Supercomputers to focus brains on AIDS dilemma
...ced early deaths. Structural biology and molecular dynamics computer simulations played an important role in t...ssibilities flow out of a long series of molecular dynamics simulations by McCammon's group. These simulations have focused on the catalytic domain of HIV-1 int...Basis for DNA ejection from single phage particles
...nd with a resolution time of 750 milliseconds) the dynamics of DNA ejection from single phages. The ejected DNA was measured at different stages of the ejection process after being stretched by applied hydrodynamic flow. The study demonstrated that DNA release is not an all-or-none process, but rather is unex...Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
...te course at Scripps--that analyzed the underlying dynamics responsible for major shifts in biological and phy...odeled by traditional statistical approaches. "The dynamics are the same during warm and cold periods, thus they are not true regimes," said Sugihara of the Phy...Insects, viruses could hold key for better human teamwork in disasters
...e researchers hope to advance understanding of the dynamics of communication and knowledge networks among first responders is by "'learning' basic principles on how bees and ants are able to effectively self-organize based on local information," said Contractor, who directs the Science of Networks in Communit......spread of rabies depends on predicting the spatial dynamics of the disease - where new outbreaks might occur a...h DL, Childs JE, Real LA (2005) Predictive spatial dynamics and strategic planning for raccoon rabies emergence in Ohio. PLoS Biol 3(3): e88. ...Visualizing siRNA in Mammalian Cells: Fluorescence Analysis of the RNAi Effect
...uorescence microscopy we have analyzed the dynamics of siRNA localization. Our studies revealed that the majority of both GAPDH and c-myc siRNA was localized to the nuclear periphery. In addition, in vivo siRNA strand separation was observed, supporting similar observations fro......2662. 2. Milligan, G. (1999). Exploring the dynamics of regulation of G protein-coupled receptors using green fluorescent protein. Br. J. Pharmacol. , 128 : 501510. 3. Cubitt, A.B., Heim, R., Adams, S.R., Boyd, A.E., Gross, L.A. & Tsien RY. (1995). Understanding, improving and using green fluo...Bioscience clusters: Too many or room for more?
...this area received the highest weight). Economic dynamics of the state: the number of start-up and fast-growing companies. State's capacity for innovation expressed through R&D spending, venture capital investments, and patent filings. State's digital infrastructure. State's access to global markets. ...Energy conservation might take us farther than renewable fuels
...orities have to be reviewed as some transportation dynamics have radically changed, yet ridership on some of these mass transit providers have not. If you ride on some of the commuter trains, you know that schedules and stops haven't changed in years. Trains still stop at certain locations on every run, even......e partnership was formed, Underwood said that team dynamics and personal initiative played a large role. It honestly has to do with the intangibles of relationship, he said. The people that are more responsive are going to get a first opportunity to work with our company....El Ni?o cycles linked to cholera outbreaks
...a peak in cholera. These results indicate that the dynamics of cholera in Bangladesh are consistent with a remote forcing by ENSO. The climate-disease story might be even more complicated and needs further research. In the case of Bangladesh, "another mediating factor in the ENSO-cholera relation might be the...Anti-fungal drug - Griseofulvin may help treat cancer
...lude by saying- "A mild suppression of microtubule dynamics by griseofulvin in tumor cells, combined with the effects of more powerful drugs working through other mechanisms, might provide a therapeutic advantage for treatment of certain tumors." The work is a collaborative work between Wilson's lab, in UCS...T-waves to sweep over imaging technology
... mail, and help researchers understand the complex dynamics involved in protein folding. Objects at room temperature emit thermal energy in the THz range. This radiation is extremely useful for sensing and imaging objects, with major advantages over other techniques. T-ray systems offer more than just images...Generic Drugs Usage In US Can Save $20 Billion – Express Script Surve
...d on an evaluation of clinical efficacy and market dynamics of branded and generic medications. Steve Miller, MD, Express Scripts Vice President, Research said, 'We have only scratched the surface in taking advantage of the money-saving potential of clinically sound generic drugs, as additional generics come...Fluorescent markers to distinguish Trypanosoma brucei strains causing Sleeping Sickness
...infecting site genotypes and the tracking of their dynamics have been // ficult with traditional methods based...some infections and their implications for disease dynamics and control. The authors assert that they will be of specific interest to researches addressing ecol...Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
...ought to result when these drugsinterfere with the dynamics of microtubule filaments that areresponsible for the long-distance transport of important cellularcomponents within nerve cells. Mitotic kinesins are essential to mitosis, and, unlike tubulin,appear to have no role in other cellular functions. Cytok...New Study Reveals Limitations of a Complex and Challenging Global Tuberculosis Drug Marketplace
First comprehensive study of market dynamics offers insights intowhat will be needed to get new...d results from the firstcomprehensive study of the dynamics of the global TB drug marketthat offers a detailed analysis of how today's TB medicines reachpatient...Telomerase Presentations at the AACR 2007 Annual Meeting
...hout the AACR meetingon the regulation of telomere dynamics and telomerase activityelucidates the potential for telomerase-inhibiting molecules in thetreatment of cancer. Cancer Stem Cells Cancer stem cells (CSCs) are a rare sub-population ofself-renewing, immortal tumor cells capable of differentiating i...EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models
...l proliferation by interfering with themicrotubule dynamics required for cell division. This interferenceblocks the cell cycle sequence, leading to cell death(apoptosis). About EntreMed EntreMed, Inc. is a clinical-stage pharmaceutical companydeveloping therapeutic candidates primarily for the treatment ofc...Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting
...ought toresult when these drugs interfere with the dynamics of microtubulefilaments that are responsible for the long-distance transport ofimportant cellular components within nerve cells. Mitotic kinesins are essential to mitosis, and, unlike tubulin,appear to have no role in unrelated cellular functions.Cy...