Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
...ly and turned up the function of sterol responsive element binding proteins. These important parts of the mechanism activate many key genes of lipid biosynthesis involving the pathways of cholesterol and triglycerides; these genes directed the liver to manufacture more cholesterol, which it does in the form ...Novel Enzyme Shows Potential As An Anti-HIV Target
...ral transcripts called the trans-acting responsive element (TAR). Tat binding to TAR requires recruiting the enzyme cyclin-dependent kinase 9 (CDK-9) to the HIV promoter (where transcription begins). CDK-9 chemically modifies the RNA polymerase and enhances its transcribing efficiency. The transcription pro...An HIV Protein Plays a Surprising Role in Gene Activation
...ging viral RNA called the transactivation response element (TAR). Once bound, Tat recruits a cellular complex called P-TEFb (consisting of two subunits) to the HIV promoter, and enhances RNA polymerase's transcribing capacity. Previous studies in yeast had shown that activators appear to stimulate transcript...New Clues Add 40,000 Years to Age of Human Species
...everal decades, the Kibish fossils have been a key element in arguments for an ancient origin of modern humans in Africa, yet one for which the age and provenance of the fossils was repeatedly contested,?notes Fleagle. At the request of their Ethiopian colleague Zelalem Assefa, now at the National Museum of......ics, new biological sciences, and the unique human element that Internet communication now provides" says Jefferson. ...DASGIP BioBlock from DASGIP AG
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...e following enhancer elements: cyclic AMP response element (CRE), serum response element (SRE), nuclear factor B (NF- k B), activator protein 1 (AP-1), serum response factor (SRF), ...Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results
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...he luciferase gene downstream from abasic promoter element (TATA box) joined to five tandem repeats of the 17-bpGAL4 binding element, was used in the experiment to optimizing the trans-reportingsystem. The cis-reporter plasmid was used in experiments to optimize the cis-reportingsystem, as indicated in the F...Is there a link between bones and memory?
...s of long-term estrogen exposure may be a critical element in the preservation of verbal memory with aging," Zhang and colleagues conclude....A new treatment for liver cancer
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