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Cytotoxic in Medical News

Micromet and MedImmune to Present New Clinical Data for Anti-CD19 BiTE(R) Antibody at American Society of Hematology Annual Meeting Showing Objective Clinical Responses in Relapsed Non-Hodgkin's Lymphoma Patients

... selectively direct and activate an individual's cytotoxic T-cells, the body's most potent killer cells, to ... These cytolytic synapses enable the delivery of cytotoxic proteins from T-cells into tumor cells, ... antibodies that activate a patient's own cytotoxic T cells to eliminate cancer cells. Micromet is ...

Micromet's BiTE(R) Antibodies Reveal Unique Mode of Action

... antibodies are designed to transiently connect cytotoxic T cells with cancer cells leading to a tightly ... elimination of cancer cells. In this process, cytotoxic T cells are activated, which causes them to ... These cytolytic synapses enable the delivery of cytotoxic proteins from T cells into tumor cells, ...

4th ESU master class on medical treatment for urological cancer held in Barcelona, Spain

... module 2 'Immunotherapy and targeted therapies' and module 3 'Systemic cytotoxic chemotherapy and palliation'. Each module comprises short ... treatment, chemoprevention, immunotherapy, targeted therapies and systemic cytotoxic chemotherapy and palliation, supplemented with case discussions and ...

Early treatment of systemic onset JIA with anakinra restores the IL-18 response

... function which compromises their immune systems, since NK cells (a type of cytotoxic lymphocyte, or white blood cell, that is capable of killing infected ... patients flared following anakinra treatment. *NK cells are a type of cytotoxic lymphocyte that constitute a major component of the innate immune system. ...

European Commission and United States Food and Drug Administration (FDA) Both Approve New Options for Patients With Certain Primary Brain Tumors

... In addition to the new presentations, TEMODAL (temozolomide), a cytotoxic agent, is currently approved in oral form as 5mg, 20mg, 100mg, 140mg, 180mg and 250mg capsules in Europe. cytotoxic agents are designed to impact the replication of cells that divide ...

Telik Announces Fourth Quarter and 2008 Year End Financial Results and 2009 Financial Guidance

... and Telik's two leading preclinical oncology drug candidates: a cytotoxic prodrug, TLK58747, and dual Aurora-VEGFR inhibitor, TLK60404. The company ... SCIN, 3) advancing its two leading preclinical oncology drug candidates: a cytotoxic prodrug, TLK58747, and dual Aurora-VEGFR kinase inhibitor, TLK60404, 4) ...

Craig W. Philips Takes Helm at CTI

... activity and has demonstrated activity in combination with standard cytotoxic agents as well as with newer targeted therapies in preclinical, ... activity and has demonstrated synergism in combination with standard cytotoxic agents as well as with newer targeted therapies in preclinical ...

Micromet, Inc. Reports First Quarter 2008 Financial Results

... represent a new class of antibodies that activate a patient's own cytotoxic T cells, considered the most powerful "killer cells" of the human immune ... T cell attacks. These cytolytic synapses enable the delivery of cytotoxic proteins from T cells into tumor cells, ultimately inducing a ...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Demonstrates Pre-clinical Activity in Glioblastoma Multiforme

... MP470, its clinical-stage multi-targeted tyrosine kinase inhibitor, is cytotoxic to glioblastoma multiforme cell lines (Abstract No. 178). Activity was ... synergistic with radiation. Glioblastoma multiforme is often resistant to cytotoxic therapies and radiation, due to increased DNA repair and the inhibition of ...

Micromet Receives Regulatory Approval to Conduct a Phase 2 Clinical Trial Investigating MT103 (MEDI-538) in Patients with Acute Lymphoblastic Leukemia

... T cell attacks. These cytolytic synapses enable the delivery of cytotoxic proteins from T cells into tumor cells, ultimately inducing a ... represent a new class of antibodies that activate a patient's own cytotoxic T cells to eliminate cancer cells. Micromet is developing MT103 in ...

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Cytotoxic in Medical Technology

Pharmatek's Highly-Potent and Cytotoxic (HP/C) Facility Positions It as Industry Leader in Development and Manufacturing of HP/C Compounds

... Effectiveness Of New Highly-Potent And cytotoxic (HP/C) Facility Through Airborne Particulate ... and manufacturing of highly-potent and cytotoxic compounds. "The testing results of our HP/C ... services to include highly potent and cytotoxic compounds, and do it in the safest possible way," ...

Nventa Presents Findings on Proprietary Toll-like Receptor 3 (TLR3) Agonist, Poly-ICR, at World Vaccine Congress

... a disease-specific antigen can induce both cytotoxic T-cell and antibody (B-cell) immune responses against that antigen. cytotoxic T-cells, also referred to as CD8 T-cells, are ... near future; Poly-ICR's ability to induce both cytotoxic and antibody immune responses; and our ...

AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Ovarian Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108

... first drug in a clinical study that targets the cytotoxic activity of doxorubicin specifically to ... of a synthetic peptide carrier and a well-known cytotoxic agent, doxorubicin. The design of this product ... the specific binding and selective uptake of the cytotoxic conjugate by LHRH-receptor-positive tumors. ...

Clinical Data Published in 'Science' Show Tumor Regressions in Relapsed Lymphoma Patients Treated with T Cell Engaging BiTE Antibody Blinatumomab

... may relate to the high anti-tumor activity of cytotoxic T cells recruited by blinatumomab," commented ... These cytolytic synapses enable the delivery of cytotoxic proteins from T cells into tumor cells, ... class of antibodies that activate a patient's own cytotoxic T cells, considered the most powerful "killer ...

Nventa Develops Proprietary Vaccine Adjuvant

... a disease-specific antigen can induce both cytotoxic (T-cell) and antibody (B-cell) immune responses against that antigen. cytotoxic T-cells, also referred to as CD8 T-cells, are ... vaccines; Poly-ICR's ability to induce both cytotoxic and antibody immune responses; our expectation ...

Micromet Announces Presentation of Five Posters Related to Its Proprietary BiTE Antibody Platform at Annual Meeting of American Association for Cancer Research

... can be delivered subcutaneously, and show that cytotoxic T cell activity is not impaired by long-term BiTE ... These cytolytic synapses enable the delivery of cytotoxic proteins from T cells into tumor cells, ... class of antibodies that activate a patient's own cytotoxic T cells, considered the most powerful ...

Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer

... of a physician qualified in the use of cytotoxic anti-cancer therapy. Malignant pleural ... is given in combination with other cytotoxic agents; most of these patients had pre-existing ... (Usually when given in combination with other cytotoxic agents and with pre-existing cardiovascular ...

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

... convenience." About temozolomide TEMODAL (temozolomide), a cytotoxic agent, is currently approved in oral form as 5mg, 20mg, 100mg, 140mg, 180mg and 250mg capsules in Europe. cytotoxic agents are designed to impact the replication of cells that divide ...

Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells

... autoimmune diseases, presented data from a preclinical study(1) showing cytotoxic activity of anti-EpCAM antibody adecatumumab (MT201) against KRAS-mutated ... represent a new class of antibodies that activate a patient's own cytotoxic T cells, considered the most powerful "killer cells" of the human immune ...

Micromet's BiTE Antibody Blinatumomab (MT103/MEDI-538) Demonstrates Durable Responses in Patients with Relapsed Non-Hodgkin's Lymphoma

... T cell attacks. These cytolytic synapses enable the delivery of cytotoxic proteins from T cells into tumor cells, ultimately inducing a ... represent a new class of antibodies that activate a patient's own cytotoxic T cells, considered the most powerful "killer cells" of the human immune ...

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Cytotoxic in Biological News

A double-barreled immune cell approach for neuroblastoma

... from the body too quickly to have an anti-cancer effect. However, cytotoxic T cells that already have a natural receptor for the Epstein-Barr virus ... effect they trampoline off the virus and onto the tumor." Thus these cytotoxic T-lymphocytes remain in the body because they are constantly stimulated by ...

American Chemical Society's Weekly PressPac -- June 25, 2008

... of polyphenols. The polyphenols work not only to prevent generation of cytotoxic compounds, but also as compounds which prevent the absorption of cytotoxic compounds from the gastrointestinal tract into the blood stream. MTS ...

New drug shows promise in treating drug-resistant prostate cancer

... to try to develop drugs that prevent that renewed resistance." For years, no treatment was available for CRPC; recently paclitaxel a strongly cytotoxic drug was approved. ...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

... the tumor occurs. After conversion to the active form of the drug, the more resistant hypoxic cells are exposed to high concentrations of released cytotoxic agent, which can also diffuse into the oxygenated regions of a tumor cell. The Phase 1/2 trials are investigating the safety and activity of ...

Viral recombination another way HIV fools the immune system

... of more complex strains of HIV." Part of the immune system's response against HIV is carried out by HIV-specific CD8 T cells, also called cytotoxic T lymphocytes (CTLs), which can identify and kill virus-infected cells. Previous PARC/MGH research showed that the effectiveness of the CTL response ...

Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer

... the study, IIBB-CSIC-IDIBAPS researchers describe how the increase of cholesterol in the mitochondrial membrane plays a key role in the resistance to cytotoxic agents acting via mitochondrion, including doxorubicin, a common drug in chemotherapy. This research has been developed in the framework of the ...

Research identifies first method for testing, assessing drug treatments for Chagas' disease

... develops a stable, protective memory. This idea of memory is at the heart of the study, and it involves T-cells, specifically one kind called cytotoxic or killer T-cells, which are blood-borne white blood cells that destroy T. cruzi-infected cells in the case of Chagas disease and virally infected ...

Yale scientists create artificial 'cells' that boost the immune response to cancer

... that lead to T-cell proliferation in the body. It also causes a fast and effective stimulation of the patients T-cells particularly T-cells of the cytotoxic type important for eradicating cancer. Safe and efficient T-cell stimulation and proliferation in response to specific antigens is a goal of ...

Cells get sprayed

... suitable for a large variety of cell typesmammalian cell cultures and bacteria, as well as living tissue, as was demonstrated with bird embryos. No cytotoxic reagents that could damage the cells are needed; only pure water or a cell-tolerated saline solution are used. An entire plate of cell cultures can ...

Researchers discover new tumor defense system

... encourage the body's natural defenses, such as cytotoxic T lymphocytes, to aid in destroying tumors. ... of reasons including a loss of the ability of the cytotoxic T lymphocytes to recognize the tumor and a ... that tumors secrete fatty acids which inhibit the cytotoxic T lymphocytes' ability to kill tumor cells. ...

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Cytotoxic in Biological Technology

The Breast Cancer Therapeutics Market in Australia

... adverse effects on normal cells when compared to cytotoxic chemotherapeutic drugs. New offerings must ... for chemotherapy. "Due to higher cost compared to cytotoxic and hormonal therapies, the use of targeted ... of these highly specific therapies with existing cytotoxic and hormonal therapies will soon become the ...

Patent for Making Combination Chemotherapy Work Better

... for why today's concurrent HER1 blocker / S-Phase cytotoxic protocols achieve only a fraction of the ... enrichment relative to administrations of S-Phase cytotoxic chemotherapy. "With less than one third of cancer cells in the S-Phase, today's cytotoxic protocols only extend life expectancy by a few ...

AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108

... first drug in a clinical study that targets the cytotoxic activity of doxorubicin specifically to ... of a synthetic peptide carrier and a well-known cytotoxic agent, doxorubicin. The design of this product ... the specific binding and selective uptake of the cytotoxic conjugate by LHRH-receptor-positive tumors. ...

Pharmatek Announces Official Opening of New Highly-Potent & Cytotoxic Development and Manufacturing Facility

... Pharmatek to Serve Growing Highly-Potent and cytotoxic Compound Market SAN ... announced the opening of its highly-potent and cytotoxic facility located in San Diego. The 18,000 sq. ... to the development of highly-potent and cytotoxic drug product for early phase clinical trials. ...

AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers

... first drug in a clinical study that targets the cytotoxic activity of doxorubicin specifically to ... About AEZS-108 AEZS-108 is a targeted cytotoxic peptide conjugate which is a hybrid molecule ... the specific binding and selective uptake of the cytotoxic conjugate by LHRH-receptor-positive tumors. The ...

Viventia Biotech to Explore Strategic Alternatives - Reports Positive Pivotal Phase III Interim Efficacy Data

... cell markers, conjugated to highly potent cytotoxic proteins. Viventia's three lead products target ... a humanized antibody fragment conjugated to the cytotoxic protein Pseudomonas exotoxin A. The drug is in a ... the Company's proprietary deimmunized form of the cytotoxic protein Bouganin, and is designed for systemic ...

AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment

... (formerly ZEN-012) follow-up multi-targeted cytotoxic candidates at the AACR-NCI-EORTC ... The abstract #C218 entitled, "Highly Potent cytotoxic Compounds with Inhibitory Effects on Tubulin ... were equal to or more efficient in exerting cytotoxic activity in tumor cell lines and inhibiting ...

Pharmatek Adds Cytotoxic and High-Potent Drug Development Capabilities to San Diego Laboratory

... Pharmatek Now Offers Contract cytotoxic & High-Potent Analytical, ... Inc. today announced the addition of cytotoxic and high-potent drug development capabilities to ... expansion was driven by an increase in demand for cytotoxic and high-potent drug development and ...

AEterna Zentaris Presents Data Supporting Evaluation of AEZS-108 in Prostate Cancer at ASCO Meeting

... that it presented results supporting the evaluation of its targeted cytotoxic peptide conjugate compound, AEZS-108 (formerly AN-152), in prostate ... the concept of targeting prostatic LHRH receptors to deliver cytotoxic therapy based on LHRH analogs, such as AEZS-108. A copy of the ...

Medarex Announces Allowance of Investigational New Drug Application for Company's First Antibody-Drug Conjugate, MDX-1203

... from its proprietary technology. MDX-1203 is comprised of a potent cytotoxic prodrug chemically linked with a fully human anti-CD70 antibody. CD70 is ... Conjugate platform. Medarex's proprietary ADC technology uses a cytotoxic agent that is a potent, synthetically manufactured prodrug (a DNA ...

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Cytotoxic in Biological Definition

Antigen

... secrete cytokines . The cytokines then activate cytotoxic lymphocytes T (CTL), antibodies secreting ... with class I histocompatibility molecules . If cytotoxic CD8 + T cells recognize them, they begin to ... of the infected cell. In order to keep the cytotoxic cells from killing cells just for presenting ...

Immune system

... that are unique to every individual. T cells, a group that encompasses cytotoxic T lymphocytes ( CTLs ), the cells that kill virally-infected cells, ... they develop in the thymus ). There are two major types of T cells: cytotoxic T cells (T C cells) recognize infected cells by using T-cell ...

T cell

... stage of development occurs. There are many types of T cells: cytotoxic T cells (CD8 + ) destroy infected cells. These cells function as 'killer' or cytotoxic cells because they are able to destroy target cells which express specific ...

Cytotoxic T cell

... A cytotoxic (or T C ) T cell is a T cell (a type of white blood cell ) which has on its surface antigen receptors that can bind to fragments of antigens ...

Major histocompatibility complex

... in the cytosol, it is the primary way for a virus-infected cell to signal to T cells. It interacts exclusively with CD8+ T cells (also known as cytotoxic T cell lymphocytes or CTLs). The fate of a virus-infected cell is almost always apoptosis , or programmed cell death, initiated by the CD8+ T cell. ...

Proprioception

... pyridoxamine). Most of the impaired function discontinues shortly after the intake of vitamins returns to normal. Impairment can also be caused by cytotoxic factors such as chemotherapy . External links The Imperial Society of Teachers of Dancing A comprehensive Alexander Technique site ...

Stem cell

... been used to treat cancer patients with conditions such as leukemia and lymphoma . During chemotherapy , most growing cells are killed by the cytotoxic agents. These agents not only kill the leukemia or neoplastic cells, but also the stem cells needed to replace the killed cells as a patient ...

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Cytotoxic in Biological Dictionary

Helper T cell

... These cells are unusual in that they have no cytotoxic or phagocytic ... Their major role is ... T cells do not directly kill infected cells, as cytotoxic T cells do. Instead they help activate cytotoxic T cells and macrophages to attack infected ...

Effector cell

... that stimulate or ... Tutorial : Assay: cytotoxic Cell Effector Function Studies Genetic ... antigen specific receptors and ... Effector cytotoxic T Lymphocytes (CTL) bind targets (infected cells ... associated ... and ability to estimate cytotoxic effector cell frequency, the GrB ELISPOT ...

Cytotoxic T cell

... A cytotoxic T cell belongs to a sub-group of T ... toward the end of an ... T cells . αβ ( cytotoxic CD8+, Helper CD4+/Regulatory) · γδ. NK cells ... and ... The best understood CD8+ T cells are cytotoxic T lymphocytes (CTLs) ... Movie showing ...

T lymphocytes

... How is a tumour destroyed by T lymphocytes ? ... CD8 T cells are cytotoxic and are often called cytotoxic T lymphocytes (CTLs) ... Lymphocytes . CD40L on T helpers (CD4+) ...

T cell

... of the immune system. These cells are unusual in that they have no cytotoxic or phagocytic ... T cells get their name from the organ ... about T cell in the free online English dictionary and encyclopedia. cytotoxic t ... T cell - a small lymphocyte developed in the thymus; it ... ...

Cell-mediated immunity

... activation of macrophages, natural killer cells (NK), antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an ... immunity is particularly active against virus-infected cells, ... cytotoxic T cell mediated immunity . Cyotoxic T lymphocyte. Giant cells. ...

B lymphocytes

... in ... B cells! CD8+ T cells. The best understood CD8+ T cells are cytotoxic T lymphocytes (CTLs) ... T lymphocytes (CTLs); Th2 helper cells for ... cells) ... B cells! CD8+ T cells. The best understood CD8+ T cells are cytotoxic T lymphocytes (CTLs) ... B lymphocytes . colostrum. cytokines. ...

Lymphocytes

... specific peptide antigens through the receptors on their lymphocytes . monocytes ... consist of lymphocytes and monocytes with ... cytotoxic T lymphocytes (CTLs) that kill virus-infected and, perhaps, tumor cells ... One cannot watch cells crawling, dividing, segregating their ...
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