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Disulfide in Medical News

JCI table of contents: Feb. 21, 2008

... and Harvard Medical School, Boston, have identified a role for protein disulfide isomerase (PDI) in blood clot formation (also known as thrombus formation) ... outweigh the benefits. TITLE: A critical role for extracellular protein disulfide isomerase during thrombus formation in mice AUTHOR CONTACT: Bruce ...

Engineering chimeric polypeptides to illuminate cellular redox states

... the linker, sense the redox potential of the environment and form disulfide bonds upon oxidation. Under oxidative conditions intramolecular disulfide bonds can form, shifting the free energy minimum from the α-helix, to ...

Individuals Who Apply Pesticides Are Found to Have Double the Risk of Blood Disorder

... Of the chemicals studied, a significantly increased risk of MGUS was observed among users of dieldrin (an insecticide), carbon-tetrachloride/carbon disulfide (a fumigant mixture), and chlorothalonil (a fungicide). The MGUS risk for these agents increased 5.6-fold, 3.9-fold, and 2.4-fold, respectively. ...

Capsules encapsulated

... anchored to the cholesterol units and thus attached to the polymer film. Subsequently, more polymer layers are added and then cross-linked by disulfide bridges into a gel by means of a specially developed, very gentle cross-linking reaction. In the final step, the silica core is etched away without ...

Enzyme with a sugar antenna

... team was finally able to correctly attach the individual fragments, fold the enzyme into its natural form, and correctly couple the cysteines into disulfide bridges to form a functional RNase C. ...

Study Findings Could Help In Developing A Better Drug Delivery System

... of the key mechanisms of this breakdown is disulfide reduction, which involves the breaking of chemical bonds. It was thought that disulfide reduction relied on the movement of the material ... lysosomes. However, the research showed that disulfide reduction occurred even when such components were ...

Molecular Basis Of ALS Found

... the pathogenesis of ALS by forming intermolecular disulfide bonds," said Siddique. "This phenomenon is in ... a copper ion, a zinc ion and an intramolecular disulfide linkage -- a bond within an SOD1 molecule that stabilizes the structure. Intermolecular disulfide bonds, or cross-links, are incorrect bonds that ...

Garlic a day keeps cancer away

... it also has powerful anti-cancer properties. A substance called diallyl disulfide in garlic is known to make the gut produce enzymes that clear out ... particles. Now two New Zealand scientists have fed varying levels of disulfide to rats and found it increased levels of the cancer-protecting gut enzymes ...
Disulfide in Medical Products

Free Activin AB ELISA Test

Description:... FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:... FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:... FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in ...
Company:Diagnostic Systems Laboratories, Inc.

MIS/AMH ELISA Test

Description:... Substance (MIS), also known as Anti-Mullerian Inhibiting Substance (AMH), is a glycoprotein dimer composed of two 72 kDa monomers linked by disulfide bridges (1). MIS/AMH belongs to the transforming growth factor-? (TGF-?) superfamily which includes TGF-? and the various inhibin and activin ...
Company:Diagnostic Systems Laboratories, Inc.
Disulfide in Medical Dictionary

Cirrhosis

... In serious cases, and when chronic , hepatitis c an lead to cirrhosis , ... periplasm; periplasmic binding protein s; periplasmic protein disulfide oxidoreductase; periplasmic space; periplast; periplocin; peripneumonic; peripneumony; peripolar; peripolar cell ; peripolesis; periporitis; ...
Disulfide in Biological News

Sulfurous ping-pong in the urinary tract

... PNAS . ETH Zurich researchers crossed the disulfide bridge The discovery of the signal transfer ... between two sulfur atoms in a protein chain, disulfide bridges, play an important role. While examining ... cause urinary tract infections: two genes for the disulfide bond formation machinery were clustered with the ...

Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues

... redox-regulated reactions, TRXs can transfer hydrogen to convert a disulfide bridge formed between two cysteine amino acids to their unbridged thiol forms. These TRX-responsive disulfide bridges have regulatory functions in numerous cellular processes, ...

Researchers discover cell's 'quality control' mechanism

... 'manufacturing defects' and degrades it before it can be distributed." The ERdj5 enzyme is the first protein found to be capable of breaking the disulfide bonds that hold the misfolded proteins together in the ER. Once those bonds are broken, the researchers say ERdj5 also helps other enzymes and ...

Biophysical Society announces winners of 2008 Student Travel Awards

... across Biological Membranes. Ling Wu, University of Illinois at Chicago, Conformational Study of Different Beta-turns Coupled to a Cyclic disulfide Bond to Model the Turn Roles in -hairpin Stability. Qianru Yu, The Pennsylvania State University, Fluorescence-based Biochemistry on Intrinsic ...

Restoring tamoxifen sensitivity in resistant breast cancer cells

... at Frederick, Md., found that the effectiveness of tamoxifen in cell cultures and in mice can be fully restored by the use of a compound called disulfide benzamide, or DIBA. The investigators confirmed their study hypothesis about DIBA's effect on tamoxifen resistance by using the compound in mice that ...

Venom doc tracks down snake bioweapons

... where those with a very stable molecular structure ?those that are rich in the amino acid cysteine, which enables proteins to form intramolecular disulfide linkages. "These structures provided an excellent framework for the 60-80 million years of 'evolutionary tinkering' that have turned these proteins ...
Disulfide in Biological Technology

Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice

... of sequences from the RANTES protein. CKEY2 was shown to be stable and formed the secondary structural motif found in RANTES when stabilized by disulfide bridged cysteines at both ends of the peptide. The scientists demonstrated that CKEY2 disrupts PF4-RANTES heteromer formation by binding ...

Efficient Primary Structure Elucidation of Disulfide-bridged Peptides

... The primary structure determination of disulfide bridged peptides is greatly facilitated using a ... technologies provides information on complex disulfide structures Methods ... cleaved with immobilised trypsin to eliminate disulfide exchange during digestion, and iodoacetamide was ...

High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation

... of plasmid instability in recombinant bacterial cultures. Biotechnol. Bioeng., 33, 49-61 Komives, E. A. 1994. Expression of Highly disulfide Bonded Proteins in Pichia pastoris, Structure. 2,1003-1005 Modak, J. M. and H. C. Lim. 1989. Simple nonsingular control approach to fed- ...

Purification and Characterization of beta-Lactoglobulin Genetic Variants A and B Using Preparative Electrophoresis and Isoelectric Focusing

... alanine (Ala) in the B variant. All variants contain five cysteine residues, four of which are involved in forming intrachain disulfide bridges. The function of βLG is not yet clear, although binding and transport of retinol, small hydrophobic ligands and ...

Decontamination and inhibition of ribonucleases

... pancreatic RNase A. The pancreatic ribonucleases are small enzymes (15 kd) and consist of a single polypeptide chain with four disulfide bridges. RNase A is a single-strand specific endoribonuclease that is active over a wide pH range, is resistant to metal chelating ...
Disulfide in Biological Products

Origami(DE3) Glycerol Stock from Novagen

Description:... (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytoplasm. Studies have shown that expression in ... since the thioredoxin fusion tag further enhances the formation of disulfide bonds in the cytoplasm. The Origami(DE3)pLacI host is compatible with ...
Company:Novagen

Origami(DE3)pLysS Glycerol Stock from Novagen

Description:... (trxB) and glutathione reductase (gor) genes, which greatly enhances disulfide bond formation in the cytoplasm. Studies have shown that expression in ... since the thioredoxin fusion tag further enhances the formation of disulfide bonds in the cytoplasm. The Origami(DE3)pLacI host is compatible with ...
Company:Novagen

Custom Peptide Synthesis from Raybiotech, Inc.

Description:... Peptide-Protein Conjugation Quantities to Kilograms Multiple disulfide Bridges Complex Peptides/Peptidomimetics Special amino acids and their derivatives Phosphorylated/Biotinylated Structures Peptide labeling ...
Company:Raybiotech, Inc.

ProFound Label Transfer Sulfo SBED Protein:Protein Interaction Reagent from Pierce Biotechnology, Inc.

Description:... avidin biotin-binding protein support. Amine group-specific reactivity Nonspecific photoreactivity Thiol-cleavable disulfide (S-S) linkage A Biotin handle: This biotin transfers from a labeled purified bait protein to a captured prey protein (Figure 2), which makes it ...
Company:Pierce Biotechnology, Inc.

Mts-Atf-LC-Biotin Label Transfer Reagent, 5 mg. from Pierce Biotechnology, Inc.

Description:... prey protein or prey protein-containing lysate, the Atf moiety is activated with UV light capturing the interacting complex. Reduction of the disulfide bond formed by reaction of -SH with the Mts group of the label-transfer reagent results in the transfer of the biotin label from the bait protein to ...
Company:Pierce Biotechnology, Inc.

Mts-Atf-Biotin Label Transfer Reagent, 5 mg from Pierce Biotechnology, Inc.

Description:... prey protein or prey protein-containing lysate, the Atf moiety is activated with UV light capturing the interacting complex. Reduction of the disulfide bond formed by reaction of -SH with the Mts group of the label-transfer reagent results in the transfer of the biotin label from the bait protein to ...
Company:Pierce Biotechnology, Inc.

BL21 Competent Cell Set* from Novagen

Description:... enable you to maximize the yield and activity of your target proteins, including stringent control over basal expression levels, the ability to form disulfide bonds in the cytoplasm for proper folding and activity, and alleviating codon usage incompatibilities. Every strain of Novagen’s competent ...
Company:Novagen

Free Activin B ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:... FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin AB ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:... FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:... FSH release. Inhibins are heterodimers consisting of a common a-subunit linked to either a A subunit (Inhibin A) or B subunit (Inhibin B) by disulfide bridges, and in contrast to the Activins, inhibit FSH release. Messenger RNA studies demonstrate that both Inhibin and Activin are most abundant in ...
Company:Diagnostic Systems Laboratories, Inc.

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Disulfide in Biological Definition

Antibody

... and two identical light chains connected by disulfide bonds . There are five types of heavy chain: ... the heavy and light chains are not linked with disulfide but with noncovalent bonds. The IgA found in ... are covalently linked together with disulfide bonds, usually as a pentamer or a hexamer. It has ...

Disulfide bond

... A disulfide bond ( SS-bond ), also called a disulfide bridge , is a strong covalent bond between two ... their side chains, they normally do so through a disulfide bond. The particular side chain involved is the ...

Endoplasmic reticulum

... Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...

Protein biosynthesis

... post-translational modification . This is may include the formation of disulfide bridges or attachment of any of a number of biochemical functional ... chain, leaving a protein consisting of two polypeptide chains connected by disulfide bonds. External links Protein Synthesis DNA Workshop ...

Endoplasmic reticulum

... Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...

Endoplasmic reticulum

... Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...

Endoplasmic reticulum

... Glycosylation involves the attachment of oligosaccharides . disulfide bond formation and rearrangement. disulfide bonds stabilize the tertiary and quaternary structure of many proteins. ...

Amino acid

... hydrophobic (Nagano, 1999) 121.16 5.05 1.92 10.70 8.37 Under oxidizing conditions, two cysteines can join together by a disulfide bond to form the amino acid cystine . When cysteines are part of a protein, insulin for example, this enforces tertiary structure. D ...

Keratin

... strands called intermediate filaments. These proteins contain a high percentage of sulfur -containing amino acids , largely cysteine , which form disulfide bridges between the individual molecules, resulting in a fairly rigid structure. Human hair is approximately 14% cysteine. There are two main ...

Protein

... by hydrogen bonds . The tertiary structure is held together primarily by hydrophobic interactions but hydrogen bonds , ionic interactions, and disulfide bonds are usually involved too. The process by which the higher structures form is called protein folding and is a consequence of the primary ...

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Disulfide in Biological Dictionary

Disulfide bridge

... In chemistry, a disulfide bond is a covalent bond, usually derived by the ... The linkage is also called an SS-bond or disulfide bridge . The overall connectivity is therefore C-S-S-C. The ... In chemistry, a disulfide usually refers to the structural unit composed ...

Intermembrane space

... ... GO:0005758 : mitochondrial intermembrane space [161 gene products] ... Mitochondria articles relating to ' intermembrane space ' ... A disulfide relay system in the intermembrane space of mitochondria that mediates protein ... Intermembrane space - Wikipedia, the free ...

Denaturation

... Denaturation . l. Any modification in conformation not ... Water content affects heat denaturation . l. Other consequences. Splitting of disulfide bonds ... Zoology information, history, articles and research from Academic Journals, Newspapers, and magazines at HighBeam.com. Free Trial, ...

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Other Contents
(Date:9/22/2014)... A surprising new study pulls back the curtain on ... differences in payment and income between physicians who perform ... , Contrary to perception, the research indicates, the physician ... and other procedure-performing doctors. , The new findings counter ... pay per minute explains why doctors who perform procedures ...
(Date:9/22/2014)... Mozes HealthDay Reporter MONDAY, ... American parents are aware of online physician-rating sites, and more ... their children, according to a new national study. The ... -- further suggest that negative online ratings may dissuade parents ... recommended by a neighbor. Conversely, a positive online rating ...
(Date:9/22/2014)... South Asians living in Canada have a higher rate ... compared with while people, McMaster researchers have found. ... Canadian Medical Association Journal (CMAJ Open) and may ... the fastest-growing ethnic groups in the country is the ... Canada, comprising about three percent of the population. They ...
(Date:9/22/2014)... researchers have published a pilot study showing the ... people with multiple sclerosis (MS). Improvements were ... and pain. "Development and effectiveness of a ... Description and outcomes" was epublished ahead of print ... of MS Care (doi: 10.7224/1537-2073.2013-045). The authors ...
(Date:9/22/2014)... Two new prescription devices approved by the U.S. Food ... people with migraine headaches who don,t tolerate migraine medications ... -- the Cefaly -- is designed to prevent migraines, ... meant to be used when migraines first start, according ... looking for alternative migraine treatments. Because these devices aren,t ...
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(Date:9/21/2014)... of children with autism are significantly less likely to ... than the mothers of children who are developing normally, ... Institute has found. , Low iron intake was associated ... child if the mother was 35 or older at ... suffered from metabolic conditions such as obesity hypertension or ...
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