people with IHH and Kallmann syndrome, researchers found seven mutations of CHD7 that weren't present in ...

Salk Scientists - Links Between Cancer and Aging

... with a functional WRN gene showed decreased DNA damage compared to untreated cells, which was predictable: the WRN gene encodes a protein called a helicase that unwinds tightly coiled DNA strands when cells divide. Loss of WRN protein in individuals with Werner Syndrome is responsible for the disease. ...

Heart disease and strokes connected to a motor protein mechanism

... Chemistry Assistant Professor Charalampos Kalodimos and his coworkers, in the article, "Disorder-order folding transitions underlie catalysis in the helicase motor of SecA." Identifying the way this motor protein works is significant because it may lead to the development of new pharmacological therapies ...
Helicase in Biological News

Researchers probe a DNA repair enzyme

... to prevent and repair such damage. Mutations in the human members of this helicase family impede DNA repair and may contribute to breast cancer, Fanconi ... be physiological targets for this helicase. On making these mutations, the helicase no longer behaves like its supposed to, said graduate student Robert Pugh, ...

GUMC discovery highlights new direction for drug discovery

... were the first to make a recombinant EWS-FLI1 fusion protein. They used it to discover that the fusion protein stuck to another protein, RNA helicase A (RHA), a molecule that forms protein complexes in order to control gene transcription. "We believe that when RHA binds to EWS-FLI1, the combination ...

DNA template could explain evolutionary shifts

... each cell that results from the division has the same genetic code. That means it must replicate its DNA. During this process, an enzyme called a helicase separates the two strands, breaking the hydrogen bonds between the A T and G C base pairs. The two separating strands become the replication fork. ...

Leemor Joshua-Tor, PhD, CSHL biologist and WSBS dean, is named an HHMI Investigator

... of DNA through its channel and how it utilizes ATP to do this. Additional work is under way in the lab to determine more comprehensively how this helicase complex works. Leemor Joshua-Tor was born in Israel and trained at Tel-Aviv University, where she earned a B.Sc. in chemistry, and at the ...

Copy number variation may stem from replication misstep

... each cell that results from the division has the same genetic code. That means it must replicate its DNA. During this process, an enzyme called a helicase separates the two strands, breaking the hydrogen bonds between the A T and G C base pairs holding the strands together. The two separating strands ...

Biophysical Society announces winners of 2008 Student Travel Awards

... Water-in-Oil Droplet on Hydrogel Bilayers. Christopher P. Toseland, MRC-National Institute for Medical Research, London, United Kingdom, helicase Superfamily 1 and 2 ATPase Mechanisms. Martijn E. van Raaij, University of Twente, Enschede, The Netherlands, Quantitative Atomic Force ...

Scientists discover new regulating mechanism in cells

... by retroviruses ?to control the making of certain essential proteins, including some involved in cancer. The mechanism uses an enzyme called RNA helicase A (RHA), which is made by the cell. The study by researchers with The Ohio State University Comprehensive Cancer Center ?Arthur G. James Cancer ...

Molecular DNA switch found to be the same for all life

... others proteins to dock onto the initiator complex," said Berger. "These other proteins can help add layers of complexity, such as assisting with helicase loading or inactivating the initiator after replication has begun. The open rings also probably allow DNA to interact with the interior of the ...

Enzyme crystal structure reveals 'unexpected' genome repair functions

... The study is being published in an advance online version of the journal Molecular Cell. The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double ...
Helicase in Biological Technology

Evaluation of FlashPlate in a Helicase Assay

... a high throughput screening (HTS) platform for a helicase functional assay. helicase activity was measured on a streptavidin coated ... and economical basis for the evaluation of DNA helicase enzyme activities. Introduction ...

siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)

... the phosphorylation-dependent sub-cellular location domain (PSLD) of DNA helicase B (13). In this cell line a nuclear localization sequence (NLS) within the ... 13. Gu, J. et al. Cell cycle-dependent regulation of a human DNA helicase that localizes in DNA damage foci. Mol. Biol. Cell. 15 (7), ...

RNA Interference and Gene Silencing: History and Overview

... RH. (1999). Mut-7 of C. elegans , required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNase D. Cell 99 : 133-141. (

siRNA Design: It's All in the Algorithm

... could be incorporated into RISC to the exclusion of the other strand. The authors hypothesized that an RNA helicase responsible for unwinding siRNAs selects a strand for incorporation into the RISC based on the ease with ...
Helicase in Biological Definition

RNA

... enzyme binds to special promoter regions on the DNA helix; these regions mark the beginning of a gene. The DNA double helix is unwound by the helicase activity of the enzyme. RNA is then synthesised so that it is complementary to one of strands in the DNA . The strand from which the RNA is encoded ...
Helicase in Biological Dictionary

Replication fork

... be merged into this article or section. ... helicase unwinds DNA at the replication fork , the ... Enzymes ... As replication occurs, the helicase molecules are pushed toward the fork where ... ... fork reversal was proposed to occur (i) in helicase mutants (in a ... ... part and the open part ...

Primase

... . ... In bacteria, primase binds to the DNA helicase forming a complex called the primosome. ... ... subunits, which catalyzes the ... ... DnaB helicase and Its Complex with a Domain of DnaG Primase ... as well. ... ... has both primase and helicase ... this study, we report the development of a ...

Helicase

... Pre-replication complex: helicase (dnaA, dnaB, T7) - Primase (dnaG) - DNA ... ... from "http://en.wikipedia.org /wiki/ helicase " ... infosite on helicases, maintained by Eckhard Jankowsky ... The RNA helicase resource. RNA helicases from the bakers yeast. ...

Heteroduplex

... with ... Heteroduplex with early melted sequences. ... ... Mer3 helicase Stimulates 3′–5′ Heteroduplex Extension by Rad51 ... Conversely, Mer3 helicase blocks DNA heteroduplex extension in the 5′ 3′ direction. ... ... ...

Replication bubble

... fork be merged into this article ... strands continue to unwind on each side of the bubble , forming replication forks. ... ... by a DNA helicase and the result is the foprmation of a replication bubble . At ... The replication of our cellular DNA occurs from an internal point ... ... ...

Amino Terminus

... nine amino acids in length and have an Acetyl amine terminus and a free ... In other helicases, the amino terminus can recruit the helicase to its site of ... Additionally, the amino terminus of Rrm3p contains a putative PCNA interaction ... To determine if the amino terminus ...

Abiotic stress

... stress ... ... IN RESPONSE TO ABIOTIC STRESS ... FUNCTIONS OF ABIOTIC STRESS -REGULATED RNA ... Abiotic stress induction of RNA helicase gene expression ... Abiotic stress Workshop. Faba bean - 2006. Ascochyta - 2006. GL-Pro - Brussels - 2006 ... and diversity of abiotic ...

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