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Enzyme in Medical News

Patents Issued Covering Stable Tablet Formulation and Once Daily Dosing Regimen for Kuvan

... (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with ... developed world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for ... in most protein-containing foods. If the active enzyme is not present in sufficient quantities, Phe ...

Patient Enrollment Complete for Phase I/II Clinical Trial for GALNS for Morquio A Syndrome

... has developed and manufactures two FDA-approved enzyme replacement therapies, one for the treatment of ... conditions caused by the underlying enzyme deficiency. The incidence estimates for ... clinical and pre-clinical trials related to the enzyme replacement therapy for MPS IVA; the content and ...

Solvay Pharmaceuticals, Inc. Announces Commercial Availability of CREON(R) (Pancrelipase) Delayed-Release Capsules

... CREON(R) is the first and only pancreatic enzyme product (PEP) to receive FDA approval under new ... CREON(R) is the first "zero-overfill" pancreatic enzyme product, meaning that the capsules target 100% of ... that CREON(R) is the first and only pancreatic enzyme product to receive FDA approval and to meet the ...

Verenium and Add Food Service GmbH Announce Commercial Distribution Partnership for Fuelzyme(R) and Veretase(TM) Enzymes

... agreement. Add Food Service is a leading enzyme solutions company for both industrial and food ... jointly pursuing the development of additional enzyme products for starch processing and the ... companies for the development of new innovative enzyme products for starch processing is an opportunity ...

Lung Enzyme Both Friend and Foe

... WEDNESDAY, June 17 (HealthDay News) -- An enzyme involved in the development of emphysema also ... that mice that didn't have the gene to make this enzyme could not clear bacteria well and were more ... activity comes from a small part of the enzyme that's structurally and sequentially unique. ...

Structures from the human immune system's oldest branch shed light on a range of diseases

... both involving a central component of an enzyme important to the complement system of the immune ... a microbe, the proteins ultimately form a complex enzyme called C3 convertase, initiating a cascade of ... central component of C3 convertase, C3b forms an enzyme complex that cleaves its parent molecule C3, ...

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Enzyme in Medical Technology

Shire Reports Positive Results From First of Three Phase III Trials of velaglucerase alfa for Type 1 Gaucher Disease and Provides Important Updates on Interactions With FDA

... Phase III studies of velaglucerase alfa, its enzyme replacement therapy in development for ... proprietary technology, in a human cell line. The enzyme produced has the exact human amino acid ... Gaucher Disease results from a specific enzyme deficiency in the body, caused by a genetic ...

Shire Receives Fast Track Designation for velaglucerase alfa for Gaucher Disease

... (FDA) for velaglucerase alfa, its enzyme replacement therapy in development for the ... proprietary technology, in a human cell line. The enzyme produced has the exact human amino acid ... Gaucher Disease results from a specific enzyme deficiency in the body, caused by a genetic ...

Shire has Filed a Treatment Protocol for Velaglucerase Alfa for Gaucher Disease

... a treatment protocol for velaglucerase alfa, its enzyme replacement therapy in development for the ... proprietary technology, in a human cell line. The enzyme produced has the exact human amino acid ... Gaucher Disease results from a specific enzyme deficiency in the body, caused by a genetic ...

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... enroll approximately 60 subjects who are naive to enzyme replacement therapy (ERT) or who have not ... and females with Fabry disease as compared to enzyme replacement therapy (ERT). The Agency agrees ... resulted in increased levels of the target enzyme (a-Gal A), as measured in white blood cells and ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... and biological effects of restoring SERCA2a enzyme activity in heart muscle cells. The enzyme levels are decreased in late stages of heart ... of the heart to contract properly. Replacing the enzyme may restore function and reverse heart failure. ...

Celladon Corporation Announces Presentation of First-in-Human Gene Transfer to Treat Heart Failure at the 12th Annual Meeting of the American Society of Gene Therapy

... Safety Profile and Biological Effects of SERCA2a enzyme Replacement SAN DIEGO, May 26 /PRNewswire/ ... that results from its genetically targeted enzyme replacement therapy for advanced heart failure, ... of heart failure is the depletion of SERCA2a enzyme in heart muscle cells, which results in abnormal ...

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Enzyme in Medical Products

Prolactin ELISA Kit

Description:... Prolactin ELISA Kit is enzyme immunoassay kit for the quantitative determination of Human Prolactin (PRL) concentration in serum. enzyme immunoassay (EIA) permits the routine ... reproducible, rapid and specific assay. This enzyme immunoassay method makes it possible to measure ...
Company:Anogen

TPO (Ab) EIA Thyroid Function 012-MDKAM-1 Thyroid Peroxidase

Description:... The anti-TPO test kit is a solid phase enzyme immunometric assay (ELISA) in microplate format. ... to the antigen are specifically recognized by the enzyme labeled antibodies, and a sandwich complex is formed. An excess of enzyme conjugate is washed out. Phase 3: A ...
Company:ALPCO Diagnostics

TG (Ab) EIA Thyroid Function 012-MDKAT-1 Thyroglobulin anti-tg

Description:... The anti-TG test kit is a solid phase enzyme immunometric assay (ELISA) in microplate format. ... to the antigen are specifically recognized by the enzyme labeled antibodies, and a sandwich complex is formed. An excess of enzyme conjugate is washed out. Phase 3: A ...
Company:ALPCO Diagnostics

ACE - REA Hypertension / Cardiac Evaluation, Cardiovascular 001-RK-ACD Angiotensin Converting Enzyme

Description:... Angiotensin Converting enzyme (ACE), also known as Kininase II, is a dipeptidyl ... as soluble enzyme. Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II. The enzyme also mediates the cleavage of a synthetic ...
Company:ALPCO Diagnostics

Insulin Jumbo EIA Diabetes and Obesity Markers 008-10-1113-99

Description:... The ALPCO Insulin ELISA is a solid phase two-site enzyme immunoassay. It is based on the direct sandwich ... wells. A simple washing step removes unbound enzyme labeled antibody. The bound conjugate is ... ALPCO Insulin ELISA is a solid phase two-site enzyme immunoassay. It is based on the direct sandwich ...
Company:ALPCO Diagnostics

Streck-Kleen Enzymatic Cleanser

Description:... use on Coulter MD Series instruments that require manual addition of an enzyme cleaner. Maximum enzyme activity is a feature of this product. The shelf life of Streck-Kleen is ...
Company:Streck

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Enzyme in Medical Definition

Hematopathology

... pathology Clinical chemistry - Hematopathology - Transfusion medicine - Medical microbiology - Diagnostic immunology enzyme assay - Mass spectrometry - Chromatography - Flow cytometry - Blood bank - Microbiological culture - Serology v • d ...

Medical procedure

... Symptomatic treatment Fluid replacement therapy Palliative care Hyperbaric oxygen therapy Oxygen therapy Gene therapy enzyme replacement therapy Intravenous therapy Kinesiotherapy Phage therapy Serotherapy Respiratory therapy Vision therapy ...

Pathology

... pathology Clinical chemistry - Hematopathology - Transfusion medicine - Medical microbiology - Diagnostic immunology enzyme assay - Mass spectrometry - Chromatography - Flow cytometry - Blood bank - Microbiological culture - Serology v • ...
Enzyme in Medical Dictionary

Absorption

... liver if the gallbladder has been removed), enzyme s from the pancreas , and a normal intestine s. ... gallbladder problems not enough digestion enzyme s stomach surgery ( gastrectomy ) problems ... blood stream, the nervous system, hormone s and enzyme s, all working together. Most digestion and ...

Alpha

... amounts. ALPHA -ANTITRYPSINS - A specific enzyme ( alpha 1 antitrypsinase) that when absent ... deficiency Congenital lack of an enzyme that leads to cirrhosis of the liver and ... NEIL SA DIC K, MD: 5 alpha reductase is an enzyme that is felt to play a major role in genetic ...

ALP

... ALP HA -ANTITRYPSINS - A specific enzyme ( alp ha 1 antitrypsinase) that when absent ... a blood test that measures the amount of the enzyme ALP (alkaline phosphatase). R ALP H L. ... (ionized) ALP (alkaline phosphatase) iso enzyme ... ...

ALT

... ALT (alanine aminotransferase): An enzyme normally present in liver and heart cells ... into the blood stream, causing levels of the enzyme to rise. ALT ERNATIVE & COMPLEMENT ... ا"طبي ... ALT (Alanine Aminotransferase) - enzyme or protein that leaks from the damaged liver ....

Amino acids

... s and chemotherapy . - Amino Acids - enzyme - Hepatic - Necrosis - Penis - Protein ... s. With added amino acids , antioxidants, enzyme s and herbs, it might seem like dietary ... amino acids , dietary substances such as enzyme s, and food extracts, such as the isoflavones ...

Amylase

... An amylase test measures the amount of this enzyme in a sample of blood taken from a vein or in a sample of urine . Amylase is an enzyme that helps digest glycogen and starch. It is ... escapes into the blood . AMYLASE : An enzyme secreted by the salivary gland s and the ...

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Enzyme in Biological News

Experimental treatment halts hypoxic-ischemic brain injury in newborns

... CINCINNATI Inhibiting an enzyme in the brains of newborns suffering from oxygen ... according to the researchers. The enzyme in this case, tPA, normally breaks down proteins ... leads to increased tPA activity. The enzyme then damages the brain blood vessels and the ...

'Corrective genes' closer thanks to enzyme modification

... Chemistry . "Our team modified and decoded an enzyme structure," says Joelle Pelletier, a professor at ... that our intervention allowed the heart of the enzyme to increase its mobility. This unusual mobility caused the enzyme to resist the chemotherapy agent methotrexate a ...

University of Minnesota research leads to new technology to protect human health

... Minnesota's BioTechnology Institute, developed an enzyme that is used in Bioo Scientific's new ... in the MaxDiscovery Melamine Test kit and the enzyme will be produced in the BTI Pilot Plant ... associate in Wackett's lab, discovered the enzyme while conducting research on biodegradation of ...

Munich researchers discover new target for tailored antibiotics

... step in bacterial isoprene synthesis. The crucial enzyme has a most unusual structure, similar to a ... of the terminal step catalyzed by the IspH enzyme remained stubbornly elusive. Earlier measurements ... and for many years the crystal structure of the enzyme that would provide the proof could not be ...

Toxin detection as close as an inkjet printer

... and the resulting bio-ink forms a thin film of enzyme that is entrapped in the silica on paper. When the enzyme is exposed to a toxin, reporter molecules in the ... The research showed that the printed enzyme retains full activity for at least two months ...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

... of the basic causes of asthma." The enzyme is involved in the metabolism of arachidonic ... disorders, Hammock explained. "It's an enzyme in the same arachidonic biochemical pathway ... cell biologist Sarjeet Gill discovered the enzyme in 1969 at UC Berkeley. Hammock holds a joint ...

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Enzyme in Biological Technology

DuPont and Arzeda Collaborate to Develop Improved Crops to Increase Productivity

... Custom enzyme Design Technology to Bring More Options to Global ... and are currently inaccessible using traditional enzyme engineering approaches. Arzeda was founded by ... and further develop its computational enzyme design technology. Arzeda's team includes the ...

Kuvan Receives Priority Review Status From Health Canada

... (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with ... developed world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for ... in most protein-containing foods. If the active enzyme is not present in sufficient quantities, Phe ...

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

... SNAP or CLIP tag, which is essentially a suicide enzyme with a capability of one successful reaction ... expressed on the cell surface. "Given that enzyme substrate reactions have the highest order of ... only when the substrates come in contact with the enzyme active site," observes Dr. Basu. "Hence, ...

The Journal of Cardiac Failure Publishes Results From Celladon Corporation's First-in-Human Phase 1/2 Clinical Trial in Advanced Heart Failure

... Safety and Biological Effects of SERCA2a enzyme Replacement Using Gene Transfer SAN DIEGO, ... MYDICAR(R) (AAV1/SERCA2a), a genetically targeted enzyme replacement therapy for advanced heart failure, ... attempt to rescue a failing heart by replacing an enzyme known to play a critical role in normal cardiac ...

BioMarin Receives Notice of Allowance for Once Daily Dosing Patent for Kuvan

... (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with ... developed world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for ... in most protein-containing foods. If the active enzyme is not present in sufficient quantities, Phe ...

Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting

... to maintain elevated levels of the target enzyme (a-Gal A), as measured in white blood cells, and ... gene, which result in deficient activity of the enzyme alpha-galactosidase A (a-Gal A). Deficient a-Gal ... A, which facilitates proper trafficking of the enzyme to the lysosomes, where it is needed to break ...

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Enzyme in Biological Products

Gelzyme enzyme from Invitrogen

Description:... Gelzyme is an agarose-digesting enzyme isolated from Pseudomonas atlantica. Gelzyme enzyme cleaves simple carbohydrate bonds in agarose ... DNA manipulation. DNA isolated with Gelzyme enzyme can be used for restriction endonuclease ...
Company:Invitrogen

Mouse Anti-Porcine Pyruvate Dehydrogenase (PDH), complex Immunocapture Kit Monoclonal Antibody, Protein G-Agarose Conjugated, Clone 15D3G9C11 from MitoScience LLC

Description:... of the complex. Pyruvate dehydrogenase is a key enzyme in energy metabolism. It converts pyruvate that ... described for measuring this activity while the enzyme is still bound to the capture beads or fixed in a ... diabetes (NIDMM) and the response of the enzyme complex to diet, exercise and ....
Company:MitoScience LLC

FailSafe PCR System w/choice of two PreMix Tubes from EPICENTRE Biotechnologies

Description:... This system uses EPICENTRE's FailSafe™ PCR enzyme Mix, a unique blend of thermostable enzymes that ... to determine error rates, the FailSafe enzyme Mix has a fidelity at least 3 times higher than ... The system includes the FailSafe™ PCR enzyme Mix and a choice of two FailSafe™ PreMixe ...
Company:EPICENTRE Biotechnologies

FailSafe PCR PreMix Selection Kit from EPICENTRE Biotechnologies

Description:... This system uses EPICENTRE's FailSafe™ PCR enzyme Mix, a unique blend of thermostable enzymes that ... to determine error rates, the FailSafe enzyme Mix has a fidelity at least 3 times higher than ... The system includes the FailSafe™ PCR enzyme Mix, an extensively tested set of 12 ...
Company:EPICENTRE Biotechnologies

MasterAmp Taq DNA Polymerase Kit from EPICENTRE Biotechnologies

Description:... above 70°C, it was the first thermostable enzyme used for PCR and remains the predominant enzyme for that purpose. The enzyme has an intrinsic 5'?3' structure-dependent ...
Company:EPICENTRE Biotechnologies

FailSafe PCR System w/choice of 8 PreMix Tubes from EPICENTRE Biotechnologies

Description:... This system uses EPICENTRE's FailSafe™ PCR enzyme Mix, a unique blend of thermostable enzymes that ... to determine error rates, the FailSafe enzyme Mix has a fidelity at least 3 times higher than ... The system includes the FailSafe™ PCR enzyme Mix and a choice of 8 FailSafe™ Premix ....
Company:EPICENTRE Biotechnologies

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Enzyme in Biological Definition

Active site

... The active site of an enzyme is the binding site where catalysis occurs. ... inhibition , the inhibitor binds to the enzyme at another site, the allosteric site , and this causes a structural change in the enzyme such that the active site is rendered useless. ...

Allostery

... In biochemistry , an enzyme or other protein is allosteric if its ... Nemethy, and Filmer. Both postulate that enzyme subunits exist in one of two conformations, ... The concerted model of allostery postulates that enzyme subunits are connected in such a way that a ...

Allostery

... In biochemistry , an enzyme or other protein is allosteric if its ... Nemethy, and Filmer. Both postulate that enzyme subunits exist in one of two conformations, ... The concerted model of allostery postulates that enzyme subunits are connected in such a way that a ...

Apoptosis

... nucleus, is cell suicide triggered by the nuclear enzyme poli(ADP-ribose) polymerase-1, or PARP-1. This enzyme plays a crucial role in maintaining genomic ... and purified interleukin-1-beta converting enzyme (ICE) in human cells, and succeeded in cloning ...

ATPase

... reaction releases energy , which the enzyme (in most cases) harnesses to drive other ... mitochondria and chloroplasts is an anabolic enzyme that harnesses the energy of a transmembrane ... a molecule of adenosine triphosphate (ATP). This enzyme works when a proton moves down the concentration ...

Competitive inhibitor

... acts on the same active site as the normal enzyme substrate . The substrate molecules cannot enter ... In this mode of inhibition, the activity of the enzyme is completely blocked by the inhibitor and ... the concentration of substrate does not restore enzyme activity. The kinetics of these activities is ...

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Enzyme in Biological Dictionary

Transposase

... Transposase is an enzyme that binds to the ends of a transposon and ... HyperMu™ MuA Transposase is a hyperactive. enzyme that is at least 50 times more active ... MuA ... and thus ... Tn5 transposase is the key enzyme in forming transposomes for random transposon ...

Transcriptase

... DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into ... transcriptase , a viral DNA polymerase enzyme that retroviruses need to reproduce. ... Reverse transcriptase is a common name for an enzyme that functions as a RNA ... All retroviruses ...

Telomerase

... Telomerase is an enzyme that adds specific DNA sequence repeats to ... material, ... telomerase ( ) n. An enzyme that is found in the telomeres of chromosomes ... of a major domain of telomerase , the enzyme that helps maintain telomeres – small ...

Reverse transcriptase

... DNA polymerase, is a DNA polymerase enzyme that transcribes single-stranded RNA into ... reverse transcriptase , a viral DNA polymerase enzyme that retroviruses need to reproduce. Moloney ... is an RNA-directed DNA polymerase. This enzyme can synthesize a complementary DNA strand ...

Retrovirus

... that is replicated in a host cell via the enzyme reverse transcriptase to produce DNA from its ... to RNA, retrovirus particles also contain the enzyme reverse ... When a retrovirus infects a cell, ... is a type of RNA virus that contains the enzyme reverse ... The genome of the retrovirus is ...

Restriction enzymes

... A restriction enzyme is an enzyme that cuts double-stranded or single stranded DNA ... archaea, are thought to ... restriction enzyme n. Any of a group of enzymes that catalyze the ...

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Other Contents
(Date:8/23/2014)... Cardiomyopathy (heart muscle disease) is ... myocardium (the heart muscle) for any reason, usually ... (breathlessness) and peripheral edema (swelling of the legs). ... dangerous forms of irregular heart beat and sudden ... is dilated cardiomyopathy. , Clinical trial report, “Cardiomyopathy ...
(Date:8/23/2014)... New York (PRWEB) August 23, 2014 ... from the 2012 GranuFlo and NaturaLyte dialysis concentrate ... litigation underway in U.S. District Court, District of ... updated docket report issued by the U.S. Judicial ... at least 2,028 claims are pending in the ...
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(Date:8/23/2014)... New York, NY (PRWEB) August 23, 2014 ... Times (NYT) reported on a data breach suffered ... nationwide, that saw the compromise of 4.5 million records ... and social security numbers. According to Mandiant, who was ... attack emanated from an advanced group of cyber ...
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(Date:8/22/2014)... is available in German . ... in PCFs proteins are fixated in a way so ... Next, the HZB and Fudan University researchers are planning ... functional materials. Their findings are being published today in ... , Proteins are sensitive molecules. Everyone knows that ...
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(Date:8/21/2014)... -- A new study of American singles found ... have the highest orgasm rates. On average, men ... their sexual orientation making little difference. For women, ... women experience orgasm 62.9 percent of the time ... this pattern varies with women,s sexual orientation, with ...
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