Bioartificial kidney under study at MCG
...ation and clear and metabolize cytokines that help direct the immune system. The new device for kidney failure adds billions of kidney cells that can perform many of these important kidney functions. Human proximal tubule cells are collected from kidneys obtained by the National Disease Research Interchang...UCSB scientists probe sea floor venting to gain understanding of early life on Earth
...he earliest life here and perhaps elsewhere." The direct linkages between life and planetary processes on the volcanically active, deep-sea, mid-ocean ridge system can only be understood through tightly integrated studies across a broad range of disciplines in geophysics, geology, chemistry, biology, and o...Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
..., can only repair these lesionsthrough a much less direct and elaborate process called nucleotideexcision repair.In the new work, Dr. Bert van der Horst and colleagues studied theeffects of CPD and 6-4PP lesions by providing mice with transgenesencoding CPD and 6-4PP photolyase enzymes.Although mice do not ...Novel technology detects human DNA mutations
...otide Polymorphism (SNP) genotyping, which is the direct detection of a particular gene and the extent to which it is normal or mutated. The technology, reported in the February 2005 (Volume 33, Number 2), issue of Nucleic Acids Research, allows detection of a SNP in an unknown genotype with a greater than...Controversial drug shown to act on brain protein to cut alcohol use
... decrease alcohol craving in the rats, suggestinga direct link between Ibogaine's desirable actions and GDNF."If we can alter the GDNF pathway, we may well have a new treatmentagainst alcohol and drug addiction without the unwanted side effects ofIbogaine," Ron said.Colleagues in the research and coauthors ...HP GenomeWide siRNA from QIAGEN
...gned siRNAs Genomewide, predesigned siRNAs for a direct route to successful RNAi Ready-to-use, convenient matching solutions for SYBR Green based quantitative RT-PCR Cost-effective RNAi and downstream analysis Convenient online ordering at GeneGlobe...Anti-JIP 1 / 2 (SH3) Polyclonal Antibody, Unconjugated, Clone ZMD.177 from Invitrogen
...n overexpressed. A recent study has discovered a direct interaction between JIP1 and amyloid-b-precursor protein (APP), the precursor to the b-amyloid peptide that comprises the amyloid plaques characteristic of Alzheimers disease, in the adult mouse brain. Taken together with previous reports of active J...Small Non-coding RNA Discovery Microarray - Comprehensive Service from LC Sciences
...esign, which enables highly sensitive and specific direct detection of small RNAs (1). This comprehensive service includes custom probe design (according to submitted target RNA sequences) using custom defined parameters, synthesis of the arrays, small RNA enrichment from your total RNA sample (upon request...Agilent 7500ce from Agilent Technologies
...removal in complex sample matrices, allowing the: direct analysis of key elements in estuarine and open ocean seawater ultratrace measurement of Se and Se isotope ratio analysis in biological sample matrices ultratrace measurement of As, Se and Cr in clinical sample matrices The 7500ce incorporates a ......formance (LA-ICP-MS), providing a solution for the direct analysis of challenging solid samples. A range of accessories to further expand the productivity and capabilities of the new ICP-MS series are available. Options like the Clean Room Pack, Productivity Pack and SPS3 autosampler, provide solutions fo...Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems
...gene arecotransfected into mammalian cells, either direct or indirect phosphorylation ofthe fusion trans-activator protein by the uncharacterized gene productwill cause increased transcription of the luciferase gene from the reporterplasmid. Thus, increased luciferase activity indicates that the uncharacter...A Versatile Power Supply for All Electrophoresis Applications
...t-in StrataTherm temperaturecontroller that allows direct regulation of sequencing gel temperatures. TheSmartPower 4000 power supply is programmable, and can store up to 15user-defined and named programs. A built-in timer can be used for elapsed-timemonitoring and for automatic timing of runs. Both current ......nerate recombinantadenoviruses. The first involves direct ligation of the gene of interest intothe adenoviral genome. The scarcity of unique restriction sites and theprohibitive size of the genome (36 kb) make this method technically challenging.The second and more widely used method involves cloning the ge...Safe Production of High-Titer Retrovirus
...ace andfacilitates infection of the target cell by direct interaction with celltype-specific receptors; thus the host range of the virus is dictated not by theDNA vector but by the choice of the env gene used to construct thepackaging cell. The packaging cell line is transfected with the vector DNA and, at...Optimizing Transfection Conditions for Studying Signal Transduction Pathways
...d,increased luciferase expression indicates either direct or indirecttranscriptional activation. The PathDetect cis-reporting systemscan also be used to evaluate the effects of extracellular stimuli or compoundsof interest on each particular enhancer element. Cell lines possess unique properties, such as t...Bypass Heart Surgery Performed Without General Anesthesia
A minimally invasive direct coronary artery bypass (MIDCAB) procedure was performed at Pittsburgh while the patient was awake. The operation was done under thoracic epidural anesthesia. This approach may help in discharging the patient early from the hospital. Dr. Zenati from t...Nasal Spray Could Take Drugs Direct to Brain.
...ch Center in St. Paul, Minnesota, reported that “a direct path from the nose to the brain” could breach the blood-brain barrier, which protects the brain from foreign substances, including drugs. Senior investigator Dr. William H. Frey II said that his team used a nasal spray to deliver insulin-like growth...Depression may cause delayed wound healing
...matic Medicine”. Psychological factors could have direct and indirect effects on the rate of wound healing, according to the researchers. Depression and other psychological problems have been shown to affect the immune system, which may keep a wound from healing on time, they note. Another possibility, ac...Avoid sudden death by quick cooling
...efore restarting it, so that the heart's cells can direct their energies toward repairing themselves rather than being required to start pumping blood right away. At the Argonne National Laboratory in Argonne, Illinois, Becker and his colleagues are developing a material that could be injected into the lun......etaining excess fluid. These new findings should direct physicians' attention towards simple measures that can detect those patients most at risk. In this study, these two signs heralded an increased risk of death from heart failure....PSA TestingHow Much is Too Much?
...h prostate size and that the test thus serves as a direct measure of benign prostatic hyperplasia. Stamey noted that the assay is also helpful for monitoring patients following prostate removal because it can indicate residual prostate cancer that has metastasized. As with many disease screens, PSA tests n...When Volume Matters, Immunoassay Systems Deliver
...ogram and mouse control. MultiCalc software allows direct linkages to a mainframe or LAN. Bayer HealthCare Diagnostic Division, Tarrytown, N.Y., a unit of the German firm Bayer AG, produces the ADVIA Centaur system, designed for flexible operation and integration with diverse laboratory automation systems. ......t frequently caused by health care providers after direct contact with patients. In January 2000, the Soci...r results. In 2004 two screening methods for the direct detection of nasal colonization by MRSA were approved for marketing in the US by the FDA. Both meth...Near-Patient Testing: The Advantages of C-Reactive Protein in Hematological Testing
...nge of diagnostic markers to monitor infection and direct treatment. However, as economic rationalization becomes a necessity throughout the health care sector, it is apparent that such areas of frequent laboratory testing may need careful consideration and revision. Hematology is just one of these areas ......e Dabigatran etexilate is an investigational oral direct thrombininhibitor that specifically and reversibly... 3trials that are designed to investigate the oral direct thrombininhibitor as a potential treatment and prophylaxis for severalthromboembolic disease conditi...