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Genotype in Medical News

Surveyed Physicians Will Treat Over 50 Percent of Hepatitis C Genotype 1-Infected Patients With the Protease Inhibitor Telaprevir

... more than 50 percent of their hepatitis C virus genotype 1-infected patients and will prescribe ... boceprevir for the treatment of hepatitis C virus genotype 1-infected treatment-naive patients, over 60 ... improvements in sustained virologic response in genotype 1-infected patients is the most important ...

New Report Just Published: World Hepatitis C Virus And Therapeutics Market Report

... High Mutation Rates Keep HCV Elusive II-4 genotype I - Least Responsive and Most Common Variant of ... RNA Test II-35 HCV Core Antigen EIA II-36 genotype Tests II-36 Liver Biopsy II-36 Treatment ... React Poorly to Treatment II-43 genotype 1 - The Most Prevalent HCV Strain II-44 Table ...

New Treatment Combo Better Against Hepatitis C

... show. Current treatment for hepatitis C (HCV) genotype 1, the most common subtype, is a combination of ... 40 to 50 percent of patients infected with HCV genotype 1 can be cured by standard of care, but nothing ... these drugs are approved, say to any patient with genotype 1 hepatitis C, we've got a two-out-of-three ...

Valeant Pharmaceuticals Highlights Taribavirin Phase IIb 60-Week Data Presentation at European Association for the Study of Liver (EASL) Annual Meeting

... After Treatment (SVR12) In Naive Patients With genotype 1 Chronic-Hepatitis C", with an oral presentation ... population of subjects infected Hepatitis C genotype 1. At the end of week 60, the statistically ... open-label study in 278 treatment-naive, genotype 1 patients evaluating taribavirin at weight-based ...

2-day results predict ultimate response to therapy in chronic hepatitis C

... (SVR). About one-half of patients infected with genotype 1 do not achieve SVR. Studies have shown that ... Americans. A recent study of those with chronic genotype 1 HCV infection found that only 28 percent of ... States, monitored 341 patients with chronic HCV, genotype 1, who underwent therapy with peginterferon and ...

In Hepatitis C Virus Treatment, Interviewed Experts Indicate That Telaprevir- and Boceprevir-Based Regimens Have Advantages Over Pegasys/Ribavirin in Sustained Virologic Response

... effect on sustained virologic response in genotype 1 patients as the attribute that most influences ... higher sustained virologic response in genotype 1 patients with only 24 weeks of treatment ... advantage in efficacy in patients infected with genotype 1 over the current peginterferon/ribavirin ...

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Genotype in Medical Technology

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... C virus (HCV) infection. Patients with HCV genotype 1, the most common and hardest to treat form of ... Treatment Duration in Chronic Hepatitis C genotype 1-Infected Slow Responders: Final Results of the ... (ribavirin, USP) combination therapy in genotype 1-infected patients who have slow response to ...

Human Genome Sciences Reports Positive Late-Breaker Results at EASL from ACHIEVE Phase 3 Trials of Albuferon(R) in Patients with Chronic Hepatitis C

... ACHIEVE 1 was conducted in patients infected with genotype 1 virus, and ACHIEVE 2/3 was conducted in ... In ACHIEVE 1, 1331 treatment-naive patients with genotype 1 chronic hepatitis C were initially assigned to ... and even death. Patients infected with the genotype 1 hepatitis C virus account for approximately 75% ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

... at 800 mg bid, 2.9 log10 (range of 2.2 to 3.4). genotype 1a patients demonstrated median reductions of 1.4 ... and 800 mg bid, respectively. In 10 of the 12 genotype 1a patients who received ANA598, viral load was ... at the end of the three days of treatment. genotype 1b patients demonstrated median reductions of 2.6 ...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

... patients with chronic hepatitis C virus (HCV) genotype 1 were presented at the 44th European Association ... of the Liver (EASL) 2009 Annual Meeting.(2) genotype 1 is the most common and hardest to treat form of ... and treatment-experienced patients with HCV genotype 1. In this study, low doses of ritonavir were ...

FDA Approves an Expanded Indication for Peginterferon-Based Combination Therapy for Patients With Chronic Hepatitis C

... bridging fibrosis or cirrhosis, or HCV genotype 1 infection. It is estimated that more than ... Overall, previous relapsers, patients with HCV genotype 2 or 3, or those initially treated with ... bridging fibrosis or cirrhosis, or HCV genotype 1 infection. "Based on a patient's treatment ...

Human Genome Sciences Announces Positive Results in Second of Two Phase 3 Trials of Albuferon(R) in Chronic Hepatitis C

... alfa-2a dosed weekly in patients with genotype 1 chronic hepatitis C - - Patients ... with ribavirin in treatment-naive patients with genotype 1 chronic hepatitis C (p=0.0008). Albinterferon ... Phase 3 results in patients infected with the genotype 1 virus, evaluated together with the previously ...

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Genotype in Medical Products

Alpha-1-Antitrypsin & Alpha-1-Antitrypsin Genotype with Reflex to Alpha-1-Antitrypsin Phenotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

Hepatitis C Virus RNA Quantitative by Real-TimePCR with Reflex to Genotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories

Hepatitis C Virus Quantitative with Reflex to Hepatitis C Genotype

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Genotype in Medical Definition

Personalized medicine

... Personalized medicine is the use of detailed information about a patient's genotype or level of gene expression and a patient's clinical data in order to select a medication , therapy or preventative measure that is particularly ...
Genotype in Medical Dictionary

Respect

... by the bite of the tsetse fly. South American trypanosomiasis , or Chagas' disease , is caused by T. GENOTYPIC ASSAY: A test that determines the genotype of an organ ism, such as a virus . With respect to HIV , a genotypic assay can provide information about viral mutation s, which is ...
Genotype in Biological News

Known genetic risk for Alzheimer's in whites also places blacks at risk

... in future studies that explore why the APOE genotype is a risk factor for Alzheimer's disease, a ... By understanding the mechanism by which the genotype confers risk, scientists could potentially ... the risk of developing Alzheimer's disease, APOE genotype alone is not enough to predict the disease," she ...

Common gene variants influence risk factor for sudden cardiac death

... said Newton-Cheh. The QTGEN investigators examined the effect of a genotype score comprised of all 14 variants tested together. The top 20 percent of the population with the highest genotype scores had 160 to 210 percent higher risk of prolonged QT interval ...

Identifying mega-targets for high-yield plant breeding

... evaluate every single candidate genotype. Predicting the performance of a genotype is difficult due to the multiple breeding objectives and the many environmental conditions of genotype evaluation. Therefore, finding adapted elite genotypes is challenging if ...

SNPs affect folate metabolism in study of Puerto-Rican adults

... previous work showing that, under certain conditions, those with the TT genotype have a significantly lower risk for colorectal cancer than CC and CT ... for other potentially confounding factors, those with the MTHFR 677TT genotype displayed folate concentrations 4.6% lower than CC genotypes and CT ...

How 'hidden mutations' contribute to HIV drug resistance

... was funded by the Canadian Institutes for Health Research (CIHR). HIV genotype testing is now widely established in HIV drug resistance screening. ... for some time. "It's extremely time-consuming and expensive to validate genotype testing," he said. "However, we probably will be testing these areas in a ...

Student study bolsters case for adding a rare sunflower to the endangered species list

... consists of about 20 to 40 genetic individuals. If they have the same genotype then they are the same genetic individual. There can be ten stalks growing together that you would think are ten plants. But, when you genotype them, you find they are all the same genetic individual. The fact that ...

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Genotype in Biological Technology

Valeant Pharmaceuticals Reports Encouraging Final Results With Taribavirin Phase IIb Study

... interferon. The study in treatment naive genotype 1 infected subjects was of standard design, ... open-label study in 278 treatment-naive, genotype 1 patients evaluating taribavirin at weight-based ... disclosed as Study 204), 278 treatment naive, genotype 1 patients were randomized with the following ...

Anadys Pharmaceuticals Reports First Quarter 2009 Financial Results and Highlights

... at 800 mg bid, 2.9 log10 (range of 2.2 to 3.4). genotype 1a patients demonstrated median reductions of 1.4 ... 400 and 800 mg bid, respectively. In 10 of the 12 genotype 1a patients who received ANA598, viral load was ... at the end of the three days of treatment. genotype 1b patients demonstrated median reductions of 2.6 ...

INFORM-1 Clinical Trial Amended to Further Explore Promising Direct Antiviral Regimen in HCV Patients

... 14 days in treatment-experienced patients with genotype 1 HCV infection who have been previously treated ... F consists of null responder HCV patients with genotype 1 infection who have been treated with pegylated ... patients chronically infected with HCV genotype 1. The original study protocol consisted of four ...

Romark and Chugai Pharmaceutical Enter Into Exclusive Licensing Agreement for Nitazoxanide in Japan

... of hepatitis C virus (HCV) replication in HCV genotype 1-derived replicon cell lines, and in vitro ... with chronic hepatitis C infected with HCV genotype 4. Phase II clinical trials are ongoing in the United States in patients with HCV genotype 1. About Romark Laboratories Romark ...

Romark Announces Presentation of New Data for Controlled Release Nitazoxanide in Chronic Hepatitis C

... in treatment-naive patients infected with HCV genotype 4, 82% (n=17) and 100% (n=16) of patients ... activity in a small number of patients with HCV genotype 4. We look forward to reporting interim data from ... tablet in patients with chronic hepatitis C genotype 1 later this year." In the Phase I study, ...

Pharmasset Reports Fiscal First Quarter 2009 Financial Results

... day add-on study with R7128 in non-responder, HCV genotype 2 and genotype 3 patients in first half of 2009; -- Report ... add-on study with R7128 in treatment naive, HCV genotype 1 patients in first half of 2009; -- Report ...

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Genotype in Biological Products

SNP Scoring Service from Polymorphic DNA Technologies, Inc.

Description:... is a 24 sample minimum. Our price is $3.00 per genotype (this includes both directions). $2.00 per genotype for one direction. There is no "redo" charge. We ... very large. Robust Polymorphic DNA can provide genotype results for any SNP. Sanger sequencing is ...
Company:Polymorphic DNA Technologies, Inc.

GenomeLab SNPstream Genotyping System from Beckman Coulter

Description:... for seamless genotyping. The system operates at a consistent cost per genotype or per sample, regardless of run throughput, allowing users to ... from primer design to 384-well plate setup, image data analysis and genotype calling. *GenomeLab is a family of genetic analysis tools from Beckman ...
Company:Beckman Coulter

LIGHT DIAGNOSTICS™ Calicivirus Genotype 1&2 OligoDetect® from CHEMICON

Description:... The Light Diagnostics Calicivirus genotype 1&2 Typing OligoDetect assay is applicable for the qualitative detection of calicivirus RNA generated by an in-house validated in vitro nucleic acid ...
Company:CHEMICON
Genotype in Biological Definition

Hardy-Weinberg principle

... after one generation of random mating , the genotype frequencies at a single gene locus will become ... drift . Assortative mating will only change the genotype frequencies of those genes that are desired. ... ) aa ( q 2 ) So the final three possible genotype frequencies, in the offspring, if the alleles are ...

Homozygote

... on the two corresponding chromosomes (e.g. the genotype is AA or aa ). A homozygous dominant genotype occurs when a particular locus comprises two ... trait (e.g. AA ). A homozygous recessive genotype occurs when a particular locus comprises two ...

Parthenogenesis

... This genetic similarity can be beneficial if the genotype is well suited to a stable environment, but ... if a new predator or pathogen appears and a genotype is particularly defenseless against it, an ... the genetic recombination that produces a novel genotype in each individual. Similar arguments apply to ...

Phenotype

... Phenotype is determined to some extent by genotype , or by the identity of the alleles that an ... of molecular biology . The interaction between genotype and phenotype has often been described using a simple equation: Phenotype = genotype + Environment A phenotype is any detectable ...

Population genetics

... map the resulting population ( P 2 ) back to genotype space ( G 2 ) where Mendelian genetics can ... biology, or development , that transform a genotype into phenotype. We will refer to this as the " ... traditional population genetics operating in the genotype space and the biometric theory used in plant ...

Allele frequency

... of alleles -- in other words, to evolution . Besides selection, these forces include genetic drift , mutation and migration . Compare genotype frequency . Example If there are ten individuals in a population and at a given locus there are two possible alleles, A and a , then if the ...

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Genotype in Biological Dictionary

Phenotype

... The distinction between phenotype and genotype is fundamental to the ... The phenotype of an organism is the ... 2. Partial genotype and Partial Phenotype ... Phenotype is the ... human being has a unique phenotype . ... genotype and Phenotype . Definition. the outward physical ...

Genotype

... The genotype is the genetic constitution of a cell, an ... has two allele forms, dominant A ... genotype n. The genetic makeup, as distinguished from the ... of an organism or ... the relation between genotype and phenotype is illustrated, ... ...

Adaptive landscape

... reproductive success. It is assumed that every genotype has a well ... Notes on Sewall Wright: ... landscape • epistasis • evolution • genotype ... adaptive landscape . Click here to ... an adaptive landscape , first one specifies a genotype space, and then ... An adaptive landscape ...

Homozygosity

... and can later be bred to homozygosity to reduce the need to confirm genotype of each litter. ... ... and therefore will not result in ... ... Sciences > biology > genetics > genetic resources > genotype > homozygosity ... Resources in homozygosity : No resources ...

Heterozygote

... A heterozygote advantage describes the case in which the heterozygote genotype has a higher relative fitness than either the homozygote dominant or ... heterozygous advantage ) describes the case in which the heterozygote genotype has a higher relative What is a(n) heterozygote – Our zoology ...

Wild-type

... type Xenopus laevis are very ... Lab bred frogs never are exposed to the same rigid standards ... wild type - The most frequent allele or genotype found in nature, or a specified ... Science Magazine ... A fertilized wild - type ovule. ... Definition of wild type from ...

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