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Genes in Medical News

Carnegie Mellon develops innovative method to detect genetic causes of complex diseases

... underlying an entire regulatory network of genes or traits that are responsible for complex ... we can look for associations between networks of genes and clinical traits." Severe asthma, for ... diseases," Xing said, "so we can identify the genes that underlie disease processes, understand the ...

Silenced genes as a warning sign of blood cancer

... Such labels are found particularly often in genes which act as important inhibitors of pathogenic ... believe that the first chemically deactivated genes trigger whole cascades of changes in the genetic ... by regulating the activity of their respective genes very specifically. Although every single gene is ...

TGen-led team is 1 of 7 selected for $1 million skin-cancer grants

... study: Identification of Novel Melanoma Risk genes Using High-throughput Genomics. "The ... efforts,'' Dr. Brown said. "Identifying the genes that mediate development of melanoma will give ... the best form of cure. Characterization of the genes influencing melanoma risk is critical towards ...

Genes key to staph disease severity, drug resistance found hitchhiking together

... horizontal gene transfer, whereby resistance genes move from one bacterium to another. Staph bacteria also can exchange virulence genes using the same mechanism, but this was previously ... of New Jersey. "The discovery that bundled genes determine virulence and antimicrobial resistance ...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

... St. Jude scientists identify new genes implicated in childhood acute myeloid leukemia ... also performed DNA re-sequencing of 25 genes that are commonly mutated in adult AML. Point ... less than one point mutation per patient in the genes sequenced. The scientists also reported just 21 ...

Scientists discover key event in prostate cancer progression

... androgens bind with these receptors to activate genes that control cell growth. The researchers show ... receptors are reprogrammed to regulate a group of genes involved in a different, later, phase of cell ... how they become active in that disease and what genes they regulate to promote tumor growth." The ...

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Genes in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... for 'knocking out,' or mutating, specific genes to understand their function," said Howard Jacob, ... out an inserted reporter gene and two native rat genes without causing measurable effects on other ... 90 percent of the rat's 25,000-30,000 estimated genes are analogous to those in humans and mice, and ...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

... the successful knockout of two preselected genes in a Chinese hamster ovary (CHO) cell line. The ... technology for specifically editing target genes in mammalian cells," stated Philip Gregory, D. ... rapid generation of cell lines in which multiple genes have been knocked out. Our proven ability to ...

More Gene Mutations Linked to Autism Risk

... extra copies of DNA segments - were found in the genes of children with autism spectrum disorders ... Philadelphia. This study also uncovered two novel genes in which variations were found, BZRAP1 and ... Interestingly, key variants of these genes were transmitted in some, but not all, of the ...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

... than in children without ADHD. Many of those genes were already known to be important for learning, ... study in 2003, we expected to find a handful of genes that predispose a child to ADHD," said study ... Hospital. "Instead, there may be hundreds of genes involved, only some of which are changed in each ...

Alfacell Provides Shareholder Update

... that there are specific chemotherapy resistance genes which not only are present in untreated ... reaction, measured the levels of the MDR and nfkB genes after treatment with the drug. Striking decreases in all of these genes in the mesothelioma cell lines were seen after ...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

... also plays an important role in regulating genes in humans. When gene regulation is ... and patients, better knowledge of how those genes perturb normal development may enable researchers ... as the first study in human cells to identify genes that are dysregulated when cohesin doesn't work ...

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Genes in Medical Products

Oncotype DX

Description:... certain types of chemotherapy. The assay performed using formalin-fixed, paraffin-embedded tumor tissue analyzes the expression of a panel of 21 genes and the results are provided as a Recurrence Score™ (0-100). The gene panel was selected and the Recurrence Score calculation was derived ...
Company:Genomic Health, Inc.
Genes in Medical Definition

Personalized medicine

... sometimes starting with natural history. The key task is to find genes and gene variations that play a role in a disease. The first step is to ... incidence of disease. The exciting news is that cancer predisposition genes and families are being identified by genetic testing and research at a ...

Pathology

... Treatment Surgery - Chemotherapy - Radiation therapy - Immunotherapy - Experimental cancer treatment Misc. Tumor suppressor genes / oncogenes - Staging / grading - Carcinogenesis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-related ...

Medicine

... Drug ampoules Genomics and knowledge of human genetics is already having some influence on medicine, as the causative genes of most monogenic genetic disorders have now been identified, and the development of techniques in molecular biology and genetics are ...

Ocular oncology

... Treatment Surgery - Chemotherapy - Radiation therapy - Immunotherapy - Experimental cancer treatment Misc. Tumor suppressor genes / oncogenes - Staging / grading - Carcinogenesis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-related ...
Genes in Medical Dictionary

Chromosome

... tomography (CT) ... The chromosome : genes are arranged in precise arrays all along the ... to localize one or more tumor suppressor genes in this region. A gene on chromosome 17 ... for a percentage of familial cases. genes are contained by, and arranged along the length ...

Chromosomes

... cell . Chromosomes contain thousands of genes that are stored in DNA, the basic genetic ... tumor suppressor or tumor -progressive genes may lie on chromosomes 16q and 1p as evidenced ... their shape, and help control the activity of genes . histone deacetylase ... Clotting factors are ...

Gene Therapy

... is known as SCID. Gene therapy Specific genes in your body might direct cells to manufacture ... of experimental treatment s in which cell genes are altered. Gene therapy looks ... low cholesterol levels. Since the mutant genes in this genetic disorder have been identified, ...

Genetic

... so scientists have known for a long time genes are at least partial ly to blame. ... ( Genetic ally Engineered Foods ) Cancer genes (Onco genes ) Cystic Fibrosis , Nutrition al Considerations ...

Genes

... genes Definition: genes are the basic units of heredity . A gene is a ... protein . There are approximately 30,000 genes . ...

Genetics

... are passed along from parents to offspring. genes are contained within the chromosomes found in ... so scientists have known for a long time genes are at least partial ly to blame. Allergies ... to 75%. Genetics Certain inherited genes appear to contribute to incontinence . In 1995, ...

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Genes in Biological News

Carnegie donates landmark clones to biology

... Department of Plant Biology have cloned genes to produce membrane proteins that may initiate the instructions for genes to turn on in the nucleus. They just donated 2010 of the clones for genes that function in the cell's interaction with its ...

Drug-proof zebrafish reveal secrets of addiction

... Webb and her colleagues discovered a set of 139 genes that respond inappropriately to amphetamine in ... conditions in either genotype. In addition to genes involved in pathways classically associated with ... as the authors demonstrate, several of these genes are expressed in neurogenic domains of the adult ...

UC San Diego engineer provides insights to decades-old DNA squabble

... we have to ask the question why are these genes misfiring? In the end, it boils down to the ... mutations in the oncogenic or tumor suppressor genes that lead to cancer or you could have ... the proteins that regulate chromatin around these genes leading to cancer." The next step for Arya and ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... example of cancer that develops when embryonic genes are upregulated. As a result, brain tumor cells ... recorded expression of PTN and ALK, as well as genes along this pathway. "We found that they are ... patients with increased expression of these genes had significantly poorer outcomes in an analysis ...

Reprogramming human cells without inserting genes

... has discovered a novel way to turn on stem cell genes in human fibroblasts (skin cells) without the risks associated with inserting extra genes or using viruses. This discovery opens a new ... adult organism. In the pluripotent state, several genes are known to be active, helping to control the ...

First genetically-engineered malaria vaccine to enter human trials

... the vaccine the research team had deleted two key genes in the Plasmodium falciparum parasite which ... of malaria most deadly to humans. By removing the genes the malaria parasite is halted during its liver ... produce similar results in humans. "Although two genes have been deleted the parasite is still alive and ...

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Genes in Biological Technology

Bacteria pack their own demise

... from the editorial board. It's in the genes For years, Nathalie De Jonge, Remy Loris and ... way of providing extra protection to important genes the toxin-antitoxin (T-A) system. These T-A genes are tucked in near ...

First genetically engineered malaria vaccine to enter human trials

... the vaccine the research team had deleted two key genes in the Plasmodium falciparum parasite which ... of malaria most deadly to humans. By removing the genes the malaria parasite is halted during its liver ... produce similar results in humans. "Although two genes have been deleted the parasite is still alive and ...

febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment

... enables up-to-date profiling and enrichment of genes and SNPs of interest using Gene Expression ... ncRNA analysis as well as targeted enrichment of genes for Next-Generation Sequencing (NGS). ... gaps, completes the list of protein-coding genes to a number of 20,210 and identifies 439 long, ...

Syngenta and Evogene to Collaborate on Soybean Nematode Resistance

... with Evogene, Ltd., focusing on identifying plant genes related to soybean nematode resistance. Under the ... receive exclusive licensing rights to candidate genes discovered by Evogene for use in soybean. ... trait discovery program, creating new sources of genes for biotech traits to strengthen our current ...

Israeli scientists show bacteria can plan ahead

... to lactose, and found that, in addition to the genes that enable it to digest lactose, the gene ... wine yeast feel the heat, they begin activating genes for dealing with the stresses of the next stage. ... had evolved to stop activating their maltose genes at the taste of lactose, only turning them on ...

DNA2.0 Awarded US Patents for Breakthrough Gene Optimization Technology -- Company's Unique Algorithm Enables Expression Yields up to 50 Times Greater than Competing Approaches

... 12/184,240--claim methods for designing synthetic genes to reliably increase levels of recombinant ... come to us for synthetic genes, they want those genes to express. The broad and fundamental claims in ... patents, speak to our leadership in designing genes for protein expression." Expression of ...

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Genes in Biological Products

GenomeLab GeXP Genetic Analysis System from Beckman Coulter

Description:... standard multiplexed PCR analysis to just a few genes at a time. GenomeLab GeXP delivers more genes per reaction and more samples per run, removing ... effectively look at the expression of 20 to 30 genes in a single reaction per well. Ideal for ...
Company:Beckman Coulter

Functional Genomics & Pharmacogenomics from Dominion Pharmakine S.L.

Description:... induced changes in the expression levels of the genes in that system can be detected, studied, ... compared to each other, covering a broad range of genes at a glance. Automatized scanning of the ... images in which features representing individual genes are automatically identified. Global ...
Company:Dominion Pharmakine S.L.

Rice Oligo Microarray Kit, 22K from Agilent Technologies

Description:... 22K enables researchers to simultaneously characterize thousands of rice genes associated with biological functions, growth processes, and biotic and ... coverage of 60% of the rice (japonica) genome focuses on well annotated genes selected by Dr. Shoshi Kikuchi, (Japan) National Institute of ...
Company:Agilent Technologies

pTriEx™-4 DNA from Novagen

Description:... vectors have been extensively tested for performance with various target genes in all three expression systems. In each case, expression was similar to ... vector 1 is uniquely designed to allow rapid characterization of target genes in multiple expression systems. With this vector a single recombinant ...
Company:Novagen

Goat Anti-BRF2 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Background Information BRF2 is one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. BRF2 is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters ...
Company:GeneTex

Mouse Anti-Human Complex IV, assembly factor SURF1 Monoclonal Antibody, Unconjugated, Clone 21H2BG4 from MitoScience LLC

Description:... is consistent with it acting to catalyze Complex IV assembly. In cells where cytochrome c oxidase assembly is incomplete because of mutations in genes for structural subunits of the enzyme SURF1 is significantly over-expressed. This is evident in Rho0 fibroblasts which are missing mtDNA and hence ...
Company:MitoScience LLC

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Genes in Biological Definition

Antibody

... know as somatic recombination. This is when genes are selected (variable (V), diversity (D) and ... it is the area where these V, D and J genes are found - otherwise known as the ... the immune system would require many more genes than exist in the genome . Instead, as Susumu ...

Barr body

... pattern of female calico cats ; pigmentation genes on the X chromosome are activated in different ... to be inert, but in fact a small number of genes remain active and expressed in some species. These genes are generally those which are present on the ...

Biology

... similar morphological stages and include similar genes . Evolution: the central principle of ... by Carl Woese . Trees constructed with other genes are generally similar, although they may place ... the basic structures of living systems: cells , genes etc., a second grouping considers the operation ...

Biodiversity

... genetic diversity - diversity of genes within a species. There is a genetic ... (richness in the different processes to which the genes ultimately contribute) The lattermost ... geneticists , biodiversity is the diversity of genes and organisms . They study processes such as ...

Bioinformatics

... databases. These data are analyzed to determine genes that code for proteins , as well as regulatory sequences. A comparison of genes within a species or between different species ... in sequence analysis is the automatic search for genes and regulatory sequences within a genome. Not ...

Cancer

... . Cancer is, ultimately, a disease of genes . Typically, a series of several mutations is ... involves both oncogenes and tumor suppressor genes . Oncogenes promote cancer when "switched on" by a mutation, whereas tumor suppressor genes prevent cancer unless "switched off" by a ...

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Genes in Biological Dictionary

Y chromosome

... base pairs (the building blocks of DNA) ... genes on the Y chromosome are among the estimated 20,000 to 25,000 total genes ... Y chromosome infertility is a ... researchers say that there is a dramatic loss of genes from the human Y chromosome that could ...

X chromosome

...... The X chromosome carries a couple thousand genes but few, if any, of these have ... The X ... base pairs (the building blocks of DNA) ... genes on the X chromosome are among the estimated 20,000 to 25,000 total genes ... X-chromosome or X chromosome ( ) n. ...

Tumor suppressor

... below, a large number of tumor suppressor genes ... Thus far, about 30 tumor suppressor ... a ... ) ( cell and molecular biology ) A class of genes which, when mutated, predispose an individual to ... source for information on Tumor Suppressor genes and Proteins. ... Search Tumor Suppressor ... ...

Transgenic plant

... Transgenic plants possess a gene or genes that have been transferred from a different ... that have been genetically modified by inserting genes directly into a single plant cell Transgenic plants possess a gene or genes that have been transferred from a ... 5 ...

Transgenic

... Transgenic plants possess a gene or genes that have been transferred from a different ... that have been genetically modified by inserting genes directly into a single plant cell ... crops which have been genetically modified with genes from ... Transgenic System, Transgenic ...

Tet resistance

... resistance to macrolides (10), and tet genes coding for ribosomal ... resistance genes have been found in anaerobes (3, 18), only the ... general a greater diversity of tet resistance genes was detected in the high ... were tested by PCR ...

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(Date:10/2/2014)... October 02, 2014 The Business ... 2014 BIG Awards for Business program. The BIG ... with a proprietary judging process scored by well-known ... globe. , “The winners this year epitomize what ... Managing Director of the Business Intelligence Group. “The ...
(Date:10/2/2014)... October 02, 2014 BamboofloorChina.com is a ... products have won great appreciation from the global customers ... working hard to make more excellent items. All its ... to help all clients. , The company has ... to its website. Furthermore, the company’s marketing specialist ...
(Date:10/2/2014)... Maureen Salamon HealthDay Reporter ... Middle-aged women with a neurotic personality style and prolonged ... disease, new research suggests. Tracking 800 women over ... were most anxious, jealous and moody -- which they ... double the risk of developing Alzheimer,s compared to women ...
(Date:10/2/2014)... Oct. 1, 2014 (HealthDay News) -- Genes may interact with ... study suggests. The genetic risk occurs in about 13 ... The finding could help these people reduce their heart disease ... diet and stress management, the Duke University researchers said. ... and found a strong link between variations in the EBF1 ...
(Date:10/2/2014)... HealthDay Reporter WEDNESDAY, Oct. ... highway may raise your risk for high blood pressure, a ... those who lived within 109 yards of a busy road ... pressure than women living at least half a mile away, ... the importance of our physical environment on our health and ...
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(Date:9/30/2014)... have in common? Unlike most eukaryotic multicellular organisms ... these organisms are all polyploid, meaning they have three ... 3 and 4 sets of chromosomes, respectively, and strawberries ... fact most plant species are polyploid. Polyploidy, or genome ... only recently, with the development of molecular tools, has ...
(Date:9/30/2014)... Ecker, a Salk professor and Howard Hughes Medical ... have been named recipients in the 2014 round ... (NIH) through the BRAIN (Brain Research through Advancing ... The grant, announced September 30, provides more than ... over three years. , The BRAIN Initiative, launched ...
(Date:9/30/2014)... of Medicine reports positive results of a phase ... subset of lung cancer marked by rearrangement of the ... with advanced non-small cell lung cancer testing positive for ... with 3 complete responses and 33 partial responses. Median ... disease to resume its growth after being slowed by ...
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