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Expression in Medical News

Covance to Acquire Seattle-Based Gene Expression Laboratory from Merck & Co., Inc.

... Covance will acquire Merck's Seattle-based Gene expression Laboratory that performs genomics services such as genotyping, gene sequencing and gene expression profiling. "The acquisition of this ... occupancy of the site and operation of the Gene expression Laboratory on August 17, 2009. "The ...

MEK4, genistein and invasion of human prostate cancer cells

... by assessing cell invasion and gene and protein expression of mitogen-activated protein kinase 4 (MEK4) and ... Overexpression of MEK4 increased MMP-2 expression and cell invasion in prostate cancer cells; decreased MEK4 expression had the opposite effect. Computer modeling showed ...

Millennium Pharmaceuticals Inc./Lymphoma Research Foundation funds lymphoma research

... bone marrow. MCL is characterized by over expression of the gene cyclin D1 due to a chromosomal ... Dr. Fu and his co-workers have found that higher expression of miR-17~92 is directly correlated with poorer ... These findings indicate that higher miR-17~92 expression induces abnormal activation of a pathway in tumor ...

Smoking increases potential for metastatic pancreatic cancer

... Related Cancers Center. Nicotine promotes the expression osteopontin, and high levels of osteopontin have ... behavior. The researchers correlated OPNc expression with the patients' smoking history. OPNc expression was found on 87 percent of the invasive PDA ...

Bcl6 gene sculpts helper T cell to boost antibody production

... HOUSTON - expression of a single gene programs an immune system helper ... the team reported that that IL-6 and IL-21 induce expression of Bcl6 in the absence of transforming growth ... Another set of experiments showed that Bcl6 expression inhibits a T cell from differentiating into Th17, ...

Study Shows a Link Between Schizophrenia & Genetic Mutations

... of small, non-coding RNAs that down-regulate the expression of a variety of genes and are scattered over the ... demonstrated alterations in miRNA function or expression levels. The overwhelming majority of ... be feasible to treat schizophrenia by restoring expression of normal microRNAs in the central nervous system ...

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Expression in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... rat antibody production. Inactivation of rat IgM expression is the first step in generating rats that ... paper. "Inactivation of endogenous rat antibody expression is essential for human antibody expression in genetically engineered animals. To solve this ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... Monia. Antisense Reduction of FGFR4 Gene expression Lowers Body Weight and Adiposity and Improves ... cAMP Response Element Binding Protein (CREB) expression Lowers Plasma Glucose and Lipids in Diabetic ... B.P. Monia. Inhibition of Transthyretin expression by Antisense Oligonucleotides Lowers RBP4 ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... entitled "Enhancer of Zeste Homologue 2 (EZH-2) expression in breast cancer: a novel marker and potential ... School of Medicine. "We wanted to see how much expression of the protein was present. We were surprised ... positive. Scientists found that the increased expression of EZH-2 meant an increase in tumor size and an ...

Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women

... - Largest Genomic Study Comparing Gene expression in Female and Male Patients Presented at ASCO ... is the largest genomic study to compare gene expression in female and male patients, and results support ... (Abstract #549), analyzed quantitative gene expression by gender status in estrogen receptor (ER) ...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

... properly. Cohesin's role in dysregulation of gene expression (regulating the degree to which specific genes ... compared to controls, and also detected gene expression profiles that were unique to CdLS. Importantly, said Krantz, the expression levels of genes corresponded to the severity of ...

Another LNA-based RNA Inhibitor Enters Clinical Trials

... animal studies, EZN-3042 inhibited Survivin expression and tumor growth. It also potentiated the ... against survivin, inhibits survivin expression and confers taxol sensitivity" "EZN-3920, ... RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathway and ...

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Expression in Medical Products

Dual Media Kit

Description:... Media Set, different from commonly used protein expression procedures using Luria Broth (LB) or other ... is not a good medium for repression of protein expression during cell expansion, nor is it ideal for protein expression when inducer is ....
Company:Zymo Research Corporation

Leptin Soluble Receptor ELISA Test

Description:... level of the hypothalamus and acts via specific receptors to control the expression of the appetite stimulator, neuropeptide Y (NPY). This feedback mechanism ... for the precise regulation of long term energy balance [4]. Leptin expression and levels are consistently associated with body adiposity and body mass ...
Company:Diagnostic Systems Laboratories, Inc.

Valentino Eyewear

Description:... The latest VALENTINO eyewear collection is a refined expression of sophisticated luxury, balancing ultimate feminine, chic styles against understated, minimalist mens ....
Company:Safilo Group

Chanel Optical Collection

Description:... double C to the quilted effect. Combining the purity of black with the sparkle of Strass and other light reflections, the frames magnify the expression in a sporty-fashion ....
Company:Luxottica Group

QuantiGene 2.0 RNA Quantification System

Description:... QuantiGene 2.0 is a reagent and probe system used together to quantify gene expression knockdown. The high throughput plate based system is a sandwich nucleic acid hybridization assay that provides a unique approach for RNA detection ...
Company:Sigma-Aldrich

MammaPrint Breast Cancer Diagnostic Test

Description:... MammaPrint is a gene expression profiling test that predicts the risk of metastasis in breast cancer patients. It is based on groundbreaking research performed at the Netherlands ...
Company:Agendia Corporate

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Expression in Medical Definition

Therapeutic gene modulation

... modulation refers the practice of altering the expression of a gene at one of various stages, with a view ... in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the ... aids the recipient directly. Modulation of gene expression can be mediated at the level of transcription by ...

Thymocyte

... are classified into a number of distinct maturational stages based on the expression of cell surface markers. The earliest thymocyte stage is the double ... thymocytes reactive to peripheral organs, the gene AIRE drives the expression of multiple peripheral antigens, such as insulin, creating an ...

Autoimmune regulator

... that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin , in the thymus . [3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease. [4] References ...

Central tolerance

... and bone marrow (B cells), when maturing lymphocytes are exposed to self antigens. Self antigens are present in both organs due to endogenous expression within the organ and importation of antigen due to circulation from peripheral sites. In the case of T cell central tolerance, additional sources of ...

Forehead lift

... emotions Patients commonly request rejuvenation surgery on the forehead because the area is large enough to comprise the major focal and expression point of the upper face , the eyes notwithstanding. Given time and gravity , the muscles that hold the forehead smooth become loose and weak, ...

Neuropsychiatry

... A good example of this is Tourette syndrome , which Ferenczi (1921), although never having seen a Tourette patient, suggested was the symbolic expression of masturbation caused by sexual repression. However, starting with the efficacy of neuroleptic drugs in attenuating symptoms (Shapiro, Shapiro and ...

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Expression in Medical Dictionary

Gene

... of these protective substances. Gene expression and DNA Repair Research Interest: expression of mRNA in eukaryotic cells requires several ... Hicks in December 2005. Disclaimer ... gene expression profiling A research method that measures ...

Palsy

... facial palsy . The facial nerve controls the muscle s of emotion and expression in the face. This nerve also carries taste sensations from the front ... nerve . The 2 facial nerve s control movement of the muscle s of expression on each side of your face. Bell's palsy is a disorder caused by ...

Speech problems

... poorly articulated speech, such as slurring. Aphasia is impaired expression or comprehension of written or spoken language. Speech impairment can ... poorly articulated speech, such as slurring. Aphasia is impaired expression or comprehension of written or spoken language. Speech problems such ...

Acute

... Newsletter Series based on the roundtable "Man aging Acute Uncomplicated Cystitis in Women in the Era of Antibiotic Resistance " ... MUCLIN expression and posttranslational processing are altered in two pancreatic disease s, cystic fibrosis and acute pancreatitis , and these changes may relate ...

Acute pancreatitis

... calcium and other nutrients from food ( malabsorption syndrome ), bone problems, kidney disease , acute pancreatitis , ... MUCLIN expression and posttranslational processing are altered in two pancreatic disease s, cystic fibrosis and acute pancreatitis , and these changes may relate ...

Adenoviruses

... like the adenoviruses , are often recognized and destroyed by the immune system so their therapeutic effects are short-lived. Maintaining gene expression so it performs its role properly after vector delivery is difficult. ...

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Expression in Biological News

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... and other brain tumor tissues also recorded expression of PTN and ALK, as well as genes along this ... drive cancer. But in the case of PTN and ALK, the expression data suggest that these are drivers patients with increased expression of these genes had significantly poorer outcomes ...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... development, promotes cancer by activating the expression of the known oncogene, MYC, according to ... After their previous studies demonstrated that expression of the protein encoded by the DLX5 gene ... for cancer showed that they could promote the expression of MYC by transfecting cells with DNA strands ...

Will IVF work for a particular patient? The answer may be found in her blood

... Dr. Allen and her team chose to examine the gene expression patterns in RNA extracted from peripheral ... genes showed a more than two-fold difference in expression in early clinical pregnancy compared with a ... pathways that were most over-represented in this expression were concerned with angiogenesis (the growth of ...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... Scientists have discovered gene expression differences that could lead to better ways to ... junctions between tendons and bones). Using gene expression technology a method by which scientists can determine the relative levels of expression of thousands of different genes at the same time ...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

... response including increased control of gene expression through RNA interference (RNAi) in somatic ... signaling pathway did exhibit somatic cell expression of genes usually active only in germline cells. ... and stress response also increased the expression of germline markers. "The idea that somatic ...

Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds

... experiments have shown that "knocking-down" expression of the gene that encodes the production of the ... found to be abnormally short and misshapen when expression of the OPHN1 gene was acutely reduced. A ... a mutation." By manipulating OPHN1 gene expression on the postsynaptic side of the gap, the team was ...

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Expression in Biological Technology

Nanotech particles affect brain development in mice

... of titanium dioxide (TiO2) affects the expression of genes related to the central nervous system in ... while pregnant showed alteration in gene expression related to neurological dysfunction. Ken ... researchers were able to demonstrate changes in expression of hundreds of genes. According to Takeda, ...

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

... of VEGF, while sparing the physiological VEGF expression necessary to maintain the growth and function of ... PTC299 through PTC's proprietary GEMS (Gene expression Modulation by Small-Molecules) technology by ... inhibitors, while sparing the physiological VEGF expression necessary to maintain the growth and function of ...

OMT announces a breakthrough in the development of a novel human antibody platform

... paper. "Inactivation of endogenous rat antibody expression is essential for human antibody expression in genetically engineered animals. To solve this ... to the inactivation of endogenous antibody expression described in the "Science" article. Previously, ...

First Catalog Cancer Biochip for Sequence Capture Now Available from febit

... "Molecular signatures defined by large-scale gene expression profiling are at the forefront in developing new ... fingerprinting methods, including mRNA and miRNA expression profiling. Both of these high-throughput methods ... minimizing experimental variation. HybSelect and expression profiling can easily be performed in the ...

Data on WaferGen's SmartChip(TM) System to be Presented at 3rd Annual Rediscovering Biomarkers Conference

... will present differential gene expression data between matched normal lung ... system is currently the focus of ongoing gene expression research collaborations with scientific teams at ... and validate therapeutically-relevant gene expression biomarkers in areas including chronic obstructive ...

febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment

... of New Sequence Data into Biochips for Gene expression Profiling and Sequence Capture for ... of genes and SNPs of interest using Gene expression Profiling, SNP-Detection, ncRNA analysis as well ... This array allows the performance of a microarray expression profiling as well as a targeted Next-Generation ...

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Expression in Biological Products

Origami(DE3) Glycerol Stock from Novagen

Description:... in the cytoplasm. Studies have shown that expression in Origami(DE3) yielded 10-fold more active protein than in another host even though overall expression levels were similar (1). Origami hosts are ... The Origami(DE3)pLacI host is compatible with expression from pETBlue and pTriEx vectors. The trxB and gor ...
Company:Novagen

GenoStat Inducible Expression System from Upstate

Description:... The GenoStat Inducible expression System provides tightly regulated control of exogenous gene expression in mammalian cells and is capable of repeated on/off expression kinetics. This degree of control is mediated by ...
Company:Upstate

Origami(DE3)pLysS Glycerol Stock from Novagen

Description:... in the cytoplasm. Studies have shown that expression in Origami(DE3) yielded 10-fold more active protein than in another host even though overall expression levels were similar (1). Origami hosts are ... The Origami(DE3)pLacI host is compatible with expression from pETBlue and pTriEx vectors. The trxB and gor ...
Company:Novagen

Pichia Protocols: Methods in Molecular Biology from Invitrogen

Description:... of key procedures for use of the Pichia pastoris expression System. Methods developed by the leaders in Pichia expression are provided as detailed, step-by-step protocols. ... book will guide you from choosing the appropriate expression vector, through strain construction and analysis, ...
Company:Invitrogen

E. coli Expression System with Gateway Technology from Invitrogen

Description:... The E. coli expression System with Gateway Technology is designed to create E. coli expression clones containing the T7 promoter. The expression clones are ready for transformation ...
Company:Invitrogen

Baculovirus Expression System with Gateway Technology from Invitrogen

Description:... The Baculovirus expression System with Gateway™ Technology is designed ... plasmids containing the polyhedrin promoter. The expression cassette is transferred to the baculovirus genome ... bacmid DNA is then used for transfection and expression in insect cells. The ...
Company:Invitrogen

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Expression in Biological Definition

Bioinformatics

... structure prediction , prediction of gene expression and protein-protein interactions , and the ... evolutionary biology 2.1 Gene expression analysis 2.2 Protein expression analysis 2.3 Structure prediction 2.4 ...

Bioinformatics

... structure prediction , prediction of gene expression and protein-protein interactions , and the ... evolutionary biology 2.1 Gene expression analysis 2.2 Protein expression analysis 2.3 Structure prediction 2.4 ...

Morphogenesis

... these secondary gene products can regulate the expression of still other genes in a regulatory cascade. ... around the periphery of the cell cytoplasm. Gene expression in these nuclei is regulated by the Bicoid, ... tailless and knirps are all gap genes . Their expression patterns in the early embryo are determined by ...

Gene

... 2.1 Chemical structure of a gene 2.2 expression of molecular genes 2.3 Mutations and evolution ... (more at genetics , allele ). expression of molecular genes For various reasons, the ... Just as there are many factors influencing the expression of a particular DNA strand, there are many ways ...

Molecular biology

... 2 Techniques of molecular biology 2.1 expression cloning 2.2 Polymerase chain reaction (PCR) ... enzymatic type of molecule in cells . expression cloning One of the most basic techniques of molecular biology to study protein function is expression cloning. In this technique, DNA coding for a ...

Morphogenesis

... these secondary gene products can regulate the expression of still other genes in a regulatory cascade. ... around the periphery of the cell cytoplasm. Gene expression in these nuclei is regulated by the Bicoid, ... tailless and knirps are all gap genes . Their expression patterns in the early embryo are determined by ...

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Expression in Biological Dictionary

Untranslated RNA

... is a small untranslated RNA that regulates expression of two global ... The untranslated RNA DsrA ... Gene Suppresses Tumor Activity. ... expression of prohibitin 3' untranslated region ... , Untranslated :: genetics :: Differential expression of H19 and vitamin D3 upregulated protein 1 ...

Transient transfection

... where transient modification of gene expression is ... used for both transient and stable ... information on Transfection . ... Transient expression versus Stable Transfection ... Includes ... ... Article : Optimizing Transient Gene expression Genetic Engineering & Biotechnology News - ...

Transformed phenotype

... by Krev-1 is stable when cells ... 3 and PEA3 expression and the transformed and oncogenic phenotype ... ... ... (IPTG) to IR-1 cells caused the expression of the transformed phenotype ... cells ... of HT1080 human fibrosarcoma cells ... the expression of the transformed phenotype , we have ...

Transferrin receptor

... and ... Decreased transferrin receptor expression by neuromelanin cells in restless legs ... ... with a normal to increased serum ... expression of the transferrin receptor on target cell ... of cells in which transferrin receptor expression was reduced. ... Home>Technical ...

Sigma Factor

... RNA ... In the regulation of gene expression in prokaryotes, anti- sigma factors bind to ... factors provide a means of regulating gene expression in ... One such class of sigma factors ... 'Six Sigma ' Factor for Home Depot" ... expression of the secondary sigma factor sigmaX in ...

RNA interference

... interference refers to the inhibition of gene expression by small double ... use of RNA interference ... dna-directed RNA interference that enable expression of short hairpin RNAs in vivo. ... The RNA ... by which long double-stranded RNAs silence the expression of target genes. ... referred to as the RNA ...

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Other Contents
(Date:4/24/2014)... detailed atlas with environment and health maps at a ... by the UK Small Area Health Statistics Unit (SAHSU), ... based at Imperial College London, the open-access atlas allows ... study the geographical pattern of 14 diseases and conditions ... and low birth weight. Alongside this it provides maps ...
(Date:4/24/2014)... have identified a way to sensitise cancer cells to ... The study published today in Cell Reports , ... to target cells that have become resistant to treatment. ... the possible mechanisms behind resistance to chemotherapy drugs like ... , Dr Andrew Gilmore, who led the research team ...
(Date:4/24/2014)... April 24, 2014 ,Take me out to the ... and kale chips. The more likely culprits include French ... , Unfortunately for children who play youth baseball, eating ... to weight problems, according to researchers at Wake Forest ... online edition of Childhood Obesity , found that ...
(Date:4/24/2014)... aspects, the corresponding terminology, and the relevance of ... in publications on randomized controlled trials (RCTs). This ... German Institute for Quality and Efficiency in Health ... final report. , Together with external experts, IQWiG ... glioblastoma, lung cancer, malignant melanoma, and pancreatic cancer. ...
(Date:4/24/2014)... 4/24/14) Dartmouth has been awarded one of 30 ... as a Lead Academic Participating Site in its new ... recipients are a select groups of investigators charged with ... cooperative groups., The NCTN grant system reflects recommendations from ... streamlines operations to achieve four goals:, Faster ...
Breaking Medicine News(10 mins):Health News:New high-detail atlas offers tool to explore local environment and health 2Health News:New high-detail atlas offers tool to explore local environment and health 3Health News:Scientists find way to target cells resistant to chemo 2Health News:Take the bat, leave the candy 2Health News:Palliation is rarely a topic in studies on advanced cancer 2Health News:Palliation is rarely a topic in studies on advanced cancer 3Health News:Dartmouth awarded lead role in NCI clinical trials network 2Health News:Dartmouth awarded lead role in NCI clinical trials network 3
(Date:4/24/2014)... they often inject harmful proteins into the host ... However, in some plants, bacteria attack once they,ve ... Now, researchers at the University of Missouri have ... bacteriaknown mostly for attacking tomatoesto invade its host. ... that work with food-producing plants to enhance resistance ...
(Date:4/24/2014)... a commercially important sugar used as a sweetener, ... for synthesizing riboflavin and several antiviral drugs. Genetic ... the bacteria,s ability to produce D-ribose is a ... of this valuable chemical, as described in an ... journal from Mary Ann Liebert, Inc., publishers. The ...
(Date:4/24/2014)... Entomological Society of America (ESA) is very pleased to ... Journal of Insect Science from the University of ... is an international, open-access, peer-reviewed journal that ... insects and other arthropods -- from the molecular to ... medical impacts. It is freely available to individuals and ...
Breaking Biology News(10 mins):Plants send out signals attracting harmful bacteria, MU study finds 2ESA to publish the Journal of Insect Science 2
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