Chemists create 'Superbowl' molecule; May lead to better health
...ific society. The superbowl molecule belongs to a class of artificial bowl-shaped molecules that were first developed in the 1980s to mimic naturally occurring enzymes, which facilitate molecular synthesis and transport within the body. Over the years, these bowl-shaped molecules have been extensively stu...Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
...ng damage to mammalian cells becausephotolyases ?a class of enzymes capable of efficiently repairing theselesions ?have apparently been lost from placental mammals over thecourse of evolution.Thus, most mammals, including humans, can only repair these lesionsthrough a much less direct and elaborate process...Fox Chase Cancer Center scientists identify immune-system mutation
...e restriction of the T-cell receptor toward either class I or class II major histocompatibility complex (MHC) molecules. Most helper T cells carry a surface protein cal...Controversial drug shown to act on brain protein to cut alcohol use
...ar mechanism thatshould allow development of a new class of drugs to treat addictionwithout Ibogaine's side effects," said Dorit Ron, PhD, UCSF associateprofessor of neurology and also principal investigator at the GalloCenter. Ron is co-senior author of the paper with Patricia Janak, PhD,UCSF assistant pr...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...he first genome sequence to be published from this class of amitochondrial human pathogens. The analysis reveals the degradation of the E. histolytica genome in its transition from a free-living organism into a parasite of the human gut. At the same time, scientists also cataloged the retention and expans...Excalibur 3100 from Varian, Inc.
...design delivers the highest signal-to-noise in its class allowing you to analyze difficult samples such as Angstrom-thick films, low concentration of analytes in water, and trace impurities in strongly absorbing matrices. The Excalibur series also employs a large, industrial capacity desiccant cartridge wi...4000 Q TRAP LC/MS/MS System from Applied Biosystems
...w 4000 Q TRAP LC/MS/MS System opens up a whole new class of application workflows for proteomics, drug discovery, and drug development. By combining true triple quadrupole scan modes with sensitive ion trap scans in a single LC/MS/MS run, the user can achieve results that previously required multiple analy...Hybridization chamber with forced convection BFD 53 from BINDER
... Independent adjustable temperature safety device class 3.1, providing full protection against chamber over-temperature, with visual alarm Removable electrical rotation unit for up to twelve hybridization bottles Inner glass door enabling visual monitoring of chamber contents without disturbing the cham......e and lipid metabolism. Agonists include the (TZD) class of anti-diabetic agents called thiazolidinediones (TZD) or "glitazones." Rosiglitazone (Avandia) and Pioglitazone (Actos) are two PPAR agonists currently marketed for treatment of type 2 diabetes. PPAR agonists may also be therapeutically important i...Human Primary Preadipocytes and Differentiated Adipocytes
...nDifferentiated Adipocytes, researchers have a new class of reagents with whichto study human adipose biology. It is now possible to directly study the factorsthat affect human adipose differentiation, and to identify agents which maypromote or interfere with the progression of obesity. Gene expression in ...Fast and Easy Isolation of PCR-Ready Genomic DNA from Whole Blood
...lysis applications that include typing HLA class I and II alleles, 1,2,3 screening neonates, 4 detecting tumor cells, 5 and studying allelic discrimination. 6,7,8 Commercially available genomic DNA isolation kitswe designed a simple method that does not require m...Using XL1-Red Mutator Strain to Generate Esterase Variants
...lding block in the synthesis of Epothilones, a new class ofmacrolides showing taxol-like biological activity. 9 Mutation and Screening Figure 2 In Figure 2 , plasmids isolated from E. coli colonies produced during mutation cycles using ...RT-PCR Primers for the Study of Apoptosis
...as-mediated apoptosis requires the activation of a class of cysteineproteases, which include the ICE family. 4 In humans, the ICE familyincludes CPP-32 and LAP-3 proteases. Triggering of Fas by either the Fas ligandor the anti-Fas antibody rapidly stimulates the proteolytic activity of ICEproteins. Overex...New Reporter Plasmids for Studying Interferon-Stimulated Signal Transduction Pathways
...ein translation; and they induce expression of MHC class Imolecules by most cells in the body, except virus...ions of interferons are mediated by members of the class II cytokinereceptor family. Stimulation of cells with IFNs results in the dimerization oftheir recep...Special proteins to fight TB identified
...hat the study demonstrated the potential for a new class of drugs, which by inducing the bacterium to manufacture heat-shock proteins would make it vulnerable to our own natural immunity, enabling us to clear the infection. This research assumes importance because of the fact that tuberculosis kills more ...New FDA Approved Drug To Treat Migraine
...th or without aura in adults. Axert belongs to a class of drugs known as selective serotonin receptor ago...ed a low percentage of side effects. However this class of compounds has the potential to cause coronary vasospasm, and as a result Axert is not advised for...'Prozac miracle' could end in disaster
...lly addicted to an antidepressant drug in the same class as Prozac. The case, which has been filed in Calif...Is (selective serotonin reuptake inhibitors) - the class of drug of which Prozac is the best known - and which were hailed as "wonderdrugs" when they first h......ggests.The commercial polymer, Teflon, is one of a class of chemicals known as fluorinated polymers whose non-stick properties are exploited in cooking utensils, ovens and combustion engines. However, when heated, these polymers can emit a chemical known as trifluoroacetic acid (TFA) which is toxic to pl......rred to as ‘‘bone forming drugs’’. // No single class of drugs is perceived to manage osteoporosis on a standalone basis. Hormone Replacement Therapy (HRT) and bisphosphonates are the most prescribed drugs. Calcium, vitamins and alfacalcidol preparations are also prescribed for prevention. The anti-oste...Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
...cell division. Her-2/neu therefore falls into the class of proto-oncogenes. A key discovery is that some 2530% of breast cancers carry amplifications (multiple copies) of the Her-2/neu gene, which lead to overexpression of Her-2/neu protein. The over-abundance of Her-2/neu receptor accelerates the cell ......etaining the potent anti-lymphoma activity of this class of drug,"said James A. Bianco, M.D., President and CEO of CTI. "Pendingresults from this and other studies, these findings could havemajor implications for treating patients with breast cancer,lymphoma, and leukemia, where debilitating cardiac damage......aceutical company developing Anticalins(R), anovel class of targeted human protein therapeutics, today announcedsignificant progress in validating novel, effective products forthe potential treatment of asthma. In studies of its proprietaryPRS-060 Anticalin(R) candidate, the Company reports that theprotein...Alfacell Corporation to Present at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
...ic purposes while enablingthe development of a new class of targeted therapies for cancer andother life-threatening diseases. In addition to an ongoing PhaseIIIb study in malignant mesothelioma, Alfacell is conducting aPhase I/II trial of ONCONASE in non-small cell lung cancer (NSCLC)and other solid tumors......arin) Lovenox(R) is a unique chemical entity in a class ofantithrombotic agents known as low-molecular weight heparin (LMWH).The no. 1 selling low-molecular weight heparin in the world,Lovenox(R) is obtained by alkaline degradation of heparin benzylester and is about one-third the molecular size of unfrac...Medical Scientist Training Program
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