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Epitope in Medical News

CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... its flu vaccine, utilizing its proprietary L.E.A.P.S. technology (Ligand epitope Antigen Presentation System) to determine its efficacy against the more ... peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by ...

GlaxoSmithKline and Genmab Submit Arzerra(TM) (Ofatumumab) Application to FDA for the Treatment of Advanced Stage Blood Cancer

... that targets a membrane-proximal (close to the cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B-cells.(9) This epitope is different from the binding sites targeted by other CD20 antibodies ...

CEL-SCI Launches Study to Determine Long Lasting Beneficial Effects of its Rheumatoid Arthritis Vaccine

... research and development activities with its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) technology. L.E.A.P.S. is a novel T-cell ... peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to a T-cell binding ligand (TCBL) can be manufactured by peptide ...

Genmab Initiates Ofatumumab Phase II Study in Diffuse Large B-Cell Lymphoma

... fully human, next generation monoclonal antibody that targets a unique epitope of the CD20 receptor on the surface of B-cells. Other anti-CD20 antibodies currently available or in development bind to a different epitope on the CD20 receptor. Ofatumumab is being developed under a co-development ...

Genmab and GlaxoSmithKline Initiate Ofatumumab Rheumatoid Arthritis Phase III Program

... fully human, next generation monoclonal antibody that targets a unique epitope of the CD20 receptor on the surface of B-cells. This epitope is different than other anti-CD20 antibodies currently available or in ...

CEL-SCI Corporation Reports 2009 Second Fiscal Quarter Financial Results

... of new biological and stem cell produced products. Promising preclinical studies supporting the Company's proprietary L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology. The studies suggest that L.E.A.P.S. could potentially induce protection against illnesses such as ...

Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009

... Date and Time: Wednesday, April 22, 2009, 8:00 AM Abstract Number: 5433 TRC093 Abstract Title: Targeting the HU177 cryptic collagen epitope with humanized antibody TRC093 functions cooperatively with anti-VEGF therapy to inhibit tumor growth Presenter: Jennifer M. Roth, PhD, Maine ...

EpiVax Receives NIH Grant for $390,000 to Optimize HIV Vaccine Delivery

... as a stand-alone HIV antigen delivery system that obviates the dangers associated with non-specific activation of the immune system. epitope modification is an immunomodulatory approach EpiVax previously developed to reduce immunogenicity of protein therapeutics. Here, EpiVax ...

CEL-SCI Presents Favorable Data for Leaps Vaccine Technology at Prestigious Immunology Conference

... and Dr. Dan Zimmerman, CEL-SCI's Senior Vice President of Research and Cellular Immunology, demonstrated that immunization with a LEAPS (Ligand epitope Antigen Presentation System) vaccine altered the immunological hormone (cytokine) balance toward a Th1 environment. It has been shown that a Th1 ...

Gene Linked to Inflammatory Arthritis Also Raises Heart Risks

... of premature death from CVD in patients with inflammatory arthritis. The researchers said that, for RA patients in particular, having the shared epitope (SE) -- a group of HLA-DRB1 alleles with kindred amino acid traits -- plus anti-cyclic citrullinated peptide (anti-CCP) antibodies and being a ...
Epitope in Medical Technology

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

... that targets a membrane-proximal (close to the cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B cells.(4) This epitope is different from the binding sites targeted by other CD20 antibodies ...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

... research and development activities with its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) technology. L.E.A.P.S.(TM) is a novel T-cell ... peptides. The L.E.A.P.S.(TM) constructs containing the antigenic disease epitope linked to a T-cell binding ligand (TCBL) can be manufactured by peptide ...

Genmab A/S - Company Announcement: Recruitment Completed In Ofatumumab CLL Front Line Study

... fully human, next generation monoclonal antibody that targets a unique epitope of the CD20 molecule on the surface of B-cells. Other anti-CD20 antibodies currently available or in development bind to a different epitope on the CD20 molecule. Ofatumumab is being developed to treat CLL, ...

Genmab Reaches Milestone in Ofatumumab Collaboration

... next generation monoclonal antibody that targets a distinct small loop epitope on the CD20 receptor on the surface of B-cells. This epitope is different from the other anti-CD20 antibodies currently available or in ...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... function of the T lymphocytes that mediate the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds to an epitope of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic response that is a key component of the disease. ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... data at the annual American Society for Microbiology in Philadelphia, PA. This data demonstrates that vaccines utilizing its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology with specificity for particular Mycobacterium tuberculosis (TB) antigens can elicit immune ...

FDA Advisory Panel Makes Favorable Recommendation for GlaxoSmithKline and Genmab's ARZERRA(TM) (ofatumumab)

... About Ofatumumab Ofatumumab is an investigational monoclonal antibody that targets a membrane-proximal (close to the cell surface), small loop epitope (a portion of a molecule to which an antibody binds) on the CD20 molecule on B-cells. Ofatumumab also binds to the large loop of the CD20 molecule. ...

Circassia Begins Phase II Clinical Trial With Ragweed Allergy Therapy

... is a specialty biopharmaceutical company focused on the field of allergy. The company's range of allergy therapeutics utilizes its proprietary T-cell epitope desensitization technology, ToleroMune. Circassia's products offer potential major clinical benefits compared with existing therapies, and ...

Circassia's Allergy Therapy Begins Phase II Clinical Trial in Asthma Patients

... is a specialty biopharmaceutical company focused on the field of allergy. The company's range of allergy therapeutics utilizes its proprietary T-cell epitope desensitization technology, ToleroMune. Circassia's anti-allergy products offer potential major clinical benefits compared with existing therapies, ...

Circassia Completes Patient Recruitment for Phase II Clinical Trial of Toleromune(R) Allergy Treatment

... nearly 10% of Europeans suffering from the condition. Circassia's lead products target allergies utilizing the company's proprietary T-cell epitope desensitization technology, ToleroMune. In addition to ToleroMune's potential therapeutic benefits, its state-of-the-art manufacturing processes fit ...

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Epitope in Medical Products

Shandon TissueWave

Description:... tissue fixation and processing, decalcification of hard material, routine special stains where heat would accelerate the staining process, and for epitope enhancement during immunohistochemistry staining. Product Detail It is designed for greater flexibility to meet the growing workload ....
Company:ThermoFisher Scientific
Epitope in Medical Dictionary

Lymphocyte

... epithesis; epithet; epithiazide; epithumetical; epitomator; epitope; epitope library; epitope mapping; epitopes; epitopes, b- lymphocyte ; ... Blood and skin ...
Epitope in Biological News

NIH selects LIAI for major study on allergy molecular causes and possible treatments

... to scientists worldwide via the NIAIDs Immune epitope Database (IEDB), the worlds largest research ... bioinformatics along with the use of the allergy epitope information already in the IEDB. Bioinformatics ... advantage of that huge resource to improve our epitope identification algorithms based on that data, ...

LIAI completes world's most comprehensive analysis on influenza virus data

... date worldwide, drawing from the NIAID's Immune epitope Database, a new worldwide scientific resource ... the first time that all known antibody and T cell epitope information has been compiled in one place," said ... but would have no way of knowing if a particular epitope had been used one time, for example by a single ...

Touching Molecules With Your Bare Hands

... One region strongly associated with inhibiting epitope presentation to killer T cells corresponded to ... virus. These results indicate that avoiding epitope presentation during episome maintenance is key to ... will have to determine the responsible MHV-68 epitope and the mechanisms that engineer immune ....

How A Latent Virus Eludes Immune Defenses

... One region strongly associated with inhibiting epitope presentation to killer T cells corresponded to ... virus. These results indicate that avoiding epitope presentation during episome maintenance is key to ... will have to determine the responsible MHV-68 epitope and the mechanisms that engineer immune ....

New details on how the immune system recognizes influenza

... The analysis drew upon a much larger effort called the Immune epitope Database and Analysis Resources Program, which began in 2004 after NIAID ... and very little comes from humans or birds. In fact, only one antibody epitope came from a human. The LIAI researchers say more studies should be focused ...

Fragment of yellow fever virus may hold key to safer vaccine

... all homed in on one particular part of the protein coating the virus. The epitope is called E-71, signifying its address on the envelope protein. Several ... against yellow fever likely span the pairs by grabbing the essential epitope on one and the supporting amino acids on the other, ter Meulen speculates. ...

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Epitope in Biological Technology

ARIUS announces cancer stem cell antibody program successfully completes first toxicology study

... -Lead antibody targeting novel epitope of CD44 found in breast colon, and ... in animal models. ARIUS' program targets a novel epitope of CD44 that has been found in a number of cancer ... demonstrated that its antibody targets a novel epitope of CD44 that is present on the majority of human ...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

... H1N1" flu viruses, utilizing its proprietary L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology. The Company plans to ... peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by ...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

... that vaccines utilizing its proprietary L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology could potentially induce ... peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune / T-cell binding ligand (I/TCBL) can be manufactured ...

CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease

... which demonstrates how vaccines utilizing its L.E.A.P.S.(TM) (Ligand epitope Antigen Presentation System) vaccine technology can induce protection ... peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune / T-cell binding ligand (I/TCBL) can be manufactured ...

ExonHit Therapeutics Invested Strongly in 2008 for Pivotal 2009 Results

... - Expanding EHT 202 program to other CNS indications - Initiation of epitope discovery programs for ocular disorders with Allergan - ... a variety of ocular disease related models in order to discover novel epitope targets for the development of therapeutic antibodies. EHT/AGN ...

Genmab Reaches Milestones in Ofatumumab Collaboration

... next generation monoclonal antibody that targets a distinct small loop epitope on the CD20 receptor on the surface of B-cells. This epitope is different to the other anti-CD20 antibodies currently available or in ...

Genmab Announces Details of Planned Ofatumumab Phase II Study in Multiple Sclerosis

... fully human, next generation monoclonal antibody that targets a unique epitope of the CD20 receptor on the surface of B-cells. Other anti-CD20 antibodies currently available or in development bind to a different epitope on the CD20 receptor. Ofatumumab is being developed under a co-development ...

Genmab Announces Update on Recruitment of Patients in ofatumumab CLL Pivotal Study

... fully human, next generation monoclonal antibody that targets a unique epitope of the CD20 receptor on the surface of b-cells. This epitope is different to the other anti-CD20 antibodies currently available or in ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... mimic cell/cell interactions on the dendritic and T-cell surface with synthetic peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently linking the two peptides. Depending ...

PharmAthene Presents Data for SparVax(TM) and Valortim(R), a Novel Vaccine and Anti-Toxin for the Prevention and Treatment of Anthrax Infection at the 7th Annual ASM Biodefense Meeting

... monkeys (cynos) is believed to follow a similar disease course as in humans. Valortim(R), a fully human monoclonal antibody that binds to a distinct epitope on protective antigen, has demonstrated preliminary efficacy in the post-exposure prophylaxis and therapeutic settings in these animal models. ...

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Epitope in Biological Products

Custom Epitope Peptide Microarray from LC Sciences

Description:... are available as part of our comprehensive epitope Peptide Microarray Service. Custom Probe ... Screen your samples against thousands of possible epitope sequences for discovery, or zero in on known ... experiment. One experiment using our high density epitope - peptide microarray is equivalent to 40 or more ...
Company:LC Sciences

Epitope Peptide Microarray - Comprehensive Service from LC Sciences

Description:... LC Sciences provides a comprehensive epitope analysis service utilizing high density peptide ... Screen your samples against thousands of possible epitope sequences for discovery, or zero in on known ... tiling, and more. Thousands of customer specified epitope sequences can be synthesized on-chip and LC ...
Company:LC Sciences

PT ModuleTM Deparaffinization and Heat-Induced Epitope Retrieval Solution (10X) from Lab Vision

Description:... enzymatic digestion for some markers while not for others. Non-enzymatic epitope unmasking techniques have been recently introduced to improve the immunoreactivity of many antigens in formaldehyde fixed tissues. Heat-Induced epitope Retrieval (HIER) in EDTA buffer has been found to improve the reactivity ...
Company:Lab Vision

PT ModuleTM Deparaffinization and Heat-Induced Epitope Retrieval Solution (100X) from Lab Vision

Description:... enzymatic digestion for some markers while not for others. Non-enzymatic epitope unmasking techniques have been recently introduced to improve the immunoreactivity of many antigens in formaldehyde fixed tissues. Heat-Induced epitope Retrieval (HIER) in EDTA buffer has been found to improve the reactivity ...
Company:Lab Vision

Anti-Potassium Channel, TASK (TWIK-Related Acid Sensitive, TASK-1, cTBAK, Kcnk3) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... The epitope is specific for TASK and is not present in any other known proteins tested so far. SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues identical) ...
Company:CHEMICON

Rabbit Anti-QKI Polyclonal Antibody, Unconjugated from Bethyl Laboratories

Description:... The epitope recognized by A300-183A maps to the C-terminus of isoform 5 of human quaking homolog according to entry AAH19917.1 (GeneID 9444). The epitope is not found in isoforms 1, 2, 3, 4, 6, 7 or 7B according to TrEMBL ...
Company:Bethyl Laboratories

Rabbit Anti-Human PITPNB Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... protein beta isoform (PtdIns transfer protein beta) (PtdInsTP) (PI-TP-beta). [Source:Uniprot/SWISSPROT;Acc:P48739] Antigen: Recombinant Protein epitope Signature Tag ....
Company:Atlas Antibodies

Rabbit Anti-Human SP2 Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein epitope Signature Tag ....
Company:Atlas Antibodies

Rabbit Anti-Human C1QC Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... Complement C1q subcomponent subunit C precursor. [Source:Uniprot/SWISSPROT;Acc:P02747] Antigen: Recombinant Protein epitope Signature Tag ....
Company:Atlas Antibodies

Rabbit Anti-Human SYT16 Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein epitope Signature Tag ....
Company:Atlas Antibodies

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Epitope in Biological Definition

Monoclonal antibody

... produces antibodies that are specific not to an antigen, but to an epitope of that antigen. An epitope is a small piece of the antigen to which the antibody binds. Polyclonal ...

Immune system

... edition is ISBN 0815341016 . NCBI makes the 5th edition availiable electronically at [2] . See also antigen /antigenic determinant / epitope / hapten / memory cell autoimmune disorders CD4 receptor /CD8 receptor / perforin / apoptosis /clonal selection immunosuppression ...
Epitope in Biological Dictionary

Sequential Epitope

... A linear or a sequential epitope is an epitope that is recognized by antibodies by its linear ... most antibodies recognize a conformational epitope that has a specific three-dimensional shape and ...

Epitope

... An epitope , also known as antigenic determinant, is the ... The part of an antibody that recognizes the epitope is called a paratope. Although epitopes are ... sequences derived from the host that ... epitope ( ) n. A localized region on the surface of an ...

Conformational epitope

... A conformational epitope is a sequence of subunits composing an ... the immune system. A linear or a sequential epitope is an epitope that is recognized by antibodies by its linear ...

Antigenic determinant

... The part of an antibody that recognizes the epitope is called a paratope. Although epitopes are ... Visual Thesaurus. Pronunciation Symbols ... D. epitope or Antigenic Determinant ... In an antigen, ... is an alternative term for an epitope: See epitope ... www.PharmCast.com is the premier Web ...

Lampbrush

... form are useful model for ... ... on the basis of its immunofluorescent staining of lampbrush chromosome loops. ... a phosphorylated epitope stains lampbrush chromosome loops and small granules ... ... end of the short arms of lampbrush bivalent 2 in the chicken (Gallus ... ...

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Other Contents
(Date:4/17/2014)... Hospital Pediatrician-in-Chief Jon McCullers, MD, was recently invited ... of Nature Reviews Microbiology , one of ... a world-renowned infectious disease specialist, and chair of ... Tennessee Health Science Center, analyzed the epidemiology and ... 1968 pandemics, as well as more recent 2009 ...
(Date:4/17/2014)... MAYWOOD, Il. (April 17, 2014) Doctors who ... disease called lymphangioleiomyomatosis (LAM) can face an agonizing ... progression of the disease and help relieve shortness ... lung transplants, and sirolimus can cause potentially fatal ... said pulmonologist Dr. Daniel Dilling, medical director of ...
(Date:4/17/2014)... 2014-- Colic affects about one in five infants in ... visits during the first several months after birth. Research ... showing promise; however, the April 1, 2014 issue of ... reported on a study, "Probiotics and Infant Colic," concluding ... for infant colic did not reduce crying ...
(Date:4/17/2014)... 17, 2014 EcoHealth Alliance, a nonprofit organization that ... a comprehensive review today examining the current state of ... review calls for improved global surveillance strategies to combat ... outbreak of Ebola in West Africa that has claimed ... Guinea and Liberia. According to the World Health ...
(Date:4/17/2014)... led by Cesar A. Arias, M.D., Ph.D., at The ... has identified a new superbug that caused a bloodstream ... the April 17 issue of The New England ... part of a class of highly-resistant bacteria known as ... a major cause of hospital and community-associated infections. The ...
Breaking Medicine News(10 mins):Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:New MRSA superbug emerges in Brazil 2
(Date:4/17/2014)... and pathogens that devastate honeybees in Europe, Asia and ... do not appear to be impacting native honeybee populations ... researchers., The invasive pests include including Nosema microsporidia ... honeybees appear to be resilient to these invasive pests, ... control pests in Europe, Asia and the United States ...
(Date:4/17/2014)... many serious conditions such as heart disease, epilepsy and ... therapies. Unfortunately, there is still much scientists do not ... and unexpected insight into the structure of sodium channels ... - which are responsible for ,fine-tuning, the activity of ... recent edition of the Journal of Biological Chemistry ...
(Date:4/17/2014)... Ind. -- Indiana University researchers have detected new early-warning ... diabetes. This discovery could have far-reaching implications for the ... care of over 25 million Americans. , "We had ... retinas at such early stages," said Ann Elsner, professor ... and lead author of the study. "We set out ...
Breaking Biology News(10 mins):East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Structure of sodium channels different than previously believed 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
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