Navigation Links
Chaperone in Medical News

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 14 top young investigators

... is investigating the molecular mechanism by which the Hsp90 protein chaperone affects the folding of substrate proteins. The effect of Hsp90 on folding is important because this chaperone activates a wide variety of proteins that are over-expressed in cancerous ...

MU researchers find clue to cataract formation

... an increasing rate. As the number of small peptides increases in the eye, chaperone activity starts to decrease, resulting in less cleansing activity inside ... cataracts. There are a variety of causes that lead to the decrease of chaperone activity, and the presence of these small peptides accelerates the ...

Peptide discovered in scorpion venom may hold key to secretory diseases

... leading to cystic fibrosis, the location of the deletion causes the chaperone proteins which are responsible for quality assurance within cells to ... could possibly be used to increase water production, by binding to the chaperone binding sites on the chloride channel. By blocking chaperones from ...

Slices of living brain tissue are helping scientists identify new stroke therapies

... within the endoplasmic reticulum of cells, which controls protein synthesis and regulates calcium levels. When needed, the receptors appear to chaperone these proteins to the cell powerhouse, or mitochondria. In his studies, Dr. Kirov is testing to see whether these sigma receptor ligands inhibit ...

USC researchers identify novel approach for suppressing prostate cancer development

... cancer and isolate drugs that inhibit GRP78, Lee says. "To our knowledge, this is the first demonstration that inactivation of a specific molecular chaperone from the mouse prostate epithelial cells can potently block prostate cancer development and suppress the activation of AKT, which is a protein kinase ...

Researchers aim to over-stress already taxed mantle cell lymphoma cells

... machinery," Dr. Bhalla said. To help push cancer cells over the edge, the researchers are inhibiting hsp90, so the cells lose the molecular chaperone function required to maintain their fast pace. This also puts more stress on the endoplasmic reticulum. Independently hsp90 inhibitors are known to ...

'Healthy Fat' Chemical Aids Body's Metabolism

... metabolic problems, like diabetes and heart disease, normally linked to a long-term, high-fat diet. In these mice, whose fat cells lacked proteins to chaperone the fat to their normal storage cells, palmitoleate production was much higher. The excess palmitoleate signaled the muscles and the liver to improve ...

JCI online early table of contents: July 1, 2008

... targets for the treatment of congenital hypothyroidism. TITLE: The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone AUTHOR CONTACT: Peter Arvan University of Michigan, Ann Arbor, Michigan, USA. Phone: (734) 936-5006; Fax: (734) 936-6684; Email: ...

United Nations Environment Programme and Bayer Corporation Announce North American Winners of International Children's Painting Competition

... five UNEP regions of Africa; Asia and the Pacific; West Asia; Latin America and the Caribbean; and Europe. As second prize winner, Ms. Yu and a chaperone will receive an all- expense-paid trip, courtesy of Bayer, to the Chicago Botanic Garden, host venue of the North American World Environment Day ...

HSP90: New point of view on melanoma of the eye, at the MUHC

... Heat Shock Protein 90 (HSP90). HSP90 is already a therapeutic target in many other types of cancer. In fact, this protein, which is called a chaperone because it guides the actions of other proteins, is at the centre of many metabolic pathways. By disrupting HSP90s functioning, it is possible to ...
Chaperone in Medical Technology

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... develop Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders, ... range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules ... commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under ...

Amicus Therapeutics Announces Issuance of New Plicera(TM) Composition of Matter Patent

... our development programs and our pharmacological chaperone technology platform." Plicera is currently ... commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under ... range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules ...

Amicus Therapeutics Announces Positive Progress of Three Lead Clinical Programs and General Outlook for 2009

... and the growing breadth of our pharmacological chaperone technology platform, we feel this progress sets ... for Pompe patients who are not amenable to chaperone monotherapy. Amicus expects to announce ... range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules ...

Amicus Therapeutics Announces Second Quarter 2008 Financial Results

... is the third product from our pharmacological chaperone platform to enter Phase 2 development. We also ... combination treatment in Pompe patients. Other chaperone Programs: Amicus is accelerating its investment ... range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules ...

Amicus Therapeutics Presents Data from Clinical Ex Vivo Response Study and Phase 1 Studies of AT2220

... Majority of Pompe Patients May Be Amenable to chaperone Therapy ... may be treatable with our pharmacological chaperone AT2220," said John F. Crowley, President and ... range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules ...

Amicus Therapeutics Suspends Enrollment for Phase 2 Clinical Trial of AT2220 for Pompe Disease

... Shire plc, to develop and commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under the agreement, Shire ... for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to ...

Amicus Therapeutics Begins Phase 2 Clinical Trial of AT2220 in Pompe Disease

... and Europe. AT2220 is the third compound based on Amicus' pharmacological chaperone technology platform to enter Phase 2 clinical development. "We look ... for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to ...

First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs

... the work shows for the first time how members of the hsp90 family of chaperone proteins can differ from each other, while still being part of the same ... GRP94's place in this family and has already stimulated interest in this chaperone as a drug target. This understanding would allow for the long-term ...

Amicus Therapeutics Announces Successful Completion of End of Phase 2 Meeting With FDA for Amigal in Fabry Disease

... developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and ...

Anavex presents neuroprotective effects of Anavex 1-41 at the International Conference on Alzheimer's Disease 2008

... protect nerve cells from death." The Anavex Life Sciences presentation is entitled: "Neuroprotective effects of activators/agonists of the sigma-1 chaperone protein against amyloid toxicity in a mouse mode". The authors are: Tanguy Maurice (1), Vanessa Villard (1), Johann Meaner (1), Emetine Keller (1), ...
Chaperone in Biological News

Protein handlers should be effective treatment target for cancer and Alzheimer's

... Mivechi, director of the MCG Center for Molecular chaperone Biology/Radiobiology and Cancer Virology. ... know whether ramping up the activity of molecular chaperone can essentially make them act young again and ... example, when they remove a specific molecular chaperone they find Alzheimer's-like disease accelerates ...

In scientific first, Einstein researchers correct decline in organ function associated with old age

... proteins. After finding such a protein, the chaperone ferries it towards one of the cell's many ... membrane-bound sacs filled with enzymes. When the chaperone and its cargo "dock" on a receptor molecule on ... In previous work, Dr. Cuervo found that the chaperone surveillance system, in particular, becomes less ...

Biophysical Society announces new and notable symposium speakers

... Speakers and Information: The Effect of chaperone SecB on MBP Folding: A Single-molecule Study. ... the first experimental study to show how a chaperone affects a protein folding pathway. The chaperone was shown to interfere specifically with some ...

Sidestepping cancer's chaperone

... of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 chaperone Network, published in the October 19 issue of Cell, Dario C. Altieri, MD, ... this has not been well understood. And although inhibitors of a specific chaperone known as heat shock protein 90 (Hsp90) have been studied for the treatment ...

First high-res 3D structures of mammalian HSP90 protein solved

... the work shows for the first time how members of the hsp90 family of chaperone proteins can differ from each other, while still being part of the same ... GRP94s place in this family and has already stimulated interest in this chaperone as a drug target. This understanding would allow for the long-term ...

NIH awards researcher $1.5 million 'new innovator' grant for fruit-fly studies of prion proteins

... the protective effects in flies, mammalian cells and mice of so-called chaperone proteins, which work to make sure that other proteins take on their proper ... intend to use their flies to determine whether other possibly protective chaperone proteins work as well. Next, theyll check any promising leads with ...

New study reveals the protein that makes phosphate chains in yeast

... in yeast a protein called Vtc4p is responsible for the production of polyphosphates. Vtc4p is part of a protein complex called vacuolar transporter chaperone complex (VTC) that is usually found in the membranes of vacuoles pouches in which cells store molecules for later use, transport or destruction. ...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

... and researchers," said Katie Hood, CEO of The Michael J. Fox Foundation. "But to attract an industry sponsor with the resources and expertise to chaperone it through optimization, preclinical work and ultimately clinical testing, that target needs a critical mass of evidence behind it, demonstrating ...

Researchers reveal insights into hidden world of protein folding

... all proteins have to be folded-some in complex configurations-in order to function properly, and many are known to require a molecule called a chaperone to fold them. Frydman estimates that perhaps 10 percent of the proteins needing chaperones must have one that, like TRiC, is part of the subset ...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

... Disease. That link is Protein Disulphide Isomerase (PDI), a chaperone protein that is necessary for proper protein folding in times of cellular ... accumulation of misfolded proteins due to cellular stress. PDI acts as a chaperone for aggregated proteins, rearranging their chemical bonds and thus ...

More>>

Chaperone in Biological Technology

Amicus Therapeutics Announces Second Quarter 2009 Financial Results

... the remainder of 2009. Preclinical chaperone Programs Amicus continues to invest in ... assess the potential for applying its versatile chaperone technology platform to the treatment of a broad ... develop Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders: ...

Publication of Shire plc's Annual Report 2008

... and preclinical studies. Pharmacological chaperone Technology In November 2007 Shire entered ... administered, small molecule pharmacological chaperone being jointly developed for the treatment of ... PLICERA and AT-2220, three pharmacological chaperone compounds for lysosomal storage disorders in ...

Amicus Therapeutics Announces Fourth Quarter and Full Year 2008 Financial Results

... for Pompe patients who are not amenable to chaperone monotherapy. Amicus expects to discuss additional ... conferences during 2009. Preclinical chaperone Programs Amicus continues to invest in ... assess the potential for applying its versatile chaperone technology platform to the treatment of a broader ...

Amicus Therapeutics Announces First Quarter 2008 Financial Results

... that treatment with our oral pharmacological chaperone drug candidates has the potential to benefit ... areas for applying our pharmacological chaperone technology platform." Program Advancements ... (ERT) with imiglucerase to the pharmacological chaperone Plicera. Results showed that Plicera was ...

Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements

... and development investment in pharmacological chaperone platform planned for targets beyond lysosomal ... Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Shire ... Cerezyme(R) (imiglucerase) to the pharmacological chaperone Plicera(TM). Thirty patients were enrolled ...

Amicus Therapeutics Presents Positive Results From Phase 2 Extension Study of Amigal(TM) for Fabry Disease at ACMG 2009 Annual Meeting

... Shire plc, to develop and commercialize Amicus' three lead pharmacological chaperone compounds for lysosomal storage disorders. Under the agreement, Shire ... for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to ...

Amicus Therapeutics Adds Sol J. Barer, Ph.D. to Board of Directors

... stated, "2009 will be an important year for the Company as we leverage our chaperone technology and continue to advance our three lead drug candidates for ... for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to ...

Amicus Therapeutics Announces Third Quarter 2008 Financial Results

... trial of the AT2220-ERT combination treatment in Pompe patients. Other chaperone Programs: Amicus continues to invest in research and development to ... for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to ...

Amicus Therapeutics Opens Research Facility in San Diego

... "The focus of our research efforts in San Diego will be to assess new chaperone applications in diseases with high unmet medical needs and larger patient ... for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to ...

Amicus Therapeutics Announces Positive Results From Phase 2 Clinical Trials of Amigal(TM) for Fabry Disease

... results represent an important proof of concept for the pharmacological chaperone platform technology," said John F. Crowley, President and CEO of Amicus ... for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to ...
Chaperone in Biological Definition

Signal transduction

... together in a complex called aporeceptor complex , which also contains chaperone proteins (also known as heatshock proteins or Hsp s). The Hsp s are ... These receptors are located in the nucleus and are not accompanied by chaperone proteins . In the absence of hormone, they bind to their specific DNA ...
Chaperone in Biological Dictionary

Chaperone Proteins

... are performing their normal ... chaperone ( protein ), a protein that assists the non-covalent folding/unfolding ... chaperone , a small molecule which stabilizes the correct folding of a protein ... The major chaperone classes are 40-kDa heat shock protein (HSP40; ...

Chaperone protein

... are performing their normal ... chaperone ( protein ), a protein that assists the non-covalent folding/unfolding ... chaperone , a small molecule which stabilizes the ... protein ... Protein -folding Diseases and chaperone Biology ... length of the polyglutamine ...

Ribosomal RNA

... of a ribosomal RNA operon from Escherichia coli. ... Nearly a third of the 34 large ribosomal subunit proteins displayed RNA chaperone activity. ... wind their way through ribosomal RNA , acting to cement together ... ... and LSU (large subunit) ribosomal RNA sequences. ... ...

Metaphase

... click the image. • The centrosomes are at opposite poles of the cell. ... Separase is kept inactive until late metaphase by an inhibitory chaperone called securin. ... In plant cells, a cell plate forms where the metaphase plate had been. ... ...
Other Contents
(Date:8/20/2014)... York, New York (PRWEB) August 20, 2014 ... with the use of power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) ... LLP notes that two U.S. Senators from New York ... to seek a recall of the devices. In a ... Schumer, both Democrats, also implored the agency to seriously ...
(Date:8/20/2014)... contrast to evidence that the amygdala stimulates stress ... Research Center, Emory University have found that the ... during the early development of nonhuman primates. , ... Journal of Neuroscience . , The amygdala is ... important for responses to threatening situations and learning ...
(Date:8/20/2014)... Reinberg HealthDay Reporter TUESDAY, ... that dismantles a baby,s immune system is twice as common ... million infants says. This is the first evaluation of ... condition known as severe combined immunodeficiency (SCID), or "Bubble Boy" ... this condition by the boy in the bubble, who was ...
(Date:8/20/2014)... Santa Rosa, CA (PRWEB) August 20, 2014 ... is the 12 per diode panel band perfect spectrum that ... plants are most likely to use during photosynthesis. A ... spectral bands is that they almost exclusively reside between 440-480 ... 620-680 on the red side of the spectrum. The KIND ...
(Date:8/20/2014)... 2014 Braverman Eye Center is now ... their experienced surgeons trained in PresbyLasik. The Braverman Eye ... lost or inaccurate vision. Their diligent service and adoption ... making it possible for Presbyopia patients to have better ... in people in the age group of 40 to ...
Breaking Medicine News(10 mins):Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Maturing brain flips function of amygdala in regulating stress hormones 2Health News:Maturing brain flips function of amygdala in regulating stress hormones 3Health News:'Bubble Boy' Disease May Be More Common Than Thought 2Health News:'Bubble Boy' Disease May Be More Common Than Thought 3Health News:Cheap LED Grow Lights Are Quickly Being Replaced by Premium Grow Lights 2Health News:Braverman Eye Center Now Offers Multifocal PresbyLasik in Florida by Trained Surgeons 2
(Date:8/20/2014)... When are athletes who have suffered concussions ready to ... has found that high school athletes who head back ... experience a significant regression in their abilities to simultaneously ... as seen in changes in their balance and/or altered ... Ten of the 12 had returned to activity in ...
(Date:8/20/2014)... rugs and plastic bags could one day be made ... petroleum, scientists are now reporting. The novel process they ... deal with its agricultural and plastic waste problems, appear ... Athanassiou, Ilker S. Bayer and colleagues at the Italian ... constantly growing. In 2012, its production reached 288 million ...
(Date:8/20/2014)... Carolina State University researchers have developed methods for electronically ... the electrical signals moths use to control those muscles. ... remotely-controlled moths, or "biobots," for use in emergency response. ... whether we can control the movement of moths for ... says Dr. Alper Bozkurt, an assistant professor of electrical ...
Breaking Biology News(10 mins):Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3Research paves way for development of cyborg moth 'biobots' 2
Other TagsOther Tags