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exon in Medical News

IPA Now Supports Affymetrix Exon Arrays and Additional Species

... SNPs, genotyping, and RNAi. Now with the support of Affymetrix GeneChip exon Arrays, researchers using this system can use IPA for further analysis and ... excited that Ingenuity's IPA now supports Affymetrix Whole Transcript exon and Gene Arrays," stated Rob Clum, Market Development Manager, ...

JCI table of contents: Nov. 15, 2007

... the theory that abnormal inclusion of a region of the ClC-1 gene known as exon 7a in the ClC-1 mRNA (the intermediate between gene and protein) may play ... Rochester, discovered a powerful method of correcting this aberrant exon 7a inclusion and reversing myotonia in mouse models of DM1. A nucleic acid ...

The vulnerable cancer cell

... describes as a "totally new gene" in cancer research circles. "There are a couple of older papers describing STK33's genetic localization and exon structure, but otherwise nothing else is known about it." That's about to change as Gilliland and his team begin to explore why STK33 represents a ...

Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening

... are falsely identified as non-carriers," said Dr. Strom, lead investigator of the study. "Comprehensive mutation analysis using DNA sequencing and exon deletions/duplications is therefore important to resolve apparent homozygosity (the false appearance that the patient inherited the same mutations ...

First Treatment for Muscular Dystrophy in Sight: Scientists Harness Exon-Skipping in Large Animal to Successfully Treat Duchenne Muscular Dystrophy

... gene that block the effective creation of dystrophin. Because the gene's mutation could affect any of its 79 exons and sometimes more than one single exon at a time, scientists employed a "cocktail" of antisense called morpholinos to extend the range of this application. By skipping more than ...

First treatment for muscular dystrophy in sight: Scientists successfully harness exon-skipping

... gene that block the effective creation of dystrophin. Because the gene's mutation could affect any of its 79 exons and sometimes more than one single exon at a time, scientists employed a "cocktail" of antisense called morpholinos to extend the range of this application. By skipping more than a single ...

EMBL GeneCore purchases Genomatix's next generation sequencing data analysis solution

... and peak finding, and performs automated binding pattern identification. For RNAseq experiments, normalized expression values are calculated at the exon and transcript level. A special GenomeThesaurus is also provided for potential splice junctions, which allows for splice junction analysis and ...

The first autism disease genes

... which is a tightly linked protein to neuroligin, implicated in synapse formation for glutamate neurons. This revealed a hemizygous deletion of coding exon for neurexin gene for a pair of affected siblings. Accumulating evidence thus points out that neurexin/neuroligin/Shank3 (NLGN3/4, SHANK3, NRXN1) ...

Research Shows Why Statins Don't Work for Everyone

... exons that are spliced together to produce an active protein, he explained. Statins block LDL cholesterol production by binding to a particular exon when the protein is assembled. But depending on how this HMGCR splicing occurs, a statin drug has a better or worse chance of working as it should ...

Gene expression differences between Europeans and Africans affect response to drugs, infections

... Clara, CA. In the March 7, 2008, print issue of American Journal of Human Genetics, and published early online, the researchers used Affymetrix exon arrays to show that expression levels for nearly five percent of the 9,156 human genes they studied varied significantly between individuals of ...
exon in Medical Technology

Getting More From Whole-Transcript Microarrays

... on a genome-wide scale, without investing in new exon microarray technologies. Alternative ... scale, Affymetrix have developed their exon 1.0 ST platform. However, the study by Mark ... the Affymetrix Gene 1.0 ST and the Affymetrix exon 1.0 ST chips. Robinson said, "Our intention was ...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... May 2009. Riely G. J. et al. "Clinical Course of Patients with Non -Small Cell Lung Cancer and Epidermal Growth Factor Receptor Exon19 and exon 21 Mutations Treated with Gefitinib or Erlotinib." Clin. Cancer Res, 12, 839-844(2006). Available at: ...

ExonHit Reports Proof-of-Concept in Breast Cancer Diagnostic Using its SpliceArray(TM) Platform

... this technology on the market." SpliceArray(TM) biochips are ExonHit's proprietary research tools [2]. They quantify mRNA expression at the exon level. They also provide a comprehensive RNA splicing analysis across the entire human genome and enable the identification of known splice variants ...

TargeGen Announces Planned Initiation of Clinical Trial of JAK2 Inhibitor TG101348 in Myeloproliferative Disease Patients, and Presentations at ASH

... with TG101348, A JAK2 Selective Small Molecule Inhibitor, in the Presence of Myeloproliferative Disorder-Associated JAK2V617F, MPLW515K, or exon 12 Mutations -- Gerlinde Wernig & Gary Gilliland -- Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of ...

AVI BioPharma Reports Positive Pre-Clinical Influenza Data

... AVI BioPharma develops therapeutic products for the treatment of life-threatening diseases using third-generation NEUGENE antisense drugs and ESPRIT exon skipping technology. AVI's lead NEUGENE antisense compound is designed to target cell proliferation disorders, including cardiovascular restenosis. ...

AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease

... AVI BioPharma develops therapeutic products for the treatment of life-threatening diseases using third-generation NEUGENE antisense drugs and ESPRIT exon skipping technology. AVI's lead NEUGENE antisense compound is designed to target cell proliferation disorders, including cardiovascular restenosis. ...
exon in Medical Dictionary

Cold

... include weight gain , constipation , dry skin , and sensitivity to the cold . Also called underactive thyroid. hypoxia ... Natural rRNA exon sequences increased the activity and reduced the cold sensitivity of the mutant pre-rRNAs, compared to precursors with non-rRNA exons. Thus, the ...
exon in Biological News

New method provides panoramic view of protein-RNA interactions in living cells

... into some sort of message, all the spaces need to be removed; but if an exon is dropped, a different version of that protein, which could carry a very ... Nova2 binds to RNA, they could predict and directly observe whether an exon would be included or excluded in the final transcript, and which protein ...

DNA template could explain evolutionary shifts

... variation. "I think this is going to make people think very hard about copy number variation with respect to genome evolution, gene evolution and exon shuffling," said Dr. James R. Lupski ( http://www.bcm.edu/genetics/facultyaz/lupski.html ) , vice chair of molecular and human genetics at BCM and ...

Joining forces to improve lung cancer treatment

... with dose-per-fraction escalation for treatment of stage III non-small-cell lung cancer (Poland) Confirmation that EGFR mutations (deletion in exon 19, missense L858R) are the most important predictors of sensitivity to tyrosine-kinase inhibitor targeted therapies (Italy) Barbara Zolty from ...

Boehringer Ingelheim uses Genomatix' Next Generation Sequencing data analysis systems

... and peak finding, and performs automated binding pattern identification. For RNAseq experiments, normalized expression values are calculated at the exon and transcript level. A special GenomeThesaurus is also provided for potential splice junctions, which allows for splice junction analysis and ...

Genomatix joins Illumina-Connect program

... and peak finding, and performs automated binding pattern identification. For RNAseq experiments, normalized expression values are calculated at the exon and transcript level. A special GenomeThesaurus is also provided for potential splice junctions, which allows for splice junction analysis and ...

Human genes sing different tunes in different tissues

... tissue-dependent. Certain protein isoforms that are common in heart tissue, for example, might be very rare in brain tissue, so that the alternative exon functions like a molecular switch. Scientists who study splicing have a general idea of how tissue-specificity may be achieved, but they have much ...

Deep sequencing study reveals new insights into human transcriptome

... under study. In addition, a global survey of mRNA splicing events identified 94,241 splice junctions, of which 4,096 are novel, and showed that exon skipping is the most prevalent form of alternative splicing. Details are presented in the Science report of Sultan et al. "A Global View of Gene ...

Researchers discover critical detail of cellular defense against genetic mistakes

... NMD quality review depends on the physical spacing of proteins bound to the mRNA chain. If a stop reading signal occurs too far ahead of the final exon in the chain, as marked by an exon-exon junction complex (EJC), the cell concludes that the stop codon has mistakenly fallen in the middle of a set ...

Living view in animals shows how cells decide to make proteins

... intronic silencers were chopping out the IIIb exon -- and if so, in which tissues and organs -- or ... in most tissues made the same decision to silence exon IIIb, but the cells used a variety of silencers ... For example, a cell’s decision to include exon IIIb is critical because the exon’s presence or ...

RNA map provides first comprehensive understanding of alternative splicing

... different mRNAs, and thus different proteins. The exon can be spliced in or out in a binary, ... action on regulating whether the alternative exon is spliced in or out. The researchers ... inhibited by Nova and half were enhanced in their exon use by Nova, and every one very cleanly fit the ...

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exon in Biological Technology

AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy

... will start its pre-clinical phase this year." exon skipping in DMD exon skipping is a technology to neutralize genetic ... cannot take place. However, when the faulty exon is eliminated (i.e. skipped), protein synthesis ...

In vivo visualization of alternative splicing

... changes during the lifetime of the worm: Embryos and early larvae express exon 9, while adult worms express exon 10. By linking exons 9 and 10 with differently colored fluorescent ...

First Catalog Cancer Biochip for Sequence Capture Now Available from febit

... febit will stay at the forefront of cancer research and include key research study results in the next generation of febit's cancer biochips. A 2Mb exon cancer biochip will be available this summer and a 30Mb biochip is planned already for release in 2010. Multiplex NGS studies based on ...

Jivan Focuses on Solutions for Transcriptome Sequencing

... Arrays for targeted sequencing of genomes, gene families and therapeutic areas. By using Jivan's database of mRNA sequences, including exons and exon junctions, Jivan can ensure the capture of all mRNA sequences of each gene of interest, including wildtype transcripts and splice variants. For genes ...

ExonHit Launches Rat Genome SpliceArray(TM) Products to Expand High Resolution Gene Expression Profiling for use in Disease Modeling and Toxicogenomics

... transcripts is now offered through our portfolio of genomic services. The Rat SpliceArray(TM) monitors over 23,000 genes utilizing over 200,000 exon body and 180,000 splice junction regions. This comprehensive coverage enables investigators to further elucidate the enormous diversity of the rat ...

Jivan Awarded US Patent #7,340,349 for Splice Array Analysis

... The issued claims cover mathematical algorithms for determining the expression levels of splice isoforms of a gene in a sample using microarrays with exon junction probes. "The '349 Patent validates JIVAN's position as a leader in the growing market for DNA microarrays to detect alternative splicing," ...

Exelixis Reports Encouraging Interim Data From a Phase 2 Trial of XL647 as First-Line Therapy for Non-Small Cell Lung Cancer

... as their best response (8 PR and 11 SD out of 30 evaluable patients). -- Of the 8 patients who experienced partial responses, 4 had EGFR exon 19 deletions, 1 had an EGFR L858R mutation, and 3 were EGFR wild-type. -- All 6 patients with EGFR-activating mutations demonstrated clinical ...

Heteroduplex Analysis Using the DCode System

... exons 7 and 10. The heterozygous mutations from exon 7 were 1154insTC, two base insertion ... deletion (-TTC). The mutations from exon 10 were a heterozygous ΔF508, three base ... to create end products of 289 bp for exon 7 and 369 bp ...

Detection of Mutations in the CYP21 Gene Using the DCode System

... at the following nucleotide positions: exon 2: 2011 (A→C) and exon 5: 2851 (T→G). Nucleotide ... M12792; M23280. The mutant control sample for exon 6 contains the cluster-E6 mutation and ...

Identification of Disease Causing Mutations in Phenylketonuria by Denaturing Gradient Gel Electrophoresis Using the DCode System

... nM each dNTP, 800 nM each primer (MP 1: exon 1 + exon 4 + exon 13, MP2: ...

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exon in Biological Products

Ion Channel SpliceArray Service from ExonHit Therapeutics Inc.

Description:... monitors 1543 known and potential splice events derived from 441 GPCR genes. Splice events are profiled with a patent-protected combination of exon and junction probes that allow robust, specific detection of the two possible molecular species resulting from each splice event. The GPCR ...
Company:ExonHit Therapeutics Inc.

Custom Splice Arrays from ExonHit Therapeutics Inc.

Description:... spliced cDNAs aligned to the human genome. Each splice event contained in a custom SpliceArray is profiled with a patent protected combination of six exon and junction probes that allows robust, specific detection of the two possible molecular species resulting from each splice event. Custom ...
Company:ExonHit Therapeutics Inc.

Apoptosis Pathway SpliceArrays from ExonHit Therapeutics Inc.

Description:... monitors 5806 known and potential splice events derived from 609 genes. Splice events are profiled with a patent-protected combination of exon and junction probes that allow robust, specific detection of the two possible molecular species resulting from each splice event. The Apoptosis and ...
Company:ExonHit Therapeutics Inc.

GPCR SpliceArray Service from ExonHit Therapeutics Inc.

Description:... monitors 1543 known and potential splice events derived from 441 GPCR genes. Splice events are profiled with a patent-protected combination of exon and junction probes that allow robust, specific detection of the two possible molecular species resulting from each splice event. The GPCR ...
Company:ExonHit Therapeutics Inc.

Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

Description:... degradation of mdm2 proteinrequired for mdm2 modification and concurrent p53 stabilization and accumulation. This interaction is mediated by the exon 1Beta-encoded N-terminal domain of p14^ARF^ and a C-terminal region of mdm2. Deletion of the ARF-INK4a locus simultaneously impairs both the ...
Company:Lab Vision

T7 RNA polymerase from Chimerx

Description:... a T7 promoter. Transcripts can be used as hybridization probes, templates for in vitro translation, substrates in RNA processing systems, or for exon and intron mapping of genomic ....
Company:Chimerx

Protein Expression Service (Insect cell) from Exon BioSystems

Description: Full service including gene cloning, protien expression and purification of 1 liter ....
Company:Exon BioSystems

Site-directed Mutagenesis from Exon BioSystems

Description: Any form, any size, any number of mutageneses. ExonBio provides the best service with double sequecing to make sure the success of the ....
Company:Exon BioSystems

Protein Expression Service (Bacterial) from Exon BioSystems

Description: ExonBio Service provides one-stop recobinant protein shopping from cloning, expression and purification. Price including gene ....
Company:Exon BioSystems

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exon in Biological Definition

Alternative splicing

... exons in one transcribed pre-mRNA. But what is an intron and what is an exon is not decided yet. This decision is made during the splicing process. The ... in the reading frame will cause the protein to be non-functional. exon cassette mode : in this case, certain exons are spliced out to alter the ...

Exon

... and which are retained in the final mRNA molecule. In many genes, each exon codes for a specific portion of the complete protein , however, not all ... whatsoever and thus are sometimes referred to as non-coding RNA . exon trapping is a molecular biology technique that exploits the existence ...

Gene

... Eukaryotic cells splice the transcripts of a gene, by keeping the exons and removing the introns . So, the DNA strand needs to be in an exon to be expressed. Because of the complexity of the splicing process, one transcribed RNA may be spliced in alternate ways to produce not one but a ...
exon in Biological Dictionary

Exons

... entries, research information, and more. exon n. A sequence of DNA that codes information for ... second exons are noncoding, while the third exon contains a short ... An exon is a nucleic acid sequence that is ...

Exon

... An exon is a nucleic acid sequence that is ... to messenger RNA ... Depending on the context, exon can refer to the ... J. James exon For other uses, see ...

Regulatory sequence

... or is currently ... Regulatory sequence name. Organism. 1. cftr, exon 9. Homo sapiens, human. 2. cftr, exon 9 ... REGULATORY SEQUENCES ! ... And if not, would that regulatory ...

Viral oncogene

... gene MYB. Represented by 97 ESTs from 52 ... Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 15 ... Human protein-coding gene FOSB. Represented by 916 ESTs from 176 cDNA libraries. ... Homo sapiens FBJ murine osteosarcoma viral ...

Transversion

... transversion , although affecting the 11 nucleotide of the 3' ... These results indicated that the GT transversion at the first position of exon 5 ... ... of tools for the Oracle world: the schema version manager TransVersion (tv), the ... TransVersion (Description: Discuss topics of ...

Trans-splicing

... to describe data that contain the ... In addition, trans - splicing was not detected in COT of other mammals, such as ... reactions between COT exon 2 from rat and human do not produce trans - splicing . ... Trans - splicing appears to reflect an archaic form of RNA processing that is ...

Silent Mutation

... that do not result in a change to the amino acid sequence of a protein. They may occur in a non-coding region, or they may occur within an exon in a manner that does not alter the final amino acid sequence. The phrase silent mutation is often used interchangeably with the phrase ...

Self-splicing

... is shown to function in the ... In addition, even the best self - splicing constructs, which produced half as much ... Figure 2 Effect of exon context on RNA self - splicing and translation in vitro. ... Table 2 Self - splicing of a pol II transcript in vitro and in human cells ...

Primer

... because at the heart of ... Optionally enter your pre-designed forward primer . ... This controls whether the primer should span an exon junction on your mRNA template. ... Achieve a radiant complexion with foundation primer . Sephora features several of the top brands of ...

Pre-mRNA

... Links Pre - mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation ... Genome-wide survey of human alternative pre - mRNA splicing with exon junction microarrays. ... snRNAs to the pre - mRNA might be enhanced or inhibited by the presence of short ... an unclassified pre - mRNA ...

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