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Chemists create 'Superbowl' molecule; May lead to better health

...ific society. The superbowl molecule belongs to a class of artificial bowl-shaped molecules that were first developed in the 1980s to mimic naturally occurring enzymes, which facilitate molecular synthesis and transport within the body. Over the years, these bowl-shaped molecules have been extensively stu...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...ng damage to mammalian cells becausephotolyases ?a class of enzymes capable of efficiently repairing theselesions ?have apparently been lost from placental mammals over thecourse of evolution.Thus, most mammals, including humans, can only repair these lesionsthrough a much less direct and elaborate process...

Fox Chase Cancer Center scientists identify immune-system mutation

...e restriction of the T-cell receptor toward either class I or class II major histocompatibility complex (MHC) molecules. Most helper T cells carry a surface protein cal...

Controversial drug shown to act on brain protein to cut alcohol use

...ar mechanism thatshould allow development of a new class of drugs to treat addictionwithout Ibogaine's side effects," said Dorit Ron, PhD, UCSF associateprofessor of neurology and also principal investigator at the GalloCenter. Ron is co-senior author of the paper with Patricia Janak, PhD,UCSF assistant pr...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...he first genome sequence to be published from this class of amitochondrial human pathogens. The analysis reveals the degradation of the E. histolytica genome in its transition from a free-living organism into a parasite of the human gut. At the same time, scientists also cataloged the retention and expans...

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class at Biology Products

Mut S from USB Corp.

Mut S is a member of a class of proteins who function to ensure the integrity of the DNA sequence. Mut S plays an integral role in proofreading the nascent strands in DNA replication, in transcription-coupled nucleotide excision repair and in preventing chromosomal recombination...

Excalibur 3100 from Varian, Inc.

...design delivers the highest signal-to-noise in its class allowing you to analyze difficult samples such as Angstrom-thick films, low concentration of analytes in water, and trace impurities in strongly absorbing matrices. The Excalibur series also employs a large, industrial capacity desiccant cartridge wi...

4000 Q TRAP LC/MS/MS System from Applied Biosystems

...w 4000 Q TRAP LC/MS/MS System opens up a whole new class of application workflows for proteomics, drug discovery, and drug development. By combining true triple quadrupole scan modes with sensitive ion trap scans in a single LC/MS/MS run, the user can achieve results that previously required multiple analy...

Hybridization chamber with forced convection BFD 53 from BINDER

... Independent adjustable temperature safety device class 3.1, providing full protection against chamber over-temperature, with visual alarm Removable electrical rotation unit for up to twelve hybridization bottles Inner glass door enabling visual monitoring of chamber contents without disturbing the cham...

PPARGamma-Competitor Assay Kit Green from Invitrogen

...e and lipid metabolism. Agonists include the (TZD) class of anti-diabetic agents called thiazolidinediones (TZD) or "glitazones." Rosiglitazone (Avandia) and Pioglitazone (Actos) are two PPAR agonists currently marketed for treatment of type 2 diabetes. PPAR agonists may also be therapeutically important i...

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class at Biology Technology

Human Primary Preadipocytes and Differentiated Adipocytes

...nDifferentiated Adipocytes, researchers have a new class of reagents with whichto study human adipose biology. It is now possible to directly study the factorsthat affect human adipose differentiation, and to identify agents which maypromote or interfere with the progression of obesity. Gene expression in ...

Fast and Easy Isolation of PCR-Ready Genomic DNA from Whole Blood

...lysis applications that include typing HLA class I and II alleles, 1,2,3 screening neonates, 4 detecting tumor cells, 5 and studying allelic discrimination. 6,7,8 Commercially available genomic DNA isolation kitswe designed a simple method that does not require m...

Using XL1-Red Mutator Strain to Generate Esterase Variants

...lding block in the synthesis of Epothilones, a new class ofmacrolides showing taxol-like biological activity. 9 Mutation and Screening Figure 2 In Figure 2 , plasmids isolated from E. coli colonies produced during mutation cycles using ...

RT-PCR Primers for the Study of Apoptosis

...as-mediated apoptosis requires the activation of a class of cysteineproteases, which include the ICE family. 4 In humans, the ICE familyincludes CPP-32 and LAP-3 proteases. Triggering of Fas by either the Fas ligandor the anti-Fas antibody rapidly stimulates the proteolytic activity of ICEproteins. Overex...

New Reporter Plasmids for Studying Interferon-Stimulated Signal Transduction Pathways

...ein translation; and they induce expression of MHC class Imolecules by most cells in the body, except virus...ions of interferons are mediated by members of the class II cytokinereceptor family. Stimulation of cells with IFNs results in the dimerization oftheir recep...

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class at Biology Definition

Transmembrane receptor

...this and for much of what else is known about this class of receptors is based in part on studies of bacteriorhodopsin , the detailed structure of which has been determined by crystallography). The intracellular domain The intracellular (or cytoplasmic ) domain of the receptor interacts with the in...

Thermoregulation

...various animals. He found that animals of the same class of the animal kingdom showed very similar temperature values, those from the Amphibia examined being 38.5 C, Fishes 39 C, Reptilia 45 C, and various Molluscs 46 C. Also in the case of Pelagic animals he showed a relation between death temperature and...

Selective serotonin reuptake inhibitor

...ive serotonin reuptake inhibitors ( SSRIs ) are a class of antidepressants . They act within the brain to...tidepressants , which were the most commonly used class of antidepressants before the development of SSRIs. However, SSRIs have the important advantage tha...

Species

...duction , it leaves the term undefined for a large class of organisms that reproduce asexually. Biologists frequently do not know whether two morphologically similar groups of organisms are "potentially" capable of interbreeding. Further, there is considerable variation in the degree to which hybridization...

Rudolf Steiner

...ion and creativity can sometimes lead to child-led class sessions without focus or direction. To the contrary, Waldorf educators report that it is a highly structured, disciplined educational model. The emphasis on arts and creativity complements a challenging curricula. Philosophical Debate Th...

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class at Biology Dictionary

Zoology

...dy of animals . Zoomastigophorea The protozoa n class where members lack chloroplasts ; heterotrophic or saprozoic. Examples: Trypanosoma, Trichonympha, Trichomonas, Giardia. Full article >>> The University of Michigan Museum of Zoology 's Animal Diversity Web Follow the link to th...

Wild type

...st ( wild type rate), Class II grew slower and class I grew the slowest. Full article >>> 7 to 2 kbp relative to the wild type parent. Comparison of the sequence s of the wild type gene and of the mutants with insertion s revealed that the extra sequence s have inverted termin...

Vitamins

... Full article >>> Vitamins can be class ified as either water soluble, which means they dissolve easily in water, or fat soluble, which means they are absorbed through the intestinal tract with the help of lipids . Full article >>> vitamins A diverse group of organ ic m...

Virus

... Full article >>> Virus es can be class ified in several ways, such as by their geometry, by whether they have envelopes, by the identity of the host organ ism they can infect, by mode of trans mission, or by the type of disease they cause. Full article >>> A particle ...

Virology

...tudy of biological virus es: their structure and class ification, their ways to infect and exploit cells to reproduce and cause disease, ... Full article >>> Virology is the study of virus es and their properties. Properties include: Viral replication Viral pathogen esis Viral i...

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class at Medicine News

Special proteins to fight TB identified

...hat the study demonstrated the potential for a new class of drugs, which by inducing the bacterium to manufacture heat-shock proteins would make it vulnerable to our own natural immunity, enabling us to clear the infection. This research assumes importance because of the fact that tuberculosis kills more ...

New FDA Approved Drug To Treat Migraine

...th or without aura in adults. Axert belongs to a class of drugs known as selective serotonin receptor ago...ed a low percentage of side effects. However this class of compounds has the potential to cause coronary vasospasm, and as a result Axert is not advised for...

'Prozac miracle' could end in disaster

...lly addicted to an antidepressant drug in the same class as Prozac. The case, which has been filed in Calif...Is (selective serotonin reuptake inhibitors) - the class of drug of which Prozac is the best known - and which were hailed as "wonderdrugs" when they first h...

A non-stick danger

...ggests.The commercial polymer, Teflon, is one of a class of chemicals known as fluorinated polymers whose non-stick properties are exploited in cooking utensils, ovens and combustion engines. However, when heated, these polymers can emit a chemical known as trifluoroacetic acid (TFA) which is toxic to pl...

Osteoporosis Drugs: right time to take-off

...rred to as ‘‘bone forming drugs’’. // No single class of drugs is perceived to manage osteoporosis on a standalone basis. Hormone Replacement Therapy (HRT) and bisphosphonates are the most prescribed drugs. Calcium, vitamins and alfacalcidol preparations are also prescribed for prevention. The anti-oste...

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class at Medicine Products

Three-mirror Contact Lens 630

This contact class is particularly suitable for use with slit lamps which have a smaller distance between the eye and the reduction prism than the Haag-Streit 900, mirror: 3, area: fundus / iridocornea. Mirror angle 59° / 66° / 73°. Contact diameter 12 mm....

OP-1

OP-1, also known as BMP-7, is a member of a class of naturally occurring growth factors called Bone Morphogenetic Proteins. OP-1 Implant is known to induce new bone formation in both developing and mature skeletal systems. The FDA approved OP-1 Implant under the Humanitarian Device Exemption (HDE) i...

Multi-Link Vision OTW

... Coronary Stent System is Guidant's first in a new class of cobalt chromium stents. Cobalt chromium is stronger and more radiopaque than stainless steel, so a cobalt chromium stent can have similar strength and visibility as a conventional stainless steel stent with struts that are only .0032" thick. Thinn...

Multi-Link Vision RX

... Coronary Stent System is Guidant's first in a new class of cobalt chromium stents. Cobalt chromium is stronger and more radiopaque than stainless steel, so a cobalt chromium stent can have similar strength and visibility as a conventional stainless steel stent with struts that are only .0032" thick. Thinn...

Express Coronary Stent System

A fusion of first class deliverability, acute angiographic results and excellent versatility....

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class at Medicine Technology

Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy

...cell division. Her-2/neu therefore falls into the class of proto-oncogenes. A key discovery is that some 2530% of breast cancers carry amplifications (multiple copies) of the Her-2/neu gene, which lead to overexpression of Her-2/neu protein. The over-abundance of Her-2/neu receptor accelerates the cell ...

Pixantrone Combination Therapy for First-line Treatment of Aggressive Non-Hodgkin's Lymphoma Results in Reduction in Severe Toxicities Including Heart Damage When Compared to Doxorubicin-based Therapy

...etaining the potent anti-lymphoma activity of this class of drug,"said James A. Bianco, M.D., President and CEO of CTI. "Pendingresults from this and other studies, these findings could havemajor implications for treating patients with breast cancer,lymphoma, and leukemia, where debilitating cardiac damage...

Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate

...aceutical company developing Anticalins(R), anovel class of targeted human protein therapeutics, today announcedsignificant progress in validating novel, effective products forthe potential treatment of asthma. In studies of its proprietaryPRS-060 Anticalin(R) candidate, the Company reports that theprotein...

Alfacell Corporation to Present at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference

...ic purposes while enablingthe development of a new class of targeted therapies for cancer andother life-threatening diseases. In addition to an ongoing PhaseIIIb study in malignant mesothelioma, Alfacell is conducting aPhase I/II trial of ONCONASE in non-small cell lung cancer (NSCLC)and other solid tumors...

New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility

...arin) Lovenox(R) is a unique chemical entity in a class ofantithrombotic agents known as low-molecular weight heparin (LMWH).The no. 1 selling low-molecular weight heparin in the world,Lovenox(R) is obtained by alkaline degradation of heparin benzylester and is about one-third the molecular size of unfrac...

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class at Medicine Definition

Thymocyte

... cells with a T cell receptor able to bind MHC class I/II or peptide molecules with at least a weak a...ceptor requires CD8 as a coreceptor to bind to MHC class I, and CD4 as a coreceptor to bind MHC class II. At this stage thymocytes upregulate both CD4 and CD...

Pre-conditioning

... Another example is a simulated exam session for a class of students. A further example is exposure of a covert operative to simulated torture. At the community level, an example might be that of holding a fire or nuclear drill. Pre-conditioning is a vital tool in handling animals for transport or the show...

Medical Scientist Training Program

...ly in size, ranging from two trainees per academic class (e.g. University of Connecticut ) to over twenty (e.g. Washington University in St. Louis ). Additionally, several medical schools allow for the PhD portion of the MSTP to be completed at an allied institution, where research in specific fields may...

Medicine

...xic dyes that human cells did not. The first major class of antibiotics was the sulfa drugs, derived by French chemists originally from azo dyes. Throughout the twentieth century, major advances in the treatment of infectious diseases were observable in (Western) societies. The medical establishment is...

Cryostasis (clathrate hydrates)

...s, fish). [4] [5] Clathrate hydrates are a class of solids in which gas molecules occupy "cages" made up of hydrogen-bonded water molecules. These "cages" are unstable when empty, collapsing into conventional ice crystal structure, but they are stabilised by the inclusion of the gas molecule within...

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class at Medicine Dictionary

Worms

...neumonia is very large, and includes nearly every class of infecting organ ism: virus es, bacteria , bacteria -like organ isms, fungi, and parasites (including certain worms ). Full article >>> Thin, white, thread-like worms may be visible at the anal opening or in the stools . T...

Walking

... to feed self; ... Full article >>> class II - walking more than two blocks/slight limits class III - walking less than two blocks/marked limits class IV - minimal activity or rest/severe limits...

Viral Infections

...article >>> RIBAVIRIN - One of a new class of drugs used to treat viral infections called nucleocide analogues. These drugs interfere in a specific way with the mechanisms used by virus es for multi plication. Full article >>> Cause: Scientists believe that this is a group ...

Venous

...Intra venous infusions of bisphosphonates - This class of drug , often given once a month, can decrease the risk of bone fractures and improve survival in myeloma . Radiation therapy to treat tumor s in the bone ... Full article >>> INTRA VENOUS (IV): Of or pertaining to the insi...

Treatment

... program to provide experimental treatment s to a class of patients who lack satisfactory alternative treatment s. Full article >>> Treatment of partners has not been shown in clinical trials to be effective in eradicating BV but it is sometimes suggested to women with recurrent BV. F...

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(Date:9/4/2008)...NORWICH, England and ONGAR, Ireland,Sept. 4 /PRNe...ofield Media,Europe Ltd, announced on the 29th Aug... publication from Silverdog Publishing., Health a... the iconic,Health and Safety at Work Act 1974 and.... It has been relied upon by blue-chip corporates,...
(Date:9/4/2008)...-FirstCall/ -- ULURU Inc. (Amex:,ULU) today announ...Weisel,Partners Healthcare Conference at 3:15 p.m....out ULURU Inc.:, ULURU Inc. is an emerging specia...ent of a portfolio of wound management, plastic su...nd consumers improved clinical,outcomes through co...
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(Date:9/4/2008)...GE, Mass., Sept. 4, 2008 Declaring the success of...thropy, Los Angeles-based philanthropists Eli and ...sed their total gift to the Broad Institute of Har...ious gifts totaling $200 million, the Broads today...Institute, which had been launched as a 10-year "v...
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