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Caspase in Medical News

Common anesthetic induces Alzheimer's-associated changes in mouse brains

... increased activation of the cell-death protein caspase and raised levels of BACE and gamma-secretase as ... of control mice. Results at 6 hours showed that caspase levels were elevated and BACE had modestly ... that received isoflurane. At 12 hours moderate caspase activation persisted, and BACE levels were even ...

Loss of gene leads to protein splicing and buildup of toxic proteins in neurons

... discovered that this cleavage depends on the caspase 3 enzyme. Caspases cut other proteins and thus ... die when it needs to. It makes sense that these caspase might be activated when progranulin is mutated, ... mutations in progranulin leads to an increase in caspase activity, he says. Progranulin could be acting a ...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

... Bogyo said. Moreover, he said, new-generation drugs, some of them now in clinical trials, are designed specifically to turn on caspases. Because caspase activation is a very early event in apoptosis, monitoring it could speed clinicians' ability to determine whether, how and when these new drugs work, ...

Clinical study shows biological and clinical activity in relapsed leukemia patients

... Professor of the Institute of Cell and Molecular Science at Barts and The London School of Medicine, today presented in an oral session "Clinical caspase Activation in CLL by GCS-100: a Phase 2 Study" at the 10th International Conference on Malignant Lymphoma (10-ICML). The promising interim results ...

Human C-reactive protein regulates myeloma tumor cell growth and survival

... They demonstrated that CRP enhanced secretion of IL-6; binds activating Fcg receptors; activates PI3K/Akt, ERK, and NF-kB pathways; and inhibits caspase cascade activation induced by chemotherapy drugs. Further, CRP was shown to synergize with IL-6 in protecting myeloma cells from apoptosis. These ...

Leading Biotech Companies Are Interested In Acquisition Of Smaller Companies

... reasons behind acquisition of Idun Pharmaceuticals, in the development of caspase modulators, which are proteins involved in apoptosis but that remains ... a drug target. Pfizer says that it can quickly develop the potential for caspase targeting compounds, which Idun is developing for broad range of disorders ...

EpiCept Accelerates Development of Phase I Clinical Study for Cancer

... Moores Cancer Center, San Diego. EPC2407 belongs to a novel class of microtubulin inhibitors discovered by EpiCept. These compounds cause caspase activation, cell cycle arrest, and apoptotic death in cancer cells. The Phase I trial of EPC2407 is now being conducted in three U.S. cancer ...

Cells Re-Energize to Come Back From the Brink of Death

... One of the requirements for apoptosis is activation of an enzyme called caspase. The St. Jude team discovered that a cell that lacks caspase activation and cannot undergo apoptosis increases the levels of an enzyme called GAPDH in order to counteract the backup program called ...

Breakthrough In The Identity Of Compounds That Encourage Stem Cell Growth

... up-regulated several molecules involved in cell cycling and growth, such as cyclins and epidermal growth factor receptor, and decreased those such as caspase 8 which play a role in apoptosis. LXA4 had the opposite effects. Source-Eurekalert VIK ...
Caspase in Medical Technology

European Commission Approves ATRIPLA(R) (efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg), the First Once-Daily Single Tablet Regimen for Virologically Suppressed Adults With HIV-1 Infection

... million to $520 million provided on Nov. 6, 2007, which includes the up front licensing payment related to LG Life Sciences collaboration for the caspase inhibitor. Important Product Safety Information (including Boxed WARNINGS) About ATRIPLA (efavirenz 600 mg/emtricitabine 200 mg/tenofovir ...

Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR

... exposure to NEIs causes an increase in multiple markers of apoptosis including plasma membrane alterations (Annexin V binding) and caspase activation in cancer cells. NEI treatment induces cell cycle arrest, but not apoptosis, in normal cells. NEIs show potent activity as ...

Mode of Action of EpiCept-Licensed Cancer Compound Profiled at AACR

... agents. This screening technology is particularly versatile and can be adapted for almost any cell type that can be cultured, as well as measure caspase activation inside multiple cell types (e.g., cancer cells, immune cells, or cell lines from different organ systems or genetically engineered cells). ...

New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines

... agents. This screening technology is particularly versatile and can be adapted for almost any cell type that can be cultured, as well as measure caspase activation inside multiple cell types (e.g., cancer cells, immune cells, or cell lines from different organ systems or genetically engineered cells). ...
Caspase in Biological News

News tips from the Journal of Neuroscience

... cell deathcould prevent neurodegeneration, Thompson and Brenowitz infused caspase inhibitors unilaterally into HVC, a song nucleus of white-crowned ... on the infused side. These results indicate that sustained infusion of caspase inhibitors can protect telencephalic neurons from programmed cell death, ...

Cells re-energize to come back from the brink of death

... but if apoptosis fails because there is no caspase available, the backup program called ... has shown that cells that become cancerous lack caspase and other proteins needed to support apoptosis ... only dodge death from apoptosis by eliminating caspase activation, but they also foil CIDC. “Our study ...

Harvard scientists identify compounds that stimulate stem cell growth in the brain

... up-regulated several molecules involved in cell cycling and growth, such as cyclins and epidermal growth factor receptor, and decreased those such as caspase 8 which play a role in apoptosis. LXA4 had the opposite effects. ...
Caspase in Biological Technology

OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009

... of a family of compounds known as caspase activators presently in preclinical research. As the caspase family of proteases plays essential roles in apoptosis, the caspase activators offer the potential for the ...

OncoGenex Reports Third Quarter Financial Results

... of a family of compounds known as caspase activators presently in preclinical research. As the caspase family of proteases plays essential roles in apoptosis, the caspase activators offer the potential for the ...

Sonus Pharmaceuticals and OncoGenex Technologies complete business combination; OncoGenex Pharmaceuticals to commence trading on NASDAQ Capital Market today

... the maximum tolerated dose; - CSP-9222 is a caspase activator presently in pre-clinical development. caspase activators consist of small molecules that have ... development within 12-18 months. The caspase program was in-licensed in August 2008 ...

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

... is thought to mimic the activity of Smac (second mitochondria-derived activator of caspases) by binding to XIAP and preventing it from inhibiting caspase activation. Upon binding, AT-406 induces rapid degradation of cIAP-1/2 proteins and promotes apoptosis through activation of caspase-8 and the ...

Promegas Multiplexed Cell Viability and Apoptosis Assays performed on the PHERAstar

... Correlated measurement of an apoptosis marker (or caspase activity) and cell viability ... Promega Apo-ONE Homogeneous caspase 3/7 Assay, catalog no. G7790 ... of 590 nm with the PHERAstar. The caspase reagents were then added to the plates with the ...

Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35)

... Purification and catalytic properties of human caspase family members. Cell Death and Differentiation ... Kaufmann and W.C. Earnshaw. 1997. Caspases and caspase inhibitors. Trends Biochem. Sci. 22: 388393. ... 1997. Fluorometric and colorimetric detection of caspase activity associated with apoptosis. Anal. ...

Use of the HitHunter EFC Chemiluminescent Detection Kits with LEADseeker Multimodality Imaging System

... the LEADseeker Multimodality Imaging System. The caspase 3 and p38 MAPK binding assay kits were used as ... 18-1140-71

HitHunter caspase 3 EFC Chemiluminescent 90-0028-02 ... by the kit manufacturer.

1.2 Prepare caspase 3 enzyme standard curve working dilutions in ...

Translate High Yields of Biologically Active Proteins

... and incubated for 1 hr at 37C. Two proteins, caspase 3 and MAPKinase 9, were synthesized in ... ActivePro Scale-Up Reactions. caspase 3 and MAPKinase9 DNA templates were ... 1 (AK1), carbonic anhydrase 2 (CA2), caspase 3 (CASP3), and casein kinase 1 (CK1). ...

Recommendations for Successful siRNA Library Screens

... five different siRNAs found to block caspase 3 activation (a marker for apoptosis) in a ... cells were lysed and monitored for caspase 3 activity. Results for each well are graphed relative to the average caspase 3 activity from a negative control ...

Are siRNA Pools Smart?

... using etoposide one day after transfection, and caspase 3 activity was assayed three days ... here to enlarge] Figure 4. caspase 3 Activation--Single siRNAs vs. siRNA ... the cells were counted and lysed. The caspase 3 activity in the lysates was assayed ...

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Caspase in Biological Products

FAM Poly Caspase Assay Kit from B-Bridge International

Description:... fluoromethyl ketone (FMK), a potent inhibitor of caspase activity. When added to a population of cells, ... that resides on the large subunit of the active caspase heterodimer, thereby inhibiting further enzymatic ... is a direct measure of the number of active caspase enzymes that were present in the cell at the time ...
Company:B-Bridge International

CaspaTag™ Pan-Caspase In Situ Assay Kit, Fluorescein from CHEMICON

Description:... CHEMICON®s CaspaTag™ In Situ caspase Detection Kits use a novel approach to detect ... fluoromethyl ketone peptide inhibitor of caspase (FAM-VAD-FMK), which produces a green ... that resides on the large subunit of the active caspase heterodimer, thereby inhibiting further enzymatic ...
Company:CHEMICON

CaspaTag™ Pan-Caspase In Situ Assay Kit, Sulforhodamine from CHEMICON

Description:... fluoromethyl ketone peptide inhibitor of caspase (SR-VAD-FMK), which produces a red fluorescence. ... that resides on the large subunit of the active caspase heterodimer, thereby inhibiting further enzymatic ... is a direct measure of the amount of active caspase present in the cell at the time the reagent was ...
Company:CHEMICON

Caspase Inhibitor Ac-DEVD-CHO, Unconjugated from Promega

Description:... (DEVDase) activity. The concentration of inhibitor required to inhibit caspase activity must be determined empirically for each system. Ten micromolar inhibitor is sufficient to inhibit caspase activity in extracts of apoptotic THP-1 ....
Company:Promega

In Situ Pan-Caspase Assay Kit from CHEMICON

Description:... involved in upstream regulatory events (initiator caspases). An active caspase consists of two large and two small subunits that form two heterodimers ... can be detected via immunoprecipitation, immunoblotting techniques using caspase specific antibodies, or by employing fluorochrome substrates which become ...
Company:CHEMICON

In Situ Pan-Caspase Assay Kit, Sulforhodamine from CHEMICON

Description:... involved in upstream regulatory events (initiator caspases). An active caspase consists of two large and two small subunits that form two heterodimers ... can be detected via immunoprecipitation, immunoblotting techniques using caspase specific antibodies, or by employing fluorochrome substrates which become ...
Company:CHEMICON

Chaps Cell Extract Buffer (10X) from Cell Signaling Technology

Description:... Extract Buffer can be used to lyse cells under nondenaturing conditions and is recommendedfor the preparation of cell lysates to be used with our caspase signaling pathway ...
Company:Cell Signaling Technology

Rat Caspase-3 Active from BioVision

Description:... 1 unit is sufficient for 1 caspase activity ....
Company:BioVision

CaspSCREEN Caspase Screening Kit from BioVision

Description:... Detects caspase activation by flow ....
Company:BioVision

Smac/DIABLO, Human, Recombinant, E. coli from Calbiochem

Description:... ® sequence was expressed in and purified from E. coli . Smac/DIABLO is released along with cytochrome c during apoptosis and promotes caspase activation through the neutralization of IAPs, including XIAP (Cat. No. PF137). Biological activity: IC 50 ~500-1500 nM to reverse the inhibition of ...
Company:Calbiochem

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Caspase in Biological Definition

Apoptosis

... caspase-8 directly activates other members of the caspase family, and triggers the execution of apoptosis; ... membrane permeable for the release of caspase activators. Just how BAX and BAK are controlled ... domain. This results in the release of caspase activators, namely cytochrome c [11] , [12] ., ...
Caspase in Biological Dictionary

Caspase

... c and the Bcl-2 family) which activates caspase -9. ... An anti-apoptotic protein human survivin is a direct inhibitor of caspase -3 and -7" ... caspase -2 induces apoptosis by releasing proapoptotic ...

CAT assay

... dish. ... tube. 16. Store at -70 °C or proceed to CAT activity assay . ... Apoptosis can be mediated by mechanisms other than the traditional caspase ... Cathepsin Assay Kits. Cat . # Size. Price (USD) Data Sheet. Add to Cart ... ...
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