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Differentiation in Medical News

Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway

... that selected Wnt activators induce the differentiation of mesenchymal stem cells to mature, bone-forming ... small molecules that can direct lineage-specific differentiation to an osteoblast phenotype," said Paul Grayson, ... activator of the canonical Wnt pathway stimulates differentiation of mesenchymal stem cells to an osteoblast ...

Fate Therapeutics Granted Exclusive License By The Regents of the University of California to Stem Cell Modulators for Osteo-Regeneration

... small molecules that may be used to induce the differentiation of adult stem cells in the body for ... pathways and small molecules that can induce differentiation to mature, bone-forming osteoblasts offers a new ... strategies and mechanisms for lineage-specific differentiation to an osteoblast phenotype. The ability to ...

How cells change gears: New insights published in Nature Genetics

... the role of the transcriptional network during differentiation in leukemia cells could offer a glimpse into the ... factor network during the processes of differentiation and maturation into immune cells known as ... that appears to play an important role in cell differentiation in white blood cells. "It's a long shot, but if ...

Scientists Identify Key Gene That Protects Against Leukemia

... a gene that controls the rapid production and differentiation of the stem cells that produce all blood cell ... a gene that controls the rapid production and differentiation of the stem cells that produce all blood cell ... signals that regulate the proliferation and differentiation of hematopoietic stem cells, the multipotent, ...

Frost & Sullivan Honours Outstanding Achievements in Healthcare

... - 2008 European Point-of-Care Immunoassay Product differentiation Innovation Award Aesku.Diagnostics - 2008 ... Tissue Sealants & Topical Hemostats Product differentiation Innovation Award Xenometrix AG - 2009 ... 2008 European Insurance Claims Management Product differentiation Innovation Award IBM - 2008 European ...

New stem cell therapy may lead to treatment for deafness

... conditions that allowed for the progressive differentiation into neurons and hair cells with the same ... that future studies will aim to improve the differentiation system. They are currently working on using the knowledge gleaned from this study to optimize the differentiation of human embryonic stem cells into ear cell ....

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Differentiation in Medical Technology

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

... the activation of JNK kinase, a key regulator of cellular growth and differentiation of blood. TELINTRA has been shown to stimulate normal multilineage differentiation of blood stem cell precursors and induce cancer cell death in human ...

Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology

... are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. The effects of perifosine on Akt are of particular ... are pathways associated with programmed cell death, cell growth, cell differentiation and cell survival. KRX-0401 is currently in Phase 2 clinical development ...

Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity

... a member of the St. Jude Department of Genetics and Tumor Cell Biology. differentiation is the process by which genetic activity causes an immature cell type to ... years, some discoveries have challenged the long-standing belief that cell differentiation is an irreversible final process," said Oliver, the paper's senior author. ...

Neuralstem Announces Issuance of Core Technology Patent in Europe

... patent EP0915968, covering the "Isolation, Propagation and Directed differentiation of Stem Cells from Embryonic and Adult Central Nervous System of Mammals." ... and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and ...

Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models

... the Wnt pathway, a signaling pathway that is critical for cell growth and differentiation during homeostasis and pathogenesis. "This study reinforces our belief ... program, which targets a range of indications where cell regeneration and differentiation are important to disease processes, including gastrointestinal disease, ...

St. Jude Defines Eye Cancer Gene's Role in Retinal Development

... roles during prenatal development by regulating the proliferation, size, differentiation and survival of cells. Myc genes are also proto-oncogenes--genes in which ... that N-myc is not involved in regulating cell survival or neuronal differentiation in the developing retina. However, the gene is crucial for the ...

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Differentiation in Medical Products

Free Activin AB ELISA Test

Description:... (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) ... endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:... (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) ... endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:... (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) ... endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary ...
Company:Diagnostic Systems Laboratories, Inc.

BBL CHROMagar MRSA

Description:... the chromogenic substrate resulting in mauve colonies, thus permitting differentiation from other gram-positive organisms. A cephalosporin is incorporated for the differentiation of methicillin-resistant strains from methicillin-susceptible strains. BBL ...
Company:BD Diagnostic Systems

Cyto-Chex BCT Vacuum Tube

Description:... for immunophenotyping by flow cytometry. The preservative contained in Cyto-Chex BCT maintains the integrity of the white blood cell cluster of differentiation (CD) markers for up to seven days. Patient samples collected in Cyto-Chex BCT are stable at room temperature for convenient transport and ....
Company:Streck

3rd Edition City University Color Vision Test

Description:... This test displays normal protan, deutan and tritan colors, differentiation is stronger in the red/green. Significant tritan defects may be detected if used in conjunction with the Ishihara. The test includes a ...
Company:Keeler Instruments Inc.

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Differentiation in Medical Dictionary

Adhesion

... INTEGRIN-mediated interactions between cells and extracellular matrix protein s influence a variety of biological processes, such as cell growth, differentiation and migration. INCERT ( adhesion prevention ) Bioabsorbable, implantable sponge designed to prevent the formation of adhesion s postsurgically. ...

Antigen

... immune system to produce antibodies against it. HLA antigen s are the major determinants used by the body's immune system for recognition and differentiation of self from non-self (foreign substances). Prostate -specific antigen ( PSA ) is a protein produced by the cells of the prostate gland . ...

Catecholamines

... usually associated with threatening situations leading to a panic attack . Epinephrine Adrenaline ... Evidence for sympathetic neuron al differentiation may be demonstrated by immunohistochemistry, electron microscopy, or by finding elevated levels of serum catecholamines (e.g., dopamine and ...

Cell

... exists primarily to deal with virus es that are more insidious than bacteria because they invade the host (eg, human) cells, ... cell differentiation The process during which young, immature (unspecialized) cells take on individual characteristics and reach their mature (specialized) form and ...

Dietitian

... with special training in nutrition who can offer help with the choice of foods a person eats and drinks. Also called a nutrition ist. differentiation ... A dietitian is also uniquely qualified to provide counseling on associated conditions that commonly accompany celiac disease (such as ...

Endometrial cancer

... cancer is unknown, increased levels of estrogen appear to have a role. Endometrial cancer can be grouped with regard to the degree of differentiation of the adenocarcinoma , as follows: ... Endometrial Cancer Alternate Names : Adenocarcinoma of the Endometrium/ Uterus , Cancer - ...

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Differentiation in Biological News

Stem cell research: From molecular physiology to therapeutic applications

... Deng from Peking University is working on the differentiation of human embryonic stem cells into pancreatic ... embryonic and inducible pluripotent stem cell differentiation into functional pancreatic islet cells and ... Sciences. He has been studying the mechanism of differentiation and de-differentiation, cellular plasticity and ...

Xie Lab uncovers molecular machinery related to stem cell fate

... how the BAM protein affects germline stem cell differentiation and how it is involved in regulating the quality ... proper balance between stem cell self-renewal and differentiation is critical for normal homeostasis. An imbalance ... Xie Lab established that BAM controls stem cell differentiation and competition by interfering with the function ...

Scientists identify key gene that protects against leukemia

... a gene that controls the rapid production and differentiation of the stem cells that produce all blood cell ... signals that regulate the proliferation and differentiation of hematopoietic stem cells, the multipotent, ... at which HSCs are proliferating and the rate of differentiation toward the myeloid lineage that ultimately ...

Protein is key to embryonic stem cell differentiation

... role in the pathways that control decisions for differentiation or self-renewal in both human embryonic stem ... and controlling the processes that lead to differentiation of hESCs into specialized cell types. "There ... lab created mutant Shp2 mESCs and showed that differentiation was dramatically impaired as the cells ...

New 'control knobs' for stem cells identified

... Potential Controls Adipogenic and Osteogenic differentiation of Mesenchymal Stem Cells" in the November 17, ... increase in negative voltage that occurs during differentiation and suppressed fat and bone cell differentiation markers. In contrast, treatment with ...

Landmark study unlocks stem cell, DNA secrets to speed therapies

... complex process by which DNA is repackaged during differentiation -- when embryonic stem cells, jacks of all ... how replication works during embryonic stem cell differentiation gives us a molecular handle on how information is ... same genetic information in their DNA, but during differentiation they package it with proteins into 'chromatin' in ...

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Differentiation in Biological Technology

Lilly Announces Launch of Color Differentiation System for Humalog(R) and Humulin(R) U-100 Insulin Products in the United States

... injection, USP [rDNA origin)]). The Lilly color differentiation system - also used for Humalog and Humulin ... label. However, people should remember that color differentiation of insulin is not a substitute for reading ... in patients with type 2 diabetes. Color differentiation of other Humalog and Humulin U-100 ...

Many paths, few destinations: How stem cells decide what they'll be

... PU.1, transcription factors that normally favor differentiation into red and white blood cells, respectively. ... done follow-up experiments showing that stem cell differentiation can be made dramatically more efficient by ... on the shape of the landscape. Growth or differentiation factors merely increases the probability that a ...

Method to deliver molecules within embryonic stem cells improves differentiation

... McDevitt. Our method focuses on incorporating the differentiation factors directly into the cell aggregates in ... acid) (PLGA) microspheres on embryonic stem cell differentiation under different conditions by varying the ... Next, the researchers compared differentiation of untreated cells, cells mixed with empty ...

Gladstone scientists identify role of tiny RNAs in controlling stem cell fate

... factors called microRNAs may influence the differentiation of pluripotent embryonic stem (ES) cells into ... from developing into unwanted cell types. The differentiation of ES cells into heart cells or any other type of ... the role of individual miRNAs in ES cell differentiation had not previously been determined. The Gladstone ...

Stem cells' 'suspended' state preserved by key step, scientists report

... an efficient reprogramming. Chd1 is important for allowing the normal differentiation process, and it is essential for playing the 'differentiation tape' ... used to simulate normal cell specialization, the scientists detected no differentiation of cardiac muscle, and also no formation of a tissue known as primitive ...

Scientists identify gene vital to early embryonic cells forming a normal heart and skull

... a deficiency of SHP2 in neural crest cells results in a failure of cell differentiation at diverse sites in the developing embryo," said Jeffrey Robbins, Ph.D., ... the exact alterations in neural crest cell migration, expansion and differentiation that contribute to birth defects of other organ systems. ...

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Differentiation in Biological Products

GPDH Assay Kit from Takara Mirus Bio

Description:... GPDH activity increases significantly during differentiation of progenitor cells into adipocytes and, thus, ... of GPDH. This kit can be used to either screen differentiation repressors or to study mechanisms regulating differentiation of primary or established cell-line progenitor ...
Company:Takara Mirus Bio

Mouse Dopaminergic Neuron Differentiation Kit, 2nd Generation from R&D Systems

Description:... Reagents for the differentiation of mouse embryonic stem cells to dopaminergic ... conditions required for functional DA neuron differentiation of ES cells. Experimental models established ... DESIGN OF THE KIT The Mouse Dopaminergic Neuron differentiation Kit is a system designed for in ...
Company:R&D Systems

Skeletal Myogenesis Assay from CHEMICON

Description:... multiple applications in the study of muscle biology. Components: differentiation Supplement 1 ( differentiation Supplement 2 ( Myogenesis Matrix : Part No. 2 ...
Company:CHEMICON

Osteoclasts Culture Kit from B-Bridge International

Description:... The bone mineral is then solubilized and the collagen degraded. Osteoclast differentiation and function is controlled primarily by Macrophage Colony-Stimulating ... disease osteopetrosis and the absence of M-CSF results in the arrest of differentiation in the pre-osteoclast stage. B-Bridges Osteoclast Culture Kit includes ...
Company:B-Bridge International

Free Activin B ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:... (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) ... endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary ...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin AB ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:... (1). Other members incude TGF-s, bone morphogenetic proteins, growth differentiation factors, AMH/MIS (Anti-Mullerian Hormone/Mullerian Inhibiting Substance) ... endocrine role, these proteins have been shown to affect the growth and differentiation of a number of cell types, including cultured rat anterior pituitary ...
Company:Diagnostic Systems Laboratories, Inc.

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Differentiation in Biological Definition

Apoptosis

... during an organism's life cycle. For example, the differentiation of human fingers in the developing embryo ... which B and T cells are driven to proliferation, differentiation or apoptosis comprises a complex interplay ... of the nervous system, but cell lineage and differentiation inevitably led to the study of cell fate: "One ...

Morphogenesis

... with the control of cell growth and cellular differentiation . Morphogenesis is concerned with the shapes of ... various specialized cell types. Cell growth and differentiation can take place in cell culture or inside of tumor ... can diffuse and carry signals that control cell differentiation decisions in a concentration-dependent fashion. ...

Morphogenesis

... with the control of cell growth and cellular differentiation . Morphogenesis is concerned with the shapes of ... various specialized cell types. Cell growth and differentiation can take place in cell culture or inside of tumor ... can diffuse and carry signals that control cell differentiation decisions in a concentration-dependent fashion. ...

T cell

... . Thymocytes are immature T cells. The differentiation called thymic education occurs in a few stages ... midstage of T cell differentiation. At the end of differentiation they express TCRs, CD3, CD4 and CD8 molecules. ... It is important to note that not only is the differentiation of T cells controlled by thymic ...

Alga

... Filamentous - a string of non-motile cells connected together, sometimes branching Parenchymatous - cells forming a thallus with partial differentiation of tissues In three lines even higher levels of organization have been reached, leading to organisms with full tissue differentiation. These are ...

Anabolism

... organism level is as anabolic or catabolic . Anabolic processes tend toward "building up" organs and tissues. These processes produce growth and differentiation of cells and increase in body size, a process that involves synthesis of complex molecules. Examples of anabolic processes include growth and ...

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Differentiation in Biological Dictionary

Morphogenesis

... of the structure of an organism or part; differentiation and growth of tissues and organs during ... Cell. 1979 Jul;17(3) ... Keywords: cell differentiation • morphogenesis • pattern formation. ... ... of ... Mammary gland morphogenesis and. differentiation occur during postnatal development. ... The ...

Heterocyst

... that have specialized ... Heterocyst differentiation in the cyanobacterium Anabaena sp. ... ... Anabaena strain PCC 7120, ... Heterocyst differentiation is a highly regulated process, resulting in a ...... Elhai (U. Richmond) ... µM blocks heterocyst differentiation while having no effect on macromolecular ...

Differentiation

... The process of finding a derivative is called differentiation . ... 2 Notations for differentiation . 2.1 Leibniz's notation. 2.2 Lagrange's notation ... differentiation (economics), the making a product different ...

Purkinje fibers

... the cardiac conduction system ... In the avian heart, Purkinje fiber differentiation takes ... This effect was more striking in Purkinje fibers with a ... on canine purkinje fibers . Circ Res. ... Periarterial differentiation of Purkinje fibers in vivo and ET-dependent ... The definite ...

Inner cell mass

... of the inner cell - mass a layer of flattened cells, the ... differentiation of the inner cell mass from the trophoblast ... Inner cell ... the cells that can generate cells of all germ ... Blastocyst differentiation Inner cell mass and not trophoblast shell is ... Murine inner ...

Glial cells

... generally leave their place of birth to migrate to positions where ... differentiation of the first neurons and glial cells starts at around 8 hrs (stage 12) ... is no gcm expression in midline glial cells . ... Glial cell differentiation in Drosophila ... The term 'radial glial cell ' refers to their two ...

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