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Deletion in Medical News

Does 1q31.1-32.1 harbor a tumor suppressor gene related to Chinese SCC patients?

... has become an effective way to find allelic deletion regions and then to find candidate tumor ... tumor suppressor gene(s). However, the allelic deletion region contained so many genes that it was ... and found a minimal region of frequent deletion located within a 2-cM genomic segment at ...

St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia

... of cancer. The most common change was deletion of the gene for Ikaros. The gene was deleted ... whom also had lost the gene for Ikaros. The PAX5 deletion occurred in 51 percent of the BCR-ABL1 ... converted to ALL, two out of three had the deletion of the Ikaros gene; a lower percentage of those ...

St. Jude discovery offers new avenues to understanding an aggressive form of leukemia

... as "cooperating oncogenic lesions," include the deletion of a gene, IKZF1, whose protein, Ikaros, normally ... progression of cancer. The most common change was deletion of the gene for Ikaros. The gene was deleted ... whom also had lost the gene for Ikaros. The PAX5 deletion occurred in 51 percent of the BCR-ABL1 ALL ...

New Map of Genomic Variation Will Enable Disease Research

... three unique CNVs were relatively small in size, but the third CNV was a deletion in chromosome 17 that encompassed 51 genes, including several that are ... child's parents, strongly supporting the conclusion that the chromosome deletion arose spontaneously in the patient and that it caused the child's disease. ...

Gene Studies Reveal Cancer's Secrets

... in 10 percent of these patients. The mutations were associated with a deletion of the genes IKZF1 and CDKN2A/B and poor outcome. And, over four years, 71 ... looked at the number of copies of the UGT2B7 gene and found that although deletion patterns for UGT2B17 and UGT2B28 genes were between 3.4 percent and 19.9, ...

Researchers identify mechanism, possible drug treatment for tumors in neurofibromatosis

... experiments. Previously, Dr. Parada had shown that mice with a targeted deletion of the NF1 gene in their Schwann cells and an NF1+/- genetic background develop plexiform neurofibromas, while mice with the same targeted deletion and an NF1+/+ genetic makeup do not develop the tumors. Drs. Parada and ...

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Deletion in Medical Technology

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... to be either deleted or part of it is lost. One deletion that is occasionally seen in CLL patients is the ... Effective CLL therapies for patients with 17p deletion are limited. In one analysis of ... -- including high risk patients with 17p deletion and in patients where conventional chemotherapy ...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

... found four deletions of DNA in a gene recently linked to restless legs syndrome, a type of sleep disorder common in adults with ADHD. Another deletion occurred in a gene for a glutamate receptor. Glutamate is a neurotransmitter, a protein that carries signals in the brain. While ADHD medications act ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... times, either as a single agent or as part of a combination regimen. Of the 24 patients with genetic data, 17 had high genomic risk factors, such as deletion of the 17p or 11q chromosomes. At the time of the presentation, patients had received intravenous doses of TRU-016 ranging from 0.03 mg/kg to 10 ...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... 64% of patients (43/67) taking BIBW 2992 in the second-line setting experienced a partial response (75% among patients with deletion 19 and 66% in patients with L858R mutations) 31% (21/67) of patients taking BIBW 2992 in the second-line setting experienced stable disease ...

Gene Abnormality Found to Predict Childhood Leukemia Relapse

... DS, Yang W, Relling MV, Shurtleff SA, Campana D, Borowitz MJ, Pui C, Smith M, Hunger SP, Willman CL, Downing JR, and the Children's Oncology Group. deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia. NEJM . Vol. 360, No. 5. St. Jude Children's Research Hospital St. Jude ...

Reprogrammable Cell Type Depends on a Single Gene to Keep Its Identity

... in which the Prox1 genes could be deleted from LECs at different times during development or after birth. The St. Jude team found that deletion of Prox1 in LECs promoted their reprogramming into BECs as indicated by the expression of specific LEC and BEC proteins. In addition, the newly ...
Deletion in Medical Products

WardWatch v3.1.1

Features:... Companion - Hotsync of patient and event records with Windows desktop companion Patient view or event view Rapid creation, modification and deletion of patient and patient records information on desktop Sorting of patient records on any field headers; name, age, sex, MRN, bed, ward, and ...
Company:Torlesse Systems Pty Ltd

1p/19q, d(1;19) Deletion by FISH

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' ...
Company:ARUP Laboratories
Deletion in Medical Dictionary

Aarskog syndrome

... single transverse palmar crease is associated with a number of different dysmorphic disorders, including Aarskog syndrome ; de Lange syndrome ; the deletion syndrome s involving chromosomes 4p, 4q, ... ...

Carcinoma

... in March 2000. Approved in several overseas markets; investigational in the U.S. To identify tumor suppressor loci, we have completed an allelic deletion map of small cell lung carcinoma s, and are commencing on a similar map for non-sm~ cell lung cancer s. The next most common skin cancer ...

Chromosome

... in a gene found on the X chromosome . Chromosome 8p is commonly deleted in prostate cancer ; consequently, many groups have focused on using deletion mapping in an attempt to localize one or more tumor suppressor genes in this region. A gene on chromosome 17 that normally helps to ...

DiGeorge Syndrome

... DiGeorge syndrome affects about one in 4,000 birth s DiGeorge syndrome affects about one in 4,000 birth s. Most cases result from a deletion of a tiny part of chromosome 22 known as 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR). DiGeorge syndrome is a childhood ...

FSH

... to determine why the couple cannot achieve pregnancy ( infertility ). The diagnosis of FSH D can be confirmed by a DNA test disclosing the deletion of copies of a repeat motif called D4Z4 on chromosome 4. FSH D is inherited in an autosomal dominant manner. It causes the pituitary gland ...

Genetic Disorders

... in humans. Genetic disorders are caused by abnormalities ( mutation s) in your DNA. These abnormalities are formed by the erroneous addition, deletion or substitution of chemicals that make up your DNA. See all Pictures & Images Genetic disorders Almost all disease s have a genetic ...

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Deletion in Biological News

Recurrent genetic deletion linked to autism

... may underlie the development of autism." The deletion results in the loss of about 25 known genes. ... found that two out of those 180 (1.1%) had a deletion in region 16p11.2, on the short arm of chromosome ... They found two additional subjects with the same deletion (0.4%), which was seen in none of the 465 ...

Microarray analysis improves prenatal diagnosis

... and automatically to identify copy number variation, which indicates the deletion or addition of genetic material at a particular point on the genome. ... to cause the defects. In the third case, there was a relatively large deletion in an area of chromosome 3, but it was also present in the mother, who had ...

Case Western Reserve University uncovers genetic basis for some birth defects

... cells had developmental defects resembling those of human patients with a deletion that includes this gene. The patients have features that are similar to ... that we had in fact developed animal models that mimicked the human deletion syndrome," said Landreth. "This work sheds light on how these ...

Work with power grids leads to cell biology discovery

... compromise gene activity. Their network-based method does this by targeted deletion of genes, forcing the cell to either bypass the functions affected by the ... (via computer simulation) with E. coli, the researchers found that the deletion of one gene is lethal to the cell but when that same gene is removed along ...

Overeating and obesity triggered by lack of BDNF

... mice when food access was limited to that of normal mice, indicating that deletion of the Bdnf gene in the VMH and DMH does not affect the expenditure side ... exhibit behavioral abnormalities typically observed in mice with global deletion of the Bdnf gene throughout the brain, such as hyperaggression, ...

Ultraconserved elements in the genome: Are they indispensable?

... Lab senior scientist who is one of the primary authors of the study. "The deletion of these elements likely has relatively mild effects on fitness that are ... not explain why they are so ultimately conserved." The discovery that deletion of ultraconserved elements does not render mice unviable or infertile is a ...

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Deletion in Biological Technology

Scientists fix bugs in our understanding of evolution

... however, to judge if a length difference between two sequences is a deletion in one or an insertion in the other sequence. For correct alignment of ... lab. "Say we are comparing the DNA of human and chimp and can't tell if a deletion or an insertion happened. To solve this our tool automatically invokes ...

New Study Raises Questions About Prostate Cancer Therapies Targeting Insulin-Like Growth Factor Receptor

... compromised. The results were as predicted: Prostate epithelial-specific deletion of IGF-1R facilitated the emergence of aggressive prostate cancer in the ... mechanism, according to the authors. Title of the paper is "Conditional deletion of insulin-like growth factor-1 receptor in prostate epithelium." "If ...

Use it or lose it? Researchers investigate the dispensability of our DNA

... forces at work. "With this in mind, we set out to examine the genomic data, much as someone would examine archaeological data, in search of similar deletion events that have happened naturally, and more importantly, were retained in the wild." "An analogy I like to entertain is that of plate tectonics: ...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... Targets Human Double Minute 2 (Hdm2) The Hdm2 oncogene is activated in cancers through various mechanisms, including gene amplification and deletion of upstream tumor suppressors. Hdm2 over-expression induces tumor formation, and Hdm2 levels correlate with sporadic tumor incidence in humans(i). ...

NimbleGen microarrays speed genetic findings

... . One form of retardation, caused by a large deletion that spans six genes on chromosome 17, has ... were able to pinpoint the region of the specific deletion using high resolution CGH microarrays. In a ... added. Genetic inversion Although the deletion on chromosome 17 potentially accounts for only ...

Heteroduplex Analysis Using the DCode System

... base insertion (+TC) and ΔF311, three base deletion (-TTC). The mutations from exon 10 were a heterozygous ΔF508, three base deletion (-CTT), a heterozygous compound sample Q493 (C to ... a heterozygous ΔI507, three base deletion (-ATC). Samples were provided by Dr. L. ...

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Deletion in Biological Products

Kilo Sequencing Deletion Kit from Takara Mirus Bio

Description:... The deletion Kit for Kilo-Sequencing is designed to aid sequence analysis of long DNA ... cocktails are included to ensure efficient self-circularization of the deletion ....
Company:Takara Mirus Bio

pWEB::TNC Deletion Cosmid Transposition Kit from EPICENTRE Biotechnologies

Description:... The pWEB::TNC™ deletion Cosmid Cloning Kit enables you to prepare, in about two days, a complete ... primary cosmid library of genomic DNA for subsequent use in making nested deletion sublibraries. High efficiency cosmid library construction is accomplished ...
Company:EPICENTRE Biotechnologies

EZ-Tn5 Plasmid-Based Deletion Machine from EPICENTRE Biotechnologies

Description:... The EZ-Tn5™ Plasmid-Based deletion Machine is based on the simple, highefficiency Tn5 in vitro transposition system developed by Goryshin and Reznikoff, and by York et al. for ...
Company:EPICENTRE Biotechnologies

Mouse Anti-p14 ARF / p16Beta Ab-2 Mouse Monoclonal Antibody, Unconjugated, Clone 14P02 from Lab Vision

Description:... and accumulation. This interaction is mediated by the exon 1Beta-encoded N-terminal domain of p14^ARF^ and a C-terminal region of mdm2. deletion of the ARF-INK4a locus simultaneously impairs both the INK4a-cyclin D/cdk4-RB and the ARF-mdm2-p53 pathways. Epitope: N-terminal Molecular ...
Company:Lab Vision

SuperScript II RNase H- Reverse Transcriptase from Invitrogen

Description:... strand from single-stranded RNA DNA or an RNA:DNA hybrid. This enzyme is genetically engineered by the introduction of point mutations rather than a deletion in the RNase H active center. Like SuperScript™ RT SuperScript™ II RT has 106- to 107-fold reduced RNase H activity. Unlike ...
Company:Invitrogen

SuperScript II RNase H- Reverse Transcriptase from Invitrogen

Description:... strand from single-stranded RNA DNA or an RNA:DNA hybrid. This enzyme is genetically engineered by the introduction of point mutations rather than a deletion in the RNase H active center. Like SuperScript™ RT SuperScript™ II RT has 106- to 107-fold reduced RNase H activity. Unlike ...
Company:Invitrogen
Deletion in Biological Definition

Chromosome

... Cri du chat syndrome , which is caused by the deletion of part of the short arm of chromosome 5. ... syndrome , which is caused by partial deletion of the short arm of chromosome 4. It is ... Jacobsen syndrome , also called the terminal 11q deletion disorder. A very rare disorder. More information ...

Chromosomal crossover

... is the normal way for crossover to occur. If they break at slightly different loci, the result can be a duplication of genes on one chromosome and a deletion of these on the other. If they break and rejoin on opposite sides of the centromere , the result can be one chromosome being lost during cell ...

Molecular genetics

... that results from mutating a given gene. This is called reverse genetics. In some organisms, such as yeast and mice , it is possible to induce the deletion of a particular gene, creating a gene knockout . Alternatives include the random induction of DNA deletions and subsequent selection for deletions ...

Reverse genetics

... or to discover its biological function, researchers may engineer a change or disruption in it -- by site-directed mutagenesis , for example, by deletion of a gene by gene knockout (as can be done in some organisms, such as yeast and mice ) -- and only afterwards look for the effect of such ...
Deletion in Biological Dictionary

Insertion mutations

... segment, ... Frame shift mutations involve a deletion or insertion of one or two base pairs ... ... sets of insertion mutations , which ... deletion and insertion mutations can be formed in two ... mutations can be caused by an insertion or deletion of one or more letters ... An Intron-Derived ...

Frame-shift

... mutation caused by indels, ie. insertion or deletion of a number of nucleotides that is not evenly ... gene expression by codons, the insertion or deletion can ... A directed change in ... does Frame shift mutation mean in law? ... deletion and a frame shift mutation in the ...

Direct Repeats

... direct repeats argues that the majority of deletion ... nascent strand at the direct repeats ... deletion of direct repeats in retroviral genomes ... ... Thus, direct repeats are "hot spots" for deletion formation. ... ...

Deletion

... In genetics, a deletion is a mutation in which a part of a chromosome or a sequence of DNA is missing. deletion is the loss of genetic material. Any number of ... base to an entire ... The Wikipedia deletion policy describes how pages that do not meet the ...

Contiguous gene syndrome

... next to each other on a chromosome. 22q11.2 deletion syndrome is a particularly well known example. ... Contiguous gene syndrome : A disorder due to deletion of multiple gene loci that ... An example of ... A characteristic complex phenotype produced by deletion of a short Contiguous gene syndrome . ...

Frameshift Mutation

... mutation is a genetic mutation caused by indels, ie. insertion or deletion of a number of nucleotides that is not evenly divisible by three from a ... the triplet nature of gene expression by codons, the insertion or deletion can ... frameshift mutation ( ) n. A mutation in a DNA ...

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