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Glucagon in Medical News

New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes

... pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to ... JANUVIA increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent ... levels of active GLP-1 and GIP, decreased glucagon concentrations, and increased responsiveness of ...

UT Southwestern scientists discover leptin can also aid type 1 diabetics

... pancreas that raises glucose levels. Normally, glucagon is released when the glucose, or sugar, level in the blood is low. In insulin deficiency, however, glucagon levels are inappropriately high and cause the ... was mediated by complete suppression of the high glucagon levels, said Dr. Xinxin Yu, assistant instructor ...

Discovery of new signal pathway important to diabetes research

... narrow interval, and we need both insulin and glucagon to remain in good health. "A person with low ... Much more is known about insulin secretion than glucagon secretion, and so Professor Berggren's team ... cells also secreted glutamate, which facilitates glucagon release and makes it more efficient. The ...

New Diabetes Drug Shows Promise in Trial

... stimulates insulin production," Madsbad explained. "Then it also promotes glucagon release from the pancreas. It also changes appetite, and therefore you eat less." glucagon is a hormone that helps manage blood sugar levels. "We want more ...

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Takeda Receives New Information on Alogliptin (SYR-322) NDA

... insulin secretion--and it has the potential to improve pancreatic beta-cell function. Furthermore, it is known that because GLP-1 suppresses glucagon secretion from the pancreas, the production of sugar in liver cells is also suppressed. About Takeda Pharmaceutical Company Limited Located ...

Amylin, Lilly Update on FDA Review of BYETTA(R) (exenatide) Injection Monotherapy Submission

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Isis Reports Financial Results and Highlights for Fiscal year 2007

... weight gain or nausea. * Isis initiated Phase 1 studies of ISIS 325568, an antisense drug partnered with OMI, that targets the glucagon receptor, GCGR. * Isis identified a development candidate, ISIS 377131, an antisense drug also partnered with OMI that targets the ...

Takeda submits new drug application for alogliptin (syr-322) in the US

... to food, and regulate glucose balance, primarily by stimulating glucose-dependent insulin secretion. In addition, GLP-1 suppresses pancreatic glucagon secretion and subsequent liver glucose production, enhances glucose disposal, slows gastric emptying, and elicits satiety, a feeling of fullness. ...

Benefit of exenatide has not yet been proven

... body, GLP-1. Incretins are hormones that are produced in the gastrointestinal tract. In the pancreas, they stimulate insulin secretion and inhibit glucagon secretion, depending on the blood glucose level. In addition, they affect gastric as well as brain functions: they delay the emptying of the stomach ...

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Glucagon in Medical Technology

Isis Earns $5 Million Milestone Payment From Ortho-McNeil, Inc. for Initiation of Phase 1 Study of ISIS 325568

... ISIS 325568 is an Antisense Drug Targeting glucagon Receptor for Treatment ... designed to selectively inhibit the production of glucagon receptor and has demonstrated improved glucose ... responsibilities over to our partner." ABOUT glucagon RECEPTOR (GCGR), TARGET OF ISIS 325568 ...

Isis Initiates Phase 1 Study of ISIS 325568 Targeting Glucagon Receptor to Treat Type 2 Diabetes

... type 2 diabetes by inhibiting production of the glucagon receptor (GCGR). GCGR is a receptor that binds ... for future studies." ISIS 325568 Targets the glucagon Receptor (GCGR) glucagon is a hormone that opposes the action of insulin ...

One Year Study of Exenatide Treatment Showed Improved Beta-Cell Function

... BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake ... elevated levels of blood sugar, inhibiting the release of a hormone called glucagon following meals, slowing the rate at which nutrients are absorbed into the ...

One Year Study of Exenatide Treatment Showed Improved Beta-Cell Function

... BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake ... elevated levels of blood sugar, inhibiting the release of a hormone called glucagon following meals, slowing the rate at which nutrients are absorbed into the ...

Meta-Analysis of Clinical Data Showed No Increased Risk of Cardiovascular Events Associated With Exenatide Use: Data Presented at ADA 2009

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Exenatide Once Weekly Provided Sustained Improvements in Glycemic Control With Weight Loss Over Two Years: DURATION-1 Interim Long-Term Data Presented at ADA 2009

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Amylin and Lilly Announce Plans to Develop Pen Device for Exenatide Once Weekly

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

New Study First to Confirm Sandostatin LAR(R) Depot Controls Tumor Growth in Patients With Rare Gastrointestinal Tumors

... on the human body as the natural hormone somatostatin. However, octreotide is even more potent than somatostatin at inhibiting growth hormone, glucagon and insulin. Based on these attributes, octreotide has been used to treat symptoms associated with metastatic carcinoid tumors (flushing and ...

Plans for Exenatide Once Weekly NDA Submission by End of First Half of 2009 Reaffirmed Following FDA Feedback

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Takeda Submits a New Drug Application in the U.S. for Alogliptin (SYR-322) / ACTOS(R) (pioglitazone HCl) for the Treatment of Type 2 Diabetes

... response to food and regulate glucose balance, primarily by stimulating glucose-dependent insulin secretion. In addition, GLP-1 suppresses pancreatic glucagon secretion and subsequent liver glucose production, enhances glucose disposal, slows gastric emptying, and elicits satiety, a feeling of fullness. ...

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Glucagon in Medical Products

C-Peptide Chemiluminescence Immunoassay

Description:... in equimolar concentrations, fasting levels of C-Peptide are 5-10 fold higher than those of insulin owing to the longer half-life of C-Peptide. The glucagon stimulated C-Peptide determination is often used for differential diagnosis of insulin-dependent from non-insulin-dependent diabetic ....
Company:Diagnostic Automation, Inc.
Glucagon in Medical Dictionary

Glucagon

... glucagon oma Definition: glucagon oma is a tumor of the islet cells of the pancreas , which secrete the hormone s insulin and glucagon . ...

Glucagonoma

... , which secrete the hormone s insulin and glucagon . Glucagonoma s -- produce the hormone glucagon . These are the third most common endocrine ... This tumor makes too much of the hormone glucagon and causes too much sugar in the blood , a ...

Pancreas

... pancreas secretes digestive enzyme s and the hormone s insulin and glucagon . PANCREAS - The pancreas is located across the back of the ... . The pancreas produces two important hormone s: insulin and glucagon ; both of which regulate blood sugar levels and aid digestion . As a ...

Acid

... factor for gout ) High blood lactic acid Increase in blood lactic acid and failure to increase blood sugar when adrenaline or glucagon are administered High blood fats, especially triglycerides ... Folic acid , however, is an exception. "Pregnant women should be ...

Adenoma

... risk factor for gout ) High blood lactic acid Increase in blood lactic acid and failure to increase blood sugar when adrenaline or glucagon are administered ... ACTH -producing tumor - This pituitary tumor , which also is called a basophilic adrenocorticotrophic hormone ...

Adrenaline

... in the body), spinal cord injuries , ... Increase in blood lactic acid and failure to increase blood sugar when adrenaline or glucagon are administered High blood fats, especially triglycerides Inability to tolerate fasting Improvement in response to frequent feeding s ... ...

Antifreeze

... cosmetics. Lactic acidosis can be caused by taking large doses of acetaminophen and alcohol and by intravenous infusion of epinephrine , glucagon , fructose , or sorbitol. Antifreeze poisoning can also cause lactic acidosis . Notes: Antizol is also known as 4MP (4-methylpyrazole). ...

Emergency Medicine

... Anesthesiology Emergency medicine Internal medicine Orthopedic and general surgery Pathology Radiology Certification Requirements ... glucagon is an emergency medicine and must be used only as directed by your doctor. Make sure that you and a member of your family or a friend understand ...

Fructose

... this effect. Lactic acidosis can be caused by taking large doses of acetaminophen and alcohol and by intravenous infusion of epinephrine , glucagon , fructose , or sorbitol. Antifreeze poisoning can also cause lactic acidosis . Blood Pressure Improves with Lifestyle Changes Fructose ...

Gout

... risk factor for gout ) High blood lactic acid Increase in blood lactic acid and failure to increase blood sugar when adrenaline or glucagon are administered High blood fats, especially triglycerides ... Other causes of kidney stones are hyperuricosuria which is a disorder of ...

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Glucagon in Biological News

Human hormone blocker found to help prevent obesity and diabetes: study

... plasma glucose and insulin concentrations were monitored at 5-7 day intervals. Blood was taken on day 50 to measure cholesterol, triglycerides, glucagon (the hormone involved in metabolizing carbohydrate), corticosterone (involved with carbohydrates in the liver) and circulating adipokines (which play ...
Glucagon in Biological Technology

Isis Enters Broad Collaboration With Ortho-McNeil, Inc. for the Discovery, Development and Commercialization of Antisense Drugs to Treat Metabolic Diseases

... of two antisense drugs in development targeting glucagon receptor and glucocorticoid ... which selectively inhibit the production of glucagon receptor (GCGR) and glucocorticoid receptor ... with Ortho-McNeil, Inc. and J&JPRD to advance our glucagon receptor and glucocorticoid receptor drugs ...

Anesiva Grants Specific-Use License of Its Needle-Free Drug Delivery Technology to Particle Therapeutics for Diabetes Drug

... by needle injection. At present, an estimated 1-1.5 million kits with glucagon powder are sold annually in the U.S. and Europe. Those with Type 1 ... the development, testing and commercialization of needle-free injection of glucagon in the diabetic patient with severe hypoglycemia. Other applications of ...

New Drug Application for Exenatide Once Weekly Accepted for Review by FDA

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Exenatide Once Weekly New Drug Application Submitted to FDA for Type 2 Diabetes

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Exenatide Clinical Data Analysis Shows No Increased Risk of Cardiovascular Events

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

Novel Diabetes Drug Discovery Has Potential to Reverse Disease

... of islet restoration as a therapeutic approach. Pancreatic islets contain four primary cell types and are responsible for producing insulin, amylin, glucagon and other hormones critical to maintaining normal glucose regulation. Current diabetes therapies, including insulin, help to control the disease but ...

FDA Continues Review of Takeda's New Drug Application for Alogliptin (SYR-322), a DPP-4 Agent for Type 2 Diabetes

... and it has also been confirmed that they improve the functioning of the beta cells themselves. Furthermore it is known that because GLP-1 suppresses glucagon secretion from the pancreas, the production of sugar in liver cells is also suppressed and appetite is suppressed as well. About Takeda ...

Amylin Pharmaceuticals to Present Promising Data From Diabetes and Obesity Programs at ADA 2008

... and only FDA-approved incretin mimetic for the treatment of type 2 diabetes. BYETTA exhibits many of the same effects as the human incretin hormone glucagon like peptide-1 (GLP-1). GLP-1 improves blood sugar after food intake through multiple effects that work in concert on the stomach, liver, pancreas ...

DiObex and Camurus Sign License Agreement for the Development of DIO-901 in FluidCrystal(R) Extended Release Technology

... low dose glucagon) in the Camurus drug delivery technology, FluidCrystal(R). The development candidate is an extended release formulation of low dose glucagon for the prevention of insulin-induced hypoglycemia in patients with diabetes. "Intensive glycemic control is beneficial for patients with ...
Glucagon in Biological Definition

Insulin

... levels: hyperglycemic hormones (such as glucagon , growth hormone , and adrenaline ), which ... of hyperglycemic hormones (most prominently glucagon from Islet alpha cells) forces release of glucose ... See also anatomy and physiolology glucagon pancreas islets of Langerhans ...

Anabolism

... IGF1 and other insulin-like growth factors Insulin Testosterone Estrogen Classic catabolic hormones include Cortisol glucagon Adrenalin and other catecholamines Cytokines Newer hormones associated with the balance of the catabolic and anabolic states include ...

Anabolism

... IGF1 and other insulin-like growth factors Insulin Testosterone Estrogen Classic catabolic hormones include Cortisol glucagon Adrenalin and other catecholamines Cytokines Newer hormones associated with the balance of the catabolic and anabolic states include ...

Diabetes mellitus

... a type of candy disliked by the patient, to prevent concerns about unnecessary use. Other ways of treating hypoglycemia include an injection of glucagon which causes the liver to convert its internal stores of glycogen to be released as glucose into the blood. Oral or intravenous dextrose can also be ...

Homeostasis

... fat to produce heat. Sweating cools the body with the use of evaporation . Chemical regulation The pancreas produces insulin and glucagon to control blood-sugar concentration. The lungs take in oxygen and give off carbon dioxide . The kidneys remove urea , and adjust the ...

Hormone

... cholecystokinin (CCK) corticotropin-releasing hormone (CRH) erythropoietin ( EPO ) follicle stimulating hormone (FSH) gastrin glucagon gonadotropin-releasing hormone (GnRH) growth hormone-releasing hormone (GHRH) human chorionic gonadotropin (hCG) growth hormone (GH ...

Neurotransmitter

... : corticotropin (ACTH) Beta-lipotropin dynorphin endorphin enkephaline leumorphin Secretins: secretin motilin glucagon vasoactive intestinal peptide (VIP) growth hormone-releasing factor (GRF) Somatostatins: somatostatin Tachykinins : ...

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Glucagon in Biological Dictionary

Glucagon

... glucagon is an important hormone involved in ... liver to convert stored glycogen ... glucagon rescue is the emergency injection of glucagon in case of severe diabetic hypoglycemia. It is ...

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