Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
...n be fused with large, protein-based drugs such as granulocyte colony-stimulating factor (G-CSF) to create a new oral compound that is capable of surviving the journey through the gastrointestinal (GI) tract and then able to cross over into the bloodstream to be used by the body, according to research from the U...Cloned mice created from fully differentiated cells, a milestone in cloning research
...e using a fully differentiated blood cell called a granulocyte with its ancestor cells at different stages: hemat...rtainty that a fully differentiated cell such as a granulocyte retains the genetic capacity for becoming like a seed that can give rise to all cell types necessary...Researchers urge monitoring of bone health during chemotherapy
...e an eight-day course of the growth factor, called granulocyte colony-stimulating factor (G-CSF), the mice lost bone mass and experienced increased bone tumor growth when injected with cancer cells. Their study will appear in an upcoming issue of the journal Blood and is now available online. G-CSF is known b...Detection of mRNAs on Cryosections of the Cardiovascular System Using DIG-Labeled RNA Probes
...cular system (e.g., of the proinflammatorycytokine granulocyte macrophage colony stimulating factor[GM-CSF] in normal human coronary arteries, and ofinterleukin 6 [IL6] and glycoprotein gp130 in failinghuman hearts [3]). The protocol can be combined withimmunohistochemistry [4, 5], and can also be used forparaff...Therapy Boosts Chemotherapy Effects
...herapy and treatment with a growth factor known as granulocyte colony-stimulating factor, or G-CSF. While patients in the two groups initially showed similar response rates, a long-term follow up showed those in the G-CSF group had better results over time. The investigators conclude, "Sensitization of leukemic...High-Dosage of Epirubicin and Cyclophosphamide may cause AML
... AML/MDS. Other factors such as age, radiotherapy, granulocyte colony stimulating factor and tamoxifen were not independently associated with AML/MDS. Patients taking more than the standard cumulative dose of epirubicin was found to have an increased relative risk of 6.80. The standard dose of epirubicin was fo...Protective regimen for acute Graft-versus-host disease
...ells from related or unrelated donors who received granulocyte colony-stimulating factor. Of the 37 transplant recipients, only 2 had acute GVHD after hematopoietic-cell transplantation. Potent antitumor effects in patients with lymphoid malignant diseases were shown by the change from partial to complete remi...Stem Cell Therapy For Heart Attack Found To Be Ineffective
...ugh stimulation of a growth factor protein, called granulocyte colony-stimulating factor (G-CSF). The researchers conducted a randomized, double blind, placebo-controlled study (REVIVAL-2) to assess effect of G-CSF treatment in a large study population (114 patients) following a heart attack. All the study par......nto partially committed mouse blood cells known as granulocyte macrophage progenitors, or GMPs. These genetically altered cells were injected into mice, which subsequently developed AML. Through several steps of purification, the researchers winnowed down the leukemia cells from the mice to a small population ...