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Germline in Medical News

Human sperm created from embryonic stem cells

... with XY chromosomes (male) were developed into germline stem cells which were then prompted to complete ... on this technique, the cells differentiated into germline stem cells. These expressed a protein which ... further differentiation, these in vitro derived germline stem cells expressed markers which are specific ...

Testes stem cell can change into other body tissues, Stanford/UCSF study shows

... by many types of adult stem cells. They termed the cells "multipotent germline stem cells." Germ cells are those cells in the body that differentiate to ... not yet possible to completely re-create human embryonic stem cells from germline cells," said Reijo-Pera, "These cells differ in gene expression, ...

Researchers Create Embryonic-Like Stem Cells From Human Testes

... is a big leap forward in efficiency with which these people get these germline stem cells," he said. But besides the obvious fact that women can't ... make an iPS cell than to have a testicular biopsy to give rise to an adult germline stem cell," he said. More information For more on stem cells, ...

Penn Veterinary Medicine report new strategy to create genetically modified animals

... Vet, and her colleagues introduced adeno-associated virus, AAV, to male germline stem cells in both goats and mice. The study showed that AAV stably ... approach to germ line genetic modification. It also demonstrates that germline transduction and germ cell transplantation in large animals provides an ...

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

... cells, they showed that the treated cells could be incorporated into a mouse embryo and become every cell type in the adult animal -- including germline cells that would produce the next generation of mice. "These are transient, non-coding molecules that do not incorporate into the genome, ...

UCSF team closer to creating safe embryonic-like stem cells

... cells, they showed that the treated cells could be incorporated into a mouse embryo and become every cell type in the adult animal -- including germline cells that would produce the next generation of mice. "These are transient, non-coding molecules that do not incorporate into the genome, but ...

Stem Cells Spur New Eggs in Ovaries of Adult Mice

... and adult mice. The presence of these germ cells could indicate reproductive capability. Still, researchers disagreed as to whether female germline stem cells (FGSCs) do exist in mammalian ovaries after birth. So, the Chinese team isolated active female FGSCs from adult and five-day-old mice. ...

Family history of colorectal cancer linked with reduced risk of cancer recurrence

... colorectal cancer. Should this be the case, genome-wide association studies and tumor gene expression profiling studies will be warranted to identify germline and tumor-specific genetic features associated with a family history of colorectal cancer and favorable outcome following adjuvant chemotherapy. ...

CSHL scientists are part of consortium that sequences platypus genome

... of small RNAs called piwi-, or piRNAs. In platypus, in contrast to other mammals studied to date, the piRNA system appears to play an active role in germline defense, within the mature testis. In sum, Dr. Hannon noted, the small RNA complement of the platypus has highlighted both unique and conserved ...

USC study finds evidence of gender-related differences in development of colon cancer

... Research, found that specific gene variants linked to the development of colon cancer resulted in opposite survival outcomes for men and women. germline variations in the epidermal growth factor receptor (EGFR) DNA -- a gene widely expressed in colonic tissue -- has been linked with poor prognosis ...

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Germline in Medical Technology

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

... CA, Dehner LP, Desruisseau D, Jarzembowski JA, Wikenheiser-Brokamp KA, Suarez BK, Whelan AJ, Williams G, Bracamontes D, Messinger Y, Goodfellow PJ. germline DICER1 mutations in familial pleuropulmonary blastoma. Funding from the Siteman Cancer Center, Children's Discovery Institute at St. Louis ...
Germline in Medical Dictionary

Cryptorchidism

... free newsletter or manage your subscriptions Get our RSS news feed ... germline WT1 mutation s are associated with cryptorchidism and hypospadias .[21] germline mutation s in WT1, however, have also been found in about 2% of ...

Hypospadias

... ; penile erection; penile fibromatosis; penile hypospadias ; ... germline WT1 mutation s are associated with cryptorchidism and hypospadias .[21] germline mutation s in WT1, however, have also been found in about 2% of ...

Family Planning

... nutrition , weight, and eating disorders ; drug and alcohol abuse ; tobacco use ; parenting and family planning . cancer because of a germline abnormality is most useful if the knowledge can be used to prevent the development of cancer or cancer -related morbid ity and mortality once it ...

Mosaicism

... to be more common among children born to older parents (both father and mother), in a pattern consi stent with autosomal dominant inheritance with germline mosaicism (for example, ... skull ; pigment patches of the skin ; and endocrine (hormonal) disease with early puberty (early menstrual ...
Germline in Biological News

Xie Lab uncovers molecular machinery related to stem cell fate

... Xie Lab has revealed how the BAM protein affects germline stem cell differentiation and how it is involved ... been known that the BAM protein is necessary for germline stem cell differentiation, but the specific ... for stem cell development in the fruit fly germline are suggested to be translational regulators, but ...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

... cells can be considered to be immortal. These germline cells generate their offspring's somatic cells ... and behavior, which have a set lifespan and new germline cells that continue on, generation after ... that allow the 'immortality' of reproductive germline cells. Their report will appear in the journal ...

Eliminating germline lengthens fly lifespan, Brown study shows

... fruit flies live longer when they dont produce germline stem cells the cells that create eggs and sperm. ... San Francisco. Kenyon found that eliminating germline stem cells in roundworms extended their lifespan. ... and Tatar over-activated a gene that controls germline stem cells in flies, a move that eliminated the ...

Stem cell chicken and egg debate moves to unlikely arena: the testes

... factors promoting self-renewal of two neighboring stem cell populations germline stem cells, which become sperm, and SSCs, which develop into a structure ... immature SSCs but their niche support cells," said Voog. By contrast, germline stem cells appeared incapable of generating hub cells. Their study also ...

New route for heredity bypasses DNA

... functions of the cell, such as metabolism. The second, the germline nucleus, like humans' sperm and egg, is home to the DNA needed for sexual ... be reconstituted in their offspring in order for them to survive. The germline nucleus contains abundant DNA, yet 95 percent of it is thrown away during ...

Penn Veterinary Medicine report new strategy to create genetically-modified animals

... Vet, and her colleagues introduced adeno-associated virus, AAV, to male germline stem cells in both goats and mice. The study showed that AAV stably ... approach to germ line genetic modification. It also demonstrates that germline transduction and germ cell transplantation in large animals provides an ...

Stem cell research: From molecular physiology to therapeutic applications

... pES cells generated from immature oocytes in mice exhibit pluripotency resembling fES cells, as evidenced by similarly high chimera production and germline transmission. Thus, immature eggs may provide an efficient source of autologous stem cells for regenerative medicine. This group also tested whether ...

Playing it safe

... Ko and his colleagues wanted to establish clarity from the outset. To this end, they started by culturing a precisely defined type of cell, so-called germline stem cells (GSCs), from the testis of adult mice. In their natural environment, these cells can only do one thing: constantly generate new sperm. ...

CSHL scientists discover how 'companion' cells to sperm protect them from genetic damage

... to ensure that transposons remain inactive. In animals, there is good evidence that epigenetic marks are first wiped clean and then reset in the germline cells such as sperm cells that give rise to the next generation. Martienssen's group has discovered that in plants, however, epigenetic marks ...

Xie Lab characterizes niche control of stem cell function

... a niche. The findings appear in todays issue of Cell Stem Cell. The Xie Lab demonstrated that differentiation-defective Drosophila ovarian germline stem cells (GSCs), behaving like human cancer stem cells, can out-compete normal stem cells for a position in the niche. They do so by invading the ...

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Germline in Biological Technology

Exelixis Reaches Agreement with FDA on Special Protocol Assessment for XL184 Phase 3 Trial

... endpoints will be assessment of the potential relationship between germline and/or tumor DNA sequence alterations and the efficacy of XL184, as well ... form of MTC invariably have an activating mutation in RET in their germline DNA. Activating mutations in RET are also present in the tumor DNA of up ...

Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study

... of the study, the CMM has been asked to provide extensive testing and review of up to 2,200 matched samples of DNA from pediatric leukemia patients' germline blood samples and their leukemic blasts. The CMM will identify and catalog potentially critical differences it finds across these DNA samples for ...

RNA Interference and Gene Silencing: History and Overview

... C. elegans ego-1 mutants ("ego" stands for "enhancer of glp-1 "), RNAi functions normally in somatic cells, but is defective in germline cells where ego-1 is primarily expressed. In Arabidopsis SDE-1 / SGS-2 mutants ("SGS" stands for suppressor of gene silencing), ...
Germline in Biological Definition

Gene therapy

... transform either somatic cells (most cells of the body) or cells of the germline (such as stem cells , sperm and eggs ). All gene therapy so far in people has been directed at somatic cells, whereas germline engineering in humans remains only a highly controversial prospect. For ...

Evolution

... under cellular control during processes such as meiosis or hypermutation . In multicellular organisms, mutations can be subdivided into germline mutations, which can be passed on to progeny and somatic mutations , which (when accidental) often lead to the malfunction or death of a cell and ...
Germline in Biological Dictionary

Germline

... In biology and genetics, the germline of a mature or developing individual is the line ... to localize nanos mRNA to the ... 3. L1-L3: germline proliferation, survival and differentiation. 4. Late larval and adult stages: germline proliferation and gametogenesis ... ...

Germ line

... In biology and genetics, the germline of a mature or developing individual is the ... on specific molecular/developmental aspects ... germline sex-specific differences in histone ... within the germ line ? ... If you use germline in a published analysis, please cite Gusev A, ...

Somatic cells

... cells are any cells forming the body of an organism, as opposed to germline cells . In mammals, germline cells are the spermatozoa and ova which fuse during fertilization to ...

Somatic cell

... cells are any cells forming the body of an organism, as opposed to germline cells. In mammals, germline cells are the spermatozoa and ova which fuse during fertilization to ...

Somatic

... cells are any cells forming the body of an organism, as opposed to germline cells. In mammals, germline cells are the spermatozoa and ova which fuse during fertilization to ...

Penetrance

... expressivity? ... Other High- penetrance Mutations: Identifying germline mutations and somatic mutations is important for our understanding of ... of CRC and in ... Low- penetrance Genetic Predisposition: Identifying germline mutations and somatic mutations is important for our understanding of ...

Oogenesis

... Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. and degenerate during mid- oogenesis and EcR germline ... of oogenesis depends critically on the increase in ecdysone titer ... oogenesis has not been ... Oogenesis is a process that leads to ...

Gene transfer

... genetic material from another organism without being the offspring of that organism. By contrast, ... An overview of information about germline gene transfer research from the July 2002 Ethical Boundaries workshop. ... Gene transfer represents a relatively new ... Horizontal gene ...

Gene

... and encyclopedia. ... genetic marker - a specific gene that produces a recognizable trait and can be ... An overview of information about germline gene transfer research from the July 2002 Ethical Boundaries workshop. ... Gene transfer represents a relatively new ... MYSTERY MONDAY: ...

Aneuploidy

... also have abnormal numbers of chromosomes. Aneuploidy occurs during ... aneuploidy n. The state or condition of being aneuploid. ... germline aneuploidy is typically detected through karyotyping, a process in ... Aneuploidy ... Typically, the risk for aneuploidy increases with a ...

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