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Conformation in Medical News

Unlocking the key to human fertility

... the development of the embryo. Further investigations showed the same conformation to exist in the sperm of several unrelated human donors and remarkably, ... patterns to exist in the sperm of mice. DNA regions in the 'open' conformation may therefore be more vulnerable to damaging toxins, such as those in ...

CVMF Advises on How to Save Money on Veterinary Bills

... arthritis, as well as diabetes and other ailments). Avoid running with your pet on pavement Do not force dogs with "specialized" conformation to perform like a wolf (for example: toy breeds dogs cannot run alongside their owners). Gastroenteritis:   Use a leash at ALL ...

Five UCSF Scientists Elected to National Academy of Sciences

... of the same protein give rise to markedly different heritable prion states. His work established that strains are "encoded" within the conformation of the misfolded protein itself, thereby resolving one of the major mysteries of the prion field since, with no nucleic acid genome to mutate, it was ...

Researchers aim to over-stress already taxed mantle cell lymphoma cells

... pace, these now-malignant cells need increased activity of heat shock protein 90. "Cancer cells require hsp90 for keeping their proteins in active conformation to do their job. That is what cancer is addicted to," said Dr. Bhalla, Cecil F. Whitaker, Jr., M.D./Georgia Research Alliance Eminent Scholar in ...

Uncovering the Achilles' heel of the HIV-1 envelope

... is still at an early experimental stage, it provides a plausible explanation as to why previous attempts, which neglected to preserve the native conformation of the MPER necessary for eliciting a broadly neutralizing antibody with 4E10-like specificity, were unsuccessful and offers a new approach to the ...

"Dynamic Energy Landscape" of enzyme in Catalysis

... theory is that dynamic fluctuations//protein conformation or structure play a major role in enzyme ... state were "priming" the enzyme to take up the conformation of the adjacent intermediate state, facilitating ... an equilibrium shift so that the ligand-bound conformation becomes the new major sub-state. "Our study ...
Conformation in Medical Technology

Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference

... lack genetic material and are therefore incapable of replication. Because they resemble actual infectious particles, presenting proteins in the same conformation as the wild-type virus, they are able to induce a potent immune response. The HA and NA are included to induce neutralizing antibody responses to ...

Novavax Announces Top Line Results of Phase IIa Clinical Trial for Its Seasonal Influenza VLP (Trivalent) Vaccine Candidate

... lack genetic material and are therefore incapable of replication. Because they resemble actual infectious particles presenting proteins in the same conformation as on the wild-type virus, they are able to induce potent immune response. Novavax's VLP vaccine may be differentiated from other influenza vaccines ...

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

... of diffraction of the X-rays. Comparison of the two structures revealed that, when NEDD8 attaches to cullin-RING, it dramatically modifies the conformation of the enzyme, causing it to blossom from a "closed" to an "open" state. This open state eliminates the binding site for the inhibitor CAND1, ...

Novavax Announces Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program

... lack genetic material and are therefore incapable of replication. Because they resemble actual infectious particles presenting proteins in the same conformation as on the wild-type virus, they are able to induce a potent immune response. The HA and NA are included to induce neutralizing antibody responses, ...

Infinity and MedImmune to Present Preclinical Data From Study of Oral Formulation of IPI-504 At AACR

... for the treatment of cancer. Proteins are the mainstay of structural and signaling elements of all cells. Hsp90 is a molecule that maintains the conformation and activity of specific proteins in the cell -- these proteins are known as "client proteins" of Hsp90. Many cancers result from specific mutations ...

Infinity and MedImmune Announce Updated Data On Ipi-504 to be Presented At ASCO

... for the treatment of cancer. Proteins are the mainstay of structural and signaling elements of all cells. Hsp90 is a molecule that maintains the conformation and activity of specific proteins in the cell -- these proteins are known as "client proteins" of Hsp90. Many cancers result from specific mutations ...
Conformation in Medical Products

VerifyNow IIb/IIIa Assay

Description:... assay device contains all of the necessary reagents to perform this analysis. Within the well is an activator that induces the platelet to change the conformation of the GP IIb/IIIa receptor to a form that binds fibrinogen (Iso-TRAP). Additionally, the detection well also contains fibrinogen-coated microbeads ...
Company:Accumetrics
Conformation in Medical Definition

Proteopathy

... Care 9 : 403-409. PMID 16778569 . ^ Walker LC, LeVine III H (2000). "The cerebral proteopathies: Neurodegenerative disorders of protein conformation and assembly". Mol Neurobiol 21 : 83-95. PMID 11327151 . ^ Chiti F, Dobson CM (2006). "Protein misfolding, functional amyloid, and ...
Conformation in Biological News

Researchers 'see' structure of open nicotinic acetylcholine ion channels

... able to infer the structure of the open channel conformation in a living cell. The Illinois team was able to ... revealing the structure of the open-channel conformation in unprecedented detail. As the ionizable ... infer the structure of an ion channel in its open conformation as it functions in a living cell. I know when ...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

... are trying to understand how Hsp90 folds steroid receptors into the proper conformation so they work," says Dr. Ahmed Chadli, biochemist in the MCG Center for ... heat shock proteins, such as Hsp90, work to help proteins keep proper conformation and function. It can be bad news when they don't. When proteins start ...

Researchers observe single protein dimers wavering between two symmetrically opposed structures

... been found in two different conformations: the "anti" wild type (natural) conformation occurs when the "head" of one hairpin is paired with the "tail" of the ... two bound head-to-head. The anti structure is thought to be the active conformation that binds to RNA, while the syn structurefound in a mutantis inactive. ...

Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing

... between glutamate and the receptor caused the receptor to change its conformation until now. The docking site (or ligand binding domain) closes when ... To pinpoint the molecular mechanism that switches the binding domains conformation from open to closed, Mamonova used a variety of chemical-modeling ...

Vaccine blocks malaria transmission in lab experiments

... Researchers at the Johns Hopkins Malaria Research Institute have for the first time produced a malarial protein (Pfs48/45) in the proper conformation and quantity to generate a significant immune response in mice and non-human primates for use in a potential transmission-blocking vaccine. ...

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

... enabled them to see what NHREF1 looks like in both its "on" and "off" conformation. "When it is not working, the protein is in this 'off' conformation until acted upon by outside agents" Roder says. "It is a way for the cell to shut off a signaling pathway when it is not in use." According to ...

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Conformation in Biological Technology

Cleveland Clinic Recognizes New Strategies for Creating Vaccines for Avian Flu as a Top Ten Medical Innovation for 2009

... lack genetic material and are therefore incapable of replication. Because they resemble actual infectious particles presenting proteins in the same conformation as on the wild-type virus, they are able to induce potent immune responses. Novavax's VLP vaccine may be differentiated from other influenza vaccines ...

Scientists use light to control proteins

... to consider a number of factors when designing the hybrid protein, including the protein's shape, or what is referred to as its conformation. "The conformation of a protein is important in determining its function," she said. "Without the proper conformation, our protein would not have responded to the ...

Novavax Completes Enrollment of Its Seasonal Influenza VLP Vaccine Phase IIa Clinical Trial

... lack genetic material and are therefore incapable of replication. Because they resemble actual infectious particles presenting proteins in the same conformation as on the wild-type virus, they are able to induce potent immune response. Novavax's VLP vaccine may be differentiated from other influenza vaccines ...

Novavax Commences Clinical Testing of its Seasonal Influenza VLP Vaccine Candidate

... lack genetic material and are therefore incapable of replication. Because they resemble actual infectious particles presenting proteins in the same conformation as on the wild-type virus, they are able to induce potent immune responses. Novavax's VLP vaccine may be differentiated from other influenza vaccines ...

Tethered molecules act as light-driven reversible nanoswitches

... Our ability to see is based on molecules in the eye that flip from one conformation to another when exposed to visible light. Now, a new technique for attaching light-sensitive organic molecules to metal surfaces allows the ...

Novel Approach to Treat Alzheimer's and Other Diseases Offered by Targeting Cell Membrane RAFTS

... Unlike existing approaches for Beta-secretase inhibition that do not account for the intracellular location of the target protein or the different conformation that the protein may assume in this context, these RAFT inhibitors are delivered to the exact site where Beta-secretase executes its neurotoxic ...

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Conformation in Biological Products

Coating Stabilizer from ScyTek Laboratories

Description:... been developed specifically for the stabilization of adsorbed or immobilized proteins on microwell plates/strips. Coating Stabilizer maintains the conformation and activity of the antibody or protein antigen portion of the dried immunoassay components. Product is filtered at 0.2 microns. Contents: ...
Company:ScyTek Laboratories

HRP Stabilizing Diluent (MOPS Buffered) from ScyTek Laboratories

Description:... for the stabilization of Horseradish Peroxidase conjugates in solution. HRP Stabilizer prevents the loss of catalytic activity and maintains the conformation of the antibody or protein antigen portion of the conjugate. Product is filtered at 0.2 microns. Contents: Aqueous, protein-containing diluent ...
Company:ScyTek Laboratories

StabilCoat Immunoassay Stabilizer from SurModics, Inc.

Description:... PBS buffer (phosphate buffered saline), pH 7.0 7.4. This product does not contain a preservative. StabilCoat Immunoassay Stabilizer preserves the conformation and activity of dried protein components in immunoassays and can be used as a coating or lyophilization buffer to protect antibodies, enzymes and ...
Company:SurModics, Inc.

StabilCoat Plus Microsphere/Microarray Stabilizer from SurModics, Inc.

Description:... after long term storage. It also improves protein array performance by increasing signal, reducing background and effectively preserving the conformation and activity of array proteins stored long-term in a dried state. The shelf-life of StabilCoat Plus Stabilizer is 2 years when stored at 4C. ...
Company:SurModics, Inc.

StabilCoat Plus Microsphere/Microarray Stabilizer from SurModics, Inc.

Description:... after long term storage. It also improves protein array performance by increasing signal, reducing background and effectively preserving the conformation and activity of array proteins stored long-term in a dried state. The shelf-life of StabilCoat Plus Stabilizer is 2 years when stored at 4C. ...
Company:SurModics, Inc.

Complete SSCP Kit, 20 cm from Bio-Rad

Description:... The complete SSCP kit provides all the accessories necessary for casting gels for mutation detection by single-stranded conformation polymorphism analysis (SSCP) with the DCode universal mutation detection system. The kit includes a cooling finger adaptor for use with an external ...
Company:Bio-Rad

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Conformation in Biological Definition

Protein

... unique polypeptide may have more than one stable folded conformation, each conformation has its own biological activity and only one conformation is considered to be the active, or native conformation. The two ends of ...

Secondary structure

... 4 or 5 turn) E = beta sheet in parallel and/or anti-parallel sheet conformation (extended strand). Min length 2 residues. B = residue in isolated ... Proc. Natl. Acad. Sci. USA, 37:729-740 (1951). (The original beta-sheet conformation article) L. Pauling, R.B. Corey and H.R. Branson. Two ...

Tertiary structure

... inside a cell is known as the native state or sometimes the native conformation . A protein assumes tertiary structure by " folding ". An important type ... disulfide bond . One goal of bioinformatics is to predict the native conformation of a protein from its primary sequence . Conventionally, tertiary ...

Amino acid

... occurs, changing the properties of histidine and the polypeptide as a whole. It is used by many proteins as a regulatory mechanism, changing the conformation and behavior of the polypeptide in acidic regions such as the late endosome or lysosome . I Ile Isoleucine hydrophobic ....

Glucose

... D -glucose and L -glucose, but in living organisms, only the D -isomer is found. Whether a carbohydrate is D or L has to do with the isomeric conformation of the hydroxyl on carbon 5. If it is to the right in the Fischer projection , then the ring form will be the D enantiomer, if it is to the left, ...

Insulin

... For this he was awarded the Nobel Prize in Chemistry in 1958. In 1967, after decades of work, Dorothy Crowfoot Hodgkin determined the spatial conformation of the molecule, by means of X-ray diffraction studies. She also was awarded a Nobel Prize. 1. Preproinsulin ( L eader, B chain, C ...

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Conformation in Biological Dictionary

Conformation

... Chemical conformation , in chemistry, is the chemical structure of a molecule. ... Protein conformation , in molecular biology and biochemistry, a (tertiary ... Equine conformation evaluates the degree of correctness of a ...

Teat

... while helping to protect the teat canal from scabbing. ... The conformation of a beef cow's teats and udder are important in a profitable ... Females with poor udder and teat conformation are a management challenge for ... Alibaba - Teat : Teat ...

Sequential Epitope

... models has low accuracy. ... 5]The epitope may consist of either sequential or non- sequential amino acids. If non- sequential , the 3D conformation of the epitope if vital. ... Place a T in front of the characteristics unique to T cell epitopes, a B in ... 7_may be a conformational ...

RecA protein

... protein recA and its interactions with DNA have long been studied (Ogawa et al. ... When ATP is bound to recA , the protein adopts an active conformation and has a ... The search for DNA homology does not limit stable homologous pairing promoted by RecA protein ... E. coli RecA protein ...

Quaternary structure

... structure The three-dimensional structure of a protein that is often key to its enzyme function ... 8 Quaternary structure . 9 Side chain conformation ... A rule-based classifier that attempts to answer the question: Is my protein ... QuaternaryStructure Predictor: ExperimentalHomodimer ...

MSH2

... ... The human mutator gene homolog MSH2 and its association with hereditary ... Mismatch Repair Factor MSH2 -MSH3 Binds and Alters the conformation of Branched ... Rabbit polyclonal to MSH2 . ... MSH2 is involved in DNA repair as a mismatch repair protein, and ... MSH2 antibody - ...

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