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Downstream in Medical News

Sartorius Stedim Biotech Partners With Cell Culture Media Specialist SAFC Biosciences(R) to Provide World-Class Fluid Management and Liquid/Powder System Solutions

... manufacturing solutions for upstream and downstream processing and moves the 'disposable factory' ... and manufacturing of cell culture media and downstream purification products. The alliance is expected ... and development services for upstream and downstream processes in the biopharmaceutical industry. ...

Does HBV infection induce acute cellular DNA damage?

... evidence so far that the ATM/ATR kinases or their downstream pathways are triggered by HBV infection. A ... protein and increased phosphorylation of multiple downstream targets including Chk1, p53 and H2AX. In contrast ... phosphorylated form of ATM at Ser-1981 and its downstream substrate Chk2 phosphorylation at Thr-68 did not ...

New findings may improve treatment of inherited breast cancer

... Scientists have identified some of the elusive downstream molecules that play a critical role in the ... linked with BRCA1, very little is known about the downstream mediators of BRCA1 function in tumor ... These findings identify SIRT1 and Survivin as downstream mediators of BRCA1-regulated tumor suppression ...

Emory researchers identify signaling protein for multiple myeloma

... that mediates signaling in cells as critical in downstream signaling of FGFR3 in myeloma cells. Dr. ... mechanism to turn-on RSK2 by FGFR3. FGFR3 impacts downstream proteins through phosphorylation at special ... connection between the oncogenic FGFR3 and its downstream protein kinase RSK2, which plays a critical role ...

Group Health Cooperative Shows Investing in More Primary Care Pays for Itself

... Broke even on its primary care staffing investment through reduced downstream utilization costs. Emergency room/urgent care visits were 29 percent ... contact with patients through secure e-mail and phone. Decreased downstream utilization led to return on investment. "These results ...

Group Health Cooperative shows investing in more primary care pays for itself

... Broke even on its primary care staffing investment through reduced downstream utilization costs. Emergency room/urgent care visits were 29 percent less ... contact with patients through secure e-mail and phone. Decreased downstream utilization led to return on investment. "These results lay the ...

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Downstream in Medical Technology

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

... tissue confirmed inhibition of the PI3K pathway by complete absence of a downstream target (pS6). In contrast, a normal tissue (skin) demonstrated no ... high frequency in a variety of tumor types. PI3K signaling through its downstream effectors AKT and mTOR is also known to promote tumor cell survival, ...

Filter Fails to Improve PCI Outcomes in Acute Coronary Syndromes

... arterial blockages that appeared particularly likely to be a source of downstream debris during PCI. In addition, myonecrosis, or debris-caused damage to ... debris. During PCI, the FilterWire is positioned in the coronary artery downstream of the lesion; both the device and any debris are removed after the ...

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

... reproduce and metastasize, leading to cancer progression. Anti-EGFR antibody therapies work by blocking the activation of EGFR, thereby inhibiting downstream events that lead to malignant signaling. However, it is hypothesized that in patients whose tumors harbor a mutated KRAS gene, the KRAS protein ...

CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders

... forward to assessing it in the clinic for neuropathic and neurodegenerative conditions that currently have no treatment options." CXB909 is a downstream enhancer of the effects of nerve growth factor, an endogenously produced neurotrophic factor that is important for the function and survival of ...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

... can lead to cancer and aberrant PI3K pathway activity is observed with high frequency in a variety of tumor types. PI3K signaling through its downstream effectors AKT and mTOR is also known to promote tumor cell survival, proliferation, and growth. Notably, dysregulation of PI3K signaling is thought ...

Potentia Pharmaceuticals' POT-4 Drug Candidate for Age-Related Macular Degeneration Successfully Completes Phase I Clinical Trial - Prepares for Phase II

... the complement activation cascade. As C3 is the central component of all major complement activation pathways, its inhibition effectively shuts down downstream complement activation that could otherwise lead to local inflammation, tissue damage and upregulation of angiogenic factors such as vascular ...

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Downstream in Medical Products

MagNA Pure Compact System

Description:... on the LightCycler System, or on standard block cyclers), microarray analysis, genotyping reactions using the LightTyper Instrument, and many other downstream ....
Company:Roche Diagnostics

Vidiera NsP Nucleic Acid Sample Preparation Platform

Description:... The Vidiera NsP Nucleic Sample Preparation Platform provides flexible, automated extraction and downstream reaction setup. The platform can prepare up to 96 patient samples from primary tubes in just two and one half-hours, and performs onboard ...
Company:Beckman Coulter, Inc.

Celsius Control Catheter

Description:... When placed in the inferior vena cava, the TCE exchanges thermal energy directly with the blood, resulting in cooling or warming of the downstream organs and body. The Celsius Control System does not infuse fluid into the patient, nor is blood circulated outside of the body. The Temperature ...
Company:Innercool Therapies

Milli-Q Element System (non-TOC)

Description:... employ a 3-step purification process: Step 1: Plug-in Q-Gard purification packs are tailored to the feedwater source to optimize the performance of downstream purification media to ensure consistent results. Step 2: Quantum application-specific cartridges remove ionic and organic contaminants down to ...
Company:Millipore

Milli-Q Element A10 System

Description:... employ a 3-step purification process: Step 1: Plug-in Q-Gard purification packs are tailored to the feedwater source to optimize the performance of downstream purification media to ensure consistent results. Step 2: Quantum application-specific cartridges remove ionic and organic contaminants down to ...
Company:Millipore

Milli-Q Synthesis (non-TOC)

Description:... employ a 3-step purification process: Step 1: Plug-in Q-Gard purification packs are tailored to the feedwater source to optimize the performance of downstream purification media to ensure consistent results. Step 2: Quantum application-specific cartridges remove ionic and organic contaminants down to ...
Company:Millipore

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Downstream in Medical Dictionary

Mammary

... mammary arteries supply the chest wall and are close enough to the heart that they can remain attached to their blood source, with their downstream ends graft ed onto the portions of the coronary arteries needing help. Mice with mammary cancer Exp. 1: Immune system function Exp. 1: ...
Downstream in Biological News

Bacteria create aquatic superbugs in waste treatment plants

... to multiple antibiotics---up to 100 yards downstream from the discharge point into the Huron River. Xi ... tested. The bacteria in samples taken 100 yards downstream also were more likely to resist multiple drugs ... The next step, said Xi, is to see how far downstream the superbugs survive and try to understand the ...

NEWSLETTER: Antibody Fragment Production Breakthrough with 2nd Generation EBA

... Richter-Helm BioLogics has finalized the downstream process for Phase III clinical trial material ... microbial derived products, providing a superior downstream process for clinical manufacturing. Richter-Helm ... pressures and has been rewarded with a superior downstream offering in the CMO market. The Rhobust® ...

University of Michigan installs second Genomatix Genome Analyzer

... a complete, integrated analysis solution for the downstream analysis of NGS data, starting with mapped data ... add Genomatix advanced Next Generation Sequencing downstream analysis capabilities to our ongoing effort of ... The Genomatix Genome Analyzer (GGA) delivers downstream software tools and databases for the deep ...

Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA

... sites, a weak site and a much stronger site downstream of it. Only one of them can be activated to make ... that beginning point to a common ending point downstream of both beginning splice points. The research ... nucleotides in a sequence of 12 nucleotides just downstream of the stronger splice site and in 12 just ...

Transporting juvenile salmon hinders adult migration

... fish populations. Juveniles that are transported downstream on boats can lose the ability to migrate back to ... survival of fish that hatch in rivers but migrate downstream to the ocean, where they live most of their adult ... spawning grounds, but some will instead move back downstream over dams," says Keefer. This phenomenon, called ...

Newly discovered molecular switch helps decide cell type in early embryo development

... Hox genes are responsible for regulating other downstream genes, to determine body position and help form ... during early development. Sens regulates downstream genes that support the development of sensory ... "This allows us to identify other key genes downstream of Hox and Sens, determine their role in ...

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Downstream in Biological Technology

Genomatica Produces Pure BDO From Natural Sugars

... With downstream processing techniques proven cost-effective, Genomatica looks to develop ... The purification achievement proves the feasibility of critical downstream process engineering elements of Genomatica's manufacturing method for ...

SAFC Biosciences(TM) Completes Conversion of Lenexa Media Milling Facility to Animal Component Free

... a leading provider of cell culture materials and services for upstream and downstream processes in the biopharmaceutical industry and a business segment within ... of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated ...

High-quality DNA/RNA from Microorganisms in Environmental Samples

... high quality, inhibitor-free DNA and/or RNA that can be used in various downstream applications such as PCR. The Soil DNA Isolation Kit allows for the ... The purified DNA is of the highest quality and is fully compatible with downstream PCR applications, as humic substances and other PCR inhibitors are ...

Norgen Biotek Corp. Launches Four New Kits for the Purification of RNA and DNA from Plants and Fungi

... DNA and chloroplast DNA. The purified DNA can be used in a number of downstream applications including Real-Time PCR, Southern blotting and sequencing. ... The procedure yields sufficient fungal DNA to be used in a number of downstream applications including Real-Time PCR, sequencing, Southern blotting and ...

Device That Clears Debris From Artery Aids Blood Flow in PCI

... and blood clot can break loose during angioplasty and stenting, traveling downstream to occlude the tiny vessels, or microcirculation, that supply blood deep ... have been developed that either aspirate or filter out debris that travels downstream during PCI. The TAPAS study was designed to test the effectiveness of the ...

TSH Testing Raises Awareness of Importance of Thyroid Health

... between nuclear reactors and thyroid disease near NYC was made at Croton on Hudson, during this year's Clearwater Festival. The festival is held just downstream from Indian Point, the oldest operating nuclear reactor in the U.S. In keeping with Clearwater's commitment to a clean environment, it stepped up by ...

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Downstream in Biological Products

ProteoExtract Protein Precipitation Kit from Calbiochem

Description:... Additionally, proteins in solutions are often too dilute for direct downstream applications such as 2DGE. Precipitation of proteins is a protein ... be re-suspended in the buffer of choice for a wide range of proteomics downstream applications such as isoelectric focusing (IEF), 2DGE, 1DGE or for tryptic ...
Company:Calbiochem

pAcAB4 Baculovirus Transfer Vector from BD Biosciences Pharmingen

Description:... two copies of the AcNPV polyhedrin promoter and two AcNPV p10 promoters. downstream of the first p10 promoter is a Sma I cloning site, followed by polyhedrin ... Additionally, there is another polyhedrin promoter and BamH I cloning site downstream of the first p10 promoter. This vector allows simultaneous expression of ...
Company:BD Biosciences Pharmingen

Gel extraction kit from BioPioneer

Description:... * Quick and economical * High yields (60-90%) of 60bp-40kb DNA fragments. * Efficient removal of contaminants. Purified DNA can be used in any downstream application such as sequencing, labeling, restriction enzymatic digestion, ligation or transformation. * No phenol / chloroform extraction or ...
Company:BioPioneer

CapSure HS LCM Caps with 32 ExtracSure devices and 12 PrepStrips (Alignment Tray and Incubation Block required, not included) from Arcturus, now part of Molecular Devices

Description:... Microdissection. Ensure the Integrity of Microdissected Cells for downstream Molecular Analysis All CapSure LCM Caps have a patented transfer film ... from captured cells. This optimizes the recovery of these molecules for downstream molecular ....
Company:Arcturus, now part of Molecular Devices

CapSure Macro LCM Caps - Bulk Pack from Arcturus, now part of Molecular Devices

Description:... Microdissection. Ensure the Integrity of Microdissected Cells for downstream Molecular Analysis All CapSure LCM Caps have a patented transfer film ... several thousand cells on a single cap. This is particularly useful for downstream applications that require large numbers of cells to obtain enough material ...
Company:Arcturus, now part of Molecular Devices

CapSure Macro LCM Caps from Arcturus, now part of Molecular Devices

Description:... Microdissection. Ensure the Integrity of Microdissected Cells for downstream Molecular Analysis All CapSure LCM Caps have a patented transfer film ... several thousand cells on a single cap. This is particularly useful for downstream applications that require large numbers of cells to obtain enough material ...
Company:Arcturus, now part of Molecular Devices

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Downstream in Biological Definition

Apoptosis

... loop that spirals into increasing release of pro-apoptotic factors from mitochondria (see below), and the amplified activation of caspase-8. downstream from TNF-R1 and Fas activation - at least in mammalian cells - a balance between pro- (like BAX, BID, or BAD) and anti-apoptotic (Bcl-Xl and Bcl-2) ...

Barr body

... evidence suggests that the maternally inherited gene may be imprinted . It is thought that this constitutes the mechanism of choice, and allows downstream processes to establish the compact state of the Barr body. These changes include histone modifications, such as histone H3 methylation and ...

Blood

... ( amino acids , lipids , hormones ) to be transported between tissues and organs. Problems with blood composition or circulation can lead to downstream tissue dysfunction. Contents showTocToggle("show","hide") 1 Blood of different species 1.1 Humans 1.2 Small invertebrates ...

Enhancer

... transcription initiation site to affect its transcription, as some have been found to bind several hundreds of thousands base pairs upstream or downstream of the start site. Enhancers can also be found inside introns . An enhancer's orientation may even be reversed without affecting its function. ...

Promoter

... nucleotides TTGACA. Its presence allows a very high transcription rate. <-- upstream downstream 5'-XXXXXXXPPPPPXXXXXXPPPPPPXXXXGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGXXXX-3' -35 -10 Gene to be transcribed ...

Signal transduction

... pathway. Signal amplification at the transmembrane hormone receptor A receptor that has been activated by a hormone can activate many downstream effector proteins. For example, a rhodopsin molecule in the plasma membrane of a retina cell in the eye that was activated by a photon can ...

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Downstream in Biological Dictionary

Downstream

... The term downstream has several possible meanings: In geography, downstream means literally away from the source of a stream ... or air flow. By analogy with this, see also: downstream ( ) adj. In the direction of a stream's current. ...

Anchor Sequence

... is ... The anchor sequence (conserved in all six species) is located downstream from ... Use of anchor sequences in the upstream primers is ... ... This anchor is complementary to the mRNA sequence immediately downstream of the ... Between the anchor and the U-tail is the information ...

VNTR

... news, analysis, financials, upgrades, and data. Obviously, even if the DRD4 VNTR is the site of selection, strong LD in the ... The 2R VNTR downstream region contains a polymorphism pattern identical to that ... http://www. vntr .net - site internet de Ventura ... Ventura, the band, from ...

UvrA

... ... These Guidelines have been revised and agreed upon by all UVRA Town Directors. ... uvrA . Information for uvrA , and also upstream and downstream flanking ... Reported regulatory sites for uvrA : Genome coordinates. Source. Transcription factor ... Furthermore, the TFO was dissociated from ...

Upstream

... by ... 1 Why Upstream . 2 Tips On Upstreaming Patches. 3 Some Examples Of Exceptions. 4 References ... Upstream Acceptance - Fedora is downstream of many thousands of ... Shop Barnes & Noble for " Upstream : The Ascendance of American Conservatism" by Alfred S. Regnery. Find a wide ...

Trans-splicing

... Destruction of U2, U4, or U6 small nuclear RNA blocks Trans splicing in trypanosome cells ... This trans splicing model predicts that the downstream portion of ... There are large numbers of trans - splicing applications, each governed by the ... Such nonspecific trans - splicing can be ...

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(Date:9/21/2014)... Faculty and staff at Garrison Forest School ... Owings Mills, Md., kicked off the academic year by taking ... is the first independent school to receive the bands— which ... sleep patterns— as part of a pilot program with ... specialty chain. The Vivofit bands are just one tool in ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 According to latest ... the highest birth rate since 1966 (10.5 births per 1,000 ... their early 40s has risen steadily by 2 percent per ... births to women aged 50 and over) also rose, the ... there were more than nine times as many first births ...
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(Date:9/18/2014)... deep in the primitive brainstem has revealed how we ... School of Medicine and the University at Buffalo School ... second "sleep node" identified in the mammalian brain whose ... produce deep sleep. , Published online in August in ... half of all of the brain,s sleep-promoting activity originates ...
(Date:9/18/2014)... system that can operate inside the bore of an ... a biomedical research partnership program at Brigham and Women,s ... the robot, in conjunction with real-time MRI images, can ... and less discomforting for the patient. The novel system ... with greater precision. , Developed by a team of ...
(Date:9/18/2014)... No matter how many times it,s demonstrated, ... communicating creatures. , But by using a ... radically alter their behavior to suit their population. ... them are present, and act accordingly. , Once ... it may change from innocuous to pathogenic, or ...
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