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Electroporation in Medical News

Hepatitis C Therapeutic DNA Vaccine Delivered by Inovio Biomedical's Electroporation Technology Reduces Viral Load by Up to 99.7% : Clinical Data Presented at Annual Scientific Meeting of the American Association for the Study of Liver Diseases

... immune response against the virus. Inovio's electroporation technology is being used to deliver the vaccine ... using its novel method for DNA delivery – electroporation – which uses brief, controlled electrical ... statements relating to our plans to develop our electroporation drug and gene delivery technology. Actual events ...

Therapeutic DNA Vaccine Company Inovio Biomedical Reports Second Quarter 2008 Financial Results

... R&D and clinical studies using Inovio's electroporation delivery technology. More details can be found in ... that the combination of this DNA vaccine and electroporation DNA delivery was safe and well-tolerated. Patients treated using electroporation displayed higher levels of antibody and cellular ...

First evidence for DNA-based vaccination against chronic hepatitis C

... trial of a therapeutic vaccination using naked DNA delivered by in vivo electroporation (EP), antiviral effects were shown in patients with hepatitis C (HCV). ... cytomegalovirus immediate-early promoter (ChronVac-C) delivered by in vivo electroporation (EP). A first phase I/IIa clinical trial in HCV infected patients is ...

Hebrew University scientist develop technique for eliminating reblockage of arteries

... The technique employs the biophysical phenomenon of irreversible electroporation (IRE). IRE destroys cells within seconds, using very short electric field ... other structures in the treated area. While the phenomenon of irreversible electroporation was known for decades, a team led by Prof. Rubinsky developed a new mode ...

Device aims to decrease wait period for patients needing immunotherapy

... meeting of the American Society for Blood and Marrow Transplantation in Tampa, FL, today. Choi's device, called HitMeD (high throughput medical electroporation device), has been used for preclinical studies in treatment of acute lymphocytic leukemia (ALL), with early results indicating it has the potential ...

Rhode Island Hospital first in US to treat kidney tumor with new device using electrical pulses

... procedure -- the first time it has been used on a kidney tumor in the United States. NanoKnife is an image-guided device that uses "irreversible electroporation (IRE) technology" -- pulses of electricity that selectively destroy tumor cells while sparing nearby nerves, blood vessels and other delicate ...

United States Department of Defense Selects Ichor Medical Systems to Develop Biodefense Vaccine

... WIRE)--Ichor Medical Systems, whose advanced electroporation system is being used worldwide to increase the ... products based on the in vivo application of electroporation to enhance intracellular delivery of DNA drugs ... and reproducible clinical application of electroporation in a manner capable of supporting development and ...

Scientists Destroy Cancer Cells Using Electric Pulses

... cancer soon . The development of the process called irreversible electroporation (IRE) is a result of the efforts of Virginia Techbiomedical engineer ... Boris Rubinsky. For decades, researchers have been aware of electroporation increasing the permeability of a cell from none to a reversible opening to ...

Attacking therapy with electricity

... close up again so the drug stays inside. Research so far has applied electroporation to cancer chemotherapy, the delivery of DNA for gene therapy, and to the ... development, for head and neck tumours, for example. In the future, electroporation could be very widely applied for drug delivery. ...
Electroporation in Medical Technology

Breakthrough Large Scale Transfection Technology Accelerates Cell-Based Assay Development

... preparative transfection technologies which depend on expensive and complicated virus constructs, lipid based transfection agents, or small scale electroporation devices. The high efficiency and viability of cells processed by the MaxCyte ITF Inline Transfection System make it possible to focus on ...

Inovio Biomedical's DNA Delivery Technology Significantly Enhances Potency of HIV DNA Vaccine

... against HIV delivered using Inovio Biomedical's electroporation technology. The paper, titled "Effect of plasmid ... concluded: "These results indicate that in vivo electroporation appears safe and can dramatically improve the ... -- Vaccination in combination with in vivo electroporation led to a more rapid onset and enhanced ...

Inovio Biomedical's Partners to Present New Data from Two Cancer Immunotherapy Clinical Trials

... of plasmid-based immunotherapies using Inovio's electroporation delivery technology at the Third International ... of Inovio will present a general overview of electroporation delivery of immunotherapy products currently in ... products delivered using our proprietary electroporation technology," stated Avtar Dhillon, MD, Inovio's ...

Inovio: DNA delivery technology shows positive human results

... DNA Vaccine Clinical Trial Using Inovio’s electroporation DNA Delivery Technology SAN DIEGO, May 22, ... by a third party, delivered by Inovio’s electroporation technology. The results demonstrated safety, ... groups demonstrated the following points: 1. electroporation appears safe and it is well tolerated. 2. The ...

Vical's Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA Vaccine Performance; Yields Antibody Responses Comparable to Electroporation Without Tolerability Issues

... needle and syringe. In a separate animal study, electroporation following injection of unformulated vaccine ... improvements in antibody responses, but electroporation required anesthesia of the animals while ... or a constant current multi-needle device. Both electroporation devices and the Vaxfectin(TM)/needle-free device ...

Inovio Biomedical's DNA Delivery Technology Shows Safety and Enhances Gene Expression & Tumor Responses in Interim Melanoma Clinical Study Results

... a DNA-based immunotherapy delivered by Inovio's electroporation technology was safe and tolerable, facilitated ... delivery of plasmid-based IL-12 using Inovio's electroporation technology. Interim results from 24 subjects are ... against the targeted disease. Inovio's advanced electroporation devices facilitate delivery and expression of ...

Inovio Biomedical Highlights Enhanced DNA Vaccine Potency with Electroporation DNA Delivery Technology and New Devices at Gene Therapy Meeting

... hepatitis C, respectively. In all cases, Inovio's electroporation technology was well tolerated and significantly ... Sweden, supported the safety of electroporation in detailed experiments and demonstrated that ... Two other Inovio presentations reported electroporation device innovations including the Elgen 1000 ...

Vical Interim Clinical Results Demonstrate Safety and Tolerability of Inovio Biomedical's Electroporation DNA Delivery Technology

... an ongoing Phase I clinical trial using Inovio's electroporation technology for intratumoral delivery into ... is by intratumoral injection (followed by electroporation to facilitate cellular uptake) of a plasmid DNA ... by Vical add to a body of data suggesting that electroporation of plasmid-based immunotherapeutics can induce ...

Interferon Beta DNA Treatment Delivered with Ichor Technology Reduces Atherosclerosis Progression in Mice

... be consistent among different operators and patients. As a result, Ichor's TriGrid enables safe, effective and reproducible clinical application of electroporation in a manner capable of supporting development and commercialization of DNA-based products. The Ichor system is currently being used on three ...

VGX Pharmaceuticals' Novel HIV and Pandemic Influenza DNA Vaccine Candidates Trigger Robust Immune Responses and Protection in Pre-Clinical Models

... protective effects. All of the vaccines were delivered using VGX's proprietary CELLECTRA(TM) DNA Delivery Device. CELLECTRA(TM) is a novel adaptive electroporation device developed by VGX. The avian flu data was presented by Dr. Ruxandra Draghia-Akli, VGX Vice President, Immune Therapeutics Research. ...

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Electroporation in Biological News

Commercialization aim of grant supporting technology that destroys cancer cells

... development. The technology, irreversible electroporation (IRE), was invented by Davalos and Boris ... at the University of California, Berkeley. electroporation is a phenomenon that increases the permeability ... die. For decades, biologists have used reversible electroporation in laboratories to introduce drugs and genes into ...

Society of Interventional Radiology Foundation awards $191,000 in grants

... of Outcome of RFA and TACE in HCC Patients," and Christina Ma, "Evaluation of 18F-FDG PET/CT in Monitoring Tumor Ablation Efficacy of Irreversible electroporation (IRE) on Rabbit VX2 Liver Tumor," all at the UCLA Medical Center, Los Angeles, Calif., and Shantanu Gaur, Harvard Medical School, Boston, Mass., ...

Researchers test new therapy for advanced melanoma

... clinical trial because it is the first time that electroporation is being used to deliver plasmid DNA in a gene ... develop the technology used in the study. electroporation is a technique in which a hand-held device ... has been getting the gene into the cancer. If electroporation can deliver the gene to these tumors reliably and ...
Electroporation in Biological Technology

ImmunoVaccine Technologies Partners With Scancell to Advance DNA Vaccine Delivery

... for certain infectious diseases where alternative delivery methods such as electroporation may be less suitable." commented David Evans, chairman of Scancell. ... for the treatment of melanoma and will enter clinical trials using electroporation technology in early 2010. This press release contains forward-looking ...

Hebrew University scientist develop technique for eliminating reblockage of arteries

... The technique employs the biophysical phenomenon of irreversible electroporation (IRE). IRE destroys cells within seconds, using very short electric field ... other structures in the treated area. While the phenomenon of irreversible electroporation was known for decades, a team led by Prof. Rubinsky developed a new mode ...

Vista Partners Updates Coverage on Inovio Biomedical Corporation (Amex: INO); $3.57 Price Target

... Inovio Biomedical (Amex: INO ) is focused on developing multiple DNA-based immunotherapies. Inovio is a leader in developing human applications of electroporation using brief, controlled electrical pulses to increase cellular uptake of a useful biopharmaceutical. Interim human data has shown that Inovio's DNA ...

Vista Partners Updates Coverage on Inovio Biomedical Corporation (Amex: INO) With $3.52 Price Target

... Inovio Biomedical (AMEX: INO ) is focused on developing multiple DNA-based immunotherapies. Inovio is a leader in developing human applications of electroporation using brief, controlled electrical pulses to increase cellular uptake of a useful biopharmaceutical. Interim human data has shown that Inovio's DNA ...

Transient Gene Expression Following Single and Double Exponential Decay Electroporation Pulses

... Summary A double pulse format for electroporation of mammalian tissue culture cells gave ... The Twin-pulse wave delivery is a novel electroporation waveform consisting of a short ... and de Villartay described the use of double electroporation pulse format to introduce pairs of ...

Transgenic Zebrafish by Electroporation

... times for electroporation. electroporation Up to two hundred embryos are rinsed ... dish in fresh dH 2 0 at 26 C. Sham electroporation is done with PBS/-Ca ++ alone. ... indicate that over 50% of the animals survive the electroporation conditions, and that over 50% of the ...

Transformation of Filamentous Fungi by High-Voltage Electroporation

... period of exposure to DNA. However, electroporation could also be useful for introducing genes into filamentous fungi. Recently, electroporation has become a valuable technique for ... Results electroporation of germinative tubes or mycelia from T. harzianum ...

Electroporation of Yeast Artificial Chromosomes

... reasonable efficiencies with larger YACs. Several electroporation protocols have recently been reported ... used YAC cloning procedure, we investigated the electroporation of S. cerevisiae strain AB1380 (Mat a, ... reported in a previously published YAC electroporation protocol. 7 Materials and ...

Electroporation of Primary Bone Marrow Cells

... mice, washed, and resuspended in electroporation medium, at 7-9 x 10 6 cells/ml. ... (v/cm) and pulse time constant. We found that electroporation conditions of 625-750 V/cm and time ... cells. With phosphate buffered sucrose electroporation medium, the 25 F capacitor was used to ...

High Electrotransformation Efficiencies Obtained With DNA From Ligation Mixtures

... It has become clear that electroporation of E. coli results in significantly ... for directional cloning of the cDNA.) electroporation One l aliquots of the sample DNA were ... precipitation or dilution before electroporation in order to achieve optimal transformation ...

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Electroporation in Biological Products

HT 96/200 Advanced Electroporation System from BTX

Description:... BTX, the leader in electroporation products and specialty electrodes, has developed ... and large volume electroporation. The Advanced electroporation System is a breakthrough in Molecular Delivery. ... could test are all about to change. MOS Advanced electroporation Systems The Methods Optimization Systems, MOS 25 ...
Company:BTX

Gene Pulser/E. coli Pulser Cuvette Rack from Bio-Rad

Description:... the original Gene Pulser apparatus and accessory modules the most popular electroporation system available has been applied in the Gene Pulser II system, which ... II system minimizes variation among experiments and delivers consistent electroporation over the lifetime of the unit. With the Gene Pulser II system, the ...
Company:Bio-Rad

Gtporator (4 ml) from GEN-TREND s.r.o.

Description:... Highly efficient electroporation solution suitable for transfection of plasmid DNA, oligonucleotides and siRNA. Compatible with all common ....
Company:GEN-TREND s.r.o.

Gene Pulser Xcell Microbial System from Bio-Rad

Description:... The Gene Pulser Xcell microbial system, 100 to 240 V, 50-60 Hz, is used for electroporation of bacterial and fungal cells. This system includes the main unit, PC module for exponential decay delivery, ShockPod shocking chamber, 10 sterile ...
Company:Bio-Rad

Gene Pulser Xcell Eukaryotic System from Bio-Rad

Description:... The Gene Pulser Xcell eukaryotic system, 100 to 240 V, 50-60 Hz, is used for electroporation of mammalian cells. This system includes the main unit, CE module for exponential (25-3,275 microfarad range) or square-wave pulses, ShockPod ...
Company:Bio-Rad

OPTIMIX KIT FOR EUKARYOTE from Thermo Scientific

Description:... OptiBuffer is a fully optimised medium, designed for the electroporation of eukaryotic cells. OptiBuffer improves both transfection efficiencies and survival rates over PBS or other standard culture ....
Company:Thermo Scientific

Frozen-EZ Yeast Transformation II Kit from Zymo Research

Description:... and polyethylene glycol has made routine plasmid transformations and library screening easy and reliable, especially when compared to techniques like electroporation and spheroplasting procedures. The Frozen-EZ Yeast Transformation II Kit is designed to make yeast transformations easier and more efficient than ...
Company:Zymo Research

siPORTer™-96 Electroporation Chamber from Ambion

Description: Highly efficient delivery of siRNA while maintaining high cell viability Electroporate up to 96 samples simultaneously Fast: less than one hour from cell harvest to post-electroporation incubation Highly reproducible results from well-to-well Designed for use with the Bio-Rad Gene ...
Company:Ambion

ECM 630 Electroporation System from BTX

Description: ...
Company:BTX

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Electroporation in Biological Definition

Molecular biology

... either bacterial or animal cells. Introducing DNA into bacterial cells is called transformation , and can be effected by several methods, including electroporation , microinjection and chemically. Introducing DNA into eukaryotic cells, such as animal cells, is called transfection. Several different ...
Electroporation in Biological Dictionary

Electroporation

... electroporation , or electropermeabilization, is a significant ... electrical field. It is usually used ... electroporation ( i′lektrōpə′rāshən ) ( biology ) The ... cell membranes Transformation of E. coli by electroporation ... For ...

Competent

...... our competent cells feature the widest range of cloning efficiencies available. ... competent cell performance for your chemical and electroporation transformations. ... What makes a person " competent ?" Who designates a competent person? ... Does a competent person have to be a ...
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(Date:7/9/2014)... has risen dramatically in Western societies. One frequently cited ... and have fewer infections than previous generations, thereby delaying ... researchers at Sahlgrenska Academy, University of Gothenburg, monitored children ... the immune system in relation to allergic disease. All ... Vstra Gtaland Region, half of them on farms that ...
(Date:7/8/2014)... Restoration has been awarded up to $15 million by ... four -year project aiming to help brain-injured people restore ... neurosurgery, engineering, neurobiology, psychology and physics will collaborate to ... the brain. , Memory is the process in which ... store it and retrieve it. Certain types of illnesses ...
(Date:7/8/2014)... hygiene rates were found to be three times higher ... there were no auditors present, according to a study ... The study, titled, "Quantification of the Hawthorne effect in ... a retrospective cohort study," published today on-line in the ... author Dr. Jocelyn Srigley, who did the study as ...
(Date:7/8/2014)... have increased risks of dying at a young age ... stroke, diabetes, and kidney and liver diseases, according to ... large studies of people from three countries. The study, ... part of the National Institutes of Health, found that ... dramatic reduction in life expectancy compared with people of ...
(Date:7/8/2014)... Military physicians will soon pick up joysticks instead of ... with serious health threats. , James Gerard, M.D., a professor ... grant from the Department of Defense Office of Naval ... a video game that will train physicians on pediatric emergency ... use one of the most popular tools gaming ...
Breaking Medicine News(10 mins):Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 2Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 3Health News:NCI study finds extreme obesity may shorten life expectancy up to 14 years 2Health News:Save, don't kill: SLU pediatrician to develop educational video game for training military physician 2
(Date:7/9/2014)... ranges in which animals can be found, concern mounts ... an increased range for a host mean new territory ... a team of UC Santa Barbara scientists, including parasitologists ... in the Journal of Biogeography , Hechinger, Kuris ... may happen: Hosts may actually lose their parasites when ...
(Date:7/9/2014)... Emerging fungal pathogens pose a greater threat ... population declines of amphibians, bats, corals, bees and ... Florida published in the prestigious journal Nature ... immunological resistance to a deadly chytrid fungus implicated ... resistance is important because it is the basis ...
(Date:7/9/2014)... children with traumatic injuries have identified an immune ... develop a hospital-acquired infection. The study, led by ... in June in the journal Shock , ... lead to the clinical implementation of quick-turnaround immune ... immune system damage following critical illness or injury ...
Breaking Biology News(10 mins):Not at home on the range 2Not at home on the range 3Not at home on the range 4USF study: Amphibians can acquire resistance to deadly fungus 2Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3
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