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Gliomas in Medical News

Delivering Chemo Directly Into Brain Tumors Shows Promise

... Survival times for those with malignant gliomas increased, study found MONDAY, May 4 ... clinical trials, researchers report. Malignant gliomas are difficult to treat using standard ... are better than any treatment for recurrent gliomas we have now," said study author Dr. Jeffrey ...

Brain Tumor Drug May Help Spur Cancer's Return

... have identified cells in brain tumors called gliomas that have stem cell-like qualities and are able ... chemotherapy drugs. "Current treatment for gliomas works for a while and then usually fails," ... -- which is the standard treatment for gliomas -- actually increased the number of ...

Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers

... Better models for research into human gliomas are urgently needed. Last year alone, about ... About 77 percent of malignant brain tumors are gliomas and their prognosis is usually bleak. While they ... incurable even with current therapies. gliomas originate in brain cells known as "glia" and are ...

Mayo Clinic identifies best treatments for long-term survival in brain tumor patients

... Clinic study found that patients with low-grade gliomas survived longest when they underwent aggressive ... ). gliomas are a type of brain tumor that form in the brain ... can spread within the nervous system. Low-grade gliomas are malignant and slow growing; overall, ...

Mayo Clinic Identifies Best Treatments for Long-Term Survival in Brain Tumor Patients

... Clinic study found that patients with low-grade gliomas survived longest when they underwent aggressive ... ). gliomas are a type of brain tumor that form in the brain ... can spread within the nervous system. Low-grade gliomas are malignant and slow growing; overall, ...

Radiologists use special MRI to identify brain cancer early

... and University College, London. Low-grade gliomas are primary brain tumors that grow slowly over several years. Eventually, almost all low-grade gliomas progress to high-grade gliomas, which carry a poor prognosis. Patients with low-grade gliomas are often young and may remain clinically well ...

Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology

... glioblastoma (GBM) and malignant anaplastic gliomas (AA). Ph II Study - Interim Results Twenty-five patients with advanced malignant gliomas were treated with a loading dose of 600 mg (150mg ... activity observed in patients with anaplastic gliomas is of great interest as these patients are in ...

New chemotherapy regimen prolongs survival in difficult-to-treat childhood brainstem gliomas

... Barcelona, Spain: Childhood brainstem gliomas (BSGs) are rare but can be very difficult to ... with high grade gliomas, while in low grade gliomas the response was comparable with the best ... many centres use radiation therapy for high-grade gliomas and diffuse intrinsic pontine tumours, the ...

Drummer Eddie Cleland Resumes Life After Brain Surgery and Tells About it at Conference

... Cleland's tumor was a diffuse astrocytoma, also called a Grade II glioma. gliomas arise from glial cells, which provide support for nerve cells in the brain. Low-grade gliomas (Grade I and II) are considered pre-malignant. Although not yet cancers, ...

UAB joins elite brain cancer research group

... and principal investigator for the Ivy Genomics-Based Medicine Project. gliomas are tumors that arise by transformation of the body's glial cells, which ... The consortium members strive to unravel how genetic differences between gliomas can lead to more effective and even personalized treatments for patients. ...

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Gliomas in Medical Technology

Vion Pharmaceuticals Announces Initiation of a Phase I/II Trial of Cloretazine(R) (VNP40101M) in Combination with Temodar(R) in Adult Brain Tumors

... with Temodar(R) (temozolomide) in relapsed or progressive adult malignant gliomas had been initiated at the Robert H. Lurie Cancer Center under the ... of research, there has been little progress in the treatment of malignant gliomas which recur after primary therapy. We are pleased to support Dr. Raizer's ...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

... of age. (NCI SEER Data) There are 12 major types of childhood cancers, and of these leukemias, brain and other central nervous system tumors (ie, gliomas and medulloblastomas) account for over 50% of the new cases. The remainder of new cases include extracranial tumors such as neuroblastomas, Wilms ...

New Imaging Analysis Predicts Brain Tumor Survival

... is amazing for brain tumors," says study author Craig Galban, Ph.D., assistant professor of radiology at the U-M Medical School. High grade gliomas have a high mortality rate, with people surviving only an average of 12 months after diagnosis. Typically, patients receive six to seven weeks of ...

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

... and for the treatment of newly diagnosed GBM concomitantly with radiotherapy and then as maintenance treatment. About Malignant gliomas The worldwide incidence rate of primary malignant brain and central nervous system tumors, using the world standard population, is 3.7 per ...

Bradmer reports progression free survival data from previous Phase II glioblastoma multiforme trials

... free survival as a predictor of overall survival in glioma patients. The article included data from 597 adult patients with recurrent high-grade gliomas that enrolled in Phase II trial protocols collected by the North American Brain Tumor Consortium between 1998 and 2002. The study concluded that ...

CuraGen Announces Initiation of Phase II Trial of CR011-vcMMAE in Patients with Advanced Breast Cancer

... II study of CR011-vcMMAE in patients with melanoma is currently enrolling patients, and preclinical studies with CR011-vcMMAE for the treatment of gliomas are ongoing. About Breast Cancer Breast cancer is the most common cancer in women and a leading cause of death in the United States. According to ...

St. Jude Finds Young Age May Give Survival Advantage to Children With Certain Brain Tumors

... to have a better prognosis when compared to older children. Different biological properties also seem to play a role in the latter case. Brainstem gliomas account for 10 to 15 percent of all brain tumors in children; and DPGs account for 80 percent of brainstem tumors in childhood. Although MRI ...

Sangamo BioSciences Announces Presentation of Data on ZFP Therapeutic for Glioblastoma at American Association for Cancer Research (AACR) Meeting

... of GBM demonstrating that the T-cells were capable of killing tumor cells in the presence of the glucocorticoid dexamethasone. About Gliomas gliomas are the most common type of primary brain tumors; 20,000 cases are diagnosed and 14,000 glioma-related deaths occur annually in the United States. ...

Pharmion to Present Clinical Data on Commercial and Pipeline Products at 2007 American Society of Clinical Oncology (ASCO) Meeting

... Place Convention Center, S Hall A2 A phase II trial of thalidomide (Thal) and procarbazine (Pro) in adults with recurrent or progressive malignant gliomas (MG) -- G. Lesser, MD; Abstract #2067; June 4, 2007; 1:00-5:00pm; McCormick Place Convention Center, S Hall A2 Satraplatin Oral Presentation: ...
Gliomas in Medical Dictionary

Gliomas

... gliomas are tumor s that most commonly arise from a ... named for their star-like appearance. Mixed gliomas are brain tumors that contain more than one ... the highest grade present in the tumor . gliomas refer to a class of tumor s that can be found ...

Brain tumor

... trials are also being conducted to evaluate its use in the treatment of primary brain tumor s (gliobla stoma multi forme), childhood gliomas , pancreatic cancer , and stage III non-small cell lung cancer . Identify the location of a suspected brain tumor , inflammation , ...

Brain Tumors

... Clinical trials are also being conducted to evaluate its use in the treatment of primary brain tumor s (gliobla stoma multi forme), childhood gliomas , pancreatic cancer , and stage III non-small cell lung cancer . Some important causes of increased pressure from cerebral spinal fluid and ...

Cerebrum

... most often arise in the cerebrum whereas in children, they may arise in the brain stem, cerebrum , and cerebellum . Astrocytomas are gliomas , brain tumors derived from glial, or supportive, cells. Coma is the result of damage to the brain stem and cerebrum that may be caused by ...

Clinical Trials

... M ALT lymphoma s that involve H. pylori. Clinical trials and experimental therapies are available for patients with relapse d high-grade gliomas at specialized centers. Current trials include novel medications as well as new methods for the delivery of more traditional agents. In clinical ...

Neurofibromatosis

... brown patches of pigment on the skin , called cafi-au-lait spots. Neurofibromatosis Children with neurofibromatosis type I and brain stem gliomas may have a different prognosis than other patients who have intrinsic lesion s. neurofibromatosis An inherited disorder that causes dark ...

Neurology

... in London, where I go every six months for a check-up. References Cohen ME, Duffner PK, Heffner RR, et al.: Prognostic factors in brainstem gliomas . Neurology 36 (5): 602-5, 1986. [PUBMED Abstract] ... Other Related Web Sites: National Institute of Neurological Disorders American Academy of ...

Pancreatic Cancer

... Clinical trials are also being conducted to evaluate its use in the treatment of primary brain tumor s (gliobla stoma multi forme), childhood gliomas , pancreatic cancer , and stage III non-small cell lung cancer . Mills (1988) also found pancreatic cancer to be associated with ...

Pons

... to 15% of primary brain tumor s in children; average age is 6 years old May grow to very large size before symptoms are present ... Brain stem gliomas may occur in the pons , the midbrain, the tectum, the dorsum of the medulla at the cervicomedullary junction, or in multi ple regions of the ...

Primary brain tumor

... Clinical trials are also being conducted to evaluate its use in the treatment of primary brain tumor s (gliobla stoma multi forme), childhood gliomas , pancreatic cancer , and stage III non-small cell lung cancer . Primary brain tumor s originate in the brain and can be noncancerous ( ...

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Gliomas in Biological News

Veterinary college researcher studying brain tumors in people and animals

... by the National Institutes of Health (NIH). gliomas are an aggressive and deadly form of brain cancer ... has emerged as an excellent model for studying gliomas in humans. Every year about 120,000 new cases ... loss of balance, blindness and other problems. gliomas arise from glial cells, according to Rossmeisl, ...

Fluorescent cancer cells to guide brain surgeons

... gliomas are malignant brain tumors that arise from glial (supporting) cells of the brain. gliomas are often resistant to chemotherapy. These tumors grow fine extensions ...

Invasion of the brain tumors

... gliomas are highly malignant and invasive tumors with tendrils that extend far ... at the University of Calgary injected immunocompromised mice with human gliomas and compared invasive cells (which left the primary tumor site) to ...

Researchers uncover mechanism of action of antibiotic able to reduce neuronal cell death in brain

... novel therapies to treat Alzheimer's disease, amyotrophic lateral sclerosis, Huntingtons disease, epilepsy, stroke/ischemia, dementia and malignant gliomas RICHMOND, Va. (May 9, 2008) Virginia Commonwealth University researchers have discovered how an antibiotic works to modulate the activity of a ...

UAB wins $5.7M neurofibromatosis grant

... therapy regimens, to treat human cancerous tumors associated with NF. Such tumors can grow and damage the nerve sheath, and they can appear as gliomas in and around the optic nerve. In addition to managing the NF Consortium operations center, UAB will be enrolling adults and children in NF ...

Last chance for media to register for ECCO 14 -- the European Cancer Conference

... Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer Improved treatment for difficult childhood brainstem gliomas First molecular profiling of colon cancer patients accurately predicts survival Quality of life after endometrial cancer treatment can be ...

Mouse brain tumors mimic those in human genetic disorder

... seen in humans. Unlike most tumors, optic pathway gliomas associated with NF1 typically stop growing after ... three weeks old, developing into optic pathway gliomas by two months of age. After that time-period, ... and expansion," Gutmann explains. Optic pathway gliomas in humans are typically surrounded by ...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

... their work into human clinical trials. gliomas are highly invasive tumors with poorly defined ... to deliver genes directly to tumor cells, but gliomas are especially challenging because of their ... to produce IL-23 were injected into intracranial gliomas and other areas of the brain. Treated animals ...

Targeted virus compels cancer cells to eat themselves

... was 39 cubic millimeters, while those receiving the other virus had an average tumor volume of 200 cubic millimeters. Among mice with malignant gliomas in the brain, those treated with three injections of hTERT-Ad on average lived 53 days. Those receiving the control adenoviruses lived on average 29 ...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

... more potent viral doses." The glioblastoma multiforme study, which opened today, is designed to test the safety of the virus for the treatment of gliomas and enable biological monitoring of anti-tumor activity. "The measles virus we are using in the glioblastoma multiforme trial provides a ...

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Gliomas in Biological Technology

Diffusion Pharmaceuticals Announces Completion of a $2.9 Million Private Placement and Company Presentations at Upcoming Industry Conferences in Geneva, Switzerland and Naples, Florida

... which include a multi-center Phase I/II clinical trial in peripheral arterial disease patients and a Phase I trial in patients with high-grade gliomas at Johns Hopkins University . These clinical trials are designated NCT00725881 and NCT00826930 , respectively, on the clinicaltrials.gov ....

Pharmacyclics Reports Fourth Quarter and Fiscal 2008 Financial Results

... and chief executive officer of Pharmacyclics. "Enrollment in two Phase 2 trials with motexafin gadolinium for adult brain tumors and childhood gliomas also continues under sponsorship of the National Cancer Institute and we are planning to conduct a pivotal Phase 3 trial with motexafin gadolinium in ...

NIMOTUZUMAB CLINICAL DATA PRESENTED AT ASCO ANNUAL MEETING

... observed with the other drugs in its class." "Phase III trial of nimotuzumab for the treatment of newly diagnosed diffuse intrinsic pontine gliomas in children and adolescents" (Abstract number 2058): This poster reported data from a multi-centre Phase III study evaluating the feasibility and ...

ONCOSCIENCE AG, THE EUROPEAN PARTNER OF YM BIOSCIENCES, ANNOUNCES COMPLETION OF PATIENT ENROLLMENT IN PHASE III BRAIN CANCER TRIAL OF NIMOTUZUMAB

... a unique observation in these end-stage patients and has generated considerable interest. More than half of the high-grade brain cancers or gliomas over-express epidermal growth factor receptor (EGFR) and for the most advanced brain cancers, glioblastoma multiforme (GBM), the level of expression ...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

... used in gene silencing studies. Silencing of Focal Adhesion Kinases Malignant gliomas such as glioblastomas are a leading cause of CNS tumor-related death. At the root of the problem is the ...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

... used in gene silencing studies. Silencing of Focal Adhesion Kinases Malignant gliomas such as glioblastomas are a leading cause of CNS tumor-related death. At the root of the problem is the ...
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