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Fragment in Medical News

Discovery may result in new test to determine predisposition to cancer

... cells and then transformed them with a DNA fragment that detects the efficiency and the accuracy of ... The key in this experiment was that the DNA fragment was not irradiated. In this way, the researchers ... of double strand break repair in the DNA fragment that did not receive any radiation. The effect ...

Enzyme with a sugar antenna

... ligation". In this technique, one peptide fragment is attached to the terminal cysteine group (sulfur-containing amino acid) of a second peptide fragment by means of a thioester groupa selective reaction ... synthesis to make the critical peptide fragment that has the sugar antenna. ...

JCI online early table of contents: Jan. 12, 2009

... T cells that recognize HLA-B27 bound to a defined fragment of the viral protein RdRp. New understanding ... why HCV finds it hard to mutate the RdRp fragment enough to escape the CD8+ T cell immune response. ... response by mutating several parts of the RdRp fragment of interest. Each of the mutations affected the ...

Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs

... The discovery of the cytoplasmic small RNA fragment of the non-coding MALAT1 molecule, which the CSHL ... to alert the cell that the long non-coding RNA fragment that it originally split off from-- MALAT1--is ... within the nucleus while expelling the mascRNA fragment into the cytoplasm is still elusive. "The answer ...

Researchers discover new way to reverse poor circulation and heal wounds

... Hocking had already built this heparin-binding fragment separately from its larger parent protein. ... team injected the heparin-binding fibronectin fragment into anesthetized animals. As expected, the fragment alone triggered a rapid and reversible dilation ...

Structures from the human immune system's oldest branch shed light on a range of diseases

... Netherlands, have determined the structure of C3 convertase and of the C3b fragment in complex with factor H. The work appears this month in two companion ... of immune-related diseases. "It was a surprise to see that the factor H fragment is spread across the entire C3b complex," notes Lambris. Factor H ...

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Fragment in Medical Technology

ESBATech's Antibody Fragment Enters Phase Ib/IIa in Ophthalmology

... Delivery of ESBA105, an Anti-TNF Alpha Antibody fragment in Patients Undergoing Cataract Surgery ... -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced the initiation of a ... the surgery. ESBA105 is a single-chain antibody fragment directed against TNF-alpha, a major mediator of ...

ESBATech's Antibody Fragment Enters Phase I/IIa Clinical Development in Osteoarthritis with the Potential for Disease-Modifying Activity

... -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced the initiation of ... development of its anti-TNF alpha antibody fragment ESBA105 in osteoarthritis (OA). This ... directly to the affected joint, the antibody fragment quickly and efficiently distributes to the ...

ESBATech Raises Additional CHF 23M (USD 22M), Extending Series B Venture Financing

... -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced that the company ... trials. ESBA105 is a single-chain antibody fragment directed against TNF-alpha and is developed in ... the company to be the leader in antibody fragment therapeutics." Graham Boulnois, Ph.D., Partner ...

ESBATech's Lead Antibody Fragment Enters Clinical Development for Ophthalmic Indications

... -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced the initiation of ... ESBA105 is a single-chain antibody fragment directed against TNFa. It is being developed ... ESBA105 represents a new generation of antibody fragment therapeutics that have favourable biochemical ...

Ono Enters into a New Fragment-Based Drug Discovery Agreement with Evotec

... computational chemistry, structural biology, biochemical, and NMR based fragment screening in combination with its high-quality fragment libraries. In the collaboration it is combined with Evotec's expertise in ...

ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies

... a Huntington Disease (HD) target chosen by CHDI, ActiveSight will screen fragment libraries using X-ray crystallography to visualize fragments that bind to ... fragment libraries, and is pursuing lead development on promising fragment hits. The CHDI project will be overseen by Vicki Nienaber, Ph.D. at ...
Fragment in Medical Products

Small Fragment Plate and Screw System

Description:... The Small fragment Plate and Screw System provides a unique option ... (bunion or hallux valgus correction). The Small fragment Plate and Screw Set is a complete tray of ... the rehabilitative period. Overall, the Small fragment Plate and Screw Set provides fast, easy, ...
Company:Arthrex

TC-100 Large Fragment Set

Description:... Smith & Nephew can provide. The TC-100 Large fragment Set, which is designed for fixation of fractures ... such as the humerus, tibia and femur. The Large fragment Set offers similar implants and instruments to the Small fragment Set; however, the ...
Company:Smith & Nephew, Inc. - Orthopedics

TC-100 Pelvic Fragment Set

Description:... Smith & Nephew can provide. The TC-100 Pelvic fragment Set, which contains a comprehensive implant and ... to their anatomical condition. The Pelvic fragment Set consists of three trays: an instrument tray that contains a combination of small and large fragment instruments to accommodate 3.5 mm, 4.5 mm and 6.5 ...
Company:Smith & Nephew, Inc. - Orthopedics

ACE Titanium Large Fragment System

Description:... have been applied to a new generation of implants. DePuy ACEs Large fragment plates and screws offer greater strength, increased biocompatibility and ... the need for pre-tapping, saving valuable time in the OR. The Large fragment System contains broad and narrow Active Compression Plates (A.C.P.) which ...
Company:DePuy Orthopaedics, Inc.

TC-100 Small Fragment Set

Description:... and support that only Smith & Nephew can provide. The TC-100 Small fragment Set, which is used to restore the anatomical condition of the radius, ... additional implants and instruments not found in the traditional small fragment ....
Company:Smith & Nephew, Inc. - Orthopedics

TC-100 Mini Fragment Set

Description:... and support that only Smith & Nephew can provide. The TC-100 Mini fragment Set, which is designed for fixation of fractures in small bones of the hand and foot. The Mini fragment Set consists of a single tray with removable instrument, drill bit and ...
Company:Smith & Nephew, Inc. - Orthopedics

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Fragment in Medical Dictionary

Calcium stones

... the lower pole of the kidney are less likely to pass. Very hard stones such as those made of cystine or certain kinds of calcium stones , may not fragment very well. PCNL ... ...

Dorsal

... it remains latent (lies low) for years. Colles fracture is also referred to as the "silver fork" deformity, because the distal fracture fragment is usually angulated upwards ( dorsal angulation). The resultant "bend" in the wrist results in the familiar appearance of a fork. Scorpionfish, ...

EKG

... electrical activity of the heart . ESWL (Extracorporeal shock wave lithotripsy )The use of focused shock waves, generated outside the body, to fragment kidney stones . GravelThe debris which is formed from a fragmented kidney stone. An EKG usually is done whenever a heart -related problem is ...

Hematoma

... - This is one of the most serious types of bleeding that can occur inside the head as a result of a skull fracture . It happens when a sharp fragment of bone cuts through one of the major blood vessels in the skull . A wound, bruise , or hematoma (a collection of blood and fluid ...

Leukocytes

... neutrophil s ( granulocyte s) ... A computer analyzes changes in leukocytes , a type of blood cell . If your blood cells flatten, fragment or disintegrate in response to an extract, it's considered evidence of allergy . Applied kinesiology testing. The earliest finding is within the ...

Lithotripsy

... , bladder , ureter s, or gallbladder . Alternative Names: ... Lithotripsy Definition Lithotripsy is the use of high-energy shock waves to fragment and disintegrate kidney stones . The shock wave, created by using a high-voltage spark or an electromagnetic im pulse , is focused on the stone. ...

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Fragment in Biological News

UMMS researchers publish DNA identification of czar's children

... bloodstain DNA profile for all DNA systems matched with that of the bone fragment DNA profiles, and so we could conclude the identity of the putative ... of Y- chromosome markers demonstrated further the link between the bone fragment of putative Alexei to his father Tsar Nicholas II and the distant paternal ...

A simple fusion to jump-start evolution

... to be the same size, but the efficiency of the reactions was dependent on fragment size (larger is better, though efficiency drops again after reaching around 100) and the similarity of the fragment sequences. The researchers note that this spontaneous fusing, or ...

Researchers coat titanium with polymer to improve integration of joint replacements

... and bone with the titanium implants coated with the engineered fibronectin fragment over the uncoated or RGD-coated titanium. Garca and Petrie tested the ... mechanical fixation of the implants coated with the engineered fibronectin fragment over the implants with the other coating and uncoated titanium. In ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... could theoretically bind. We found just the right one." They collaborated with ESBAtech in Switzerland who created a small single-chain antibody fragment in yeast that would itself bind to the sweet spot, blocking ALK's interaction with PTN. In the present study, the researchers successfully tested the ...

Sex in the Caribbean: Environmental change drives evolutionary change -- eventually

... forms are unmistakable," explained O'Dea. "You can clearly see the first individual that founded a sexual colony, while a clonal colony preserves the fragment from the previous colony from which it cloned." As predicted, clonal bryozoans rapidly disappeared from the record as the Caribbean was isolated. ...

The tiny difference in the genes of bacteria

... for every bacterial strain. To identify a certain strain, the HZI researchers use short DNA fragments, marked with certain dyes. Each dyed DNA fragment recognizes a single tandem repeat, binding at it. As a result, the researchers receive, for example, six red fragments binding a tandem of six ...

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Fragment in Biological Technology

ForteBio Launches New Assay Capabilities for High-Sensitivity Protein Quantitation and Fragment Screening on Its Octet(R) Platform

... - for high-sensitivity protein quantitation and fragment screening, respectively - for use on the ... using streptavidin biosensors. The new fragment screening assay methodology extends the company's ... kinetic characterization and screening of fragment libraries that include compounds in the 150 to ...

Frost & Sullivan Recognizes ESBATech's Innovation in Developing Antibody Fragments for Biologic Therapeutics

... of ESBATech's proprietary single-chain antibody fragment therapeutics addresses and overcomes many of the ... of all 1.5 million naturally occurring antibody fragment frameworks resulted in highly-stable, ... humanized scFv non-aggregating antibody fragment being evaluated in treating a number of ...

ESBATech's Antibody Fragments Demonstrate Penetration into the Eye with Topical Delivery via Eye Drops

... -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced that it ... retina, and choroid. ESBATech's lead antibody fragment ESBA105 is a TNFa antagonist that is scheduled to ... size. The primary advantage of human antibody fragment is their ability to penetrate tissues much better ...

ESBATech Announces Successful Completion of Phase I Clinical Study for Lead Antibody Fragment in Ophthalmic Indications

... Sept. 8 /PRNewswire/ -- ESBATech AG, a leading developer of antibody fragment therapeutics, today announced that the company has successfully completed ... dose escalation study in Switzerland. ESBA105 is a single-chain antibody fragment directed against TNF-alpha, and it is being developed initially for ...

Nuevolution Announces Worldwide Technology Cross-Licensing Agreement With GSK

... The company has developed Chemetics(R), a unique, patent protected hybrid of proven wet chemistry and molecular biology which represents the ultimate fragment based lead discovery technology. Chemetics(R) enables rapid synthesis and DNA-tagging of hundreds of millions of chemically diverse drug-like small ...

ForteBio Launches Two Revolutionary High-Throughput, Label-Free Instruments: The Octet(R) RED384 and the Octet QK384

... products, announced today that it has launched two next-generation instruments: the Octet RED384 for protein, peptide, small molecule and fragment screening; and the Octet QK384 for protein and antibody assays. The new instruments will debut this week at the 2009 American Association of ...

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Fragment in Biological Products

BioPrime Plus Array CGH Indirect Genomic Labeling Module from Invitrogen

Description:... systems combine a highly concentrated exo-Klenow fragment of DNA polymerase I and random primers to ... experiments. Exo-Klenow is a mutant of the large fragment of the DNA polymerase I holoenzyme that has both ... Plus Systems and Modules. It contains exo-Klenow fragment (40 U/ l), 2.5X random primer solution ...
Company:Invitrogen

Exo- Klenow Fragment (Cloned) from Ambion

Description:... Exonuclease-free Klenow fragment is a genetically engineered Klenow polymerase in ... of exonuclease activity makes Exo- Klenow fragment the enzyme of choice for isotopic or biotin ... dideoxy method. Quality Control The Exo- Klenow fragment is thoroughly tested for nonspecific ...
Company:Ambion

BioPrime Array CGH Genomic Labeling System from Invitrogen

Description:... systems combine a highly concentrated exo-Klenow fragment of DNA polymerase I and random primers to ... experiments. Exo-Klenow is a mutant of the large fragment of the DNA polymerase I holoenzyme that has both ... Plus Systems and Modules. It contains exo-Klenow fragment (40 U/ l), 2.5X random primer solution ...
Company:Invitrogen

Fragment Library I: Large Volume with mixtures from ActiveSight

Description:... A ready-to-use kit for a single fragment based screening project: 384 Individual ... soak solutions for a complete structure based fragment screening project. Includes CD-ROM containing a full description of each fragment including pdb and cif files for fitting and ...
Company:ActiveSight

ExcelGel DNA Analysis Kit from GE Healthcare, formerly Amersham Biosciences

Description:... convenience and detection sensitivity. Category: DNA Sequencing & fragment Analysis, Manual fragment Analysis and Mutation ....
Company:GE Healthcare, formerly Amersham Biosciences

TempliPhi 100 Amplification Kit from GE Healthcare, formerly Amersham Biosciences

Description:... consumables needed for template preparation. Category: DNA Sequencing & fragment Analysis, Automated Sequencing & Genotyping & and fragment Analysis, Template Preparation and Sample ....
Company:GE Healthcare, formerly Amersham Biosciences

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Fragment in Biological Definition

Genetic fingerprinting

... method is a buccal swab . Next, restriction fragment length polymorphism (RFLP) analysis is performed ... has been introduced: AFLP, or amplified fragment length polymorphism. This new technique is ... year sentences. See also restriction fragment length polymorphism (RFLP) paternity test ...

Polymerase chain reaction

... template, which contains the region of the DNA fragment to be amplified Two primers , which ... USD 2,500 in 2004 . Primers The DNA fragment to be amplified is determined by selecting ... exactly match the beginning and end of the DNA fragment to be amplified. They anneal (adhere) to the ...

Restriction enzyme

... 1 Sites of cleavage 2 fragment complementarity and splicing 3 Restriction ... each cleave DNA by a different mechanism. fragment complementarity and splicing Because ... spontaneously in a test tube. Thus, a sticky-end fragment will readily reunite with ...

Antibody

... known as the complementarity determining region 3 (CDR3). The Fc fragment is the stem of the "Y" and is composed from two heavy chains that each ... and light chains can be fused together to form a single chain variable fragment (scFv), which retains the original specificity of the parent ...

Hydrolysis

... , while the other contains a carboxylic acid functional group. The fragment of the parent molecule that was originally a carboxylate gains a hydrogen ion from the additional water molecule. The fragment that was originally an alkyl group collects the remaining hydroxyl ...

Okazaki fragment

... An Okazaki fragment is a relatively short fragment of DNA that is created by primase and Pol III along the lagging ...

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Fragment in Biological Dictionary

RFLP

... 1985, Sir Alec Jeffreys developed restriction fragment length polymorphism ( RFLP ), which quickly ... form of ... RFLP Method - Restriction fragment Length Polymorphism. RFLP (often pronounced ... In Chapter 10 , we learned that, if a cloned DNA fragment is used ... Encyclopedia article of RFLP at ...

Restriction fragment

... A restriction fragment is a DNA fragment resulting from the cutting of a DNA strand by ... In 1985, Sir Alec Jeffreys developed restriction fragment length polymorphism (RFLP), which quickly ...

Okazaki fragments

... An Okazaki fragment is a relatively short fragment of DNA created on the lagging strand during DNA ... are between 1,000 to 2, ... Okazaki fragment ( ′ōkə¦zäkē ′fragmənt ) ( cell and molecular ...

Megabase cloning

... , Molecular cloning , ... ... of large DNA fragment cloning is preparation of megabase -size DNA ... Digestion of Megabase DNA, ... of large DNA fragment cloning is preparation of megabase -size DNA ... Megabase . The expanding world of large DNA ... fragment Cloning Products and ... When clones within ...

Lagging strand

... The resulting structure has ... An Okazaki fragment is a relatively short fragment of DNA created on the lagging strand during ... polymerase is then free to continue Okazaki fragment ... On the other hand, the lagging strand ...

Klenow Fragment

... The Klenow fragment is a large protein fragment produced when DNA polymerase I from E. coli is ... and the 3’ ... The large or Klenow fragment of DNA polymerase I has DNA polymerase and ...

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