Navigation Links
crystallography in Medical News

New Jersey-Based Biotech Start-Up Nexomics Biosciences Gets Off the Ground

... scale protein production, Nuclear Magnetic Resonance (NMR), and X-ray crystallography for use in drug discovery efforts. Nexomics Biosciences has signed a ... scale protein production, Nuclear Magnetic Resonance (NMR), and X-ray crystallography for use in drug discovery efforts. The company provides customers with ...

Double binding sites on tumor target may provide future combination therapy

... doorway, keeping hormones from binding and signaling tumor growth. X-ray crystallography provided a snapshot of the interaction between Erbitux and the ... in Cancer Cell, Ferguson and Merck colleagues found again using X-ray crystallography -- that matuzumab binds in a different place from Erbitux. Their binding ...

First look at an enzyme target for antibacterial and cancer drugs

... Advanced Light Source (ALS), Berger and Dong obtained high resolution, 3-D crystallography images of the DNA binding and cleavage core of a topo II enzyme taken from ... multiple-wavelength anomalous diffraction (MAD) and monochromatic protein crystallography capabilities. The high brightness of the x-ray beams and the ...

Potent peptides inhibit HIV entry into cells

... the structure of these peptides bound to the target protein using x-ray crystallography at the NSLS. In this technique, researchers analyze how an extremely ... of future inhibitors," said paper co-author Annie Heroux, a biologist and crystallography specialist at Brookhaven Lab. This structure-assisted design led to the ...

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

... an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its portfolio of next-generation therapeutic candidates with the potential to address ...

BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology

... BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for ...

BioCryst to Present at the 11th Annual BIO CEO & Investor Conference

... . The presentation will be archived for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

BioCryst Pharmaceuticals to Announce Fourth Quarter and Year End 2008 Financial Results on February 6, 2009

... Web cast will be archived and available for replay for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

E. coli persists against antibiotics through HipA-induced dormancy

... the molecular details of HipA's role in multidrug tolerance and HipB's role keeping HipA under wraps in a series of experiments: Using X-ray crystallography to determine and then compare the structures of several HipA complexes, they showed that HipA has a serine/threonine protein kinase fold and that it ...

Scientists reveal structure of new botulism nerve toxin subtype

... analyzed the molecular-level structures of various fragments of botulinum neurotoxin subtypes A to F, and that of the whole neurotoxin B, using x-ray crystallography at the National Synchrotron Light Source (NSLS) at Brookhaven Lab. In this technique, scientists beam high-intensity x-rays at a crystalline sample ...

More>>

crystallography in Medical Technology

ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies

... chosen by CHDI, ActiveSight will screen fragment libraries using X-ray crystallography to visualize fragments that bind to the target. The fragments will then ... Nienaber, Ph.D. at ActiveSight, a pioneer in the utilization of X-ray crystallography for Fragment-based screening and lead development. "We are pleased to ...

BioCryst Pharmaceuticals Reports Positive Results of Shionogi & Co. Sponsored Phase 3 Studies of i.v. Peramivir for Influenza

... BioCryst is a biopharmaceutical company that has developed a diverse pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for ...

BioCryst Provides Peramivir Update and Reports First Quarter 2009 Financial Results

... BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for ...

BioCryst Pharmaceuticals to Announce Peramivir Update and First Quarter 2009 Financial Results on May 8, 2009

... cast will be archived and available for replay for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

Jubilant Enters Research Collaboration With AstraZeneca

... disciplines to include Discovery biology, medicinal chemistry, structural biology, pharmacology, toxicology, pharma chem, molecular modeling, crystallography and information technology supporting discovery efforts. For more information please visit: http://www.jubilantbiosys.com About ...

Data from Phase 2 Study of Peramivir in Patients Hospitalized with Influenza Presented at the XI International Symposium on Respiratory Viral Infections

... Phase 3 program of peramivir in outpatient influenza underway. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC

... can be open to either side of the membrane. Prior to this Protein Tomography(TM) study, great efforts were made to prove this mechanism both by x-ray crystallography and indirectly by site directed mutagenesis. (Logo: http://www.newscom.com/cgi-bin/prnh/20080220/294289 ) "Obtaining structures of ...

Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science

... synthetases with editing sites, which are also excellent targets for anti-microbial drugs," said Cusack, whose group performed the X-ray crystallography which revealed how AN2690 binds to LeuRS. Anacor is now leveraging that knowledge to create new boron-containing drugs designed to target systemic ...
crystallography in Biological News

The structure of the Mre11 protein bound to DNA

... performed both high-resolution protein crystallography and small-angle x-ray scattering (SAXS), which ... of samples in crystals using macromolecular crystallography (MX). Scott Classen of Berkeley Lab's Physical ... very far from the sample," says Classen. "While crystallography can give you nice pictures of static molecules, ...

Properties of unusual virus revealed in research

... now a postdoctoral researcher at the University of Rochester, used X-ray crystallography to obtain a high-resolution three-dimensional image of the N4 phage's RNA-polymerase and DNA molecule. "By modifying the crystallography conditions, Michael obtained an extremely high-resolution picture of the ...

Researchers study virus with unusual properties

... now a postdoctoral researcher at the University of Rochester, used X-ray crystallography to obtain a high-resolution three-dimensional image of the N4 phage's RNA-polymerase and DNA molecule. "By modifying the crystallography conditions, Michael obtained an extremely high-resolution picture of the ...

New approach builds better proteins inside a computer

... and suggesting new ideas for drug design. Researchers often rely on x-ray crystallography to determine a proteins structure bombarding the molecule with x-rays and ... by using it to improve data on protein structures derived using both x-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy. NMR spectroscopy ...

Discovery of the cell's water gate may lead to new cancer drugs

... yeast aquaporin. The results will be published in the journal PLoS Biology . Highest resolution The structure has been determined using X-ray crystallography and is the highest resolution structure that has been determined for a membrane protein. The unique high resolution has enabled the scientists to ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

... he said. The structural work is being done in collaboration with Andrea Mattevi, professor of molecular biology, who co-ordinates the protein crystallography group at the University of Pavia. Sobrado's team includes graduate and undergraduate students. "It is an opportunity for undergraduates to learn ...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

... these interactions contributed to the strength of binding. For these answers, Schalch and the CSHL team made use of Joshua-Tor's expertise in X-ray crystallography the science of determining the exact position of atoms and bonds within a molecule by creating a crystal, which is then probed with powerful x-rays. ...

Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy

... Aller, Ph.D., a postdoctoral fellow in Chang's laboratory and first author of the new study. Once the scientists succeeded in performing the x-ray crystallography and solving the structure, they found that the mouse protein P-gp, which is 87 percent identical to its human counterpart, has the shape of an upside ...

Antibody key to treating variant CJD, scientists find

... prevent the development of the disease. To understand the 'connection' between the antibody and the protein, scientists at Liverpool used X-ray crystallography technology to build a three-dimensional picture of the binding between an antibody called ICSM18 designed to 'stick' effectively to prion proteins ...

Scientists unlock the secrets of C. difficile's protective shell

... scientists from Imperial College London, funded by the European Union Seventh Framework Programme and the Medical Research Council. They used X-ray crystallography techniques to produce the first ever high-resolution images of the structure of LMW-SLP, one of the two proteins that make up C. difficile 's ...

More>>

crystallography in Biological Technology

Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria

... that can be used to create a picture of the molecule; however, X-ray crystallography could not be used to characterize the chlorosomes in green bacteria ... in their compositions had prevented scientists from using X-ray crystallography to characterize the internal structure." To get around this problem, ...

Zenobia Therapeutics, Inc. Begins Operations as a Fragment-Based Lead Discovery Company

... Corporation, where she built a diverse team of protein biochemistry, X-ray crystallography and drug discovery experts. Before that, Dr. Nienaber was the Senior Director of Lead Discovery and crystallography at SGX Pharmaceuticals, where she oversaw strategic drug discovery and ...

Lilly to Acquire SGX Pharmaceuticals

... structures of key Lilly drug targets utilizing SGX's proprietary x-ray crystallography technology. The ongoing collaboration also provides Lilly with access to ... SGX-CAT, which is a state-of-the-art synchrotron facility enabling X-ray crystallography and protein structure determination built by SGX at the Advanced Photon ...

CRELUX and ProQinase establish joint crystal-grade kinase protein and structures platform

... CRELUX will continue to provide customers with crystallization and x-ray crystallography services. CRELUX will support ProQinase by performing crystallization ... CRELUX. “The combination of CRELUX’s expertise in protein crystallography and ProQinase’s know-how in kinase cloning and expression makes the ...

BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009

... an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its portfolio of next-generation therapeutic candidates with the potential to address ...

Jubilant to Work With Endo Pharmaceuticals on Drug Development

... of over 300 scientists specializing in multiple disciplines including biology, chemistry, structural biology, pharmacology, molecular modelling, crystallography and information technology to support collaborations with global pharma companies in USA, Europe and Japan.For more information visit: ...

Zenobia Therapeutics Successfully Completes Initial Phase of Its Service Agreement With Syntonix Pharmaceuticals

... Director of Chemistry at Syntonix. About Zenobia Zenobia provides a commercial fragment library and access to their structural biology, crystallography and fragment-based lead discovery expertise through partnerships, consulting and collaborations. Zenobia's internal programs combine fragment-based ...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

... BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for ...

Jubilant and BioLeap Announce New Partnership in Drug Discovery

... of over 300 scientists specializing in multiple disciplines including biology, chemistry, structural biology, pharmacology, molecular modeling, crystallography and information technology to support collaborations with global pharma companies in USA, Europe and Japan. About Jubilant Organosys ...

BioCryst to Present at the J.P. Morgan 27th Annual Healthcare Conference

... . The presentation will be archived for ninety days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing ...

More>>

crystallography in Biological Products

Fragment-based Screening Services from ActiveSight

Description:... ActiveSight, the leading provider of X-ray crystallography services for structure-based drug design, offers fragment-based screening ... novel, high-affinity inhibitors. Relying on state-of-the-art Rigaku X-ray crystallography automation, ActiveSight can screen up to 100 protein structures a day for ...
Company:ActiveSight

Cartesian Honeybee System for protein crystallization from Genomic Solutions

Description:... High-throughput protein crystallography involves using many of the automation concepts from High Throughput ... requirements are similar to those for HTS: Low volume: traditional crystallography plates have 24 or 48 wells with well volumes of 100s of microliters. For ...
Company:Genomic Solutions

Labware Carriers from Tecan

Description:... 24-, 96- or 384-well plates. Reagent troughs, MALDI targets and microscope slide adapters. High density formats such as 1536-well plates and crystallography plates. Temperature-controlled carriers can heat or cool reagents, e.g. media for cell-based applications, microplates and tubes. Disposable ...
Company:Tecan

CrysScreen protein crystallography software from Tecan

Description: CrysScreen is a software package that provides crystallographers with an intuitive user interface for custom buffer creation, set-up of experimental conditions and data management in crystallization trials. The software helps crystallographers through the most critical steps in automated protein ...
Company:Tecan
crystallography in Biological Definition

X-ray crystallography

... X-ray crystallography is a technique in crystallography in which the pattern produced by the ... of blood on the decks of whaling ships. X-ray crystallography played a major role in elucidating the ...

Biophysics

... work Maurice Wilkins & Rosalind Franklin , pioneers of DNA crystallography Francis Crick , co-discover of DNA structure and the genetic code Max Perutz & John Kendrew , pioneers of protein crystallography Other notable biophysicists Howard Berg , characterized ...

Ion channel

... of their molecular structure by Roderick MacKinnon using X-ray crystallography won a share of the 2003 Nobel Prize in Chemistry . Because of their ... examine what channels "look like." Particularly in cases where the crystallography required removing channels from their membranes with detergent, many ...

Protein

... . This protein was the first to have its structure solved by X-ray crystallography by Max Perutz and Sir John Cowdery Kendrew in 1958, which led to them ... unknown class of organic compounds. See also Biochemistry crystallography Denatured protein Intein Peptide Prion Proteinoid ...

Proteomics

... protein structures in three-dimensional space. Common methods are x-ray crystallography and NMR spectroscopy . Interaction proteomics . This concerns the ... the relative mass of a protein and its isoelectric point . X-ray crystallography and nuclear magnetic resonance are used to characterize the ...

Louis Pasteur

... molecules, it was quite an achievement, but Pasteur then went on to his more famous work in the field of biology/medicine. His doctoral thesis on crystallography got him a position of professor of chemistry at the Facult (College) of Strasbourg . In 1854, he was named Dean of the new College of Science ...

Molecular biology

... Foundation at the time and believed that biology was about to undergo a period of significant change given recent advances in fields such as X-ray crystallography . He therefore channeled significant amounts of (Rockefeller Institute) money into biological fields. Further reading Keith Roberts, Martin ...

Secondary structure

... shown in colour, and random coil in white, there are no beta sheets in shown. This protein was the first to have its structure solved by X-ray crystallography by Max Perutz and Sir John Cowdery Kendrew in 1958, which led to them receiving a Nobel Prize in Chemistry . In biochemistry and ...

Structural biology

... use to determine their structures generally involving measurements on vast numbers of identical molecules at the same time. These methods include crystallography , NMR , Electron Microscopy and circular dichroism . Most often researchers use them to study the static " native states " of macromolecules. But ...

Tertiary structure

... is to predict the native conformation of a protein from its primary sequence . Conventionally, tertiary structures are deduced through crystallography or multidimensional NMR . The study of protein tertiary structure is known as structural biology . See also: primary structure -- secondary ...

More>>

crystallography in Biological Dictionary

X-ray diffraction

... and physical properties of materials and thin films. ... X - ray crystallography is a method of determining the arrangement of atoms within a crystal, in ... matter, especially crystals, with accompanying variation in x-ray crystallography n. The study of crystal structure by means of x-ray diffraction . ... ...

Structural biology

... Goldberg. Christopher D. Lima. Stephen B. ... The Structural Biology Center (SBC) operates a national user facility for macromolecular crystallography at Sector 19 of the Advanced Photon Source at Argonne ... The New York Structural Biology Center is a 501 (c) (3) corporation incorporated ... ...

Molecular biology

... ... Molecular Biology Topics. Carbohydrate Conversion. Dough. Heterotroph Hypothesis ... How genetics, biochemistry, microbiology, and crystallography converged to form molecular biology , despite early parochialism of some scientists. Department of Molecular and Cell Biology . School of ...
Other Contents
(Date:7/12/2014)... Recently, iFitDress.com, one of the world’s leading ... red evening gowns . What’s more, all these hot outfits ... The company’s senior spokesman states, “We are proud to announce ... is an enjoyable shopping experience. In addition to the big ... low prices do not always mean bad quality. All the ...
(Date:7/12/2014)... 2014 Fresh off their respective performances in ... meet on September 5th at Sun Life Stadium in an ... some of the brightest stars in the world of football ... will be treated to some of the best talent in ... as the third best team in the world according to ...
(Date:7/12/2014)... By Dennis Thompson ... -- There,s no way to guarantee that a surgical technique ... tiny incisions won,t increase the risk of spreading cancer to ... Friday. The advisory panel to the Food and Drug ... -- called laparoscopic power morcellation -- should sign a written ...
(Date:7/12/2014)... Demand Response Management Systems is a ... reducing the imbalance between energy supply and demand. With ... rolled out (due to increasing pressure on the grid) ... in controlling residential appliances and thermostats for load reduction. ... American region, and with government mandates and benefits for ...
(Date:7/12/2014)... July 12, 2014 Tylenol lawsuits ... to move forward in the federal multidistrict litigation ... Pennsylvania, Bernstein Liebhard LLP reports. According to a ... Lawrence F. Stengel has ordered the deposition of ... Stengel found that the witness’s testimony concerning the ...
Breaking Medicine News(10 mins):Health News:Discounted Red Evening Gown Announced by iFitDress.com 2Health News:Brazil Vs. Colombia Tickets Sun Life Stadium: Ticket Down Slashes Ticket Prices for Friendly Match Between Colombia and Brazil 2Health News:Brazil Vs. Colombia Tickets Sun Life Stadium: Ticket Down Slashes Ticket Prices for Friendly Match Between Colombia and Brazil 3Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 2Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 4Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: U.S. District Judge Overseeing Federal Tylenol Liver Damage Litigation Orders Deposition of Former McNeil President, Bernstein Liebhard LLP Reports 4
(Date:7/11/2014)... that cannabinoid receptor type 1 can inhibit ... and reduce neurotransmitter release. However, some scholars ... increase extracellular Ca2+ influx and increase neurotransmitter ... Tongji Hospital Affiliated to Tongji Medical College, ... used whole cell voltage-clamp and calcium imaging ...
(Date:7/10/2014)... Colo. , June 27, 2014  The ... the National Institute of Standards and Technology (NIST) ... of its academic research and forensic science expert ... The Board is an element of the NIST,s ... members are among the first appointments made to ...
(Date:7/10/2014)... N.Y. , July 2, 2014 It ... (ABD) to announce the appointment of the world-renowned Thoracic ... Board of Directors. Dr. Ginsburg, with over ... facilities: NY Presbyterian Hospital and Good Samaritan Regional Medical ... Pacemaker since the late 1980,s and is considered an ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2
Other TagsOther Tags