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Catabolism in Medical News

JCI online early table of contents: May 1, 2009

... defects in PP2Cm may be responsible for some cases of MSUD. TITLE: Protein phosphatase 2Cm is a critical regulator of branched chain-amino acid catabolism in mice and cultured cells AUTHOR CONTACT: Yibin Wang David Geffen School of Medicine, University of California, at Los Angeles, Los Angeles, ...

Tools for more accurate dosage of drugs against HIV/AIDS and malaria

... loose its effectiveness for an individual patient, and explain why", says Daniel Rshammar. Further work involved using a model to describe how the catabolism of the anti-malarial drug artemisinin increases and the concentration of the drug decreases when patients take this drug. When artemisinin was given ...

GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.

... of MEVACOR may involve both reduction of VLDL-C concentration, and induction of the LDL receptor, leading to reduced production and/or increased catabolism of LDL-C. Apolipoprotein B also falls substantially during treatment with MEVACOR. Since each LDL particle contains one molecule of apolipoprotein B, ...

Intake of Polyphenol Speeds Up Fatty Acid Catabolism

... a polyphenol that is highly abundant in the human diet, such as onions, apples and tea. Boer found that lung cells had a greater fatty acid catabolism if the rats constantly received quercetin in their feed. The energy-sensing protein SIRT1 is an important regulatory protein that can prolong ...
Catabolism in Medical Technology

Cytochroma Reports Positive Phase I Clinical Data for CTA018 Injection

... be both a strong activator of the Vitamin D signaling pathway and a potent inhibitor of CYP24, the intracellular enzyme responsible for normal catabolism of Vitamin D hormones. Based on its mechanism of action, CTA018 is expected to be effective in treating secondary hyperparathyroidism but safer than ...
Catabolism in Biological News

American Society for Microbiology honors Katharine R. Clapham

... an International Scholar of the Howard Hughes Medical Institute, in Rosario, Argentina, where she carried out research on genes involved in lipid catabolism during sporulation in B. subtilis. This research was funded by the Herchel Smith Harvard Summer Undergraduate Research Fellowship. In 2007, Ms. ...

New chimeric mouse model for human liver diseases, drug testing

... murine model for hereditary tyrosinaemia type I, developed by researchers at Oregon Healthy & Science University. An enzymatic defect in the tyrosine catabolism results in a toxic accumulation of byproducts within hepatocytes unless the mice are treated with a drug called NBTC. Withdrawing the drug allows ...

New player in commitment to life as a fat cell

... said Iphigenia Tzameli of Harvard Medical School, one of the study's first authors. "This enzyme was originally known in association with the catabolism of purines into uric acid, the production of reactive oxygen species, and its involvement in gout. It has never been looked at in the context of fat ...

Gene linked to rare disease activates fat breakdown

... (ATGL) up to 20-fold. "We knew that the enzyme responsible for CDS must be very important for fat breakdown, but its involvement in neutral lipid catabolism remained unexplained," Zechner said. "The discovery that CGI-58 acts as a very potent activator offers a new picture of how stored fat is broken down ...
Catabolism in Biological Technology

PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice

... adenosine has been termed a "retaliatory metabolite" that targets multiple pathways of cellular stress and myocardial injury to counter net ATP catabolism and, as such, acts as a key regulator of cellular energetics. Endogenous adenosine protects cells from multiple pathways of injury such as ...

ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems

... are an organism's low-molecular-weight molecules (e.g., amino acids, peptides, lipids, carbohydrates) -- biochemical byproducts that result from catabolism (breakdown), anabolism (build up), and from gut fauna and flora. By understanding and detecting metabolic differences between normal and diseased ...

Cytochroma and Mitsubishi Tanabe form partnership for chronic kidney disease therapies in U.S. and Asia

... designed to be a strong activator of the vitamin D signaling pathway as well as a potent inhibitor of CYP24, the intracellular enzyme responsible for catabolism of vitamin D hormones. Based on its mechanism of action, CTA018 is expected to be more effective in treating SHPT and safer than currently available ...

Glossary for The BioPharm Guide to Fermentation and Cell Culture

... and so on. cascade effects A series of events that result from one initial cause. catabolites Waste products of catabolism , by which organisms convert substances into excreted compounds. cell culture Cells taken from a living organism and grown under ...
Catabolism in Biological Definition

Carbohydrate

... and Polysaccharides 5 Nutrition 6 catabolism 7 See also 8 External links ... groups need to be removed from the blood. catabolism There are three metabolic pathways of carbohydrate catabolism : glycolysis citric acid cycle ...

Cell metabolism

... such a creating cellular structure; and catabolism , in which a cell breaks down complex molecules ... 1 Anabolism 2 catabolism 2.1 Carbohydrate catabolism 2.2 ...

Citric acid cycle

... pathways that are involved in fuel molecule catabolism and ATP production. The citric acid cycle ... cytoplasm in prokaryotes . Fuel molecule catabolism (including glycolysis ) produces acetyl-CoA , ... acid cycle is the second step in carbohydrate catabolism (the breakdown of sugars). Glycolysis breaks ...

Citric acid cycle

... pathways that are involved in fuel molecule catabolism and ATP production. The citric acid cycle ... cytoplasm in prokaryotes . Fuel molecule catabolism (including glycolysis ) produces acetyl-CoA , ... acid cycle is the second step in carbohydrate catabolism (the breakdown of sugars). Glycolysis breaks ...

Metabolism

... molecules ( anabolism ) and their breakdown ( catabolism ). Metabolism usually consists of sequences of ... pathways 1.1 General pathways 1.2 catabolism 1.3 Anabolism 1.4 Drug metabolism 1.5 ... (Krebs cycle, tricarboxylic acid cycle) catabolism Catabolic pathways that breakdown complex ...

Cellular respiration

... per molecule of glucose (compare to the approximately 38 of aerobic respiration). See also Citric acid cycle Carbohydrate catabolism External links A detailed diagram of glycolysis ...

Glycolysis

... Glycolysis is the initial metabolic pathway of carbohydrate catabolism . The most common and well-known form of glycolysis is the Embden - Meyerhof pathway. The term can be taken to include alternative pathways, such ...

Phosphorylation

... expense of solar energy by photophosphorylation in the chloroplasts of plant cells. Phosphorylation of sugars is often the stage of their catabolism . It allows cells to accumulate sugars because the phosphate group prevents the molecules from diffusing back across their transporter. ...

Protein

... every function performed by a cell, including regulation of cellular functions such as signal transduction and metabolism . For example, protein catabolism requires only a few enzymes termed proteases . Mechanisms of protein regulation Various molecules and ions are able to bind to specific ...

Thermoregulation

... of oxidationundergone not by any particular substance or in any one place, but by the tissues at large. Wherever destructive metabolism ( catabolism ) is going on, heat is being set free. When a muscle does work it also gives rise to heat, and if this is estimated it can be shown that the muscles ...

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Catabolism in Biological Dictionary

Catabolism

... catabolism is the set of metabolic pathways that break down ... into smaller units and release energy. In catabolism , large molecules such as polysaccharides, ... such as monosaccharides, ... Protein catabolism is the breakdown of proteins into amino acids ...

Proteolysis

... enzymes called proteases or by intramolecular digestion. A protease is any enzyme that conducts proteolysis , that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in the polypeptide chain, which form a molecule of protein. In other ...

Anabolism

... Anabolism . Gluconeogenesis · Glycogenesis · Photosynthesis (Carbon fixation) ... Anabolism is the building up of complex molecules, while catabolism is their breakdown. ... When anabolism exceeds catabolism, net growth occurs. ... Information about anabolism in the free online English ...

Adenine

... adenosine. ... Best ADENINE links & users bookmarks collection on www.supanova.com.au domain! ... Management of adenine nucleotide catabolism differs among skeletal muscle ... Purine bases are Adenine , Guanine and Hypoxanthine (examples of purine ... Adenine : a pyrimidine ...

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