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Drosophila in Medical News

2008 Gruber Genetics Prize awarded to Allan Spradling of Carnegie Institution

... cell niche using ovary tissue from the fruit fly, drosophila melanogaster. Spradling went on to define the ... cell behavior within their niches. His work on drosophila stem cells and niches has helped guide mammalian ... successful method for inserting genes into the drosophila genome. Spradling subsequently applied engineered ...

Drosophila drug screen for fragile X syndrome finds promising compounds and potential drug targets

... Scientists using a new drug screening method in drosophila (fruit flies), have identified several drugs and ... their current experiment, Emory scientists used a drosophila model lacking the FMR1 gene. These fruit flies ... "Our discovery of glutamate toxicity in the drosophila model of fragile X syndrome allowed us to develop ...

January American Naturalist highlights

... display traits in the Australian fruit fly, drosophila serrata. Both male and female drosophila serrata use a set of pheromonal displays during ... "Mating frequency and inclusive fitness in drosophila melanogaster" Nicholas K. Priest (University ...

Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers

... of the Public Library of Science Genetics . "We can now use the power of drosophila genetics to uncover genes that drive these tumors and identify novel ... first author Renee Read, who spearheaded the project. "We developed the drosophila model to figure out how these genes specifically regulate brain tumor ...

Cancer stem cell marker also drives transcription in normal cells

... H2B in mammals. Importantly, the deubiquitylation module of the drosophila TFTC/STAGA complex was an enhancer of position effect variegation and counteracted heterochromatin silencing while both the drosophila and the human deubiquitylation module were shown to be required for full ...

For the fruit fly, everything changes after sex

... behaviour. They focus on the reproductive behaviour of the fruit fly drosophila melanogaster. Two years ago, the team was able to identify the fruitless ... which was developed over the past few years by the Dickson group. This drosophila RNAi Library is a collection of 22,000 fly strains and has recently been ...

Carnegie Mellon algorithm charts evolution of genetic networks during fruit fly life cycle

... new algorithm developed by Carnegie Mellon University computer scientists has revealed for the first time how genetic networks in the fruit fly, drosophila melanogaster, evolve during the insect's life cycle. Scientists have known that the relationships between fruit fly genes change over time, but ...

Monell Center receives $100,000 Grand Challenges Explorations grant

... in Philadelphia. The Grand Challenges Explorations mosquito project is an extension of his longstanding interests in taste and feeding. Breslin's drosophila Chemosensory Laboratory at Monell uses the fruit fly as a model to understand the relationships between genetics, chemosensation, and feeding. ...

Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer

... at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco. In their studies with the fruit fly, drosophila melanogaster, at the Mayo Clinic College of Medicine in Minnesota, scientists found a link between the "Seven-In-Absentia" or SINA gene and the ...

Scientists identify key roadblock to gene expression

... the first time, a detailed map of how the building blocks of chromosomes, the cellular structures that contain genes, are organized in the fruit fly drosophila melanogaster. The work identifies a critical stop sign for transcription, the first step in gene expression, and has implications for understanding ...
Drosophila in Medical Technology

Fruitfly Model of a Neuropathic Disease Demonstrates Novel Role for Proteins in the Family of aTyr Pharma's Product Class

... activities. When the mutations found in humans are introduced into the drosophila genome, the flies develop neurological defects that correspond to CMT in ... resected from ancient proteins such as tRNA synthetases. This work in drosophila illustrates a surprising disease-causing role for tRNA synthetases that is ...

Researchers Discover Gene For Rare Skin Disorder

... PORCN gene has been studied in mice and fruit flies, very little is known about the genes function in humans, said Dr. Van den Veyver. The mouse and drosophila porcupine proteins are known to be important for the secretion of Wnt proteins from the cells that produce them. Wnt proteins are involved in early ...
Drosophila in Medical Dictionary

Membrane

... basement membrane . demonstrated that members of the LDL receptor-related protein (LRP) family, LRP5 and LRP6 (which are homologues of the drosophila Arrow protein that are required for Wingless signaling), function as Wnt co-receptors for the seven-pass trans membrane ... Characterised by an ...

Mutation

... or acquired. Acquired mutation s are caused by repeated insults from triggers (e.g. We have characterized a loss-of-function mutation in the drosophila RhoA homologue, Rho1. Most cases of CJD are not caused by exposure to another person with the disease but by an acci dental mutation in brain ...
Drosophila in Biological News

Carbon nanoparticles toxic to adult fruit flies but benign to young

... to adults. The scientists found that larval drosophila melanogaster showed no physical or reproductive ... carbon nanoparticles in their food. Yet adult drosophila experienced a different fate. Tests showed adults ... in the dust." The scientists immersed adult drosophila in a control test tube and test tubes containing ...

Protecting cells from their neighbors

... fails, the embryo dies. Made in the fruit fly drosophila melanogaster , this finding could be universal. ... mechanisms. "Most of the processes described in drosophila can be extrapolated to other organisms. Given ... universal", explains Casanova. In the 1960s, drosophila was the model in which researchers described a ...

The story of X -- evolution of a sex chromosome

... 150 million years ago, while in the fruit fly drosophila melanogaster, a laboratory favorite, the sex ... sex chromosomes in a rare western fruit fly, drosophila miranda, a darker-colored cousin of D. ... from the original sex chromosome that appeared in drosophila nearly 100 million years ago, a second originated ...

Flies may reveal evolutionary step to live birth

... genes. The fly is one of a dozen species of drosophila to have recently had their genomes sequenced, ... in the semen of the well-known lab fruit fly, drosophila melanogaster, stimulate egg laying in the female. ... exclusive access. One other fly in the study, drosophila yakuba, also occasionally laid larvae instead of ...

What is wild? Odor attraction among different wildtype Drosophila

... Vinegar flies ( drosophila melanogaster ) show a highly selective behavior ... are very likely to show the original phenotype of drosophila melanogaster behavior: they respond as other ... showed that the different behaviors of the eight drosophila varieties cannot be diagnosed just as impaired ...

Spradling receives Gruber Foundation Genetics Prize for new genetic techniques

... of researchers to determine the function of drosophila genes and their human counterparts. Together, these advances inaugurated the modern era in which drosophila serves as a versatile model organism for studying ... and disease. Spradling subsequently used the drosophila system to advance our understanding of stem ....

Fruit flies show how salmonella escapes immune defenses

... and the study's lead scientist. "Using the drosophila system allowed us to express bacterial proteins ... pathways and apoptotic reaction as in the drosophila model. A mutant form of the salmonella lacking ... more cell death in the mouse intestine. "Using drosophila genetics, we found a biochemical crossroad ...

Epigenetic regulation by the MMB/dREAM complex

... RB tumor suppressor gene function together in the drosophila MMB/dREAM complex to epigenetically regulate mitotic cell cycle progression. drosophila MMB/dREAM includes proteins encoded by the Myb ... gene expression at the level of a single-cell in drosophila larval imaginal wing discs. They found that flies ...

International team compares 12 fruit fly genomes

... in the journal Nature. The team, known as the drosophila 12 Genomes Consortium, represented 16 countries ... genetics and one of the paper's co-authors. drosophila (fruit flies) are one of most studied and most ... its proteins. Understanding gene regulation: drosophila continue to offer signs -- and questions In ...

Specific brain protein required for nerve cell connections to form and function

... and function correctly. The discovery, made in drosophila fruit flies may lead to advances in ... is the first to successfully demonstrate in a drosophila model the consequences that mutating this ... nerve cells. The hope is that such studies in drosophila will one day clarify the role neurexin plays in ...
Drosophila in Biological Technology

New technique allows simultaneous tracking of gene expression and movement

... California, Los Angeles, who carried out the fluorescent experiments in drosophila flies. When the flies are illuminated with blue light, the authors' video ... protein is used as a reporter for specific gene expression in drosophila and other organisms. -Our methods should be readily adaptable to such ...

Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries

... patients with nerve injuries that have been irreversible up to now. drosophila as model organism The drosophila melanogaster fruit fly is an important, low-cost model organism with a 60% ...

Stem cells stand up for themselves

... shapes stem cells, not vice versa. O'Reilly et al. found evidence for more active stem cells while studying how the cells anchor themselves in the drosophila ovary. Previous work indicated that ovary stem cells attach to the niche through the protein E-cadherin. O'Reilly et al. tested whether the stem ...

J. Craig Venter Institute Names Robert Friedman, Ph.D., Deputy Director of West Coast Facility

... in 2002, Dr Levy worked at Celera Genomics and was involved in developing computational tools for gene discovery and functional annotation in the drosophila and the first human genome sequences. Dr. Levy received a B.Sc. in Molecular Biophysics at the University of Leeds, UK, and his Ph.D. in cell and ...

SUPERIOR RNA FOR DEMANDING APPLICATIONS

... mouse and rat tissues, human brain regions, human and drosophila cell lines and E.coli* Human Tissues & Cell Line- 100 g ... from specific human, mouse and rat tissues and human and drosophila cell lines* 5 g Quality and stability checked ...

Rice Centromere, Supposedly Quiet Genetic Domain, Surprises

... in theory, to construct an artificial chromosome. In most organisms, including the critical model organisms such as the mouse, the fruit fly drosophila melanogaster and the plant Arabidopsis thaliana, centromeres have proved to be nearly intractable for sequencing. The rice centromere is ...

Using the DCode System to Identify DNA Sequence Variation for Studies of Population Structure in Marine Organisms

... immediately downstream from the forward (GC-clamped) primer. For this region, we substituted the homologous sequence from drosophila yakuba inferred from a manual alignment of oyster and fly 16S sequences, in order to construct a theoretical melting profile of ...

Quantitative Analysis of Protein-DNA Associations in Vivo Using Real-Time PCR, Rev A

... years to identify the association of histone complexes and transcription factors with specific genomic DNA targets in cells of drosophila or yeast. As shown in Figure 1, the technique first involves the treatment of cells with formaldehyde or ultraviolet light to ...

A Better Way to Isolate RNA AND Protein From the Same Sample

... gel electrophoresis, Northern blot, or Western blot. SCR represents a scrambled siRNA sequence. (B) 5 x 10 5 Schneider's drosophila cells were treated for 48 hours in a 6 well plate with 10 nM of the indicated dsRNA prepared with Ambion's MEGAscript ...
Drosophila in Biological Products

GIBCO Schneider's Drosophila Medium (1X) liquid from Invitrogen

Description:... Schneider's drosophila Medium is formulated for the expression of heterologous proteins in drosophila S2 ....
Company:Invitrogen

COPAS 500 from Union Biometrica

Description:... is one of our most versatile systems, ideal for use by multiple labs with different applications. Applications include all stages of C. elegans, drosophila embryos to first instar larvae, other like-sized model organisms, cells, pollen, seeds and beads even delicate cell clusters such as pancreatic ...
Company:Union Biometrica

Schneider's Drosophila - Insect medium from AppliChem GmbH

Description:... Schneider's drosophila - Insect ...
Company:AppliChem GmbH

Schneider's Drosophila Medium (1X) liquid from Invitrogen

Description: Modified and insect cell culture ....
Company:Invitrogen

Mouse Anti-Drosophila Yan Drosophila protein Antibody, Unconjugated from Developmental Studies Hybridoma Bank

Description: anti-Yan ...
Company:Developmental Studies Hybridoma Bank

Drosophila S2 Cells (Schneider's Drosophila Medium) from Invitrogen

Description: Drosophila S2 cells are used for heterologous protein expression in the Drosophila Expression System (DES). The S2 cell line was derived from a primary culture of late stage (20-24 hours old) Drosophila melanogaster embryos (1). This versatile cell line grows rapidly at room temperature ...
Company:Invitrogen
Drosophila in Biological Definition

Drosophila

... drosophila melanogaster drosophila subobscura drosophila is a genus of small flies whose members are ...

Morphogenesis

... 1 Anterior-posterior axis patterning in drosophila 1.1 Maternal effect genes 1.2 Gap genes ... Anterior-posterior axis patterning in drosophila Morphogenesis of the fruit fly drosophila melanogaster starts with the construction of ...

Morphogenesis

... 1 Anterior-posterior axis patterning in drosophila 1.1 Maternal effect genes 1.2 Gap genes ... Anterior-posterior axis patterning in drosophila Morphogenesis of the fruit fly drosophila melanogaster starts with the construction of ...

Thomas Hunt Morgan

... zoology , and macromutation in the fruit fly drosophila . His most important contributions to science ... the carriers of genes . Because of his work, drosophila became one of the major model organisms in ... working on the embryonic development of drosophila melanogaster (the common fruit fly) at ...

Cell growth

... by fusion of thousands of myocytes . Genetic studies of the fruit fly drosophila have revealed several genes that are required for the formation of ... in cytosolic components from adjacent cells through cytoplasmic bridges ( drosophila ) or by internalization of nutrient storage granules (yolk granules) by ...

Developmental biology

... Sea urchin Round worm Caenorhabditis elegans Fruit fly drosophila melanogaster ( drosophila embryogenesis ) Plants ( Plant embryogenesis ) Arabidopsis ...

Molecular evolution

... by assertions by other geneticists that more than 50 percent of drosophila loci were heterozygous , a claim they initially doubted. In order to ... results in 1966 which showed high levels of genetic variation in drosophila via protein electrophoresis , the theoretical results from the infinite ...

Alternative splicing

... has been transcribed from the DNA , it includes several introns and exons . In nematodes , the mean is 4-5 exons and introns; in the fruit fly drosophila there are more than 100 introns and exons in one transcribed pre-mRNA. But what is an intron and what is an exon is not decided yet. This decision ...

Arabidopsis

... ), are one of the model organisms for studying plant sciences, including genetics and plant development. Similarly as mouse and fruit fly ( drosophila ) are used as model organisms to understand human biology, Arabidopsis thaliana is used to study agronomic crops. The genome of Arabidopsis , ...

Biology

... tissues , organs and anatomy . Model organisms for developmental biology include the round worm Caenorhabditis elegans , the fruit fly drosophila melanogaster , the zebrafish Brachydanio rerio , the mouse Mus musculus , and the weed Arabidopsis thaliana . Physiology of organisms ...
Drosophila in Biological Dictionary

Polytene

... phylogenetics polytene by cisevol to the group drosophila ... Polytene Chromosomes of drosophila ... fruit fly oocyte possess polytene ... that each consist ... Polytene Chromsomes of drosophila virilis ... Polytene chromosomes are ...

P elements

... a transposon that is present in the fruit fly drosophila melanogaster and is used widely for mutagenesis ... - white phosphorus and red ... drosophila P Elements ... Incomplete members P ... P elements have provided valuable tools for drosophila geneticists. ... Denotes a paragraph. ... Sets ...

Malpighian tubule

... the Malpighian tubule (insect kidney) ... The drosophila melanogaster Malpighian tubule provides a ... Fluid secretion by the Malpighian tubule of drosophila melanogaster is ... of anion and cation transport in Malpighian tubules of drosophila melanogaster. ... Definition of malpighian ...

Drosophila

... drosophila is a genus of small flies, belonging to the ... a reference to the characteristic ... drosophila melanogaster is a two-winged insect that belongs ... model organisms ... FlyBase: a database for drosophila genetics and molecular biology ... and Chris ...

Tubulin

... Tubulin was long thought to be specific to eukaryote. Eukaryote ... drosophila has four ß- tubulin genes: each encodes a distinct isoform. ... ... into zygotic mitotic spindles. ... The four ß- tubulin genes of drosophila each encode a distinct isoform. ... The ß3- tubulin gene encodes a ...

Transposable element

... Genetic transformation of drosophila with transposable element vectors" ... A wiki specially ... element clusters in the set of ... Genetic transformation of drosophila with transposable element vectors" ... A wiki specially dedicated to ...

Recombination nodules

... Synaptonemal complex and recombination nodules in wild-type drosophila melanogaster females. ... Gene conversion, recombination nodules , and ... ... Synaptonemal complex and recombination nodules in wild-type drosophila melanogaster females. ... Recombination nodules in spermatocytes and a ...

Optic lobes

... and mab5A6 stainings ... differentiation of the optic lobes in drosophila melanogaster. ... optic lobe n. Either of two lobes of the ... gene sol. Represented by 70 ESTs from 12 cDNA libraries. ... drosophila melanogaster small optic lobes (sol), transcript variant D, mRNA. PA ...

MicroRNA

... Systems ... the mature versus the precursor form of the microRNA ? ... drosophila microRNA targets. drosophila targets ... miRanda software for microRNA target prediction (not ...

Inverse PCR

... Nested, QC, RACE, ... Step by step protocol, by EJ Rehm, Berkeley drosophila Genome Project, USA. ... Inverse PCR & Cycle Sequencing of P ... " Inverse PCR and Cycle Sequencing Protocols" by E. Jay Rehm. Berkeley drosophila Genome Project ... Inverse PCR and Sequencing Protocol on 5 Fly ...
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