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Circadian in Medical News

NUVIGIL Jet Lag Disorder Data Presented at the SLEEP 2009 23rd Annual Meeting of the Associated Professional Sleep Societies

... travel." Jet lag disorder is an acute circadian rhythm sleep disorder that results from rapid ... a person adjusts to the new local time. circadian rhythm sleep disorders are disruptions in a ... to sleep, stay awake and function normally. circadian rhythm sleep disorders can be caused by many ...

Genetic pathway responsible for link between body clock disturbance and worsening arthritis

... 10 June 2009: The genes that regulate human circadian rhythm, or 'the body clock', are significantly ... a novel biochemical pathway in which the circadian regulatory gene CRY was found to up-regulate ... with the genetics behind an individual's circadian rhythm and, specifically, that certain body clock ...

Researchers develop light-treatment device to improve sleep quality in the elderly

... often result from a disruption of the body's circadian rhythmsbiological cycles that repeat ... light is the most effective at stimulating the circadian system when combined with the appropriate light ... and dark patterns are the major synchronizer of circadian rhythms to the 24-hour solar day," said Mariana ...

A 'light bulb' moment for people with dementia

... pattern linked to the 24-hour biochemical circadian cycle of the hormone melatonin. Depending on the ... Research Center."Light is a good stimulus for the circadian system, which regulates your sleep-wake cycles," ... better when given at the appropriate time in the circadian cycle. As a safe, non-pharmacological ...

Scripps research scientists model 3D structures of proteins that control human clock

... cryptochrome proteins that control the mammalian circadian clock because they aren't in a sufficiently ... protein known as cryptochrome that modulates the circadian clock. "This is an amazing, and very puzzling, ... may also go some way to explain some fascinating circadian clock disorders that have been found in mice and ...

Internal Clock and Metabolism May Be Linked

... plays an important role in coordinating people's circadian clocks and metabolism has been identified by U.S. researchers. The circadian clock governs daily cycles of feeding, activity ... said their finding of a connection between the circadian clock and metabolism in animals could improve ...

Night Shift Work Hard on the Heart

... 24-hour sleep/wake clock, commonly known as the circadian rhythm. To explore how such a misalignment ... had eaten and slept across all phases of the circadian cycle, as they followed a daily schedule ... fashioned along 28-hour blocks. The results: circadian misalignment provoked a drop in levels of the ...

UNC study supports role of circadian clock in response to chemotherapy

... driver of this oscillatory behavior is the circadian clock, which keeps the biochemical, behavioral ... brain. Because of the important role that the circadian clock plays in regulating the daily rhythms of ... fell in synchrony with the oscillations of the circadian clock. Thus, the researchers demonstrated that ...

Another reason to avoid high-fat diet -- it can disrupt our biological clock

... intake, but also can affect the balance of circadian rhythms everyone's 24-hour biological clock, ... While light is the strongest factor affecting the circadian clock, Dr. Oren Froy and his colleagues of the ... signaling pathway components exhibited normal circadian rhythmicity. Fasting resulted in a phase advance. ...

Immune System Works Better at Night

... at night, consistent with the hypothesis that circadian proteins upregulate restorative functions such as ... release issued by the conference organizers. circadian rhythm paces the human body as well as the fruit ... that bacterial infection threw off the insects' circadian rhythm, and not having this internal clock ...

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Circadian in Medical Technology

Cephalon Announces Positive Results from a Phase Three Study of NUVIGIL in Jet Lag Disorder

... and fatigue. Jet lag disorder is an acute circadian rhythm sleep disorder that results from rapid ... a person adjusts to the new local time. circadian rhythm sleep disorders are disruptions in a ... to sleep, stay awake and function normally. circadian rhythm sleep disorders can be caused by many ...

Clinical Trial Results on the Sleep-Promoting Effects of Vanda Pharmaceuticals' Circadian Regulator Tasimelteon (VEC-162) Published in The Lancet

... journals, results of clinical trials of its novel circadian regulator, experimental compound tasimelteon ... sleep-promoting effects of tasimelteon, a novel circadian regulator that acts by resetting the body clock. ... and Golombek(2) discuss the implications of the circadian regulatory and sleep-promoting effects of ...

Phase III Data Show Vanda Pharmaceuticals' Tasimelteon (VEC-162) Significantly Improves Sleep in Patients with Chronic Insomnia

... The mechanism of action of tasimelteon as a circadian regulator gives Vanda the opportunity to explore its use for the treatment of circadian rhythm sleep disorders as well as chronic primary ... primary insomnia. "These results suggest that circadian misalignment may play an important role in the ...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

... but undergoes natural variations which follow a circadian pattern. Highest levels are reached during ... symptoms. A large study has revealed a marked circadian periodicity in the onset of myocardial infarction ... and plasma that make up the blood. Circadian: a circadian rhythm is a roughly 24-hour cycle in ...

Phase IIIb Clinical Data Validate the Overall and Cardiovascular Safety Profile of Cycloset (A Quick Release Formulation of Bromocriptine Mesylate) in Patients with Type 2 Diabetes

... decades of preclinical and clinical research have focused on investigating circadian neuroendocrine regulation of metabolism, particularly in relation to ... as a single timed (morning) daily dose, Cycloset(TM) is believed to act on circadian neuronal activities within the hypothalamus to reset abnormally elevated ...
Circadian in Medical Products

Leptin IRMA Test

Description:... this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short ...
Company:Diagnostic Systems Laboratories, Inc.

Leptin ELISA Test

Description:... this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short ...
Company:Diagnostic Systems Laboratories, Inc.

Cortisol RIA Test

Description:... urine in an unbound (free) form. Cortisol levels follow a ACTH-dependent circadian rhythm with peak levels in the early morning and a nadir at night. Increased amounts of ACTH and cortisol are also secreted independently of the circadian rhythm in response to physical and psychological stress [4,5]. Elevated ...
Company:Diagnostic Systems Laboratories, Inc.

TSH ELISA Test

Description:... occurs with a subsequent rapid decline over several hours [3]. Postnatal secretion of TSH is relatively age- and sex-independent and occurs in a circadian pattern with a nadir in the late afternoon and a peak at approximately midnight. Measurement of serum TSH levels have been used in the diagnostic ...
Company:Diagnostic Systems Laboratories, Inc.

TSH IRMA Test

Description:... occurs with a subsequent rapid decline over several hours [3]. Postnatal secretion of TSH is relatively age- and sex-independent and occurs in a circadian pattern with a nadir in the late afternoon and a peak at approximately midnight. Measurement of serum TSH levels have been used in the diagnostic ...
Company:Diagnostic Systems Laboratories, Inc.

Cortisol EIA Kit

Description:... Cortisol is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is secreted with a circadian periodicity, and peaks just prior to waking in the morning. Cortisol is often elevated in major depressive disorder, certain forms of hypertension, ...
Company:Cayman Chemical

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Circadian in Medical Definition

Ultradian

... individual stages of sleep that occur within intervals of an organism's circadian rhythm , and especially to refer to the 90 minute ultradian cycle in human ... (Dr. Claudio Stampi is a sleep expert). circadian Rhythms factor in Rapid-Cycling Bipolar Disorder. [4] Barrios C, ...
Circadian in Medical Dictionary

Circadian

... circadian Rhythm Disorder Overview A person’s circadian rhythm is an internal biological clock that ... according to an approximate 24-hour period. circadian Abnormalities. Cluster attacks often occur ...

Endocrine System

... system is involved. Most of a person’s body systems demonstrate circadian variations. The body systems with the most prominent circadian variations are the sleep-wake cycle, the temperature regulation system, ...

Genetic

... colon and breast cancer s. To uncover components of the plant circadian clock, a genetic screen utilizing a clock output reporter ... found that mutants in the ZTL protein presents a longer period of the circadian clock. Familial adenoma tous polyp osis (FAP) is a genetic ...

Protein

... rich foods of animal origin. To uncover components of the plant circadian clock, a genetic screen utilizing a clock output reporter ... found that mutants in the ZTL protein presents a longer period of the circadian clock. AFP ( Alpha feto protein ) A tumor marker. Alopecia The ...

Gene

... early ambulation; early deceleration; early development; early diastolic murmur ; early gene ; ... In higher plants, the importance of the circadian clock is reflected by the fact that its rhythm influences such diverse activities as gene transcription, gas exchange and transpiration, ...

Irregular sleep

... multi ple sleep episodes without evidence of recognizable ultradian (a series of shorter biological rhythms occurring within a 24-hour period) or circadian features of sleep and ... People with regular habits have faster reaction time and are happier than those with irregular sleep ing times. ...

Nephropathy

... lesser risk but should be monitored for nephropathy or renal failure. it is a useful ' first -line treatment for patients with an excessive circadian blood pressure amplitude (a condition which, even in the absence of high blood pressure , is associated with increased risk of developing ...

Respect

... its relatively risk-free nature, ... The goal of this project is to clarify the function of the ZTL family of protein s with respect to the circadian clock. ...

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Circadian in Biological News

MicroRNAs grease the cell's circadian clockwork

... that reaches a peak once a day. A large number of circadian genes are expressed by organs such as the liver, ... little was known about their function within the circadian clockwork. The study by Ueli Schibler's team, ... is tightly embedded in the output system of the circadian clock in hepatocytes. This microRNA regulates ...

Two new studies on circadian rhythms

... of temperature compensation: why the 24-hour circadian rhythm does not change with temperature when ... adds clarity to the molecular underpinnings of circadian clocks, the finely tuned cellular timekeepers that drive most organisms. circadian systems are biological oscillators that ...

A biological basis for the 8-hour workday?

... PHILADELPHIA - The circadian clock coordinates physiological and behavioral ... or 8 hours, indicating that shorter cycles of the circadian rhythm are also biologically encoded. Using a ... for better understanding disruptions to normal circadian rhythms that contribute to a host of pathologies ...

UNC study: Tinkering with the circadian clock can suppress cancer growth

... at Chapel Hill have shown that disruption of the circadian clock the internal time-keeping mechanism that ... shown that the disruption of the body's natural circadian rhythms affects people's health. One of the ... models, they did not always see such an effect. circadian rhythms in humans and in mice are controlled by ...

How your body clock avoids hitting the snooze button

... to reset themselves on a molecular level. circadian clocks regulate the daily fluctuations of many ... in the length of the day mean that an animal's circadian clock often has to reset itself on a molecular ... of Biological and Chemical Sciences study the circadian clocks of Drosophila, a type of fruit fly. ...

When it comes to sleep research, fruit flies and people make unlikely bedfellows

... of Missouri-Kansas City have shown that the circadian rhythms (sleep/wake cycles) of fruit flies and ... is one of only a few possible drug targets for circadian problems that can lead to seasonal affective ... functions 24 hours a day and has produced more circadian problems than our ancestors ever faced," said ...

Immunity stronger at night than during day

... known as phagocytosis oscillates with the body's circadian rhythm, according to Stanford researchers who ... at night, consistent with the hypothesis that circadian proteins upregulate restorative functions such as ... the relationship between innate immunity and circadian rhythm, which is the oscillating protein clock or ...

Circadian clock may be critical for remembering what you learn, Stanford researchers say

... The circadian rhythm that quietly pulses inside us all, guiding ... Norman Ruby has shown that having a functioning circadian system is critical to the hamsters' ability to ... as do all animals. But hamsters whose circadian system was disabled by a new technique Ruby and ...

Biologists identify genes controlling rhythmic plant growth

... of plant growth hormones, plant light sensors and circadian rhythms that permit plants to undergo rhythmic ... growing population." "It was known that the circadian clock confers an adaptive advantage to plants in ... interplay of light sensing, plant hormones and circadian rhythms that leads to a pronounced rhythmic ...

Circadian rhythm-metabolism link discovered

... researchers have found a molecular link between circadian rhythms our own body clock and metabolism. The ... protein called CLOCK that regulates the body's circadian rhythms, works in balance with another protein ... one of the world's leading researchers on circadian rhythms. The study appears in the July 25 issue ...

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Circadian in Biological Technology

Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe

... allows for the first time the restoration of the circadian rhythms of depressed patients.(1) ... of depression through the restoration of circadian rhythms Valdoxan is the result of an ... antagonist. As a result, Valdoxan resynchronises circadian rhythms that are profoundly disrupted in ...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

... pressure is not static but undergoes natural variations which follow a circadian pattern. Highest levels are reached during the morning, which then decline ... vessels, and the cells and plasma that make up the blood. Circadian: a circadian rhythm is a roughly 24-hour cycle in the physiological processes of living ...

Respironics Acquires Apollo Light Systems, Inc., Expands into Circadian Rhythm Device-Based Therapy Market

... use BRITEWAVE(TM) technology to create specific wavelengths that produce a circadian response while eliminating UV hazards, and the goLITE(R) Series Handheld ... is a scientifically validated and effective treatment for sleep and circadian rhythm related disorders such as jet lag, chronic insufficient sleep and ...

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

... adults. Vanda will also present two posters on tasimelteon at APA. Tasimelteon is an investigational compound in development for the treatment of circadian rhythm sleep disorders, including transient insomnia caused by jet lag. The following two posters discussing data from Fanapt(TM) clinical ...

Vanda Pharmaceuticals Reports First Quarter 2009 Results

... its efforts on the design and evaluation of clinical development options for tasimelteon, its compound for sleep and mood disorders, including circadian Rhythm Sleep Disorders. FINANCIAL DETAILS * Operating Expenses. First quarter 2009 R&D expenses of $2.3 million, ...

Genetic clock makers at UC San Diego publish their 'timepiece' in Nature

... "Circadian clocks are hugely complicated. It's hard to know what the essential modules are, but based on our synthetic clock, it looks as though circadian clocks could have easily started as some kind of primitive negative feedback loop, with the positive loop coming later to regularize it," said Hasty. ...

Nitec Pharma Expands Senior Management Team

... and pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is LodotraTM, a circadian cytokine modulator (CCMTM) based on a night time release formulation of prednisone, for the treatment of rheumatoid arthritis (RA) -addressing in ...

Nitec's IND Application for Clinical Development With Lodotra Accepted by the FDA

... pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is Lodotra(R), a circadian cytokine modulator for the treatment of rheumatoid arthritis (RA). Nitec was originally founded in 2004 as a spin-out of Merck KGaA. The Company is ...

Nitec Pharma AG Announces Appointments of CEO & CFO in Preparation for Launch of Lodotra(R)

... pain. Nitec is headquartered in Reinach, Switzerland, with a subsidiary in Mannheim, Germany. The Company's most advanced product is Lodotra (R), a circadian cytokine modulator for the treatment of rheumatoid arthritis (RA). Nitec was originally founded in 2004 as a spin-out of Merck KGaA. The Company is ...
Circadian in Biological Products

Porcine Leptin ELISA Kit from Diagnostic Systems Laboratories, Inc.

Description:... this kind of regulation has been suggested. Serum leptin levels follow a circadian rhythm, which seems to be regulated predominantly by postprandial increases in insulin and the normal circadian rhythm of cortisol. Although these hormones do not work in the short ...
Company:Diagnostic Systems Laboratories, Inc.

NightOWL II LB 983 NC100 from BERTHOLD TECHNOLOGIES GmbH & Co. KG

Description:... with an extreme sensitive camera to detect low level light in animals or plants in tumor research, infectious disease research, gene expression, circadian rhythm or Western blots. NightOWL is the only imager with a motor-driven camera inside the light-tight cabinet. This function allows close-up images ...
Company:BERTHOLD TECHNOLOGIES GmbH & Co. KG

NightOWL II LB 983 NC320 from BERTHOLD TECHNOLOGIES GmbH & Co. KG

Description:... Equipped with a very sensitive camera to detect low level light in animals or plants in tumor research, infectious disease research, gene expression, circadian rhythm, gels and Western blots. NightOWL is the only imager with a motor-driven camera inside the light-tight cabinet. This function allows close-up ...
Company:BERTHOLD TECHNOLOGIES GmbH & Co. KG
Circadian in Biological Definition

Photobiology

... of the effects of light on living organisms . The field encompasses many biological phenomena, including photosynthesis , visual processing , circadian rhythms , and ultraviolet radiation effects. There are numerous professional societies devoted to the study of photobiology, the largest of which ...
Circadian in Biological Dictionary

Urea cycle

... or more of the ... Feature article describes urea cycle disorders, their diagnosis, and treatment. ... Hereditary urea cycle abnormality. circadian Rhythm - Definition of ... ...

Photobiology

... study of the interactions of light and living organisms. The field includes the study of photosynthesis, photomorphogenesis, visual processing, circadian rhythms, bioluminescence, and ultraviolet radiation effects. The division between ionizing radiation and nonionizing radiation is typically ...

Optic lobes

... of Optic lobe . ... Optic lobe Definition. Find Definitions For Any Word.Get Your Free ... The bilaterally paired optic lobe circadian pacemakers of the cricket Gryllus ... medulla bilateral neurons, connecting the medulla areas of the two optic lobes . ... optic lobes ...

Hypothalamus

... items. The hypothalamus is a small area at the base of the brain, weighing ... 2 Inputs to the hypothalamus . 3 Homeostatic, allostatic, and circadian control systems ... Hypothalamus . You don't need to be Editor-In-Chief to add or edit content to WikiDoc. ... Review articles on Hypothalamus . ...

Hepatocytes

... hepatodynia ... Novel in vitro system for primary culture of hepatocytes ... hepatocytes and the desynchronization and damping of circadian rhythm. ... ... liver transplantation, transplanted hepatocytes must proliferate efficiently ... Recently, small hepatocytes and oval cells ...
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