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Conformational in Medical News

ImQuest Presents New Anti-HIV Drug and Topical Microbicide Development Results on Lead Pyrimidinedione Products IQP-0410 and IQP-0528

... Dr. Buckheit presented detailed mechanism of action evaluations performed with IQP-0410, demonstrating that the compound targets a newly defined conformational cell surface target formed upon attachment of the virus to prevent the entry of HIV into the cells. This molecular target will be exploited by ...

Atypical protein kinase C stabilizes SRC-3 levels in breast cancer cells

... SRC-3 protein levels by inducing phosphorylation of a particular region of SRC-3. Specifically, phosphorylation of C-terminal residues induced a conformational change that made SRC-3 more resistant to degradation by the core proteasome. This effect of aPKC required estrogen and estrogen receptor and was not ...

Engineering chimeric polypeptides to illuminate cellular redox states

... technique called Frster resonance energy transfer (FRET). The absence of polypeptide linkers able to sense the redox state by undergoing a conformational change was the major obstacle to a FRET-based redox sensor. The researchers designed the linker sequence such that in its reduced state the linker is ...

First look at an enzyme target for antibacterial and cancer drugs

... where it is cleaved. The near folding-in-half of the DNA segment helps enable topo II to recognize where it should disentangle DNA strands. Large conformational changes in the topo II accompany the DNA deformation, creating a bipartite catalytic site that positions the DNA backbone near a reactive tyrosine ...

Caught in the act: The dynamic dance of enzymes

... toward the active state, Kern and co-workers were able to detect picosecond (one millionth of one millionth of a second) changes, the fast smaller conformational motions, as well as the millisecond large-scale motions that are a result of the many fast motions. This work will lead to understanding the ...

In the Forefront of Research into Protein Folding and Macromolecular Complex Assembly

... The full reference for Dr. Ashcroft's article in the Journal of the American Society of Mass Spectrometry is: Monitoring co-populated conformational states during protein folding events using ESI-IMS-MS, D. P. Smith, K. Giles, R. H. Bateman, S. E. Radford, A. E Ashcroft, J. Am. Soc. Mass ...

Journal of Alzheimer's Disease special issue explores multifaceted aspects of AD

... used. Cristina Lanni and colleagues from the University of Pavia (Italy) discuss the methodologies that have been used to identify an altered conformational status of p53 in fibroblasts of AD patients. They explain that this alteration may be related to exposure to low amounts of soluble A peptide, not ...

The structural basis of familial hypertrophic cardiomyopathy is revealed

... at the attachment sites, thus demonstrating a structural basis for the change in function of the mutant myosin. Dr. Hanein illustrates how the conformational instability within the sarcomere affects ability of the heart to function properly and may lead to compensatory hypertrophy in cardiac muscle tissue, ...

Adlyfe Appoints Roxanne Duan as Vice President of Research

... are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with amyloid aggregation (and eventual amyloid plaque formation). These aggregates are associated ...
Conformational in Medical Technology

Adlyfe Study on the Detection of Misfolded Proteins Published in the Journal Transfusion

... with Adlyfe's proprietary peptides produces a conformational change that transduces a fluorescent signal. ... signal is generated as additional ligands undergo conformational changes. This is the basis for the ... on regions of the target protein known to undergo conformational changes (structural changes in shape) associated ...

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

... "And in many cases, this process is probably regulated by just the kind of conformational change that our findings reveal. So, we believe that these findings offer overall insight into how conformational change can activate these kinds of ligases." Other authors of this paper ...

Adlyfe Strikes Translational Medicine Partnership With Wyeth Pharmaceuticals for Alzheimer's Biomarker Assay

... are amino acid sequence matched to target amyloids of interest. Ligand sequences are selected based on regions of the target protein known to undergo conformational changes (structural changes in shape) associated with amyloid aggregation (and eventual amyloid plaque formation). These aggregates are associated ...

New Insight Into the Controls on a Go-To Enzyme

... renders it a target of calpastatin attachment and thus inhibition. "This new structural information on calpastatin and on calpain's conformational changes not only explains a lot about calpain's regulation," Green said. "It also gives us information we can use to develop targets for drugs that ...

YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy

... noted that, "According to our models, nimotuzumab inhibits the EGFr signaling both by inhibiting the binding of EGF to domain III of EGFr and by a conformational change of EGFr that is necessary to shape the EGF binding site." "These two studies provide independent confirmation of earlier research ...
Conformational in Medical Definition

Proteopathy

... , type 2 diabetes , amyloidosis , and a wide range of other disorders (see Table). [3] [4] The proteopathies are also called protein conformational diseases , [5] because a change in the 3-dimensional folding (conformation) of a protein increases the tendency of the protein to misfold and ...
Conformational in Biological News

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... hemaglutinin (HA). Binding to the stem prevents a conformational change in the protein that is necessary for viral ... highly conserved because it undergoes a dramatic conformational change to allow entry of viral RNA into the host ... conserved pocket in the HA stem, inhibiting the conformational change required for membrane fusion and viral ...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... hemaglutinin (HA). Binding to the stem prevents a conformational change in the protein that is necessary for viral ... highly conserved because it undergoes a dramatic conformational change to allow entry of viral RNA into the host ... conserved pocket in the HA stem, inhibiting the conformational change required for membrane fusion and viral ...

The key to unlocking the secret of highly specific DNAzyme catalysis

... Web site. Understanding the relationship between conformational change and reaction is important in obtaining ... modes for functions for which metal-dependent conformational change (induced fit) is required in some cases ... their research team studied the metal-dependent conformational change and cleavage activity of a particular ...

6 young ASU faculty earn NSF Career awards

... initiation and DNA replication. Their binding is characterized by large conformational changes, involving the (partial) folding or unfolding of the protein and ... give insight into how the molecular recognition processes are coupled to conformational dynamics. The knowledge gained is expected to lead to a better ...

St. Jude study gives new insights into how cells accessorize their proteins

... "And in many cases, this process is probably regulated by just the kind of conformational change that our findings reveal. So, we believe that these findings offer overall insight into how conformational change can activate these kinds of ligases." ...

Berkeley researchers identify photosynthetic dimmer switch

... in pH as a result of excess solar energy results in CP29 undergoing a conformational change which alters the reduction potential of excitonically-coupled ... that produces radical cations. Furthermore, it appears that this conformational change is reversible, which opens the possibility of being able to tune ...

Researchers 'see' structure of open nicotinic acetylcholine ion channels

... studies of the structure of the closed channel, Grosman concluded that the conformational changes that allow the channel to open are quite subtle. The five subunits ... when opening the gate. There are many good reasons why I think a subtle conformational change is advantageous from an evolutionary point of view, Grosman said. ...

Flexible neck in cell-receptor DC-SIGN targets more pathogens

... binds to a pathogen, binding sites on the cell receptor rearrange slightly, to adapt to the target surface and maximize the bond. This 5 nanometer conformational change is binding-induced, and made possible by a flexible linker in the neck, the researchers report. "The protein neck region acts as a stiff, ...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

... has lots of clinical implications," Deniz says. "Small mutations in proteins could throw off the delicate balance of energy that is needed between conformational structures of proteins in a cell, leading to disease. If so, a drug might be able to reverse those kinds of imbalances." ...

New research helps explain how connexin hemichannels are kept closed

... Tang et al. in the June issue of JGP (2). The report, along with a recent publication from Verselis et al. (3), provides new information about the conformational changes that occur within the loop gate. In addition, the concurrent unveiling of a high-resolution structure of a connexin channel has been a ...

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Conformational in Biological Technology

New force-fluorescence device measures motion previously undetectable

... we now have a technique that can detect subtle conformational changes of a biomolecule at an extremely low ... energy transfer, we can measure the resulting conformational changes with nanometer precision. By probing the ... of the transient species present during the conformational changes. Based on our previous studies, we knew ...

First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes

... (JASMS). Prof. Ashcroft's paper titled, Monitoring Copopulated conformational States During Protein Folding Events Using Electrospray Ionization-Ion ... American Society of Mass Spectrometry is: Monitoring co-populated conformational states during protein folding events using ESI -IMS-MS, D. P. Smith, K. ...

Sandia researchers construct carbon nanotube device that can detect colors of the rainbow

... of chemical and electrical impulses that ultimately trigger nerve impulses. In the nanoscale color detector, light strikes a chromophore and causes a conformational change in the molecule, which in turn causes a threshold shift on a transistor made from a single-walled carbon nanotube. "In our eyes the neuron ...

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

... and Chief Scientific officer. "Since a number of years we have been working on developing our CLIPS technology through which we can synthesize 3D conformational mimics of protein active sites , allowing us to do site-specific immunization to come up with functional antibodies against very difficult targets ...

Rapid hit confirmation and early hERG liability testing using the IonWorks HT system

... ability to maintain a population of ion channels in a particular conformational state due to the lack of voltage control. The traditional ... Thus, a population of channels can be driven to a particular conformational state, which may affect drug binding. The low throughput ...

Ca++-Induced G Protein Coupled Receptor (GPCR) Activation Monitored via Aequorin Luminescence in the LMax Microplate Luminometer (MaxLine Application Note #42)

... and the luminophore coelenterazine 1,2 emits blue light (469 nm) upon binding calcium ions (Figure 1). The binding of Ca ++ to aequorin induces a conformational change resulting in the oxidation ofcoelenterazine through an intramolecular reaction. This bioluminescent processpresents an advantage over Ca ++ ...

Measurement of Molecular Beacons in the SpectraMax Gemini Spectrofluorometer (MaxLine Application Note #36)

... are held in close proximity by the arms and thefluorescence is internally quenched. When the probe hybridizes to the targetmolecule, it undergoes a conformational change resulting in separation of thefluorophore and quencher, and restoration of fluorescence. Molecular beacons areappealing because they can be ...

Rapid, High Throughput Mutation Discovery Using Fluorescent SSCP on the ABI PRISM 3100 and 3100Avant Genetic Analyzers

... single-stranded DNA molecules assume unique conformations that vary depending on their nucleotide sequence. The change of only one base may cause a conformational change in the DNA molecule that is sufficient to be detected on a non-denaturing polymer, e.g., electrophoretic mobility differences compared with ...

Monitoring fluorescence resonance energy transfer (FRET) between GFP fusions in lysates of the yeast Saccharomyces cerevisiae using the Varian Cary Eclipse

... a powerful tool to monitor interactions at the protein level, within an intact cell or organism. It is possible to use FRET to measure conformational changes in a molecule tagged with two GFP variants in response to the binding of ligands such as calcium1, or the interaction ...

Protein Truncation Tests Using the DCode System

... Summary The versatile DCode system can be used for multiple mutation detection techniques, including single-stranded conformational polymorphism (SSCP), conformation-sensitive gel electrophoresis (CSGE) and denaturing gradient gel electrophoresis (DGGE). ...

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Conformational in Biological Products

MDR1 Shift Assay from CHEMICON

Description:... The CHEMICON MDR1 Shift Assay provides a convenient method to probe conformational changes in MDR1 that occur upon transport of MDR1 substrates. Thus, the ... (DMSO) are provided as positive and negative controls for inducing the conformational change in MDR1. Concentrated PBS (10x) and a BSA solution are included as ...
Company:CHEMICON
Conformational in Biological Definition

Allostery

... subunits are connected in such a way that a conformational change in one subunit is necessarily conferred to ... subunits are not connected in such a way that a conformational change in one induces a similar change in the ... to relaxed state, it does not propagate the conformational change to adjacent subunits. Instead, substrate ...

Allostery

... subunits are connected in such a way that a conformational change in one subunit is necessarily conferred to ... subunits are not connected in such a way that a conformational change in one induces a similar change in the ... to relaxed state, it does not propagate the conformational change to adjacent subunits. Instead, substrate ...

ATP synthase

... postulated that ATP synthesis is coupled with a conformational change in the ATP synthase generated by rotation ... synthase and was able to determine that Boyer's conformational model was essentially correct. In the crystal ... are fixed in place. This rotation forces a conformational change in the F 1 particle, eventually leading ...

Enzyme

... Catalysis. These works demonstrated the role of conformational transformations in catalytic reactions. ... Z.D. Urushadze, Yu.I. Kharkats. Electronic and conformational Interactions in Enzyme Catalysis.- In: E.L. ... of Kinetic Parameters of Reactions with the conformational Transformations.- In: E.L. Andronikashvili (Ed.), ...

Ion gradient

... the help of the solar driven enzyme bacteriorhodopsin , here it is used for driving the molecular motor enzyme ATP synthase to make the necessary conformational changes required to synthesize ATP. Proton gradients are also be made by bacteria by running ATP synthase in reverse, this is used to drive ...

Myosin

... muscle tissue . Together with actin filaments, myosin provides the mechanism for muscle contraction , utilizing energy from ATP . The specific conformational rearrangements throughout the chemo-mechanical transduction process are still not known. The Muscle is composed of single muscle cells (sometimes ...

Protein

... rearrangements, these tertiary or quaternary structures are usually referred to as " conformations ," and transitions between them are called conformational changes. The primary structure is held together by covalent peptide bonds , which are made during the process of translation . The secondary ...

Quaternary structure

... complexes also possess quaternary structure. Examples include nucleosomes and microtubules . Changes in quaternary structure are called conformational changes . It is through such changes, which underlie cooperativity and allostery in "multimeric" enzymes, that many proteins undergo regulation ...

Signal transduction

... of the hormone. Transport of the hormone to the target cell. Recognition of the hormone by the hormone receptor protein, leading to a conformational change. Relay and amplification of the signal that leads to defined biochemical reactions within the target cell. The reactions of the target ...

Transmembrane receptor

... ligand, the pore becomes accessible to ions, which then pass through. In other receptors, the transmembrane domains are presumed to undergo a conformational change upon binding, which exerts an effect intracellularly. In some receptors, such as members of the 7TM superfamily, the transmembrane domain may ...

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Conformational in Biological Dictionary

Sequential Epitope

... In contrast, most antibodies recognize a conformational epitope that has a specific three-dimensional ... to T cell epitopes, a B in ... 7_may be a conformational epitope rather than a sequential epitope ...... ... usage bias - competent - complementary - conformational epitope - congenital ... tagged site - ...

C-terminus

... target='_blank'>Full article >>> Role of conformational change in the C-terminus of β2-microglobulin in dialysis ... Conclusions: conformational changes in the C-terminus of β2m may play an ...... ... of 6 histidines at the C-terminus led to conformational ... cated from the C-terminus of the MSP, or ...

Conformational epitope

... A conformational epitope is a sequence of subunits composing ... In contrast, most antibodies recognize a conformational epitope that has a specific three-dimensional shape and its ... conformational epitopes are an important form of epitope ...

RNA polymerase

... REVERSIBLE BINDING OF RNA POLYMERASE TO PROMOTER SITES. REVERSIBLE conformational CHANGES IN RNA POLYMERASE . conformational CHANGES IN THE DNA ... Transcription Is Catalyzed by RNA Polymerase ...

DNA gyrase

... to ... Quinolone binding to the gyrase - DNA complex induces a conformational change that ... DNA gyrase is the intracellular target of the quinolone group of ... ... have used limited proteolysis to identify conformational changes in DNA gyrase . ... DNA gyrase is a type II topoisomerase ...

Pseudoknot

... ," indicated by the presence of crossed arcs in ... Of the 43 sequences, 11 are pseudoknot -free (namely the tRNA sequences and five ... conformational loops that we call pseudoknot core units, using the theory of ... We also find that the entropy of a pseudoknot loop depends not only on its .....

Okazaki fragments

... I uses. its exonuclease ... discontinuous units called Okazaki fragments . The polymerase moves in the 5'Ë3' direction. ... Energetic and conformational contributions to the stability of Okazaki fragments . ... It uses material from the Wikipedia article " Okazaki fragments " ... Definition ...

Carboxyl Terminus

... usage examples and terminus quotes. ... the negatively charged carboxyl termini of the rhinovirus coat ... carboxyl terminus undergoes conformational ... tional changes that occur at the carboxyl terminus of G ... carboxyl terminus is highly mobile in its GDP-bound ... ... occurring ...

Beta sheet

... build beta - sheet unobserved yet in PDB, as long ... The strands of the beta sheet are not fully extended due to the constraints of ... conformational and geometrical properties of beta - sheets in proteins. ... Paper Sculpture installation at the Stamp Staircase, Somerset House, London. 7-19 ...
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(Date:7/30/2014)... uses reversible epigenetic processes to regulate its genes, and ... a picture of the genome regulation taking place in ... Genome Biology and illustrates how the truffle ... genes,. The authors say this may shed light on ... Black truffles (Tuber melanosporum), also known as Prigord truffles, ...
(Date:7/30/2014)... American Chemical Society (ACS) announced today that David L. ... ACS Biomaterials Science & Engineering as editor-in-chief. With ... the new journal will feature high-quality research in the ... or naturally derived materials that interact with living or ... it reflects the tremendous growth in the field of ...
(Date:7/30/2014)... The Governing Board of the Entomological Society of America ... for 2014. The election as a Fellow acknowledges outstanding ... following: research, teaching, extension, or administration. The following Fellows ... Annual Meeting -- which will be held November 16-19, ... BOSQUE-PREZ is a professor with the Department of ...
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