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Conserved in Medical News

CSHL scientists are part of consortium that sequences platypus genome

... noted. CSHL study shows small-RNA roles are conserved in platypus In a related paper, published ... interference (RNAi). That the RNAi mechanism is conserved by evolution in the monotremes is hardly ... of the platypus has highlighted both unique and conserved roles for miRNAs and piRNAs in monotremes; at the ...

Insmed Provides Update on Supply of IPLEX(TM)

... The Company has determined that its limited inventory on hand must be conserved for the treatment of existing patients. Following the previously ... receiving IPLEX(TM) to ensure that our current limited inventory is conserved in order to maintain their drug supply as long as possible, while allowing ...

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

... of the most remarkable findings of our work is that we identified a highly conserved region in the neck of the influenza hemagglutinin protein to which humans ... head of the HA protein and do not readily generate antibodies against the conserved region in the neck. "An important goal is to redirect the immune ...

Evolution and epilepsy

... along the axon. They also found that these anchoring sequences were conserved in the potassium and sodium channels of vertebrates over 350 million years ... combination of channels clustered together on nerves has been completely conserved for about 400 million years in all types of vertebrates underlines its ...

Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage

... issue: “Chronic Lymphocytic Leukemia Cells Recognize conserved Epitopes Associated with Apoptosis and Oxidation”, ... type of normal B lymphocyte. Chronic Lymphocytic Leukemia Cells Recognize conserved Epitopes Associated with Apoptosis and Oxidation. Rosa Catera and ...

Penn researchers discover new target for preventing and treating flu

... a pocket in the channel next to the location where amantadine fits that is conserved in all influenza A viruses. This newly discovered space could be the target for new drugs. "Inhibitors that target this cavity adjacent to two highly conserved amino acids in M2 might reclaim the M2-blocking class of drugs so that ...

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Conserved in Medical Technology

Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans

... responses against the matching H5 antigen and the conserved NP and M2 antigens were detected in a majority of ... the trivalent vaccine. Responses against conserved antigens could provide protection against serious ... encoding consensus sequences of two highly conserved influenza virus proteins: nucleoprotein (NP) and ...

Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor

... active-site atoms of HIV protease representing a conserved atomic substructure that cannot be altered by mutations. This conserved substructure then served as the target for ... a structure-based approach that targets highly conserved regions of the protease enzyme while minimizing ...

Intercell Starts a Phase I Clinical Trial for a New Streptococcus pneumoniae Vaccine

... vaccine candidate is a recombinant subunit vaccine consisting of three conserved surface proteins from Streptococcus pneumoniae . Two of these proteins ... the pathogen. Intercell's novel vaccine candidate is composed of highly conserved proteins of Streptococcus pneumoniae that have the potential to protect ...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

... www.supergen.com . About SGI-1776 SGI-1776 inhibits the three human PIM kinases (PIM-1, PIM-2 and PIM-3). PIM kinases are highly conserved serine-threonine kinases that are key regulators in many signaling pathways implicated in cancer. When expressed, PIM kinases are strong survival ...

Intercell Announces Initiation of Further Phase II Clinical Trial of V710 an Investigational Vaccine to Prevent S. aureus Infection

... We look forward to continued progress of the program building on clinical data obtained so far." The S. aureus vaccine candidate is based on a conserved protein antigen discovered by Intercell and licensed to Merck & Co., Inc. in 2004 on an exclusive worldwide basis. Merck is responsible for clinical ...

Strategic Diagnostics Launches Initial Oncology-Targeted Antibody Reagent Catalog

... stain disease-associated proteins across thousands of clinical biopsy samples. More targeted studies have shown the ability to differentiate highly conserved proteins in cell sorting assays, the ability to react with traditionally elusive proteins of interest, and be directed through SDI's design ...

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Conserved in Medical Products

QualiTrace

Description:... and prints a calibration report The audit trail feature records entries by the user and any changes in key setup options. Complete device history is conserved intact ...
Company:Gilson, Inc
Conserved in Biological News

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... A subtypes because they bind to the highly conserved stem region of H5 type hemaglutinin (HA). Binding ... the stem region of hemaglutinin is highly conserved because it undergoes a dramatic conformational ... the heavy chain of the mAb inserts into a highly conserved pocket in the HA stem, inhibiting the ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... A subtypes because they bind to the highly conserved stem region of H5 type hemaglutinin (HA). Binding ... the stem region of hemaglutinin is highly conserved because it undergoes a dramatic conformational ... the heavy chain of the mAb inserts into a highly conserved pocket in the HA stem, inhibiting the ...

Scientists uncover new class of non-protein coding genes in mammals with key functions

... thousands of such genes and that they have been conserved across mammalian evolution. "The challenge in ... are transcribed into lincRNAs, and that these are conserved across mammals. "The epigenomic marks revealed ... sequence then revealed that the genes are highly conserved in mammalian genomes, which strongly suggested ...

Scientists shed light on evolution of gene regulation

... DNA segments that are bound to GATA1 have been conserved in the genomes of related animals. They also found that the GATA1-bound DNA segments that are conserved among mammals do act to control the level of ... are said to be conserved. A portion of these conserved sequences shows a particularly high level of ...

CSHL team traces extensive networks regulating alternative RNA splicing

... which are surprisingly extensive and highly conserved by evolution, help scientists gain insights into ... of 28 different vertebrate species. From conserved networks to disease targets Experimental ... The fact that the predicted targets were conserved during evolution across distantly related species ...

Thumbs up -- a tiny ancestral remnant lends developmental edge to humans

... that certain regions of genomesthose which are conserved across many species over evolutionary time and do ... screened across these species to find the most conserved regions, but where humans had many more changes ... the identification and characterization of these conserved noncoding sequences and the changes they induce ...

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Conserved in Biological Technology

Growing old together: Yeast, worms and people may age by similar mechanisms

... This report describes the identification of conserved aging-related genes in simple model organisms ... Previous studies have implicated a number of conserved genes in model organisms as regulators of aging, ... the degree to which aging-related genes are conserved across the genome among distantly related ....

First H1N1 Swine Flu Vaccine, Replikins-Based, Is Ready Now for Testing Worldwide

... chairman, Dr. Samuel Bogoch, found that some of these regions have been conserved for decades. In H1N1 last year the company detected the highest ... that H1N1 would strike this year, has been used to manufacture synthetic conserved Replikin vaccines against both these influenza strains, Replikins H5N1 ...

Beyond associations: Colorectal cancer culprit found

... colorectal cancer, and found that it resides in a DNA sequence that is conserved in many other species so well conserved that they were able to use xenopus frogs as a model organism to test the ...

Confirmation of Bogoch Replikins Influenza Patents by Harvard-CDC and Scripps-Crucell Data

... which they named Replikins, which are shared across flu strains, conserved over time, associated with the last three pandemics of 1918, 1957 and ... 2. Ekeirt, D.C. et al. "Antibody Recognition of a Highly conserved Influenza Virus Epitope." Science DOI: 10.1126-science.1171491, Science ...

Symbiotic microbes induce profound genetic changes in their hosts

... genetic changes in a tiny squid, including a set of evolutionarily conserved genes that may hold the secrets to developing a mutually beneficial ... numbers of environmental bacteria These genes might be considered the core conserved responses of animals to interactions with bacteria" along tissue surfaces ...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

... more lethal new virus. That is what happened in the case of the Spanish flu pandemic. CEL-SCI's efforts to fight this virus are focused on using conserved epitopes from essential proteins to be found in the A influenza virus for H1N1, H1N5, swine, bird flu and Spanish influenza to create an effective ...

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Conserved in Biological Products

Rabbit Anti-JNK1, phospho (Thr183 / Tyr185) Polyclonal Antibody, Unconjugated from GeneTex

Description:... is also characterized by their requirement for dual phosphorylation at a conserved threonine and tyrosine residue for enzymatic activation and both must be ... are characterized by their requirement for dual phosphorylation at a conserved T-E-Y motif. While JNK1 is activated by dual phosphorylation at a T-P-Y ...
Company:GeneTex

Rabbit Anti-Mint3 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents

Description:... interacting protein (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In ... carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a ...
Company:ABR-Affinity BioReagents

Rabbit Anti-Evolutionarily conserved signaling intermediate in Toll pathway Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description:... Evolutionarily conserved signaling intermediate in Toll ...
Company:GenWay Biotech, Inc.

Anti-Sodium Channel, NaB2 (B2 subunit of Voltate-Gated Na+ Channel, Scn2b) Polyclonal Antibody, Unconjugated from CHEMICON

Description:... Nabeta2 is not present in any other known proteins. SPECIES REACTIVITIES: It is expected to work on human because the immunogen sequence is highly conserved (17/19 residues). Reactivity with other species has not yet been ....
Company:CHEMICON

Rabbit Anti-Fruit fly (Drosophila melanogaster) SARA Polyclonal Antibody, Unconjugated from Abcam

Description:... Synthetic peptide: PVPKEMEQPV QTEEEDVELP conjugated to KLH, corresponding to amino acids 281-300 of Fruit fly (Drosophila melanogaster) SARA. conserved sequence unique to SARA. Entrez Gene ID: 9372 Swiss Protein ID: ...
Company:Abcam

Human BMP-5 ELISA development Kit, DuoSet Economy Pack from R&D Systems

Description:... including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Similar to other TGF-beta family proteins, BMPs are highly conserved across animal species. This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure ...
Company:R&D Systems

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Conserved in Biological Definition

Actin

... also bind to ADP . An ATP-actin complex polymerizes faster and dissociates slower than an ADP-actin complex. Actin is also one of the most highly conserved proteins, differing by no more than 5% in species as diverse as algae and humans. Contents showTocToggle("show","hide") 1 ...

Enzyme

... region widely dispersed, instead tending to keep the amino acids involved in each active region compacted fairly closely together in the chain and conserved against mutation, separating these regions by long stretches of 'spacer' amino acids where mutation is much less critical (although some mutations in ...

Genomics

... biological discoveries. If a particular DNA sequence or pattern is present among many members of a clade , that sequence is said to have been conserved among the species. Evolutionary conservation of a DNA sequence may imply that it confers a relative selective advantage to the organisms that ...

Insulin

... to human insulin (2 amino acid difference for bovine insulin, 1 amino acid difference for porcine). Insulin is a protein which has been very strongly conserved across evolutionary time. Differences in suitability of beef, pork, or fish insulin preparations for particular patients have been primarily the ...

Intron

... of a gene. Intron evolution There are two competing theories as to the evolutionary origin of introns, which is usually studied in a highly conserved family of genes such as the actins . In the introns-early model ancestral genes are believed to have included a large number of introns, some of ...

Actin

... also bind to ADP . An ATP-actin complex polymerizes faster and dissociates slower than an ADP-actin complex. Actin is also one of the most highly conserved proteins, differing by no more than 5% in species as diverse as algae and humans. Contents showTocToggle("show","hide") 1 ...

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Conserved in Biological Dictionary

Evolutionarily conserved

... In biology, conserved sequences are similar or identical sequences ... science that aims to apply genetic ... conserved sequence - "similar or identical sequences that may occur within ... Evolutionarily conserved developmental pathways ... of mitosis require ...

Conserved sequence

... In biology, conserved sequences are similar or identical sequences ... of Conservation (genetics) were merged into conserved sequence . ... The term conserved sequence is encountered more often, ...

Ubiquitin

... ( yü′bikwə′tin ) ( biochemistry ) A small, 76-amino-acid, highly conserved protein present in the cytoplasm and nucleus of all eukaryotes ... functions degradation by covalent ligation to ubiquitin , a highly conserved small protein. Ubiquitin -mediated degradation of regulatory proteins ...

Retrotransposon

... in cancer cells ... Jr, Boeke JD: Human L1 retrotransposon encodes a conserved endonuclease required ... inferred from 33 non-LTR retrotransposon ... constituents ... The general structure of this retrotransposon is well conserved in both species, ... PLoS Genetics is an ... results indicate that LINE ...

Intergenic

... ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC ... conserved intergenic sequences are identified by comparing the IGRs of the ... ... Res. Microbiol. ... many intergenic regions would be too highly. conserved among the sensu stricto species to ... from S. cerevisiae that their ...

Antigenic variation

... ... Antigenic variation refers to the expression of functionally conserved moieties ... What is Antigenic Variation ?: This genetic mechanism, ... ... Antigenic variation refers to the expression of functionally conserved moieties ... The purpose of antigenic variation in Trypanosoma ...

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