Protein compels ovarian cancer cells to cannibalize themselves
... Autophagy kills when a cell entraps parts of its cytoplasm in membranes and digests the contents, leaving a ... cell essentially eats itself until it dies, its cytoplasm riddled with cavities. Location, location, ... effects. Now they've found that PEA-15 in the cytoplasm induces autophagy in cancer cells, a second ...Protein Branded As Culprit in Mad Cow Disease
... done by the researchers had found that brain deterioration follows when cytoplasm contains too much PrP. To further solidify this finding, a subsequent ... Syndrome -- a rare neurodegenerative disease in which PrP is found in cell cytoplasm -- found that some brain cells lacked Mahogunin in these mice. A similar ...Scientists at CSHL uncover new RNA processing mechanism and a new class of small RNAs
... not likely perform this function. Yet mascRNA's location in the cell's cytoplasm and its pathway of biogenesis does hint at a possible function. Spector ... molecule within the nucleus while expelling the mascRNA fragment into the cytoplasm is still elusive. "The answer will come when we identify more and more ...New nano device detects immune system cell signaling
... primed for an immune response, the concentration of calcium ion in their cytoplasm jumps up. So when the cytoplasm contains a dye that fluoresces when it comes into contact with calcium, it ...Food additive may one day help control blood lipids and reduce disease risk
... "The neighborhoods where PPAR-alpha and fatty acid synthase live aren't very close together," says Semenkovich. "The synthase is way out in the cytoplasm that's like being in the suburbs whereas the PPAR-alpha lives right in the middle of the 'city.' These are all microscopic distances, but to the ...Neuronal survival and axonal regrowth obtained in vitro
... order to do so, they used gene therapy based on use of interfering RNA. The short RNA sequences, which were made to measure, were inserted into the cytoplasm of cultured astrocytes using a viral therapeutic vector. Once in the cell, the RNA activates mechanisms which block the synthesis of the two proteins ...New Clinical Studies Confirm Mauna Kea Technologies' Cellvizio(R) GI in Range of Procedures
... in 93% of sites; resolution was sufficient in 91%. Epithelial width could be measured in 94% and villous width in 88%. Epithelial cell cytoplasm and basal cell layer regularity could only be assessed in 30% and 26%, respectively. Investigators conclude that Cellvizio(R) GI can ...Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-48 Myeloperoxidase
Description:... finely granular, diffuse staining pattern of the cytoplasm of human neutrophils. At the 2nd International ... an antigen in the azurophil granules of the cytoplasm of human neutrophils (8) and later that the ... also present in the azurophil granules in the cytoplasm of neutrophils (6,12). These antibodies were ...Nanoneedle is small in size, but huge in applications
... delivery of one or more molecules into the cytoplasm or the nucleus of living cells. In addition to ... individual fluorescent quantum dots in a cell's cytoplasm and nucleus. The quantum dots can be used for ... via "linker" molecules. When placed in a cell's cytoplasm or nucleus, the bonds with the linker molecules ...New study overturns orthodoxy on how macrophages kill bacteria
... species kill the bacteria by going into the cytoplasm and causing DNA damage," said medical ... against ROS. There are two such enzymes in the cytoplasm of S. typhimurium , called SodA and SodB, and ... that the superoxide dismutases in the bacterial cytoplasm are most likely protecting the bacterium from its ...Artificial cells, simple model for complex structure
... in developing simple experimental models for cytoplasm organization," she told attendees at the 2009 ... Association for the Advancement of Science. cytoplasm is the material that fills the cell and is ... and the nucleus. Unlike organelles, the cytoplasm is a fundamental feature of all cells. Many ...Newly identified role for 'power plants' in human cells could lead to targeted therapies
... determined that tRNAs can be imported from cytoplasm to mitochondria in rat liver cells and human ... should be able to bring a healthy tRNA from the cytoplasm into the mitochondria and correct the ... to rely on the import process that starts in the cytoplasm to transfer healthy tRNAs to damaged mitochondria ...Simple model cell is key to understanding cell complexity
... her colleagues built a model cell using as the cytoplasm a solution of two different polymers: ... work demonstrated the interrelationship of the cytoplasm and the cell membrane," said Keating. The ... a cascade in polarity. "By creating a model cytoplasm with different compositions, we demonstrated that ...Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
... complex involves the shuttling of the peptide-receptor complex from the cytoplasm to the nucleus, as well as transport receptors. The research team was ... is dependent on shuttling of the peptide and the OGF receptor from the cytoplasm to the nucleus. This discovery may provide valuable information to ...Genetic pathway critical to disease, aging found
... molecules that carry genetic information from the nucleus of a cell to the cytoplasm where proteins are made. Star-PAP is responsible for adding a critical ... that enables messenger RNA to exit the nucleus of the cell and enter the cytoplasm where the genetic message is translated into protein." The Star-PAP ...Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting
... believed to be that treatment with AF results in translocation of the arylhydrocarbon receptor (AhR; a transcriptional regulator of CYP1A1) from the cytoplasm to the nucleus, and its subsequent interaction with the xenobiotic-response element (XRE) sequence on the CYP1A1 promoter region, causing induction ...Researchers develop new way to see single RNA molecules inside living cells
... inside a cell, but the current study demonstrated that individual probes without cellular targets could be observed homogenously distributed in the cytoplasm with no localization or aggregation. With single-molecule sensitivity accomplished, the researchers investigated whether they could visualize ...Researchers outline structure of largest nonvirus particle ever crystallized
... Institute and the UCLAU.S. Department of Energy Institute for Genomics and Proteomics. Vaults are large, barrel-shaped particles found in the cytoplasm of all mammalian cells; they may function in innate immunity. As naturally occurring nanoscale capsules, vaults may be useful to engineer as ...Team demos safety of RNA therapy
... precursor to siRNA. Once the gene is incorporated into the cell's DNA, short hairpin RNA is synthesized and transported from the cell nucleus to the cytoplasm for further processing. The earlier study showed that large amounts of short hairpin RNA blocked the cell's ability to export microRNA, which uses ...PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection
Description:... reagent for highly efficient transfer of functional proteins to the cytoplasm of living cells. Unlike DNA transfection, with PULSin Protein & Antibody ... cells in culture. Advantages: Effective and robust delivery into the cytoplasm Delivery to a wide variety of cells including primary cells ...Autofluorescence Eliminator Reagent from CHEMICON
Description:... With increasing age, the autofluorescent pigment lipofuscin accumulates in the cytoplasm of many cell types, including neurons. The presence of lipofuscin granules can complicate the use of fluorescence microscopy in the central nervous ...PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection
Description:... many proteins including antibodies. Complexes are internalized via anionic cell-adhesion receptors present on all cells and are released into the cytoplasm where they disassemble. The process is general, nontoxic and delivers unmodified, functional ....PULSin Protein & Antibody Delivery Reagent from Polyplus Transfection
Description:... many proteins including antibodies. Complexes are internalized via anionic cell-adhesion receptors present on all cells and are released into the cytoplasm where they disassemble. The process is general, nontoxic and delivers unmodified, functional ....Rabbit Anti-HDAC4 Polyclonal Antibody, Unconjugated from GeneTex
Description:... Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC 4 protein in the cytoplasm. In the ...BL21 Competent Cell Set* from Novagen
Description:... the yield and activity of your target proteins, including stringent control over basal expression levels, the ability to form disulfide bonds in the cytoplasm for proper folding and activity, and alleviating codon usage incompatibilities. Every strain of Novagen’s competent cells is verified for ...