glycoprotein

Scientists discover how Ebola virus infects cells

...an et al. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science Express. Published online April 14, 2005. DOI: 10.1126/science.1110656. ...

Newly discovered protein an important tool for sleeping sickness research

...ated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies the human immune system made to fight the original a...

Breakthrough System for Understanding Ocean Plant Life Announced

...ated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies the human immune system made to fight the original a...

Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods

...logical approaches to pinpoint the multifunctional glycoprotein CD36 (also termed fatty acid transporter, FAT) as the sensor for fat. They show that lingual stimulation of CD36 by fatty acids influences behavioral and digestive physiology. CD36 gene inactivation fully abolishes both the spontaneous preference f...

Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

...losed loops of DNA), one each encoding the surface glycoprotein (GP) from the Zaire strain of Ebola, GP from the Sudan/Gulu strain, and the internal nucleoprotein (NP) from the Zaire strain. Subjects received three doses of vaccine or placebo at one-month intervals via intramuscular needleless injection. Three co...

More>>

glycoprotein at Biology Products

Human / Mouse / Rat Blood Vessels (CD31 / Von Willebrand Factor (vWF)) IHC staining Kit from CHEMICON

... molecule (PECAM-1), is a type I integral membrane glycoprotein and a member of the immunoglobulin super family of cell surface receptors. It is strongly expressed by all endothelial cells and weakly by several types of leucocytes (Parums et al., 1990). According to several studies, staining of blood vessels with...

PROTEIN PROTOCOLS Book from Pierce Biotechnology, Inc.

...g protein blots have been included. The section on glycoprotein analysis has also been expanded, and methods for the production of single chain and phage-displayed antibodies have been added....

FastPlax Titer Kit from Novagen

... the appearance of detectable levels of AcNPV gp64 glycoprotein on the cell surface as early as 824 hours post-infection. Detection is based on a high affinity monoclonal antibody against gp64, which is added directly to fixed cells. Antibody binding is detected with an anti-mouse IgG b-galactosidase conjugate fo...

Glycoprotein Isolation Kit WGA from Pierce Biotechnology, Inc.

...alic acid. High recovery Equivalent or greater glycoprotein recovery versus competitor kits and lectin resins Fast Glycoprotein purification in less than an hour Versatile Isolate glycoproteins from various sample types, e.g., human serum and cell lysate. Robust Lectin does not leach from resin...

Mouse Anti-Rhodopsin Monoclonal Antibody, Unconjugated, Clone RET-P1 from GeneTex

...e monoclonal [RET-P1] to Rhodopsin Rhodopsin is a glycoprotein which is a visual pigment in mammals, birds, amphibians, and reptiles. The rhodopsin protein is present on the photoreceptor cells in the retina. Immunogen: Membrane preparation from adult rat retina. Specificity: This antibody specifically lab...

More>>

glycoprotein at Biology Technology

Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn

... fundamental study of glycoproteins. Typically, a glycoprotein is enzymatically digested, the resulting pep...tures. In this case, as is the case for most glycoprotein analyses, MS/MS is simply not enough. Experimental Conditions Th...

Tools for Proteomic Science II

...nts of carbohydrateand their structures. Using our glycoprotein analysissystem you can determine whether or not your protein is glycosylated, whether the sugar moiety is N- orO-linked, as well as gather additional data regarding carbohydratestructures. Quantification of the sugar moietyand simultaneous staining o...

Detection of mRNAs on Cryosections of the Cardiovascular System Using DIG-Labeled RNA Probes

...n coronary arteries, and ofinterleukin 6 [IL6] and glycoprotein gp130 in failinghuman hearts [3]). The protocol can be combined withimmunohistochemistry [4, 5], and can also be used forparaffin- and methacrylate-embedded sections. Materials and Methods Preparation of D...

Continuous-Elution Electrophoresis for Purification of the Baculovirus-Expressed Coronavirus Structural Proteins, Rev A

...combinant baculovirus-expressed TGEV spike glycoprotein vaccines, Am. J. Vet. Res., 58 , 242250 (1997). 6. Stott, D. I., Immunoblotting and dot blotting, J. Immunol. Methods, 119 , 153187 (1989). 7. Wesley, R. D., et al., Differentiation between transm...

Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

...not found in human milk. 5, 6, 7, 8 βLG is a glycoprotein which exists at the normal pH of bovine milk as a dimer with a molecular weight of 36,000, and consists of two monomeric subunits with molecular weight of 18,000 (162 residues). Several genetic variants of βLG have ...

More>>

glycoprotein at Biology Definition

Zona pellucida

The zona pellucida is a glycoprotein matrix surrounding the plasma membrane of a mammalian oocyte . This structure binds spermatozoa , and is required to initiate the acrosome reaction . The zona glycoprotein, ZP3 , is responsible for sperm binding, adhering to proteins on...

Blood type

...d cells, the ABO antigen is also expressed on the glycoprotein von Willebrand factor (vWF), which participates in hemostasis (control of bleeding). In fact, blood type O predisposes very slightly to bleeding, as vWF is degraded more rapidly. Austrian scientist Karl Landsteiner was awarded the Nobel Priz...

Monoclonal antibody

...s purpose, since they cannot produce this kind of glycoprotein ). Depending on how big a part of the mouse antibody is used, one talks about chimeric antibodies or humanized antibodies . Another approach involves genetically engineered mice that produce more human-like antibodies. FDA approved monoclonal ...

Immune system

...ry nucleated cell contains molecules of a large glycoprotein called the major histocompatibility complex (MHC). These proteins have configurations and amino acid sequences that are unique to every individual. T cells, a group that encompasses cytotoxic T lymphocytes ( CTLs ), the cells that kill virally-in...

Glycoprotein

A glycoprotein is a macromolecule composed of a protein and a carbohydrate (a sugar ). The carbohydrate is usually attached to the protein in a posttranslational modification , at either asparagine , hydroxylysine , hydroxyproline , serine , or threon...

More>>

glycoprotein at Biology Dictionary

Zona pellucida

...#62; Zona pellucida The zona pellucida is a glycoprotein matrix surrounding the plasma membrane of a mammalian oocyte. This structure binds sperm atozoa, and is required to initiate the acrosome reaction . Full article >>> zona pellucida - a thick extracellular matrix surrounding the ...

VNTR

...ber of tandem repeats ( VNTR s) Variant surface glycoprotein (VSG) of trypanosomes Variation , continuous Variola virus Variolation VascularContaining vessels that conduct liquid. Full article >>> Program participants learn simplified lab techniques for amplifying two types of chromosomal ...

Vertebrates

...wo class es of intracellular lectins involved in glycoprotein trafficking are present in yeast, model in vertebrates and vertebrates , and two other class es are present in vertebrates only. Full article >>> As in vertebrate vision, visual transduction in in vertebrates occurs via a ...

Trans face

...destinations. An example is the modification of glycoprotein s (used in cell membrane s). Full article >&...inal destinations. An example is the formation of glycoprotein s (used in cell membrane s). Vesicle s from the ER have proteins . Full article >>>...

Southern blot

...oma brucei express ing different variant surface glycoprotein s (VSGs). Full article >>> Trans fer of electrophoretically separated RNA molecule s from a gel onto an absorbent sheet, which is then immersed in a labeled probe that will hybrid ize to an RNA of interest to reveal its pres...

More>>

glycoprotein at Medicine News

Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery

...dentify at-risk women is fetal fibronectin (fFN).A glycoprotein that is secreted by the fetal membrane and found in the choriodecidual junction, fFN is responsible for cellular adhesions. The level of fFN in the woman's cervicovaginal secretions is highly associated with pre-term labor and pre-term delivery. The ...

Angioplasty plus stenting better than thrombolysis for elderly patients with AMI

...e performed before intracoronary stents and use of glycoprotein IIb/IIIa antagonists were routinely employed. Therefore, Dr. Hanoch Hod, of Chaim Sheba Medical //Center in Tel Hashomer, Israel, and associates followed 130 consecutive patients aged 70 or older treated for ST-elevation AMI. Eighty-six patients wer...

Osteopontin: a useful biomarker in asbestos-related cancer

...ally treated pleural mesothelioma.Osteopontin is a glycoprotein that is over expressed in lung, breast, colorectal, gastric, and ovarian cancer and in melanoma. High levels of osteopontin have previously been shown to correlate with tumor invasion, progression, and metastases. The researchers investigated the p...

Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting

...f muscle cells. These proteins form the dystrophin glycoprotein complex. Dystrophin and DGC are also lost in Duchenne muscular dystrophy. The loss of dystrophin and damage to the DGC appear to be key players in the development of both cancer wasting and muscular dystrophy. Cancer wasting occurs most often in e...

Malfunction Of Key Growth Factor Increases Mortality Rate From Pulmonary Fibrosis In Blacks

...pproach they found that the amount of antifibrotic glycoprotein hypatocyte growth factor (HGF) was reduced in the blood and epithelial lining fluid of African-American scleroderma patients than in Caucasians.And the latest study presented in San Francisco "demonstrates that antifibrotic effects of HGF are impaire...

More>>

glycoprotein at Medicine Products

ACE - REA Hypertension / Cardiac Evaluation, Cardiovascular 001-RK-ACD Angiotensin Converting Enzyme

... weight of at least 129,000. The structure of this glycoprotein shows a single polypeptide chain, a polysaccharide residue and a zinc atom. ACE is present in many different cell types such as neuronal cells and renal proximal tubular cells, but is mostly found in endothelial cells. It is attached to the endotheli...

LH IRMA Test

Luteinizing hormone (LH) is a glycoprotein secreted by the anterior pituitary gland. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique...

LH ELISA Test

Luteinizing hormone (LH) is a glycoprotein secreted by the anterior pituitary gland. Like the FSH, hCG and TSH, the intact LH molecule is a noncovalently-linked dimer containing alpha- and beta-subunits. These glycoproteins all have homologous alpha-subunits, however each hormone has a unique...

HSV Typing ASR

...ains primers and a FAM-labeled probe targeting the glycoprotein D gene of HSV Type 1 as well as primers and an Alexa 532-labeled probe designed to detect the glycoprotein G gene of HSV Type 2. This ASR requires an instrument that can detect FAM, Texas Red, and Alexa repo...

FSH IRMA Test

Follicle-stimulating hormone (FSH) is a glycoprotein hormone secreted by the anterior pituitary gland. Like hCG, LH and TSH, the intact FSH molecule is a noncovalently-linked dimer consisting of alpha- and beta-subunits. Its production and secretion are stimulated by gonadotropin-releasing hormone (GnR...

More>>

glycoprotein at Medicine Technology

ISTA Pharmaceuticals Announces Positive Preliminary Results from Ecabet Sodium Phase IIb Study

...ival goblet cells andcorneal epithelia. Mucin is a glycoprotein component of tear filmthat lubricates while retarding moisture loss from tearevaporation. About ISTA ISTA Pharmaceuticals is an ophthalmic pharmaceutical company.ISTA's products and product candidates addressing the $3.2 billionU.S. prescription op...

Vical's Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA Vaccine Performance; Yields Antibody Responses Comparable to Electroporation Without Tolerability Issues

...ts with DNA vaccinesencoding cytomegalovirus (CMV) glycoprotein B (gB). The vaccineswere either unformulated -- using standard phosphate-bufferedsaline (PBS) -- or formulated -- using the company's Vaxfectin(TM)adjuvant in PBS. Vaxfectin(TM)-formulated vaccines were injectedwith a needle-free device. Unformulated...

Argos Therapeutics Presents Immunosuppression Data for Soluble CD83 at the American Society of Transplantation Congress 2007

...ynomologous monkey" About Soluble CD83 CD83 is a glycoprotein expressed on the cell surface of maturedendritic cells (DCs), the most potent stimulators of immuneresponses. The strong upregulation of this protein during DCmaturation suggests that it plays an important functional role inthe induction of immune re...

Mymetics' HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model

...mensional mimicry between the viral envelope glycoprotein gp41 and the IL-2 cytokine (Interleukin-2) of the infected host. Mymetics strongly believes that it is crucial to prevent the potential induction of cross-reactivity toward self-proteins, such as IL-2, post-vaccination in order to ...